CN105232056A - Automated glucometer - Google Patents
Automated glucometer Download PDFInfo
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- CN105232056A CN105232056A CN201510747142.9A CN201510747142A CN105232056A CN 105232056 A CN105232056 A CN 105232056A CN 201510747142 A CN201510747142 A CN 201510747142A CN 105232056 A CN105232056 A CN 105232056A
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 220
- 239000008280 blood Substances 0.000 claims abstract description 145
- 210000004369 blood Anatomy 0.000 claims abstract description 145
- 102000004877 Insulin Human genes 0.000 claims abstract description 110
- 108090001061 Insulin Proteins 0.000 claims abstract description 110
- 229940125396 insulin Drugs 0.000 claims abstract description 110
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 82
- 239000008103 glucose Substances 0.000 claims abstract description 82
- 238000012360 testing method Methods 0.000 claims abstract description 30
- 238000002347 injection Methods 0.000 claims abstract description 7
- 239000007924 injection Substances 0.000 claims abstract description 7
- 238000004891 communication Methods 0.000 claims description 53
- 238000001514 detection method Methods 0.000 claims description 23
- 230000001225 therapeutic effect Effects 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 15
- 238000001802 infusion Methods 0.000 claims description 9
- 230000005540 biological transmission Effects 0.000 claims description 8
- 230000005856 abnormality Effects 0.000 claims description 6
- 238000010295 mobile communication Methods 0.000 claims description 6
- 229910001172 neodymium magnet Inorganic materials 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 5
- 238000010168 coupling process Methods 0.000 claims description 5
- 238000005859 coupling reaction Methods 0.000 claims description 5
- 208000013016 Hypoglycemia Diseases 0.000 claims description 4
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 3
- 238000010009 beating Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 210000004204 blood vessel Anatomy 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 3
- 230000003068 static effect Effects 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- 238000004804 winding Methods 0.000 claims description 3
- 230000002159 abnormal effect Effects 0.000 abstract 2
- 230000007246 mechanism Effects 0.000 description 9
- 239000000243 solution Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
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- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
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- 206010020772 Hypertension Diseases 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
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- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
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- 230000001631 hypertensive effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6815—Ear
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6825—Hand
- A61B5/6826—Finger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/74—Details of notification to user or communication with user or patient ; user input means
- A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention relates to an automated glucometer which comprises insulin driving equipment, an insulin pump, pulse testing equipment, blood glucose testing equipment and a Freescale IMX6 processor. The pulse testing equipment and the blood glucose testing equipment are used for extracting pulse data and blood glucose data of to-be-tested personnel respectively, the Freescale IMX6 processor is connected with the insulin driving equipment, the pulse testing equipment and the blood glucose testing equipment, whether an abnormal pulse recognition signal is sent is determined on the basis of the pulse data of the pulse testing equipment, and whether the insulin driving equipment is controlled to drive the insulin pump to inject insulin to the to-be-tested personnel is determined on the basis of the blood glucose data of the blood glucose testing equipment. According to the automated glucometer, whether the pulse information is abnormal can be automatically tested, and automated control over insulin injection can be also achieved.
Description
Technical field
The present invention relates to medical device fields, particularly relate to a kind of automatization blood glucose meter.
Background technology
Blood glucose, refers to glucose contained in blood.Postdigestive glucose enters blood by small intestinal, and is transported to each cell in body, is the main energy sources of cell.The blood sugar concentration of normal person is relatively stable, drops within a confirmable blood glucose range.
Blood glucose must keep certain level could maintain the needs of each Organ and tissue in body.Blood sugar concentration is general to be raised after one to two hours on the feed, and drops to minimum at breakfast.Blood sugar concentration imbalance can cause various diseases, the hyperglycemia that persistence blood sugar concentration is too high and too low hypoglycemia cause serious impact all can to people's health, and the Persistent hyperglycemia caused by many reasons will cause diabetes, this is also the most significant disease that blood sugar concentration is relevant.
There is the Medical Instruments that some detect blood glucose in prior art, but all there is following defect in these blood glucose meter: (1) detecting pattern is single, can only detect blood sugar concentration; (2) testing mechanism falls behind, and structural redundancy is too high, and precision can not meet the accuracy requirement increasingly increased; (3) control mechanism of blood sugar test and insulin supply is not had, cannot according to the supply parameter of the insulin of the blood sugar content self-adaptative adjustment tested personnel of tested human body, such as, feed speed, quantity delivered etc., also need manual observation blood sugar content, manual decision's insulin to supply parameter, automatization level falls behind; (4) wireless communication interface is deficient, the parameters relevant to blood glucose can not be fed back to medical server end in time, even if there are some simple wireless communication interfaces, such as bluetooth communication interface, its matching mechanisms and connection mechanism inefficiency, can not meet the requirement of the high speed transmission data of medical device.
For this reason, the present invention proposes a kind of automatization blood glucose meter, the structure of backward blood glucose meter can be improved, pulse detection is dissolved in blood glucose meter, widen the scope of the physiological parameter of detection, improve the precision of blood sugar test, the insulin delivery system that blood glucose controls automatically can be set up, reduce artificial participation, in addition, existing Bluetooth communication mechanism can also be improved, improve speed and the efficiency of wireless data transmission, thus, improve the intelligent level of blood glucose meter on the whole.
Summary of the invention
In order to solve the technical problem that prior art exists, the invention provides a kind of automatization blood glucose meter, pulse detection equipment and blood sugar test equipment are concentrated in a detecting instrument and works simultaneously, optimize the structure of existing blood sugar test equipment, improve the precision of blood sugar test, simultaneously, add insulin pump and insulin supply control mechanism, realize the automatic control of blood sugar concentration, significantly, by improving matching mechanisms and the connection mechanism of existing bluetooth communication interface, improve the communication efficiency of blood glucose instrument wireless connections.
According to an aspect of the present invention, provide a kind of automatization blood glucose meter, described medical therapeutic equipment comprises insulin driving arrangement, insulin pump, pulse detection equipment, blood sugar test equipment and Freescale IMX6 processor, described pulse detection equipment and described blood sugar test equipment are respectively used to the pulse data and the blood glucose level data that extract tested personnel, described Freescale IMX6 processor and described insulin driving arrangement, described pulse detection equipment is connected respectively with described blood sugar test equipment, pulse data based on described pulse detection equipment determines whether to send cacosphyxia identification signal, blood glucose level data based on described blood sugar test equipment determines whether to control described insulin driving arrangement to drive described insulin pump for tested personnel's insulin injection.
More specifically, in described automatization blood glucose meter, comprising: the first resistance, one end is connected with 5V power supply, and the other end is connected with the anode of infrared receiving diode, second resistance, one end is connected with 5V power supply, and the other end is connected with one end of the 3rd resistance, 3rd resistance, other end ground connection, and there is the resistance identical with the second resistance, first two-way operational amplifier, for generation of the reference voltage of 2.5V, its anode is connected with the other end of the second resistance, and negative terminal is connected with one end of the first electric capacity, outfan is connected with the negative terminal of infrared-emitting diode, and negative terminal is also connected with the negative terminal of infrared-emitting diode, first electric capacity, other end ground connection, 4th resistance, one end is connected with the negative terminal of infrared-emitting diode, second two-way operational amplifier, anode is connected with the other end of the 4th resistance, and negative terminal is connected with the anode of infrared receiving diode, and outfan is as pulse voltage, 5th resistance, is connected in parallel between the second two-way operational amplifier negative terminal and the second two-way operational amplifier output terminal, second electric capacity, is connected in parallel between the second two-way operational amplifier negative terminal and the second two-way operational amplifier output terminal, infrared-emitting diode, is arranged on tested personnel ear blood capillary position, and for launching infrared light, the negative terminal of infrared-emitting diode is connected with the anode of infrared receiving diode, infrared receiving diode, is arranged on tested personnel ear blood capillary position, is positioned at the relative position of described infrared-emitting diode, for receiving the infrared light after transmission tested personnel ear blood capillary, Direct Digital Frequency Synthesizers, the sine wave signal that can adjust for generation of frequency and phase place uses to be used as mixing as rf frequency source, pulse-series generator, for generation of pulse train, frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated, power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated, Switching Power Supply, is used as the interface circuit between probe and power amplifier, by the signal loading after amplification in the radio-frequency receiving-transmitting coil of probe, Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static magnetic field of field intensity in the space holding tested personnel's finger, probe, be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil to be sent into by the signal of loading in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for sending pointing the deamplification obtained after interior Hydrogen Proton resonates through tested personnel, Freescale IMX6 processor, be connected with described probe, receive described deamplification, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel, described Freescale IMX6 processor is also connected to obtain described pulse voltage with the outfan of described second two-way operational amplifier, and when described pulse voltage is outside default pulse range, send cacosphyxia identification signal, when described blood sugar concentration is at default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood glucose least concentration, send the too low identification signal of blood sugar concentration, insulin memory device, for prestoring the insulin of preset capacity, liquid level detection device, be positioned at described insulin memory device, for detecting the insulin liquid level in insulin memory device in real time, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, with described Freescale IMX6 processor, described liquid level detection device is also connected that described insufficient insulin alarm signal is sent to described Freescale IMX6 processor, insulin driving arrangement, be connected with described Freescale IMX6 processor, when receiving the too high identification signal of described blood sugar concentration, the blood sugar concentration forwarded according to described Freescale IMX6 processor and the difference determination insulin pump drive singal of described default blood glucose upper concentration, described insulin pump drive singal determines value and the speed of the supply insulin of insulin pump, insulin pump, connect respectively with described insulin memory device and insulin infusion device, be connected with described insulin driving arrangement, for under the control of described insulin driving arrangement, the insulin in described insulin memory device is expelled in tested personnel's body by insulin infusion device, insulin infusion device, is detachablely embedded in tested personnel's body, for tested personnel's insulin injection, serial communication circuit, between Freescale IMX6 processor and Bluetooth matching communication equipment, for being sent to Bluetooth matching communication equipment by described blood sugar concentration and described insufficient insulin alarm signal, Bluetooth matching communication equipment, for being wirelessly transmitted to the target Bluetooth devices in connection by described blood sugar concentration and described insufficient insulin alarm signal, described Bluetooth matching communication equipment comprises the first search subset, the second search subset and coupling connexon equipment, wherein, the first search subset, according to the highest micro bluetooth network of MAC Address concentration determination Bluetooth MAC address concentration in Bluetooth Scatternet as target piconet, a Bluetooth Scatternet is made up of multiple micro bluetooth network, second search subset, searches for subset be connected with described first, in described target piconet, finds, quantity preceding by signal intensity rank and is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices, equipment connection subset, searches for subset be connected with described second, starts and is connected with the Bluetooth communication of described one or more target Bluetooth devices, wherein, between infrared-emitting diode and infrared receiving diode during pulseless, pulse voltage is 2.5V, and when there is the pulse of beating between infrared-emitting diode and infrared receiving diode, blood vessels make ear's light transmission be deteriorated, and pulse voltage is greater than 2.5V, wherein, the first two-way operational amplifier and the second two-way operational amplifier are all the two-way operational amplifier of TI company, wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is the one in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus, wherein, the one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis that Direct Digital Frequency Synthesizers adopts, wherein, when there being the quantity of Bluetooth matching communication equipment of signal for being more than or equal to 7 in described target piconet, the quantity of described one or more target Bluetooth devices is 7, when there being the quantity of Bluetooth matching communication equipment of signal for being less than 7 in described target piconet, the quantity of described one or more target Bluetooth devices is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
More specifically, in described automatization blood glucose meter: described serial communication circuit is RS232 serial communication interface.
More specifically, in described automatization blood glucose meter: described Freescale IMX6 processor is when sending cacosphyxia identification signal, the too high identification signal of blood glucose or hypoglycemia identification signal, send abnormality signal simultaneously, otherwise described Freescale IMX6 processor sends normal state signal simultaneously.
More specifically, in described automatization blood glucose meter, described medical therapeutic equipment also comprises: radio communication circuit, is connected, for sending abnormality signal or normal state signal with described Freescale IMX6 processor.
More specifically, in described automatization blood glucose meter: described radio communication circuit is 3G mobile communication interface or 4G mobile communication interface.
More specifically, in described automatization blood glucose meter, described medical therapeutic equipment also comprises: FLASH storage chip, is connected with described Freescale IMX6 processor, for prestoring default pulse range, presetting blood glucose upper concentration and default blood glucose least concentration.
Accompanying drawing explanation
Below with reference to accompanying drawing, embodiment of the present invention are described, wherein:
Fig. 1 is the block diagram of the first embodiment of automatization of the present invention blood glucose meter.
Reference numeral: 1 insulin driving arrangement; 2 insulin pumps; 3 pulse detection equipment; 4 blood sugar test equipment; 5 Freescale IMX6 processors
Detailed description of the invention
Below with reference to accompanying drawings the embodiment of automatization of the present invention blood glucose meter is described in detail.
Sugar in blood is called blood glucose, is all glucose in most cases.Energy in body needed for each histiocyte activity is most of from glucose, so blood glucose must remain on the demand that certain level could maintain each Organ and tissue in body.
The concentration of the blood glucose in human body is controlled in a very narrow scope usually, and blood glucose is too high or too low all can affect to people.In order to the blood sugar concentration in effective human body, there is multiple blood glucose meter on the market, especially having been favored by suffering from hypertensive patient.
But, blood glucose meter detected parameters of the prior art is single, testing mechanism falls behind, and lacks the robot brain system of blood sugar test and insulin supply, simultaneously, the wireless communication interface coupling of being furnished with and joint efficiency lowly, can not meet the existing requirement of hospital and patient.
For this reason, the present invention has built a kind of automatization blood glucose meter, to be integrated in a detecting instrument through the high-precision pulse monitoring equipment of structure optimization and blood glucose monitoring device, adopt the automatic control mode of blood sugar test and insulin supply and the bluetooth communication interface after optimizing, for the use of patient and hospital provides more convenience simultaneously.
Fig. 1 is the block diagram of the first embodiment of automatization of the present invention blood glucose meter, described medical therapeutic equipment comprises insulin driving arrangement, insulin pump, pulse detection equipment, blood sugar test equipment and Freescale IMX6 processor, described pulse detection equipment and described blood sugar test equipment are respectively used to the pulse data and the blood glucose level data that extract tested personnel, described Freescale IMX6 processor and described insulin driving arrangement, described pulse detection equipment is connected respectively with described blood sugar test equipment, pulse data based on described pulse detection equipment determines whether to send cacosphyxia identification signal, blood glucose level data based on described blood sugar test equipment determines whether to control described insulin driving arrangement to drive described insulin pump for tested personnel's insulin injection.
Then, continue to be further detailed the concrete structure of the second embodiment of automatization of the present invention blood glucose meter.
Described medical therapeutic equipment comprises: the first resistance, and one end is connected with 5V power supply, and the other end is connected with the anode of infrared receiving diode; Second resistance, one end is connected with 5V power supply, and the other end is connected with one end of the 3rd resistance; 3rd resistance, other end ground connection, and there is the resistance identical with the second resistance.
Described medical therapeutic equipment comprises: the first two-way operational amplifier, for generation of the reference voltage of 2.5V, its anode is connected with the other end of the second resistance, negative terminal is connected with one end of the first electric capacity, outfan is connected with the negative terminal of infrared-emitting diode, and negative terminal is also connected with the negative terminal of infrared-emitting diode; First electric capacity, other end ground connection; 4th resistance, one end is connected with the negative terminal of infrared-emitting diode; Second two-way operational amplifier, anode is connected with the other end of the 4th resistance, and negative terminal is connected with the anode of infrared receiving diode, and outfan is as pulse voltage.
Described medical therapeutic equipment comprises: the 5th resistance, is connected in parallel between the second two-way operational amplifier negative terminal and the second two-way operational amplifier output terminal; Second electric capacity, is connected in parallel between the second two-way operational amplifier negative terminal and the second two-way operational amplifier output terminal; Infrared-emitting diode, is arranged on tested personnel ear blood capillary position, and for launching infrared light, the negative terminal of infrared-emitting diode is connected with the anode of infrared receiving diode; Infrared receiving diode, is arranged on tested personnel ear blood capillary position, is positioned at the relative position of described infrared-emitting diode, for receiving the infrared light after transmission tested personnel ear blood capillary.
Described medical therapeutic equipment comprises: Direct Digital Frequency Synthesizers, and the sine wave signal that can adjust for generation of frequency and phase place uses to be used as mixing as rf frequency source; Pulse-series generator, for generation of pulse train; Frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated; Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated.
Described medical therapeutic equipment comprises: Switching Power Supply, is used as the interface circuit between probe and power amplifier, by the signal loading after amplification in the radio-frequency receiving-transmitting coil of probe; Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static magnetic field of field intensity in the space holding tested personnel's finger; Probe, be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil to be sent into by the signal of loading in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for sending pointing the deamplification obtained after interior Hydrogen Proton resonates through tested personnel.
Described medical therapeutic equipment comprises: Freescale IMX6 processor, be connected with described probe, receive described deamplification, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel, described Freescale IMX6 processor is also connected to obtain described pulse voltage with the outfan of described second two-way operational amplifier, and when described pulse voltage is outside default pulse range, send cacosphyxia identification signal, when described blood sugar concentration is at default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood glucose least concentration, send the too low identification signal of blood sugar concentration.
Described medical therapeutic equipment comprises: insulin memory device, for prestoring the insulin of preset capacity; Liquid level detection device, be positioned at described insulin memory device, for detecting the insulin liquid level in insulin memory device in real time, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, with described Freescale IMX6 processor, described liquid level detection device is also connected that described insufficient insulin alarm signal is sent to described Freescale IMX6 processor.
Described medical therapeutic equipment comprises: insulin driving arrangement, be connected with described Freescale IMX6 processor, when receiving the too high identification signal of described blood sugar concentration, the blood sugar concentration forwarded according to described Freescale IMX6 processor and the difference determination insulin pump drive singal of described default blood glucose upper concentration, described insulin pump drive singal determines value and the speed of the supply insulin of insulin pump; Insulin pump, connect respectively with described insulin memory device and insulin infusion device, be connected with described insulin driving arrangement, for under the control of described insulin driving arrangement, the insulin in described insulin memory device is expelled in tested personnel's body by insulin infusion device.
Described medical therapeutic equipment comprises: insulin infusion device, is detachablely embedded in tested personnel's body, for tested personnel's insulin injection; Serial communication circuit, between Freescale IMX6 processor and Bluetooth matching communication equipment, for being sent to Bluetooth matching communication equipment by described blood sugar concentration and described insufficient insulin alarm signal.
Described medical therapeutic equipment comprises: Bluetooth matching communication equipment, for described blood sugar concentration and described insufficient insulin alarm signal being wirelessly transmitted to the target Bluetooth devices in connection; Described Bluetooth matching communication equipment comprises the first search subset, the second search subset and coupling connexon equipment.
Wherein, the first search subset, according to the highest micro bluetooth network of MAC Address concentration determination Bluetooth MAC address concentration in Bluetooth Scatternet as target piconet, a Bluetooth Scatternet is made up of multiple micro bluetooth network; Second search subset, searches for subset be connected with described first, in described target piconet, finds, quantity preceding by signal intensity rank and is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices; Equipment connection subset, searches for subset be connected with described second, starts and is connected with the Bluetooth communication of described one or more target Bluetooth devices.
Wherein, between infrared-emitting diode and infrared receiving diode during pulseless, pulse voltage is 2.5V, and when there is the pulse of beating between infrared-emitting diode and infrared receiving diode, blood vessels make ear's light transmission be deteriorated, and pulse voltage is greater than 2.5V; Wherein, the first two-way operational amplifier and the second two-way operational amplifier are all the two-way operational amplifier of TI company.
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is the one in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus; Wherein, the one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis that Direct Digital Frequency Synthesizers adopts.
Wherein, when there being the quantity of Bluetooth matching communication equipment of signal for being more than or equal to 7 in described target piconet, the quantity of described one or more target Bluetooth devices is 7, when there being the quantity of Bluetooth matching communication equipment of signal for being less than 7 in described target piconet, the quantity of described one or more target Bluetooth devices is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
Alternatively, in described automatization blood glucose meter: described serial communication circuit is RS232 serial communication interface; Described Freescale IMX6 processor, when sending cacosphyxia identification signal, the too high identification signal of blood glucose or hypoglycemia identification signal, sends abnormality signal simultaneously, otherwise described Freescale IMX6 processor sends normal state signal simultaneously; Described medical therapeutic equipment also comprises: radio communication circuit, is connected, for sending abnormality signal or normal state signal with described Freescale IMX6 processor; Described radio communication circuit is 3G mobile communication interface or 4G mobile communication interface; Described medical therapeutic equipment also comprises: FLASH storage chip, is connected with described Freescale IMX6 processor, for prestoring default pulse range, presetting blood glucose upper concentration and default blood glucose least concentration.
In addition, operational amplifier (being called for short " amplifier ") is the circuit unit with very high-amplification-factor.In side circuit, usually jointly form certain functional module in conjunction with feedback network.He is a kind of amplifier with special Coupling circuit and feedback.Its output signal can be that input signal adds, subtracts or the result of the mathematical operation such as differential, integration.Owing to being applied in analogue computer in early days, in order to realize mathematical operation, therefore gain the name " operational amplifier ".
Amplifier is the circuit unit that an angle from function is named, and can be realized, also can be implemented in the middle of semiconductor chip by discrete device.Along with the development of semiconductor technology, most amplifier exists with the form of single-chip.Amplifier of a great variety, is widely used in the middle of electron trade.
Adopt automatization of the present invention blood glucose meter, fall behind and the technical problem of radio communication function difference for blood glucose apparatus structure in prior art, optimize the structure of existing blood glucose instrument, add pulse detection equipment and blood sugar concentration automatic controlling device, also improve the communication performance of existing bluetooth communication interface simultaneously, thus improve the level of its medical services.
Be understandable that, although the present invention with preferred embodiment disclose as above, but above-described embodiment and be not used to limit the present invention.For any those of ordinary skill in the art, do not departing under technical solution of the present invention ambit, the technology contents of above-mentioned announcement all can be utilized to make many possible variations and modification to technical solution of the present invention, or be revised as the Equivalent embodiments of equivalent variations.Therefore, every content not departing from technical solution of the present invention, according to technical spirit of the present invention to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belongs in the scope of technical solution of the present invention protection.
Claims (7)
1. automatization's blood glucose meter, described medical therapeutic equipment comprises insulin driving arrangement, insulin pump, pulse detection equipment, blood sugar test equipment and Freescale IMX6 processor, described pulse detection equipment and described blood sugar test equipment are respectively used to the pulse data and the blood glucose level data that extract tested personnel, described Freescale IMX6 processor and described insulin driving arrangement, described pulse detection equipment is connected respectively with described blood sugar test equipment, pulse data based on described pulse detection equipment determines whether to send cacosphyxia identification signal, blood glucose level data based on described blood sugar test equipment determines whether to control described insulin driving arrangement to drive described insulin pump for tested personnel's insulin injection.
2. automatization as claimed in claim 1 blood glucose meter, it is characterized in that, described medical therapeutic equipment comprises:
First resistance, one end is connected with 5V power supply, and the other end is connected with the anode of infrared receiving diode;
Second resistance, one end is connected with 5V power supply, and the other end is connected with one end of the 3rd resistance;
3rd resistance, other end ground connection, and there is the resistance identical with the second resistance;
First two-way operational amplifier, for generation of the reference voltage of 2.5V, its anode is connected with the other end of the second resistance, and negative terminal is connected with one end of the first electric capacity, outfan is connected with the negative terminal of infrared-emitting diode, and negative terminal is also connected with the negative terminal of infrared-emitting diode;
First electric capacity, other end ground connection;
4th resistance, one end is connected with the negative terminal of infrared-emitting diode;
Second two-way operational amplifier, anode is connected with the other end of the 4th resistance, and negative terminal is connected with the anode of infrared receiving diode, and outfan is as pulse voltage;
5th resistance, is connected in parallel between the second two-way operational amplifier negative terminal and the second two-way operational amplifier output terminal;
Second electric capacity, is connected in parallel between the second two-way operational amplifier negative terminal and the second two-way operational amplifier output terminal;
Infrared-emitting diode, is arranged on tested personnel ear blood capillary position, and for launching infrared light, the negative terminal of infrared-emitting diode is connected with the anode of infrared receiving diode;
Infrared receiving diode, is arranged on tested personnel ear blood capillary position, is positioned at the relative position of described infrared-emitting diode, for receiving the infrared light after transmission tested personnel ear blood capillary;
Direct Digital Frequency Synthesizers, the sine wave signal that can adjust for generation of frequency and phase place uses to be used as mixing as rf frequency source;
Pulse-series generator, for generation of pulse train;
Frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated;
Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated;
Switching Power Supply, is used as the interface circuit between probe and power amplifier, by the signal loading after amplification in the radio-frequency receiving-transmitting coil of probe;
Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static magnetic field of field intensity in the space holding tested personnel's finger;
Probe, be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil to be sent into by the signal of loading in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for sending pointing the deamplification obtained after interior Hydrogen Proton resonates through tested personnel;
Freescale IMX6 processor, be connected with described probe, receive described deamplification, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel, described Freescale IMX6 processor is also connected to obtain described pulse voltage with the outfan of described second two-way operational amplifier, and when described pulse voltage is outside default pulse range, send cacosphyxia identification signal, when described blood sugar concentration is at default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood glucose least concentration, send the too low identification signal of blood sugar concentration,
Insulin memory device, for prestoring the insulin of preset capacity;
Liquid level detection device, be positioned at described insulin memory device, for detecting the insulin liquid level in insulin memory device in real time, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, with described Freescale IMX6 processor, described liquid level detection device is also connected that described insufficient insulin alarm signal is sent to described Freescale IMX6 processor;
Insulin driving arrangement, be connected with described Freescale IMX6 processor, when receiving the too high identification signal of described blood sugar concentration, the blood sugar concentration forwarded according to described Freescale IMX6 processor and the difference determination insulin pump drive singal of described default blood glucose upper concentration, described insulin pump drive singal determines value and the speed of the supply insulin of insulin pump;
Insulin pump, connect respectively with described insulin memory device and insulin infusion device, be connected with described insulin driving arrangement, for under the control of described insulin driving arrangement, the insulin in described insulin memory device is expelled in tested personnel's body by insulin infusion device;
Insulin infusion device, is detachablely embedded in tested personnel's body, for tested personnel's insulin injection;
Serial communication circuit, between Freescale IMX6 processor and Bluetooth matching communication equipment, for being sent to Bluetooth matching communication equipment by described blood sugar concentration and described insufficient insulin alarm signal;
Bluetooth matching communication equipment, for being wirelessly transmitted to the target Bluetooth devices in connection by described blood sugar concentration and described insufficient insulin alarm signal; Described Bluetooth matching communication equipment comprises the first search subset, the second search subset and coupling connexon equipment; Wherein, the first search subset, according to the highest micro bluetooth network of MAC Address concentration determination Bluetooth MAC address concentration in Bluetooth Scatternet as target piconet, a Bluetooth Scatternet is made up of multiple micro bluetooth network; Second search subset, searches for subset be connected with described first, in described target piconet, finds, quantity preceding by signal intensity rank and is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices; Equipment connection subset, searches for subset be connected with described second, starts and is connected with the Bluetooth communication of described one or more target Bluetooth devices;
Wherein, between infrared-emitting diode and infrared receiving diode during pulseless, pulse voltage is 2.5V, and when there is the pulse of beating between infrared-emitting diode and infrared receiving diode, blood vessels make ear's light transmission be deteriorated, and pulse voltage is greater than 2.5V;
Wherein, the first two-way operational amplifier and the second two-way operational amplifier are all the two-way operational amplifier of TI company;
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is the one in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus;
Wherein, the one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis that Direct Digital Frequency Synthesizers adopts;
Wherein, when there being the quantity of Bluetooth matching communication equipment of signal for being more than or equal to 7 in described target piconet, the quantity of described one or more target Bluetooth devices is 7, when there being the quantity of Bluetooth matching communication equipment of signal for being less than 7 in described target piconet, the quantity of described one or more target Bluetooth devices is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
3. automatization as claimed in claim 2 blood glucose meter, is characterized in that:
Described serial communication circuit is RS232 serial communication interface.
4. automatization as claimed in claim 2 blood glucose meter, is characterized in that:
Described Freescale IMX6 processor, when sending cacosphyxia identification signal, the too high identification signal of blood glucose or hypoglycemia identification signal, sends abnormality signal simultaneously, otherwise described Freescale IMX6 processor sends normal state signal simultaneously.
5. automatization as claimed in claim 4 blood glucose meter, it is characterized in that, described medical therapeutic equipment also comprises:
Radio communication circuit, is connected with described Freescale IMX6 processor, for sending abnormality signal or normal state signal.
6. automatization as claimed in claim 5 blood glucose meter, is characterized in that:
Described radio communication circuit is 3G mobile communication interface or 4G mobile communication interface.
7. automatization as claimed in claim 2 blood glucose meter, it is characterized in that, described medical therapeutic equipment also comprises:
FLASH storage chip, is connected with described Freescale IMX6 processor, for prestoring default pulse range, presetting blood glucose upper concentration and default blood glucose least concentration.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510747142.9A CN105232056B (en) | 2015-11-05 | 2015-11-05 | medical therapeutic equipment |
| CN201510997497.3A CN105455823A (en) | 2015-11-05 | 2015-11-05 | Automated blood glucose meter |
| PCT/CN2016/096037 WO2017076103A1 (en) | 2015-11-05 | 2016-08-19 | Automated blood sugar meter |
| CN201680035610.2A CN107683108A (en) | 2015-11-05 | 2016-08-19 | Automate blood glucose meter |
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| CN201510747142.9A CN105232056B (en) | 2015-11-05 | 2015-11-05 | medical therapeutic equipment |
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| CN201510997497.3A Division CN105455823A (en) | 2015-11-05 | 2015-11-05 | Automated blood glucose meter |
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| CN105232056B CN105232056B (en) | 2016-11-09 |
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| CN201510997497.3A Pending CN105455823A (en) | 2015-11-05 | 2015-11-05 | Automated blood glucose meter |
| CN201510747142.9A Active CN105232056B (en) | 2015-11-05 | 2015-11-05 | medical therapeutic equipment |
| CN201680035610.2A Pending CN107683108A (en) | 2015-11-05 | 2016-08-19 | Automate blood glucose meter |
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| CN112748684A (en) * | 2020-12-21 | 2021-05-04 | 许敬梅 | Monitoring control system and device of intelligent insulin pump based on RFID |
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Also Published As
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| CN105232056B (en) | 2016-11-09 |
| WO2017076103A1 (en) | 2017-05-11 |
| CN107683108A (en) | 2018-02-09 |
| CN105455823A (en) | 2016-04-06 |
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