CN105561431A - Insulin injection control system based on blood glucose measurement - Google Patents
Insulin injection control system based on blood glucose measurement Download PDFInfo
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- CN105561431A CN105561431A CN201510957481.XA CN201510957481A CN105561431A CN 105561431 A CN105561431 A CN 105561431A CN 201510957481 A CN201510957481 A CN 201510957481A CN 105561431 A CN105561431 A CN 105561431A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4806—Sleep evaluation
- A61B5/4812—Detecting sleep stages or cycles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3303—Using a biosensor
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Abstract
The invention relates to an insulin injection control system based on blood glucose measurement. The control system comprises an automatic insulin injection sub system, a brain wave detection sub system, a blood glucose detection sub system and a Freescale MC9S12 chip, wherein the brain wave detection sub system is used for extracting brain wave data of a tested person; the blood glucose detection sub system is used for extracting blood glucose data of the tested person; the Freescale MC9S12 chip is connected with the automatic insulin injection sub system, the brain wave detection sub system and the blood glucose detection sub system; the sleeping state of the tested person is determined on the basis of the brain wave data; and the starting of the automatic insulin injection sub system is determined on the basis of the blood glucose data. By using the insulin injection control system, on one hand, whether the tested personnel enters the sleeping state or not and the sleeping depth can be automatically detected; and on the other hand, the insulin injection control can be realized.
Description
Technical field
The present invention relates to blood sugar test field, particularly relate to a kind of injection of insulin control system based on blood sugar test.
Background technology
There is the Medical Instruments that some detect blood glucose in prior art, but all there is following defect in these blood glucose meter: (1) detecting pattern is single, can only detect blood sugar concentration; (2) testing mechanism falls behind, and structural redundancy is too high, and precision can not meet the accuracy requirement increasingly increased; (3) control mechanism of blood sugar test and insulin supply is not had, cannot according to the supply parameter of the insulin of the blood sugar content self-adaptative adjustment tested personnel of tested human body, such as, feed speed, quantity delivered etc., also need manual observation blood sugar content, manual decision's insulin to supply parameter, automatization level falls behind; (4) wireless communication interface is deficient, the parameters relevant to blood glucose can not be fed back to medical server end in time, even if there are some simple wireless communication interfaces, such as bluetooth communication interface, its matching mechanisms and connection mechanism inefficiency, can not meet the requirement of the high speed transmission data of medical device.
For this reason, the present invention proposes a kind of injection of insulin control system based on blood sugar test, the structure of backward blood glucose meter can be improved, being detected by brain wave is dissolved in blood glucose meter, widen the scope of the physiological parameter of detection, improve the precision of blood sugar test, the insulin delivery system that blood glucose controls automatically can be set up, reduce artificial participation, in addition, existing Bluetooth communication mechanism can also be improved, improve speed and the efficiency of wireless data transmission, thus, improve automatization's level of blood glucose meter on the whole.
Summary of the invention
In order to solve the technical problem that prior art exists, the invention provides a kind of injection of insulin control system based on blood sugar test, brain wave checkout equipment and blood sugar test equipment are concentrated in a detecting instrument and works simultaneously, optimize the structure of existing blood sugar test equipment, improve the precision of blood sugar test, simultaneously, add insulin pump and insulin supply control mechanism, realize the automatic control of blood sugar concentration, significantly, by improving matching mechanisms and the connection mechanism of existing bluetooth communication interface, improve the communication efficiency of blood glucose instrument wireless connections.
According to an aspect of the present invention, provide a kind of injection of insulin control system based on blood sugar test, described control system comprises Automatic insulin injection subsystem, brain wave detection subsystem, blood sugar test subsystem and Freescale MC9S12 chip, described brain wave detection subsystem and described blood sugar test subsystem are respectively used to the brain wave data and the blood glucose level data that extract tested personnel, described Freescale MC9S12 chip and described Automatic insulin injection subsystem, described brain wave detection subsystem is connected respectively with described blood sugar test subsystem, the sleep state of tested personnel is determined based on described brain wave data, the unlatching of described Automatic insulin injection subsystem is also determined based on described blood glucose level data.
More specifically, comprise: detecting electrode based in the injection of insulin control system of blood sugar test described, be arranged on tested personnel's head, the voltage variety that the neuron activity for detecting brain arrives cerebral cortex by ionic conduction and formed; Difference preamplifier, is connected with described detecting electrode, for amplifying described voltage variety; Low pass filter, is connected with described difference preamplifier, for the voltage variety after amplification is carried out 100Hz low-pass filtering, to export the first filtering signal; Two-stage power frequency notch filter, is connected with described low pass filter, for carrying out the process of two-stage notch filter, to export notched signal to described first filtering signal; High pass filter, is connected with described two-stage power frequency notch filter, for carrying out 0.1Hz high-pass filtering to described notched signal, to export the second filtering signal; Level adjustment circuit, is connected with described high pass filter, carries out level adjustment process to described second filtering signal, thinks that subsequent A/D conversion is prepared; Analog to digital conversion circuit, is connected with described level adjustment circuit, the second filtering signal after level adjustment process is carried out the analog digital conversion of 8, to obtain the brain wave digital signal of tested personnel; Direct Digital Frequency Synthesizers, the sine wave signal that can adjust for generation of frequency and phase place uses to be used as mixing as rf frequency source; Pulse-series generator, for generation of pulse train; Frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated; Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated; Switching Power Supply, is used as the interface circuit between probe and power amplifier, by the signal loading after amplification in the radio-frequency receiving-transmitting coil of probe; Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static magnetic field of field intensity in the space holding tested personnel's finger; Probe, be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil to be sent into by the signal of loading in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for sending pointing the deamplification obtained after interior Hydrogen Proton resonates through tested personnel; Freescale MC9S12 chip, parallel port is adopted to be connected with analog-digital conversion circuit as described, for receiving brain wave digital signal, also be connected to receive described deamplification with described probe, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel; When there is α ripple and β ripple in described brain wave digital signal in described Freescale MC9S12 chip, export shallow sleep identification signal, when there is θ ripple and δ ripple in described brain wave digital signal, export deep sleep identification signal, when described blood sugar concentration is at default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood glucose least concentration, send the too low identification signal of blood sugar concentration; Insulin memory device, for prestoring the insulin of preset capacity; Liquid level detection device, be positioned at described insulin memory device, for detecting the insulin liquid level in insulin memory device in real time, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, with described Freescale MC9S12 chip, described liquid level detection device is also connected that described insufficient insulin alarm signal is sent to described Freescale MC9S12 chip; Insulin driving arrangement, be connected with described Freescale MC9S12 chip, when receiving the too high identification signal of described blood sugar concentration, the blood sugar concentration forwarded according to described Freescale MC9S12 chip and the difference determination insulin pump drive singal of described default blood glucose upper concentration, described insulin pump drive singal determines value and the speed of the supply insulin of insulin pump; Insulin pump, connect respectively with described insulin memory device and insulin infusion device, be connected with described insulin driving arrangement, for under the control of described insulin driving arrangement, the insulin in described insulin memory device is expelled in tested personnel's body by insulin infusion device; Insulin infusion device, is detachablely embedded in tested personnel's body, for tested personnel's insulin injection; Serial communication circuit, between Freescale MC9S12 chip and Bluetooth matching communication equipment, for being sent to Bluetooth matching communication equipment by described blood sugar concentration and described insufficient insulin alarm signal; Bluetooth matching communication equipment, for being wirelessly transmitted to the target Bluetooth devices in connection by described blood sugar concentration and described insufficient insulin alarm signal; Described Bluetooth matching communication equipment comprises the first search subset, the second search subset and coupling connexon equipment; Wherein, the first search subset, according to the highest micro bluetooth network of MAC Address concentration determination Bluetooth MAC address concentration in Bluetooth Scatternet as target piconet, a Bluetooth Scatternet is made up of multiple micro bluetooth network; Second search subset, searches for subset be connected with described first, in described target piconet, finds, quantity preceding by signal intensity rank and is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices; Equipment connection subset, searches for subset be connected with described second, starts and is connected with the Bluetooth communication of described one or more target Bluetooth devices; Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is the one in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus; Wherein, the one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis that Direct Digital Frequency Synthesizers adopts; Wherein, described two-stage power frequency notch filter adopts bandpass filtering to offset patten's design, and for offsetting the power frequency component in described first filtering signal, described power frequency component is 50Hz frequency component; Wherein, when there being the quantity of Bluetooth matching communication equipment of signal for being more than or equal to 7 in described target piconet, the quantity of described one or more target Bluetooth devices is 7, when there being the quantity of Bluetooth matching communication equipment of signal for being less than 7 in described target piconet, the quantity of described one or more target Bluetooth devices is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.More specifically, described based in the injection of insulin control system of blood sugar test, described control system also comprises: memory device, be connected with described Freescale MC9S12 chip, for prestoring described preset reference liquid level, described default blood glucose upper concentration and described default blood glucose least concentration.More specifically, described based in the injection of insulin control system of blood sugar test: described memory device is SD storage card.More specifically, described based in the injection of insulin control system of blood sugar test: described Freescale MC9S12 chip is when sending shallow sleep identification signal, deep sleep identification signal, the too high identification signal of blood glucose or hypoglycemia identification signal, send abnormality signal simultaneously, otherwise described Freescale MC9S12 chip sends normal state signal simultaneously.More specifically, described based in the injection of insulin control system of blood sugar test: described low pass filter, described two-stage power frequency notch filter and described high pass filter are integrated on one piece of surface-mounted integrated circuit.
Accompanying drawing explanation
Below with reference to accompanying drawing, embodiment of the present invention are described, wherein:
Fig. 1 is the block diagram of the first embodiment of the injection of insulin control system based on blood sugar test of the present invention.
Reference numeral: 1 Automatic insulin injection subsystem; 2 brain wave detection subsystem; 3 blood sugar test subsystems; 4 Freescale MC9S12 chips
Detailed description of the invention
Below with reference to accompanying drawings the embodiment of the injection of insulin control system based on blood sugar test of the present invention is described in detail.
At present, the blood glucose meter detected parameters that people use is single, testing mechanism falls behind, and lacks the robot brain system of blood sugar test and insulin supply, simultaneously, the wireless communication interface coupling of being furnished with and joint efficiency lowly, can not meet the existing requirement of hospital and patient.
For this reason, the present invention has built a kind of injection of insulin control system based on blood sugar test, to be integrated in a detecting instrument through the high-precision brain wave watch-dog of structure optimization and blood glucose monitoring device, adopt the automatic control mode of blood sugar test and insulin supply and the bluetooth communication interface after optimizing, for the use of patient and hospital provides more convenience simultaneously.
Fig. 1 is the block diagram of the first embodiment of the injection of insulin control system based on blood sugar test of the present invention, described control system comprises Automatic insulin injection subsystem, brain wave detection subsystem, blood sugar test subsystem and Freescale MC9S12 chip, described brain wave detection subsystem and described blood sugar test subsystem are respectively used to the brain wave data and the blood glucose level data that extract tested personnel, described Freescale MC9S12 chip and described Automatic insulin injection subsystem, described brain wave detection subsystem is connected respectively with described blood sugar test subsystem, the sleep state of tested personnel is determined based on described brain wave data, the unlatching of described Automatic insulin injection subsystem is also determined based on described blood glucose level data.
Then, continue to be further detailed the concrete structure of the second embodiment of the injection of insulin control system based on blood sugar test of the present invention.
Described control system comprises: detecting electrode, is arranged on tested personnel's head, the voltage variety that the neuron activity for detecting brain arrives cerebral cortex by ionic conduction and formed; Difference preamplifier, is connected with described detecting electrode, for amplifying described voltage variety; Low pass filter, is connected with described difference preamplifier, for the voltage variety after amplification is carried out 100Hz low-pass filtering, to export the first filtering signal.
Described control system comprises: two-stage power frequency notch filter, is connected with described low pass filter, for carrying out the process of two-stage notch filter, to export notched signal to described first filtering signal; High pass filter, is connected with described two-stage power frequency notch filter, for carrying out 0.1Hz high-pass filtering to described notched signal, to export the second filtering signal.
Described control system comprises: level adjustment circuit, is connected with described high pass filter, carries out level adjustment process to described second filtering signal, thinks that subsequent A/D conversion is prepared; Analog to digital conversion circuit, is connected with described level adjustment circuit, the second filtering signal after level adjustment process is carried out the analog digital conversion of 8, to obtain the brain wave digital signal of tested personnel; Direct Digital Frequency Synthesizers, the sine wave signal that can adjust for generation of frequency and phase place uses to be used as mixing as rf frequency source; Pulse-series generator, for generation of pulse train.
Described control system comprises: frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated; Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated; Switching Power Supply, is used as the interface circuit between probe and power amplifier, by the signal loading after amplification in the radio-frequency receiving-transmitting coil of probe; Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static magnetic field of field intensity in the space holding tested personnel's finger.
Described control system comprises: probe, be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil to be sent into by the signal of loading in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for sending pointing the deamplification obtained after interior Hydrogen Proton resonates through tested personnel.
Described control system comprises: Freescale MC9S12 chip, parallel port is adopted to be connected with analog-digital conversion circuit as described, for receiving brain wave digital signal, also be connected to receive described deamplification with described probe, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel.
Wherein, when there is α ripple and β ripple in described brain wave digital signal in described Freescale MC9S12 chip, export shallow sleep identification signal, when there is θ ripple and δ ripple in described brain wave digital signal, export deep sleep identification signal, when described blood sugar concentration is at default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood glucose least concentration, send the too low identification signal of blood sugar concentration.
Described control system comprises: insulin memory device, for prestoring the insulin of preset capacity; Liquid level detection device, be positioned at described insulin memory device, for detecting the insulin liquid level in insulin memory device in real time, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, with described Freescale MC9S12 chip, described liquid level detection device is also connected that described insufficient insulin alarm signal is sent to described Freescale MC9S12 chip; Insulin driving arrangement, be connected with described Freescale MC9S12 chip, when receiving the too high identification signal of described blood sugar concentration, the blood sugar concentration forwarded according to described Freescale MC9S12 chip and the difference determination insulin pump drive singal of described default blood glucose upper concentration, described insulin pump drive singal determines value and the speed of the supply insulin of insulin pump.
Described control system comprises: insulin pump, connect respectively with described insulin memory device and insulin infusion device, be connected with described insulin driving arrangement, for under the control of described insulin driving arrangement, the insulin in described insulin memory device is expelled in tested personnel's body by insulin infusion device; Insulin infusion device, is detachablely embedded in tested personnel's body, for tested personnel's insulin injection.
Described control system comprises: serial communication circuit, between Freescale MC9S12 chip and Bluetooth matching communication equipment, for described blood sugar concentration and described insufficient insulin alarm signal are sent to Bluetooth matching communication equipment; Bluetooth matching communication equipment, for being wirelessly transmitted to the target Bluetooth devices in connection by described blood sugar concentration and described insufficient insulin alarm signal; Described Bluetooth matching communication equipment comprises the first search subset, the second search subset and coupling connexon equipment.
Wherein, the first search subset, according to the highest micro bluetooth network of MAC Address concentration determination Bluetooth MAC address concentration in Bluetooth Scatternet as target piconet, a Bluetooth Scatternet is made up of multiple micro bluetooth network; Second search subset, searches for subset be connected with described first, in described target piconet, finds, quantity preceding by signal intensity rank and is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices; Equipment connection subset, searches for subset be connected with described second, starts and is connected with the Bluetooth communication of described one or more target Bluetooth devices.
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is the one in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus; Wherein, the one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis that Direct Digital Frequency Synthesizers adopts; Wherein, described two-stage power frequency notch filter adopts bandpass filtering to offset patten's design, and for offsetting the power frequency component in described first filtering signal, described power frequency component is 50Hz frequency component.
Wherein, when there being the quantity of Bluetooth matching communication equipment of signal for being more than or equal to 7 in described target piconet, the quantity of described one or more target Bluetooth devices is 7, when there being the quantity of Bluetooth matching communication equipment of signal for being less than 7 in described target piconet, the quantity of described one or more target Bluetooth devices is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
Alternatively, described based in the injection of insulin control system of blood sugar test, described control system also comprises: memory device, be connected with described Freescale MC9S12 chip, for prestoring described preset reference liquid level, described default blood glucose upper concentration and described default blood glucose least concentration; Described memory device is SD storage card; Described Freescale MC9S12 chip is when sending shallow sleep identification signal, deep sleep identification signal, the too high identification signal of blood glucose or hypoglycemia identification signal, send abnormality signal simultaneously, otherwise described Freescale MC9S12 chip sends normal state signal simultaneously; Described low pass filter, described two-stage power frequency notch filter and described high pass filter are integrated on one piece of surface-mounted integrated circuit.
In addition, wave filter, as the term suggests, be the device that ripple is filtered." ripple " is a physical concept widely, and at electronic technology field, " ripple " is narrowly confined to refer in particular to the process of the value fluctuations in time describing various physical quantity.This process, by the effect of various kinds of sensors, is converted into the time function of voltage or electric current, is referred to as the time waveform of various physical quantity, or is referred to as signal.Because the independent variable time is continuous value, be referred to as continuous time signal, be referred to as analogue signal habitually again.
Along with generation and the develop rapidly of digital electronic computer technology, for the ease of computer, signal is processed, create complete Theories and methods continuous time signal being transformed into discrete-time signal under sampling theorem instructs.That is, can only express primary signal by the sample value of original analog signal on series of discrete time coordinate point and not lose any information, since what these concepts of ripple, waveform, signal were expressed is the change of various physical quantity in objective world, is exactly the carrier of the various information that modern society depends on for existence naturally.Information needs to propagate, and what lean on is exactly the transmission of waveshape signal.Signal it generation, conversion, transmission each link may distort due to the existence of environment and interference, or even in quite a number of cases, this distortion is also very serious, causes signal and entrained information thereof to be embedded in the middle of noise dearly.In order to these noises of filtering, recover signal originally, need to use various wave filter to carry out Filtering Processing.
Adopt the injection of insulin control system based on blood sugar test of the present invention, fall behind and the technical problem of radio communication function difference for blood glucose apparatus structure in prior art, optimize the structure of existing blood glucose instrument, add brain wave checkout equipment and blood sugar concentration automatic controlling device, also improve the communication performance of existing bluetooth communication interface simultaneously, thus improve precision and the availability of its medical treatment detection.
Be understandable that, although the present invention with preferred embodiment disclose as above, but above-described embodiment and be not used to limit the present invention.For any those of ordinary skill in the art, do not departing under technical solution of the present invention ambit, the technology contents of above-mentioned announcement all can be utilized to make many possible variations and modification to technical solution of the present invention, or be revised as the Equivalent embodiments of equivalent variations.Therefore, every content not departing from technical solution of the present invention, according to technical spirit of the present invention to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belongs in the scope of technical solution of the present invention protection.
Claims (6)
1. the injection of insulin control system based on blood sugar test, described control system comprises Automatic insulin injection subsystem, brain wave detection subsystem, blood sugar test subsystem and Freescale MC9S12 chip, described brain wave detection subsystem and described blood sugar test subsystem are respectively used to the brain wave data and the blood glucose level data that extract tested personnel, described Freescale MC9S12 chip and described Automatic insulin injection subsystem, described brain wave detection subsystem is connected respectively with described blood sugar test subsystem, the sleep state of tested personnel is determined based on described brain wave data, the unlatching of described Automatic insulin injection subsystem is also determined based on described blood glucose level data.
2., as claimed in claim 1 based on the injection of insulin control system of blood sugar test, it is characterized in that, described control system comprises:
Detecting electrode, is arranged on tested personnel's head, the voltage variety that the neuron activity for detecting brain arrives cerebral cortex by ionic conduction and formed;
Difference preamplifier, is connected with described detecting electrode, for amplifying described voltage variety;
Low pass filter, is connected with described difference preamplifier, for the voltage variety after amplification is carried out 100Hz low-pass filtering, to export the first filtering signal;
Two-stage power frequency notch filter, is connected with described low pass filter, for carrying out the process of two-stage notch filter, to export notched signal to described first filtering signal;
High pass filter, is connected with described two-stage power frequency notch filter, for carrying out 0.1Hz high-pass filtering to described notched signal, to export the second filtering signal;
Level adjustment circuit, is connected with described high pass filter, carries out level adjustment process to described second filtering signal, thinks that subsequent A/D conversion is prepared;
Analog to digital conversion circuit, is connected with described level adjustment circuit, the second filtering signal after level adjustment process is carried out the analog digital conversion of 8, to obtain the brain wave digital signal of tested personnel;
Direct Digital Frequency Synthesizers, the sine wave signal that can adjust for generation of frequency and phase place uses to be used as mixing as rf frequency source;
Pulse-series generator, for generation of pulse train;
Frequency mixer, is connected respectively with described Direct Digital Frequency Synthesizers and described pulse-series generator, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated;
Power amplifier, is connected with described frequency mixer, for being amplified by the signal after mixed modulated;
Switching Power Supply, is used as the interface circuit between probe and power amplifier, by the signal loading after amplification in the radio-frequency receiving-transmitting coil of probe;
Nd-Fe-B permanent magnetic type magnet structure, produces a uniform static magnetic field of field intensity in the space holding tested personnel's finger;
Probe, be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil to be sent into by the signal of loading in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for sending pointing the deamplification obtained after interior Hydrogen Proton resonates through tested personnel;
Freescale MC9S12 chip, parallel port is adopted to be connected with analog-digital conversion circuit as described, for receiving brain wave digital signal, also be connected to receive described deamplification with described probe, analyze the spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain the blood sugar concentration of tested personnel; When there is α ripple and β ripple in described brain wave digital signal in described Freescale MC9S12 chip, export shallow sleep identification signal, when there is θ ripple and δ ripple in described brain wave digital signal, export deep sleep identification signal, when described blood sugar concentration is at default blood glucose upper concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood glucose least concentration, send the too low identification signal of blood sugar concentration;
Insulin memory device, for prestoring the insulin of preset capacity;
Liquid level detection device, be positioned at described insulin memory device, for detecting the insulin liquid level in insulin memory device in real time, and when insulin liquid level is equal to or less than preset reference liquid level, send insufficient insulin alarm signal, with described Freescale MC9S12 chip, described liquid level detection device is also connected that described insufficient insulin alarm signal is sent to described Freescale MC9S12 chip;
Insulin driving arrangement, be connected with described Freescale MC9S12 chip, when receiving the too high identification signal of described blood sugar concentration, the blood sugar concentration forwarded according to described Freescale MC9S12 chip and the difference determination insulin pump drive singal of described default blood glucose upper concentration, described insulin pump drive singal determines value and the speed of the supply insulin of insulin pump;
Insulin pump, connect respectively with described insulin memory device and insulin infusion device, be connected with described insulin driving arrangement, for under the control of described insulin driving arrangement, the insulin in described insulin memory device is expelled in tested personnel's body by insulin infusion device;
Insulin infusion device, is detachablely embedded in tested personnel's body, for tested personnel's insulin injection;
Serial communication circuit, between Freescale MC9S12 chip and Bluetooth matching communication equipment, for being sent to Bluetooth matching communication equipment by described blood sugar concentration and described insufficient insulin alarm signal;
Bluetooth matching communication equipment, for being wirelessly transmitted to the target Bluetooth devices in connection by described blood sugar concentration and described insufficient insulin alarm signal; Described Bluetooth matching communication equipment comprises the first search subset, the second search subset and coupling connexon equipment; Wherein, the first search subset, according to the highest micro bluetooth network of MAC Address concentration determination Bluetooth MAC address concentration in Bluetooth Scatternet as target piconet, a Bluetooth Scatternet is made up of multiple micro bluetooth network; Second search subset, searches for subset be connected with described first, in described target piconet, finds, quantity preceding by signal intensity rank and is not more than one or more Bluetooth matching communication equipments of 7 as one or more target Bluetooth devices; Equipment connection subset, searches for subset be connected with described second, starts and is connected with the Bluetooth communication of described one or more target Bluetooth devices;
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is the one in birdcage coil, toroidal winding, saddle-shaped coils, phased array coils and annulus;
Wherein, the one in direct digital synthesizers, analog phase-locked look and digital phase-locked loop is selected in the frequency synthesis that Direct Digital Frequency Synthesizers adopts;
Wherein, described two-stage power frequency notch filter adopts bandpass filtering to offset patten's design, and for offsetting the power frequency component in described first filtering signal, described power frequency component is 50Hz frequency component;
Wherein, when there being the quantity of Bluetooth matching communication equipment of signal for being more than or equal to 7 in described target piconet, the quantity of described one or more target Bluetooth devices is 7, when there being the quantity of Bluetooth matching communication equipment of signal for being less than 7 in described target piconet, the quantity of described one or more target Bluetooth devices is the quantity of the Bluetooth matching communication equipment having signal in described target piconet.
3., as claimed in claim 2 based on the injection of insulin control system of blood sugar test, it is characterized in that, described control system also comprises:
Memory device, is connected with described Freescale MC9S12 chip, for prestoring described preset reference liquid level, described default blood glucose upper concentration and described default blood glucose least concentration.
4., as claimed in claim 3 based on the injection of insulin control system of blood sugar test, it is characterized in that:
Described memory device is SD storage card.
5., as claimed in claim 2 based on the injection of insulin control system of blood sugar test, it is characterized in that:
Described Freescale MC9S12 chip is when sending shallow sleep identification signal, deep sleep identification signal, the too high identification signal of blood glucose or hypoglycemia identification signal, send abnormality signal simultaneously, otherwise described Freescale MC9S12 chip sends normal state signal simultaneously.
6., as claimed in claim 2 based on the injection of insulin control system of blood sugar test, it is characterized in that:
Described low pass filter, described two-stage power frequency notch filter and described high pass filter are integrated on one piece of surface-mounted integrated circuit.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019207007A1 (en) * | 2018-04-24 | 2019-10-31 | Imperial College Of Science, Technology & Medicine | Artificial pancreas with neural signal input |
| CN117547260A (en) * | 2024-01-11 | 2024-02-13 | 浙江普可医疗科技有限公司 | Blood glucose prediction method, system, equipment and storage medium based on sleep brain waves |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1414839A (en) * | 1999-12-28 | 2003-04-30 | 平迪产品公司 | Method and apparatus for non-invasive analysis of blood glucose |
| US20070027383A1 (en) * | 2004-07-01 | 2007-02-01 | Peyser Thomas A | Patches, systems, and methods for non-invasive glucose measurement |
| CN101125086A (en) * | 2006-08-18 | 2008-02-20 | 刘胜 | Closed-loop automatic controlling insulin-injecting system |
| CN101559252A (en) * | 2009-05-22 | 2009-10-21 | 顾磊 | Intelligent insomnia therapeutic instrument |
| CN102836481A (en) * | 2012-09-29 | 2012-12-26 | 哈尔滨工业大学 | Novel insulin pump |
| CN103598873A (en) * | 2013-09-27 | 2014-02-26 | 四川大学 | Physiological signal intelligent monitoring system based on self-adaptation wireless sensor network |
| CN203828910U (en) * | 2013-12-23 | 2014-09-17 | 上海华博信息服务有限公司 | Sleep cabin capable of monitoring human body signs in real time |
-
2015
- 2015-12-17 CN CN201510957481.XA patent/CN105561431A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1414839A (en) * | 1999-12-28 | 2003-04-30 | 平迪产品公司 | Method and apparatus for non-invasive analysis of blood glucose |
| US20070027383A1 (en) * | 2004-07-01 | 2007-02-01 | Peyser Thomas A | Patches, systems, and methods for non-invasive glucose measurement |
| CN101125086A (en) * | 2006-08-18 | 2008-02-20 | 刘胜 | Closed-loop automatic controlling insulin-injecting system |
| CN101559252A (en) * | 2009-05-22 | 2009-10-21 | 顾磊 | Intelligent insomnia therapeutic instrument |
| CN102836481A (en) * | 2012-09-29 | 2012-12-26 | 哈尔滨工业大学 | Novel insulin pump |
| CN103598873A (en) * | 2013-09-27 | 2014-02-26 | 四川大学 | Physiological signal intelligent monitoring system based on self-adaptation wireless sensor network |
| CN203828910U (en) * | 2013-12-23 | 2014-09-17 | 上海华博信息服务有限公司 | Sleep cabin capable of monitoring human body signs in real time |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019207007A1 (en) * | 2018-04-24 | 2019-10-31 | Imperial College Of Science, Technology & Medicine | Artificial pancreas with neural signal input |
| US11923063B2 (en) | 2018-04-24 | 2024-03-05 | Imperial College Innovations Limited | Artificial pancreas with neural signal input |
| CN117547260A (en) * | 2024-01-11 | 2024-02-13 | 浙江普可医疗科技有限公司 | Blood glucose prediction method, system, equipment and storage medium based on sleep brain waves |
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Application publication date: 20160511 |