CN105232990A - Traditional Chinese medicine for treating BPH combined overactive bladder syndrome - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to traditional Chinese medicine for treating a BPH combined overactive bladder syndrome. The traditional Chinese medicine is prepared from, by weight, 4-8 parts of gentiana sarcorrhiza ling et ma, 4-8 parts of ficus erecta roots, 4-8 parts of leaf of manynerve bauhinia, 4-8 parts of cluster mallow, 4-8 parts of rhizome of david woodbetony, 4-8 parts of herminium monorchis, 4-8 parts of fruits of fiverleaf akebia, 4-8 parts of leaves of delavey greenleaf elaeagnus, 4-8 parts of bigbract bulbophyllum, 4-8 parts of stems of obheartleaf, 4-8 parts of polypodium vulgare and 4-8 parts of tips of licorice roots. The medicines are combined, and the effects of invigorating the spleen, supplementing Qi, enriching Yin, nourishing the kidney and eliminating dampness and heat are achieved.

Description

A kind of Chinese medicine for the treatment of BPH and merging overactive bladder

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of BPH and merging overactive bladder.

Background technology

The syndrome of overactive bladder to be a kind of with symptoms of urgency be feature, often with frequent micturition and nocturia, can to accompany or without urge incontinence; Urodynamics can show as overactive detrusor, also can be other forms of urethra-bladder function barrier.

Benign prostate hyperplasia (benignprostatichyperplasia, BPH) is one of modal urologic disease of male being greater than 40 years old the age, and its pathologic prostatic hyperplasia incidence rate of male that the age is greater than 80 years old reaches more than 90%.Its most basic pathological change is bladder outlet obstruction (BOO) and detrusor of bladder changing function.Wherein, the detrusor instability (di) (detrttsorinstability, DI) being secondary to BPH can cause the overactive bladders (overactivebladder, OAB) such as BPH frequent micturition, urgent micturition.The lower urinary tract symptom (1owerurinarytractsymptoms, LUTs) being secondary to BPH has a strong impact on patients ' life quality.Current BPH merges Drug therapy mainly conbined usage m receptor and the α receptor blocking agent of OAB, and its effective percentage is about 80%.But it is more to there is untoward reaction, the shortcoming such as to recur after drug withdrawal, if the adverse reaction rates such as xerostomia are more than 20%.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine for the treatment of BPH and merging overactive bladder.

The present invention is achieved through the following technical solutions:

Treat the Chinese medicine that BPH merges overactive bladder, be made up of the Chinese medicine of following weight portion:

Money ginseng 4-8 part, Radix Fici beecheyanae 4-8 part, Folium Bauhiniae pernervosae 4-8 part, Semen Abutili 4-8 part, Rhizoma Pedicularis Davidii 4-8 part, musk orchid 4-8 part, Fructus Akebiae 4-8 part, Folium Elaeagni delavayi 4-8 part, solely leaf rock pearl 4-8 part, Caulis Aspidopterydis obcordatae 4-8 part, adder's-fern 4-8 part, Radix Glycyrrhizae uralensis 4-8 part.

Preferably, above-mentioned treatment BPH merges the Chinese medicine of overactive bladder, is made up of the Chinese medicine of following weight portion:

Money ginseng 5-7 part, Radix Fici beecheyanae 5-7 part, Folium Bauhiniae pernervosae 5-7 part, Semen Abutili 5-7 part, Rhizoma Pedicularis Davidii 5-7 part, musk orchid 5-7 part, Fructus Akebiae 5-7 part, Folium Elaeagni delavayi 5-7 part, solely leaf rock pearl 5-7 part, Caulis Aspidopterydis obcordatae 5-7 part, adder's-fern 5-7 part, Radix Glycyrrhizae uralensis 5-7 part.

Preferred, above-mentioned treatment BPH merges the Chinese medicine of overactive bladder, is made up of the Chinese medicine of following weight portion:

Money join 6 parts, Radix Fici beecheyanae 6 parts, Folium Bauhiniae pernervosae 6 parts, Semen Abutili 6 parts, Rhizoma Pedicularis Davidii 6 parts, musk orchid 6 parts, Fructus Akebiae 6 parts, Folium Elaeagni delavayi 6 parts, solely 6 parts, leaf rock pearl, Caulis Aspidopterydis obcordatae 6 parts, adder's-fern 6 parts, Radix Glycyrrhizae uralensis 6 parts.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of BPH and merge overactive bladder.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine of the present invention,

Money ginseng another name Radix Gentianae sarcorrhizae, little Radix Gentianae sarcorrhizae, a ginseng, derive from Gentianaceae agueweed money ginseng GentianasarcorrhizaLingetMa, be used as medicine with herb or root.Sweet in the mouth, warm in nature.Function invigorating the spleen and benefiting QI, tonifying the kidney to consolidate the essence.For body is empty after being ill, infantile malnutrition, cough due to deficiency of the lung, seminal emission, the enuresis, deficiency-heat is not moved back, children's's chronic diarrhea.

Radix Fici beecheyanae another name hair Fructus Fici Beecheyanae root is moraceae plants Fructus Fici Beecheyanae FicuserectaThumb.var.beecheyana(Hook.etArn.) root of King [F.beecheyanaHook.etArn.].Sweet in the mouth; Pungent; Warm in nature.Return lung; Spleen; Kidney channel.Function replenishing QI to invigorate the spleen; Promoting blood circulation to remove obstruction in the collateral; Expelling wind and removing dampness.Main overstrain is weak; Lack of appetite; Agalactia; Insufficiency of the spleen leucorrhea; Proctoptosis; Menoxenia; Wind syndrome of head pain; Traumatic injury; Rheumatic arthralgia.

Folium Bauhiniae pernervosae another name Radix Rumicis Japonici wind, Ren sus domestica rattan, be pulse family bauhinia many arteries and veins Bauhinia purpurea BauhiniapernervosaL.Chen, be used as medicine with root and leaf.Sweet in the mouth, acid, micro-hardship, warm in nature.Function tonifying the kidney to consolidate the essence, cough-relieving, hemostasis.Root: seminal emission, the enuresis, cough, metrorrhagia.Leaf: proctoptosis, uterine prolapse.

Semen Abutili another name Folium Malvae, sliding dish, Herba Fici Simplicissimae, Herba Capsellae cake leaf, for Malvaceae plant Semen Abutili MalvaverticillataL. is used as medicine with root, stem, Ye Jizi (Fructus Malvae).Stem, leaf: sweet, cold.Root: sweet, temperature.Function stem, leaf: clearing away heat-damp and promoting diuresis; For icterohepatitis.Root: invigorating the spleen and replenishing QI; Weak for the deficiency of vital energy, soreness of the waist and knees, the empty spontaneous perspiration of body, proctoptosis, uterine prolapse, chronic nephritis, diabetes.

Rhizoma Pedicularis Davidii another name david woodbetony rhizome, black Radix Panacis Quinquefolii.For the rhizome of goatweed David Radix seu Herba Pedicularis, rough Radix seu Herba Pedicularis, Deng Shi Radix seu Herba Pedicularis, Radix seu Herba Pedicularis attractive in appearance etc.Sweet micro-hardship, temperature.Enriching yin and nourishing kidney, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach.Control physical weakness, osteopyrexia and fever of suffering from a deficiency of the kidney, arthralgia, anorexia.

Musk orchid another name Rhizoma Tupistrae Chinensis, Herba Herminii, derive from the orchid family Herminium plant musk orchid Herminiummonorchis(L.) R.Brown., is used as medicine with whole herb with root.Nature and flavor are sweet, temperature.Function enriching yin and nourishing kidney, nourishing the stomach, regulating menstruation.For neurasthenia, dizzy insomnia, irritated thirsty inappetence, early whitening of beard and hair, menoxenia.

Fructus Akebiae another name cattle kidney fruit, June melon, little eight melons, any melon, Testis et Pentis Canis, wooden Fructus Trichosanthis Cucumeroidis, August fruit, savage's melon, Ramulus seu Fructus Caesalpiniae fruit, the lazy bag of cattle really.For the fruit of plants of Lardizabalaceae tendencies rattan HolboelliafargesiiReaub., wide leaf Fructus Akebiae HolboellialatifoliaWall. and little Hua Fructus Akebiae Holboelliaparviflora (Hemsl.) Gagnep..Bitter in the mouth; Cool in nature.Return bladder; The heart; Liver Channel.Function clearing away heat-damp and promoting diuresis; Blood circulation and channel invigorating; Promoting the circulation of QI to relieve pain.Main oliguria with reddish urine; Stranguria with turbid discharge; Edema; Rheumatic arthralgia; Traumatic injury; Galactostasis; Colicky; Uterine prolapse; Orchitis.

Folium Elaeagni delavayi another name elaeagnus conferta fruits, Yang Leishu, Radix Rubi Parvifolii, sheep milk milk, little elaeagnus conferta fruits.For leaf and the root bark of Elaeangnaceae plant Folium Elaeagni delavayi ElaeagnusviridisServ.var.delavayiLecte..Sweet in the mouth; Acid; Light; Property is put down.Return lung; Kidney; Urinary bladder channel.Function clearing away heat-damp and promoting diuresis; Tonglin Paishi; Relieving cough and asthma.Main chronic nephritis; Renal calculus; Urinary tract infection; Icterohepatitis; Chronic bronchitis; Bronchial asthma; Stomachache.

Only leaf rock pearl another name Herba Bulbophylli radiati, Moghania fluminalis(C. B. Clarke) Li, Herba sagittariae pygmaeae are blue, are the herb of orchid tooth lobe Bulbophyllum BulbopyllumpsychoonReichb.f. [B.levineiSchltr.].Sweet in the mouth; Light; Cold in nature.Function nourishing YIN and clearing away heat; Removing toxic substances and promoting subsidence of swelling.Main yin asthenia generating intrinsic heat; Calentura is thirsty; Lung-heat cough with asthma; Laryngopharynx swelling and pain; Stomatitis; Rheumatic arthralgia; Traumatic injury; Acute mastitis; Furuncle swells.

Caulis Aspidopterydis obcordatae another name is shouted lid and is passed through, and is the rattan of the Malpighiaceae plant Caulis Aspidopterydis obcordatae of falling lobus cardiacus AspidopterysobcordataHemsl..Lightly seasoned; Puckery; Cold nature.Return urinary bladder channel.Function clearing away heat and promoting diuresis; Dispelling wind and removing obstruction in the collateral.Main pyretic stranguria; Stranguria caused by urinary stone; Beriberoid pyretic arthralgia.

Adder's-fern is the rhizome of Plants of Polypodiaceae adder's-fern PolypodiumvulgareL. and Rhizoma Polygoni vivipari PolypodiumvirginianumL. ［ P.vulgareL.var.virginianumA.Eaton ］.Bitter in the mouth; Sweet; Cold nature.Function clearing away heat-damp and promoting diuresis detoxifies.Main damp and hot stranguria; Beriberoid pyretic arthralgia; Furuncle carbuncle; Rubella pruritus; Traumatic injury.

Radix Glycyrrhizae uralensis is that the last ending of glycyrrhizic legume GlycyrrhizauralensisFisch. root is divided or radicula.Sweet in the mouth; Cold in nature.GUIXIN, liver, spleen channel.Function eliminating fire and detoxication; Inducing diuresis for treating stranguria syndrome.Main pyretic stranguria; Oliguria; Pain in penis; Accumulated heat in the heart.

Overactive bladder is equivalent to the category of the traditional Chinese medical science " stranguria ".The stranguria origin cause of formation has inside and outside dividing, and its basic pathogenesis is that damp-heat in lower-JIAO pents up, and disturbance in functioning of QI, sick position is at kidney and bladder.The kidney dominating water metabolism, the urinary bladder being the viscus likened to a pond, both common main channel, conditioning aqueous vapor all over the body.When damp-heat accumulation bladder, or prolonged illness causes visceral dysfunction, then kidney and functioning of bladder unfavorable and cause stranguria.Propose in " General Treatise on the Cause and Symptoms of Diseases " " Zhu Linzhe, by suffer from a deficiency of the kidney bladder heat thus also ", " then frequent micturition of suffering from a deficiency of the kidney, bladder heat is then excessive under water, several and excessive, drenches drop and does not declare ".Later age doctor using this by kidney asthenia as the principal aspect, bladder heat for mark is as the pathogenesis basis of diagnosis and treatment stranguria, no matter deficiency-heat or excess-heat, all needs to consider the impact of damp-heat in the urinary bladder in prognosis of disease when treatment stranguria.The category that during prostatic hyperplasia belongs to, " essence is infirmity " is sick, patient mostly is gerontal patient, and suffering from a deficiency of the kidney is the Etiological pathogenesis that it is fallen ill.Exterior and interior relation between kidney and bladder, the prosperity and decline of kidney qi, directly affects gasification and the folding of bladder.With the passing of time stranguria does not heal, and thermal burn is cloudy, and wet impairment of YANG, easily causes and suffer from a deficiency of the kidney; Suffer from a deficiency of the kidney with the passing of time, damp and hot foul evil poison easily invades bladder, causes the recurrent exerbation of stranguria.Therefore, suffer from a deficiency of the kidney and to have great importance in the generation of stranguria, development and change of pathogenesis with damp-heat in the urinary bladder.The many old peoples of benign prostatic hyperplasia patients, taste virtual loss, the foundation of acquired constitution virtual loss causes the congenital foundation not enough.Therefore, suffer from a deficiency of the kidney and to have great importance in the generation of stranguria, development and change of pathogenesis with damp-heat in the urinary bladder, deficiency of spleen and stomach.BPH merge overactive bladder differentiation of tcm should from suffering from a deficiency of the kidney, stagnation of QI due to depression of the liver stays and damp-heat in the urinary bladder opinion is controlled, treatment when with invigorating the spleen and benefiting QI, enriching yin and nourishing kidney, eliminating damp-heat.

In Chinese medicine of the present invention money ginseng, Radix Fici beecheyanae merit with invigorating the spleen and benefiting QI, Rhizoma Pedicularis Davidii, musk orchid merit with enriching yin and nourishing kidney for monarch drug.Semen Abutili merit is with invigorating the spleen and replenishing QI; Folium Bauhiniae pernervosae merit is with the kidney invigorating astringency inducing; Fructus Akebiae, Folium Elaeagni delavayi merit take eliminating damp-heat as ministerial drug.Only leaf rock pearl merit is with nourishing YIN and clearing away heat; Caulis Aspidopterydis obcordatae merit is with clear sharp damp-heat in the urinary bladder.Adder's-fern merit is detoxified with clearing away heat-damp and promoting diuresis.Radix Glycyrrhizae uralensis merit is with heat-clearing and toxic substances removing, and inducing diuresis for treating stranguria syndrome is adjuvant.We's compatibility is reasonable, and all medicines share plays invigorating the spleen and benefiting QI, enriching yin and nourishing kidney, the effect of eliminating damp-heat altogether.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Money ginseng 6g, Radix Fici beecheyanae 6g, Folium Bauhiniae pernervosae 6g, Semen Abutili 6g, Herba lathyri davidii 6g, thick leaf Radix Vladimiriae 6g, Rhizoma Pedicularis Davidii 6g, musk orchid 6g, Fructus Akebiae 6g, Folium Elaeagni delavayi 6g, solely leaf rock pearl 6g, Caulis Aspidopterydis obcordatae 6g, adder's-fern 6g, Radix Glycyrrhizae uralensis 6g.

Embodiment 2

Treat the Chinese medicine that BPH merges overactive bladder, each crude drug weight proportion is as follows:

Money ginseng 5g, Radix Fici beecheyanae 5g, Folium Bauhiniae pernervosae 5g, Semen Abutili 5g, Herba lathyri davidii 5g, thick leaf Radix Vladimiriae 5g, Rhizoma Pedicularis Davidii 5g, musk orchid 5g, Fructus Akebiae 5g, Folium Elaeagni delavayi 5g, solely leaf rock pearl 5g, Caulis Aspidopterydis obcordatae 5g, adder's-fern 5g, Radix Glycyrrhizae uralensis 5g.

Embodiment 3

Treat the Chinese medicine that BPH merges overactive bladder, each crude drug weight proportion is as follows:

Money ginseng 7g, Radix Fici beecheyanae 7g, Folium Bauhiniae pernervosae 7g, Semen Abutili 7g, Herba lathyri davidii 7g, thick leaf Radix Vladimiriae 7g, Rhizoma Pedicularis Davidii 7g, musk orchid 7g, Fructus Akebiae 7g, Folium Elaeagni delavayi 7g, solely leaf rock pearl 7g, Caulis Aspidopterydis obcordatae 7g, adder's-fern 7g, Radix Glycyrrhizae uralensis 7g.

Embodiment 4

Treat the Chinese medicine that BPH merges overactive bladder, each crude drug weight proportion is as follows:

Money ginseng 8g, Radix Fici beecheyanae 8g, Folium Bauhiniae pernervosae 8g, Semen Abutili 8g, Herba lathyri davidii 8g, thick leaf Radix Vladimiriae 8g, Rhizoma Pedicularis Davidii 8g, musk orchid 8g, Fructus Akebiae 8g, Folium Elaeagni delavayi 8g, solely leaf rock pearl 8g, Caulis Aspidopterydis obcordatae 8g, adder's-fern 8g, Radix Glycyrrhizae uralensis 8g.

Embodiment 5

Treat the Chinese medicine that BPH merges overactive bladder, each crude drug weight proportion is as follows:

Money ginseng 4g, Radix Fici beecheyanae 4g, Folium Bauhiniae pernervosae 4g, Semen Abutili 4g, Herba lathyri davidii 4g, thick leaf Radix Vladimiriae 4g, Rhizoma Pedicularis Davidii 4g, musk orchid 4g, Fructus Akebiae 4g, Folium Elaeagni delavayi 4g, solely leaf rock pearl 4g, Caulis Aspidopterydis obcordatae 4g, adder's-fern 4g, Radix Glycyrrhizae uralensis 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:

1 clinical data

1.1 physical data

BPH merges OAB patient 5O example, adopting computer random number method to be divided into can matched group, treatment group, and often organize 25 examples, the data such as two groups of ages, the course of disease, prostate volume, residual urine, PSA compare, no significant difference (P>0.05), in table 1.

1.2 selected exclusion standard 1. middle-aging males (50 ~ 85 years old); 2. the symptoms such as frequent micturition, urgent micturition, dysuria are had, international contest (IPSS) >=8 point; 3. B ultrasonic confirms that prostate increases, and prostate volume >30mL; 4. B ultrasonic confirms there is residual urine, and residual urine volume <100mL; 5. overactive bladder symptom score (OABSS) >=6 point.Exclusion standard: 1. prostate specific antigen (PSA) >4ng/mL; 2. previously the history of operation such as prostate, bladder is had; 3. suffer from bladder cancer, bladder or pelvic cavity and once had chemotherapy history person; 4. neurogenic bladder person; 5. urinary system infection person; 6. vesical calculus or urethral stricture person; 7. unconsciousness, can not know and express wish person.

2 Therapeutic Method

All patients stop using prostatic hyperplasia and overactive bladder medicine 2 weeks.I group gives doxazosin mesilate tablets (trade name: can how magnificent), 1 4mg, 1 time every night.Treatment group is take can on how magnificent basis, and add the Chinese medicine composition by the embodiment of the present invention 1, be decocted in water for oral dose, every day 1 dose, add water 1000ml, decocts and be condensed into 300-500ml, and points 2 times oral, each 1 time of morning and evening.Two groups of equal medications 3 months.

Observation index: when entering to organize and treatment 3 months after, adopt IPSS, OABSS, life quality scores (qualityoflife, QOL) evaluate patient situation respectively.

Statistical method: application SPSS17.0 software carries out statistical analysis, and measurement data all represents with (x ± s), and adopt paired t-test and two independent samples t test, P<0.05 is that difference has statistical significance.

3 therapeutic outcomes

This is organized in 50 examples and occurs slight dizzy 1 example, exits treatment, 1 example lost to follow-up, effective case 48 example of actual observation, treatment group and each 24 examples of matched group.

Before 3.1 liang of group treatment cross-reference PSS comparison therapy, two groups of contrast PSS compare, no significant difference (P>O.05); After treatment, comparatively the front two groups of contrast PSS differences for the treatment of have statistical significance (P<0.05); Compare between group after treatment, treatment group comparatively matched group obviously reduces (P<0.05).In table 1.

A table 1 liang group treatment cross-reference PSS compares (x ± s)

Group	n	Before treatment	After treatment
				Matched group	24	20.23±2.74	12.81±4.26*
Treatment group	24	19.55±2.65	9.52±3.31* △

Note: compared with before treatment, * P < O.05; Matched group compares, ^△p < O.05.

Before and after 3.2 liang of group treatments, OABSS compares

Treat front two groups of OABSS to compare, no significant difference (P>0.05); Comparatively treat front two groups of OABSS differences after treatment and have statistical significance (P<0.05); Compare between group after treatment, treatment group comparatively matched group obviously reduces (P<0.05).In table 2.

Before and after table 2 liang group treatment, OABSS compares (x ± s) point

Group	n	Before treatment	After treatment
				Matched group	24	12.03±0.87	8.36±0.64*
Treatment group	24	11.94±0.83	5.78±0.88* △

Note: compared with before treatment, * P < O.05; Matched group compares, ^△p < O.05.

Before and after 3.3 liang of group treatments, QOL compares

Treat front two groups of QOL to compare, no significant difference (P>0.05); Comparatively treat front two groups of QOL differences after treatment and have statistical significance (P<0.05); Compare between group after treatment, treatment group comparatively matched group obviously reduces (P<0.05).In table 3.

Before and after table 3 liang group treatment, QOL compares (x ± s) point

Group	n	Before treatment	After treatment
				Matched group	24	4.53±0.51	3.92±1.23*
Treatment group	24	4.72±0.46	2.67±0.72* △

Note: compared with before treatment, * P < O.05; Matched group compares, ^△p < O.05.

Claims (3)

1. treat the Chinese medicine that BPH merges overactive bladder, be made up of the Chinese medicine of following weight portion:

Money ginseng 4-8 part, Radix Fici beecheyanae 4-8 part, Folium Bauhiniae pernervosae 4-8 part, Semen Abutili 4-8 part, Rhizoma Pedicularis Davidii 4-8 part, musk orchid 4-8 part, Fructus Akebiae 4-8 part, Folium Elaeagni delavayi 4-8 part, solely leaf rock pearl 4-8 part, Caulis Aspidopterydis obcordatae 4-8 part, adder's-fern 4-8 part, Radix Glycyrrhizae uralensis 4-8 part.

2. treatment BPH according to claim 2 merges the Chinese medicine of overactive bladder, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Money ginseng 5-7 part, Radix Fici beecheyanae 5-7 part, Folium Bauhiniae pernervosae 5-7 part, Semen Abutili 5-7 part, Rhizoma Pedicularis Davidii 5-7 part, musk orchid 5-7 part, Fructus Akebiae 5-7 part, Folium Elaeagni delavayi 5-7 part, solely leaf rock pearl 5-7 part, Caulis Aspidopterydis obcordatae 5-7 part, adder's-fern 5-7 part, Radix Glycyrrhizae uralensis 5-7 part.

3. treatment BPH according to claim 2 merges the Chinese medicine of overactive bladder, it is characterized in that, is made up of the Chinese medicine of following weight portion:

Money join 6 parts, Radix Fici beecheyanae 6 parts, Folium Bauhiniae pernervosae 6 parts, Semen Abutili 6 parts, Rhizoma Pedicularis Davidii 6 parts, musk orchid 6 parts, Fructus Akebiae 6 parts, Folium Elaeagni delavayi 6 parts, solely 6 parts, leaf rock pearl, Caulis Aspidopterydis obcordatae 6 parts, adder's-fern 6 parts, Radix Glycyrrhizae uralensis 6 parts.