CN105232366B - A kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid and preparation method thereof - Google Patents
A kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid and preparation method thereof Download PDFInfo
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- 235000009814 Luffa aegyptiaca Nutrition 0.000 title claims abstract description 62
- 244000302544 Luffa aegyptiaca Species 0.000 title claims abstract description 61
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims abstract description 52
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 52
- 229940106189 ceramide Drugs 0.000 title claims abstract description 52
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 52
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims abstract description 52
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- 238000000605 extraction Methods 0.000 claims description 13
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
A kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid, a kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid mainly contain the components of following parts by weight：46 parts of konjak ceramide extract, 90 95 parts of sponge gourd water stoste, 0.5 1 parts of honeysuckle compound, ceramide content is 3 5% in the konjak ceramide extract, and the sponge gourd water is the liquid that the fresh sponge gourd ground rattan of segment flows out naturally.Preparation method is to mix konjak ceramide extract with sponge gourd water, honeysuckle compound, filtering, sterilization.The present invention has good moisturizing and nourishing, crease-resistant, anti-aging and antibacterial and anti-inflammation functions.
Description
Technical field
The present invention relates to a kind of cosmetic products, and in particular to a kind of crease-resistant skin care containing konjak ceramide and sponge gourd water
Product.
Background technology
For a long time, ceramide (Ceramide) is to be considered only as a kind of lipid components in normal bio membrane structure,
The outer layer of Lipid Bilayer Structure is distributed in, the rich content in axoneure especially brain cell, and in the hair of nerve cell
Educate, regenerate and mending course in have certain effect.The research in relation to intracellular signal transduction is then found in recent years, neural acyl
Amine plays important second messenger in the biological effect of the inductions such as cytokine profiles, vitamin D, Fas and CD28 ligands and makees
With, thus participate in cell growth, proliferation, differentiation, apoptosis and damage a variety of physiology and pathologic process.The science such as medicine and biology
The further research on boundary is it is also show that the structure and function of ceramide and skin also has extremely close relationship, and in skin
Reparation, anti-aging etc. plays an important role.Therefore, ceramide has been used for the development and production of cosmetics.China
A kind of konjaku moisturizing astringent and preparation method thereof disclosed in patent（CN201110215963.X）, mainly made of konjaku flour
Konjac glucomannan is made, and product has good moistening effect.
Sponge gourd（Scientific name：Luffa cylindrica）, Delta of the Pearl River sponge gourd refers in particular to octagonal melon, is originate in India one
Kind cucurbitaceous plant, also known as snake melon, are widely cultivated in East Asia Region.Herbaceous plant is climbed up by holding on to for Curcurbitaceae, sponge gourd root system is powerful.
Vines, five ribs, green, main stem and lateral bine growth are all in great numbers, stipes tool branch tendril, easily raw adventitious root.Have inside and outside China
Distribution and cultivation.Fruit is summer vegetable, and contained all kinds of nutrition are higher in melon food, contained saponins, sponge gourd bitter taste
The substances such as matter, lymphatic temperament, wood glue, citrulling, xylan and interferon have certain special role.It is not raw-eaten, also for
It is medicinal, there is the benefits of the benefits of refrigerant, diuresis, promoting blood circulation, promoting menstruation, removing toxic substances, also antiallergy, beauty.Utilize cosmetics made of sponge gourd
It has been appeared in the newspapers that, disclosed in Chinese patent " a kind of skincare lotion and preparation method thereof " (201310376168.8), contain silk
The following substance of melon extracting solution：Tea-seed oil, cucumber juicing, bletilla striata extract, synthesis saualane etc., safety mild with property
Property it is high, beauty and skin care is made to become safe and effective, the nutrition beneficial to human body such as trace element, glycoside, polysaccharide wherein in plant
Substance can make face become smooth delicacy with nourishes rough skin.
Cosmetics and skincare product containing konjaku and sponge gourd ingredient also has been reported that a kind of disclosed in Chinese patent application " konjaku is clean
The preparation method of face breast "（201210160044.1）, by purifying konjaku micropowder, sodium carboxymethylcellulose, distilled water, Fresh Cucumber Juice,
Sucus Luffae, vitamin E and pearl powder by slurrying, squeeze the juice, the techniques such as emulsify and be prepared, have clean, deoil, de-sludging, U.S.
In vain, despeckle, crease-resistant function.But existing konjaku or sponge gourd are both needed to add a variety of other Chinese herbal medicines or other for cosmetics
Plant extracts can be only achieved more satisfactory effect, and Rhizoma amorphophalli extract is mostly the mixed extracts such as konjac glucomannan, and more progress
Dilution processing, ceramide type content of material is impure, affect moistening effect.Sponge gourd water used also uses more to be diluted
Processing, affects crease-resistant and antibacterial anti-inflammatory function.
Invention content
The purpose of the present invention is to provide a kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid, with good moisturizing
Nourishing, skin wrinkle resisting anti-aging and antibacterial and anti-inflammation functions.
In order to achieve the above objectives, embodiment of the present invention is：A kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid, it is main
To contain the component of following parts by weight：4-6 parts of konjak ceramide extract, 90-95 parts of sponge gourd water stoste, honeysuckle compound
0.5-1 parts, ceramide content is 3-5% in the konjak ceramide extract, and the sponge gourd water is the fresh sponge gourd of segment
The liquid that upper rattan flows out naturally.
As an optimization, sodium carboxymethylcellulose 0.05-0.1 is also contained in konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid
Part.
The preparation method of the konjak ceramide extract includes the following steps：
（1）Konjaku flour is put into round-bottomed flask, adds in a concentration of 95% ethyl alcohol, solid-to-liquid ratio 1:10, on round-bottomed flask
Condenser pipe is connect, condensing reflux extracts 8h at 80 DEG C, and after extraction, centrifugation is filtered with filter paper, and with petroleum ether extraction three times,
Petroleum ether layer is taken to add in a small amount of petroleum ether after being evaporated in a rotary evaporator, pours into small burning after ultrasound on ultrasonic cleaner
Cup, solvent obtain the crude extract of konjak ceramide class substance after volatilizing naturally；
（2）The crude extract of konjak ceramide class substance is dissolved in petroleum ether, preliminary purification is carried out on silica gel column chromatography,
Column chromatography silica gel first activates 1h at 100 DEG C, after being cooled to room temperature, with petroleum ether upper prop, by the oil containing ceramide crude product
Ethereal solution is slowly loaded to column top, carries out gradient elution with the petroleum ether of different ratio and ethyl acetate mixed solvent respectively.
Single injected sampling 20mg/g media, flow velocity 2ml/min collect eluent, and volatilization removes solvent, and merging obtains ceramide extraction
Object.
Step（2）In, when carrying out gradient elution with petroleum ether and ethyl acetate mixed solvent, each petroleum ether and acetic acid second
Ester volume ratio is respectively 95：5,7：3,6:4.
The extracting method of the sponge gourd water stoste is to take the rattan cut-out of sponge gourd ground, and notch is inserted into container, is flowed naturally
The liquid gone out is sterilized through precipitation, filtering up to sponge gourd water stoste.Optimization, the sponge gourd rattan is does not have also before and after the Mid-autumn Festival
There is the sponge gourd rattan of knot sponge gourd.
The honeysuckle compound of the honeysuckle compound extraction by steam distillation.
The preparation method of the present invention is to mix konjak ceramide extract with sponge gourd water, honeysuckle compound, filtering,
Sterilization.
In the present invention, ceramide has hydrone ability of associating by force very much, it in cuticula by forming reticular structure
Moisture of skin is maintained, therefore, has and keeps moisture of skin effect；Skin is in aging course, and lipid synthesis declines, cuticula
Middle ceramide content is reduced.It can increase ceramide content in horny layer of epidermis using ceramide, skin can be improved and done
The situations such as dry, furfur, coarse；Ceramide can increase epidermal keratinocytes layer thickness simultaneously, improve skin moisture holding capacity, reduce wrinkle
Line enhances skin elasticity, delay skin aging.
In the present invention, in sponge gourd water stoste containing abundant sugar, plant mucilage, vitamin and minerals etc. effectively into
Point, cuticula normal moisture content can be maintained, slows down dehydration and extends aquation, the necessary moisture of skin can be supplemented, keep flesh
Skin water is tender, fine and smooth；This sponge gourd water contains a large amount of natural moisturizing factor, and not glutinous greasy moisturizing ingredient, which can effectively releive, tightens drying
Skin, face skin is made to keep moistening, high resilience, the colour of skin is beautiful, ruddy, clean, pale；Sponge gourd water can promote new old generation
It thanks, soft absorption old useless cutin, removes deep layer dirt, inhibit melanocyte generation, coarse skin wrinkly can be effectively improved
Skin replys skin young tender bright and clean, skin quality is enabled to become soft and moist glossy；Sponge gourd water has promoting blood circulation and removing obstruction in channels, heat-clearing moisturizing effect, often
Use blackhead, acne that can effectively dispel skin of face etc.；The aqueous sweet, warm of sponge gourd and adjustable face sebum secretion, to face
Skin has salubrious, convergence, calm, the function of balance.
Honeysuckle in the present invention has effects that clearing heat and detoxicating, clearing and activating the channels and collaterals.With the gold and silver of extraction by steam distillation
Extrait does not injure skin, and fragrance is soft, can take out stains, cleaning skin makes skin keep higher water content enhancing skin
Skin vigor has the function that delay skin aging.There is the effect of certain to seborrhea scytitis.
Above-mentioned active ingredient cooperation, makes the present invention that there is good moisturizing and nourishing, crease-resistant, anti-aging and antibacterial anti-inflammatory to make
With.
Specific embodiment
Embodiment 1：
A kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid, is configured by following methods：
（1）It weighs konjaku flour to be put into round-bottomed flask, according to 1:10 solid-to-liquid ratios add in 95% ethyl alcohol, are connect on round-bottomed flask
40cm condenser pipes, condensing reflux extraction 8h under the conditions of 80 DEG C.After extraction, centrifugation（4000 turns, 10min）It is filtered with filter paper,
And with certain volume petroleum ether extraction three times, petroleum ether layer is taken to add in a small amount of petroleum ether after being evaporated in a rotary evaporator, super
Small beaker, thick the proposing of solvent konjak ceramide class substance as required after volatilizing naturally are poured on sound wave washer after ultrasound
Object；
（2）The crude extract of konjak ceramide class substance is dissolved in the petroleum ether of certain volume, in the layer of the silica gel containing 20g
Preliminary purification is carried out on analysis column.Column chromatography silica gel first activates 1h at 100 DEG C.After being cooled to room temperature, with petroleum ether upper prop, silica gel exists
A period of time is balanced in petroleum ether.Petroleum ether solution containing ceramide crude product is slowly loaded to column top.Stone is used respectively
Oily ether：Ethyl acetate（95：5）, petroleum ether：Ethyl acetate（7：3）, petroleum ether：Ethyl acetate（6:4）Carry out gradient elution.One
Secondary sample introduction 20mg/g media, flow velocity 2ml/min.Eluent is collected, volatilization removes solvent, and merging obtains konjak ceramide extraction
Object；
（3）The Mid-autumn Festival front and rear sponge gourd rattan for tying sponge gourd not yet is taken, is cut off from 30 centimeters from the ground, notch is inserted into
In bottle, diel is placed, by gained liquid precipitation 1-5 hour, filtering, ultraviolet sterilization obtains sponge gourd water stoste, 0-4 DEG C of refrigeration guarantor
It deposits spare；
（4）Konjak ceramide extract 4g, sponge gourd water stoste 95g, honeysuckle compound 0.3g are taken, first by konjaku nerve
Amide adds distilled water to be configured to 5% aqueous solution, is then mixed with sponge gourd water stoste and honeysuckle compound, homogeneous, filtering, ultraviolet
Line is sterilized, pack.Honeysuckle compound is the honeysuckle compound of extraction by steam distillation.
Embodiment 2：
The step of embodiment 1（4）In, take konjak ceramide extract 6g, sponge gourd water stoste 95g, honeysuckle compound
0.3g, sodium carboxymethylcellulose 0.08g.First by konjak ceramide add distilled water be configured to 5% aqueous solution, then with silk
Melon water stoste, honeysuckle compound and sodium carboxymethylcellulose mixing, homogeneous, filtering, ultraviolet sterilization, pack.Its
Its method is same as Example 1.
Embodiment 3
The step of embodiment 1（4）In, take konjak ceramide extract 5g, sponge gourd water stoste 95g, honeysuckle compound
0.5g, sodium carboxymethylcellulose 0.1g.First by konjak ceramide add distilled water be configured to 5% aqueous solution, then with sponge gourd
Water stoste, honeysuckle compound and sodium carboxymethylcellulose mixing, homogeneous, filtering, ultraviolet sterilization, pack.It is other
Method is same as Example 1.
Embodiment 4：
The step of embodiment 1（4）In, take konjak ceramide extract 5g, sponge gourd water stoste 90g, honeysuckle compound
0.1g, sodium carboxymethylcellulose 0.05g.First by konjak ceramide add distilled water be configured to 5% aqueous solution, then with silk
Melon water stoste, honeysuckle compound and sodium carboxymethylcellulose mixing, homogeneous, filtering, ultraviolet sterilization, pack.Its
Its method is same as Example 1.
Claims (6)
1. a kind of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid, which is characterized in that mainly contain the component of following parts by weight：Evil spirit
4-6 parts of taro ceramide extract, 90-95 parts of sponge gourd water stoste, 0.5-1 parts of honeysuckle compound, sodium carboxymethylcellulose 0.05-
0.1 part, ceramide content is 3-5% in the konjak ceramide extract, the sponge gourd water be the fresh sponge gourd of segment on the ground
The liquid that rattan flows out naturally, the konjak ceramide extract are made of method comprising the following steps：
（1）Konjaku flour is put into round-bottomed flask, adds in a concentration of 95% ethyl alcohol, solid-to-liquid ratio 1:10, it connects on round-bottomed flask cold
Solidifying pipe, condensing reflux extracts 8h at 80 DEG C, and after extraction, centrifugation is filtered with filter paper, and with petroleum ether extraction three times, takes stone
Oily ether layer adds in a small amount of petroleum ether after being evaporated in a rotary evaporator, pour into small beaker after ultrasound on ultrasonic cleaner, molten
Agent obtains the crude extract of konjak ceramide class substance after volatilizing naturally；
（2）The crude extract of konjak ceramide class substance is dissolved in petroleum ether, preliminary purification, column layer are carried out on silica gel column chromatography
It analyses silica gel and 1h is first activated at 100 DEG C, it is with petroleum ether upper prop, the petroleum ether containing ceramide crude product is molten after being cooled to room temperature
Liquid is slowly loaded to column top, carries out gradient elution with the petroleum ether of different ratio and ethyl acetate mixed solvent respectively；Once
Sample introduction 20mg/g media, flow velocity 2ml/min collect eluent, and volatilization removes solvent, and merging obtains ceramide.
2. konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid according to claim 1, which is characterized in that step（2）In, it uses
When petroleum ether and ethyl acetate mixed solvent carry out gradient elution, each petroleum ether and ethyl acetate volume ratio are respectively 95：5,
7：3,6:4.
3. konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid according to claim 1, which is characterized in that the sponge gourd water is former
The extracting method of liquid is that the sponge gourd aerial stem of plant is taken to cut off, and notch is inserted into container, and the liquid flowed out naturally is killed through precipitation, filtering
Bacterium is up to sponge gourd water stoste.
4. konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid according to claim 1, which is characterized in that the sponge gourd rattan
For there are no the sponge gourd rattans of knot sponge gourd before and after the Mid-autumn Festival.
5. konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid according to claim 1, which is characterized in that the gold and silver fragrance of a flower
The honeysuckle compound of smart extraction by steam distillation.
6. a kind of preparation method of konjak ceramide sponge gourd water moisture-keeping crease-shedding liquid as described in claim 1, which is characterized in that
First by konjak ceramide add distilled water be configured to 5% aqueous solution, then with sponge gourd water stoste, honeysuckle compound and carboxylic first
Base sodium cellulosate mixes, homogeneous, filtering, ultraviolet sterilization.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102293723A (en) * | 2011-07-30 | 2011-12-28 | 福建农林大学 | Konjak moisture retention lotion and its preparation method |
| CN102351730A (en) * | 2011-10-22 | 2012-02-15 | 恩施清江生物工程有限公司 | Method for preparing ceramide from konjac fly powder |
| CN102657593A (en) * | 2012-05-22 | 2012-09-12 | 重庆市彭水县天娇农业开发有限公司 | Preparation method of konjak facial cleanser |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293723A (en) * | 2011-07-30 | 2011-12-28 | 福建农林大学 | Konjak moisture retention lotion and its preparation method |
| CN102351730A (en) * | 2011-10-22 | 2012-02-15 | 恩施清江生物工程有限公司 | Method for preparing ceramide from konjac fly powder |
| CN102657593A (en) * | 2012-05-22 | 2012-09-12 | 重庆市彭水县天娇农业开发有限公司 | Preparation method of konjak facial cleanser |
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