CN105607530A - Blood glucose detection method based on automatic glucose meter - Google Patents
Blood glucose detection method based on automatic glucose meter Download PDFInfo
- Publication number
- CN105607530A CN105607530A CN201510745025.9A CN201510745025A CN105607530A CN 105607530 A CN105607530 A CN 105607530A CN 201510745025 A CN201510745025 A CN 201510745025A CN 105607530 A CN105607530 A CN 105607530A
- Authority
- CN
- China
- Prior art keywords
- insulin
- equipment
- signal
- blood sugar
- bluetooth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008280 blood Substances 0.000 title claims abstract description 124
- 210000004369 blood Anatomy 0.000 title claims abstract description 124
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 51
- 239000008103 glucose Substances 0.000 title claims abstract description 51
- 238000001514 detection method Methods 0.000 title claims abstract description 24
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 184
- 102000004877 Insulin Human genes 0.000 claims abstract description 92
- 108090001061 Insulin Proteins 0.000 claims abstract description 92
- 229940125396 insulin Drugs 0.000 claims abstract description 92
- 238000000034 method Methods 0.000 claims abstract description 12
- 238000004891 communication Methods 0.000 claims description 44
- 230000001225 therapeutic effect Effects 0.000 claims description 19
- 238000012360 testing method Methods 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 230000005540 biological transmission Effects 0.000 claims description 8
- 230000005856 abnormality Effects 0.000 claims description 5
- 238000010295 mobile communication Methods 0.000 claims description 5
- 229910001172 neodymium magnet Inorganic materials 0.000 claims description 5
- 208000013016 Hypoglycemia Diseases 0.000 claims description 4
- 230000002218 hypoglycaemic effect Effects 0.000 claims description 4
- 210000000496 pancreas Anatomy 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 230000003595 spectral effect Effects 0.000 claims description 3
- 238000003786 synthesis reaction Methods 0.000 claims description 3
- 238000004804 winding Methods 0.000 claims description 3
- 238000010009 beating Methods 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000007246 mechanism Effects 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 241001062009 Indigofera Species 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- NDYMQOUYJJXCKJ-UHFFFAOYSA-N (4-fluorophenyl)-morpholin-4-ylmethanone Chemical compound C1=CC(F)=CC=C1C(=O)N1CCOCC1 NDYMQOUYJJXCKJ-UHFFFAOYSA-N 0.000 description 1
- TVEXGJYMHHTVKP-UHFFFAOYSA-N 6-oxabicyclo[3.2.1]oct-3-en-7-one Chemical compound C1C2C(=O)OC1C=CC2 TVEXGJYMHHTVKP-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- ZDVYABSQRRRIOJ-UHFFFAOYSA-N boron;iron Chemical compound [Fe]#B ZDVYABSQRRRIOJ-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000005311 nuclear magnetism Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/04—Programme control other than numerical control, i.e. in sequence controllers or logic controllers
- G05B19/042—Programme control other than numerical control, i.e. in sequence controllers or logic controllers using digital processors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Physiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Automation & Control Theory (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention relates to a blood glucose detection method based on an automatic glucose meter. The method comprises that 1) the automatic glucose meter, which comprises an insulin driver, an insulin pump, a pulse detector, a glucose detector and a Freescale IMX6 processor, is provided, the pulse detector and the glucose detector are used to extract pulse data and glucose data of a detected person respectively, the Freescale IMX6 processor is connected with the insulin driver, the pulse detector and the glucose detector, whether a pulse abnormity identification signal is emitted is determined based on the pulse data of the pulse detector, and whether the insulin driver is controlled to drive the insulin pump to inject insulin into the detected person is determined according to glucose data of the glucose detector; and 2) the automatic glucose meter is used.
Description
Technical field
The present invention relates to medical device field, relate in particular to a kind of inspection of the blood sugar based on automation blood glucose meterSurvey method.
Background technology
Blood sugar, refers to glucose contained in blood. Postdigestive glucose enters blood by small intestine,And be transported to each cell in body, be the main energy source of cell. Normal person's blood sugar is denseSpend relatively stable, within dropping on a confirmable blood sugar concentration scope.
Blood sugar must keep certain level just can maintain the needs of each Organ and tissue in body. Blood sugarConcentration generally raises after one to two hours on the feed, and drops to minimum at breakfast. Blood sugar concentration imbalanceCan cause various diseases, the hyperglycaemia that continuation blood sugar concentration is too high and too low hypoglycemia all can be given peopleHealth cause serious impact, and the Persistent hyperglycemia being caused by many reasons will cause glycosuriaDisease, this is also the most significant disease that blood sugar concentration is relevant.
In prior art, exist some to detect the Medical Instruments of blood sugar, but below these blood glucose meter all existDefect: (1) detecting pattern is single, can only detect blood sugar concentration; (2) testing mechanism falls behind, knotStructure redundancy is too high, and precision can not meet the accuracy requirement increasingly increasing; (3) there is no blood sugar testWith the controlling mechanism that insulin is supplied with, cannot adjust tested according to the blood-sugar content self adaptation of tested human bodyThe supply parameter of personnel's insulin, for example, feed speed, quantity delivered etc., also need manual observationBlood-sugar content, manual decision's insulin are supplied with parameter, and automatization level falls behind; (4) radio communicationInterface scarcity, can not feed back to medical server end in time by the parameters relevant to blood sugar, evenThere are some simple wireless communication interfaces, for example bluetooth communication interface, its matching mechanisms and junctorInefficiency processed, can not meet the requirement of the high-speed transmission data of medical device.
For this reason, the present invention proposes a kind of automation blood glucose meter, can improve the knot of backward blood glucose meterStructure, is dissolved into pulse detection in blood glucose meter, widens the scope of the physiological parameter of detection, improves blood sugarThe precision detecting, can set up the insulin delivery system that blood sugar is controlled automatically, and reduce manually and participate in,In addition, can also improve existing Bluetooth communication mechanism, improve speed and the efficiency of Wireless Data Transmission,Thereby, improve on the whole the intelligent level of blood glucose meter.
Summary of the invention
The technical problem existing in order to solve prior art, the invention provides a kind of automation blood sugarInstrument, concentrates on pulse detection equipment and blood sugar test equipment in a detecting instrument and works simultaneously, excellentChange the structure of existing blood sugar test equipment, improve the precision of blood sugar test, meanwhile, add insulinPump and insulin are supplied with controlling mechanism, realize the automatic control of blood sugar concentration, particularly importantly, logicalCross matching mechanisms and the connection mechanism of improving existing bluetooth communication interface, improve the wireless connections of blood sugar instrumentCommunication efficiency.
According to an aspect of the present invention, provide a kind of automation blood glucose meter, described medical therapeutic equipment bagDraw together insulin driving arrangement, insulin pump, pulse detection equipment, blood sugar test equipment and FreescaleIMX6 processor, described pulse detection equipment and described blood sugar test equipment are respectively used to extract testedPersonnel's pulse data and blood glucose level data, described Freescale IMX6 processor and described insulin driveMoving equipment, described pulse detection equipment are connected respectively with described blood sugar test equipment, based on described pulseThe pulse data of checkout equipment determines whether to send cacosphyxia identification signal, based on described blood sugar testThe blood glucose level data of equipment determines whether to control described insulin driving arrangement to drive described insulin pumpFor tested personnel's insulin injection.
More specifically, in described automation blood glucose meter, comprising: the first resistance, one end and 5V electricitySource connects, and the other end is connected with the anode of infrared receiving diode; The second resistance, one end and 5V electricitySource connects, and the other end is connected with one end of the 3rd resistance; The 3rd resistance, other end ground connection, and haveThe resistance identical with the second resistance; The first two-way operational amplifier, for generation of the reference voltage of 2.5V,Its anode is connected with the other end of the second resistance, and negative terminal is connected with one end of the first electric capacity, output withThe negative terminal of infrared-emitting diode connects, and negative terminal is also connected with the negative terminal of infrared-emitting diode; FirstElectric capacity, other end ground connection; The 4th resistance, one end is connected with the negative terminal of infrared-emitting diode; SecondTwo-way operational amplifier, anode is connected with the other end of the 4th resistance, negative terminal and infrared receiving diodeAnode connect, output is as pulse voltage; The 5th resistance, is connected in parallel on the second two-way operation amplifierBetween device negative terminal and the second two-way operational amplifier output terminal; The second electric capacity, is connected in parallel on the second two-way fortuneCalculate between amplifier negative terminal and the second two-way operational amplifier output terminal; Infrared-emitting diode, arrangesIn tested personnel ear capillary position, for launching infrared light, the negative terminal of infrared-emitting diodeBe connected with the anode of infrared receiving diode; Infrared receiving diode, is arranged on tested personnel ear hairThin vessel position, is positioned at the relative position of described infrared-emitting diode, for receiving transmission tested personInfrared light after member ear capillary; Direct Digital Frequency Synthesizers, for generation of frequency and phase placeThe sine wave signal that can adjust is to use as mixing as rf frequency source; Pulse train occursDevice, for generation of pulse train; Frequency mixer, with described Direct Digital Frequency Synthesizers and described pulseSequencer connects respectively, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated; Power is putLarge device, is connected with described frequency mixer, for the signal after mixed modulated is amplified; Switching Power Supply,As the interface circuit between probe and power amplifier, by signal loading the penetrating to probe after amplifyingFrequently in dispatch coil; Nd-Fe-B permanent magnetic type magnet structure produces in the space that holds tested personnel's fingerA raw uniform static magnetic field of field intensity; Probe, is placed on tested personnel's finger position, is wound around radio frequencyDispatch coil, the signal of loading is sent in described Nd-Fe-B permanent magnetic type magnet structure, produces nuclear-magnetism altogetherThe phenomenon of shaking, also for sending point the deamplification obtaining after interior hydrogen proton resonance through tested personnelGo out; Freescale IMX6 processor, is connected with described probe, receives described deamplification, analyzesThe spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain tested personnel'sBlood sugar concentration, also defeated with described the second two-way operational amplifier of described Freescale IMX6 processorGo out end and connect to obtain described pulse voltage, and when described pulse voltage is outside default pulse rangeTime, send cacosphyxia identification signal, when described blood sugar concentration is during in default blood sugar upper limit concentration, send outGo out blood sugar excessive concentration identification signal, when described blood sugar concentration is during at default blood sugar least concentration, sendThe too low identification signal of blood sugar concentration; Insulin memory device, for the pancreas islet of pre-stored preset capacityElement; Liquid level detection device, is positioned at described insulin memory device, deposits for detecting in real time insulinInsulin liquid level in storage equipment, and in the time that insulin liquid level is equal to or less than preset reference liquid level, send outGo out insufficient insulin alarm signal, described liquid level detection device is also processed with described Freescale IMX6Device connects described insufficient insulin alarm signal is sent to described Freescale IMX6 processor;Insulin driving arrangement, is connected with described Freescale IMX6 processor, when receiving described blood sugarWhen excessive concentration identification signal, the blood sugar concentration forwarding according to described Freescale IMX6 processor andThe difference of described default blood sugar upper limit concentration is determined insulin pump drive signal, and described insulin pump drivesSignal deciding value and the speed of supply insulin of insulin pump; Insulin pump, with described pancreas isletElement memory device and injection of insulin equipment join respectively, are connected with described insulin driving arrangement, useUnder the control at described insulin driving arrangement, the insulin in described insulin memory device is logicalCrossing injection of insulin equipment is expelled in tested personnel's body; Injection of insulin equipment, detachable burying undergroundIn tested personnel's body, for to tested personnel's insulin injection; Serial communication circuit, is positioned at and flies to thinkBetween Ka Er IMX6 processor and Bluetooth matching communication equipment, for by described blood sugar concentration and described inInsufficient insulin alarm signal sends to Bluetooth matching communication equipment; Bluetooth matching communication equipment, forDescribed blood sugar concentration and described insufficient insulin alarm signal are wirelessly transmitted to the target indigo plant in connectionTooth equipment; Described Bluetooth matching communication equipment comprise the first search subset, second search subset andCoupling connexon equipment; Wherein, the first search subset, according to MAC Address in Bluetooth ScatternetConcentration determines that micro bluetooth network that bluetooth MAC Address concentration is the highest is as target piconet, an indigo plantTooth scatternet is made up of multiple micro bluetooth networks; The second search subset, establishes with described the first searchStandby connection, in described target piconet, find, quantity preceding by signal strength signal intensity rank and be not more thanOne or more Bluetooth matching communication equipments of 7 are as one or more target bluetooth equipments; Equipment connectsConnect subset, be connected with described the second search subset, start and described one or more target bluetoothsThe Bluetooth communication of equipment connects; Wherein, nothing between infrared-emitting diode and infrared receiving diodeWhen pulse, pulse voltage is 2.5V, between infrared-emitting diode and infrared receiving diode, existsBeat pulse time, blood vessels make ear's light transmission variation, pulse voltage is greater than 2.5V; Wherein, firstTwo-way operational amplifier and the second two-way operational amplifier are all the two-way operational amplifier of TI company; ItsIn, the radio-frequency receiving-transmitting coil that described probe is wound around be birdcage coil, toroidal winding, saddle-shaped coils,One in phased array coil and annulus; Wherein, Direct Digital Frequency Synthesizers adoptsFrequency synthesis selects that Direct Digital is synthetic, one in analog phase-locked look and digital phase-locked loop; Wherein,When having the quantity of Bluetooth matching communication equipment of signal in described target piconet when being more than or equal to 7,The quantity of described one or more target bluetooth equipments is 7, when having signal in described target piconetThe quantity of Bluetooth matching communication equipment for being less than at 7 o'clock, described one or more target bluetooth equipmentsQuantity is the quantity that has the Bluetooth matching communication equipment of signal in described target piconet.
More specifically, in described automation blood glucose meter: described serial communication circuit is RS232 serialCommunication interface.
More specifically, in described automation blood glucose meter: described Freescale IMX6 processor is being sent outWhile going out cacosphyxia identification signal, the too high identification signal of blood sugar or hypoglycemia identification signal, send out simultaneouslyGo out abnormality signal, otherwise described Freescale IMX6 processor sends normal condition letter simultaneouslyNumber.
More specifically, in described automation blood glucose meter, described medical therapeutic equipment also comprises: channel radioLetter circuit, is connected with described Freescale IMX6 processor, for sending abnormality signal or justNormal status signal.
More specifically, in described automation blood glucose meter: it is logical that described radio communication circuit is that 3G movesLetter interface or 4G mobile communication interface.
More specifically, in described automation blood glucose meter, described medical therapeutic equipment also comprises: FLASHStorage chip, is connected with described Freescale IMX6 processor, for pre-stored default pulse modelEnclose, preset blood sugar upper limit concentration and default blood sugar least concentration.
Brief description of the drawings
Below with reference to accompanying drawing, embodiment of the present invention are described, wherein:
Fig. 1 is the block diagram of the first embodiment of automation blood glucose meter of the present invention.
Reference numeral: 1 insulin driving arrangement; 2 insulin pumps; 3 pulse detection equipment; 4 bloodSugar checkout equipment; 5 Freescale IMX6 processors
Detailed description of the invention
Below with reference to accompanying drawings the embodiment of automation blood glucose meter of the present invention is elaborated.
Sugar in blood is called blood sugar, is all glucose in most cases. Each histocyte in bodyMovable required energy major part, from glucose, could be tieed up so blood sugar must remain on certain levelHold the demand of each Organ and tissue in body.
The concentration of the blood sugar in human body is controlled in a very narrow scope conventionally, the too high or mistake of blood sugarLowly all can affect to people. For the blood sugar concentration in effective human body, on the marketThere is multiple blood glucose meter, especially favored by suffering from hypertensive patient.
But blood glucose meter detected parameters of the prior art is single, testing mechanism falls behind, and lacks blood sugarThe robot brain system that detection and insulin are supplied with, meanwhile, the wireless communication interface of being furnished with mates and connectsConnect inefficiency, can not meet hospital and patient's existing requirement.
For this reason, the present invention has built a kind of automation blood glucose meter, will pass through the high-precision of structure optimizationPulse monitoring equipment and blood Sugar Monitoring integration of equipments, in a detecting instrument, adopt blood sugar test simultaneouslyWith insulin supply with automatic control mode and optimize after bluetooth communication interface, be patient and hospitalUse more convenience is provided.
Fig. 1 is the block diagram of the first embodiment of automation blood glucose meter of the present invention, described medical scienceTherapeutic equipment comprise insulin driving arrangement, insulin pump, pulse detection equipment, blood sugar test equipment andFreescale IMX6 processor, described pulse detection equipment and described blood sugar test equipment are respectively used toExtract tested personnel's pulse data and blood glucose level data, described Freescale IMX6 processor with described inInsulin driving arrangement, described pulse detection equipment and described blood sugar test equipment are connected respectively, based onThe pulse data of described pulse detection equipment determines whether to send cacosphyxia identification signal, based on describedThe blood glucose level data of blood sugar test equipment determines whether to control described insulin driving arrangement with described in drivingInsulin pump is tested personnel's insulin injection.
Then the concrete structure that, continues the second embodiment to automation blood glucose meter of the present invention entersThe explanation of one step.
Described medical therapeutic equipment comprises: the first resistance, one end is connected with 5V power supply, the other end and redThe anode of outer reception diode connects; The second resistance, one end is connected with 5V power supply, the other end andOne end of three resistance connects; The 3rd resistance, other end ground connection, and there is the resistance identical with the second resistanceValue.
Described medical therapeutic equipment comprises: the first two-way operational amplifier, and for generation of the benchmark of 2.5VVoltage, its anode is connected with the other end of the second resistance, and negative terminal is connected with one end of the first electric capacity, defeatedGo out end and be connected with the negative terminal of infrared-emitting diode, negative terminal also connects with the negative terminal of infrared-emitting diodeConnect; The first electric capacity, other end ground connection; The 4th resistance, the negative terminal of one end and infrared-emitting diode connectsConnect; The second two-way operational amplifier, anode is connected with the other end of the 4th resistance, negative terminal and infrared connecingThe anode of receiving diode connects, and output is as pulse voltage.
Described medical therapeutic equipment comprises: the 5th resistance, be connected in parallel on the second two-way operational amplifier negative terminal andBetween the second two-way operational amplifier output terminal; The second electric capacity, is connected in parallel on the second two-way operational amplifierBetween negative terminal and the second two-way operational amplifier output terminal; Infrared-emitting diode, is arranged on tested personMember ear's capillary position, for launching infrared light, the negative terminal of infrared-emitting diode and infrared connecingThe anode of receiving diode connects; Infrared receiving diode, is arranged on tested personnel ear capillary positionPut, be positioned at the relative position of described infrared-emitting diode, for receiving transmission tested personnel ear hairInfrared light after thin blood vessel.
Described medical therapeutic equipment comprises: Direct Digital Frequency Synthesizers, and for generation of frequency and phase potential energyEnough sine wave signals of adjusting are to use as mixing as rf frequency source; Pulse-series generator,For generation of pulse train; Frequency mixer, with described Direct Digital Frequency Synthesizers and described pulse trainGenerator connects respectively, adopts pulse train offset of sinusoidal ripple signal to carry out mixed modulated; Power amplifier,Be connected with described frequency mixer, for the signal after mixed modulated is amplified.
Described medical therapeutic equipment comprises: Switching Power Supply, and as the interface between probe and power amplifierCircuit, by amplify after signal loading to probe radio-frequency receiving-transmitting coil in; Nd-Fe-B permanent magnetic type magnetStructure produces a uniform static magnetic field of field intensity in the space that holds tested personnel's finger; Probe,Be placed on tested personnel's finger position, be wound around radio-frequency receiving-transmitting coil so that the signal of loading is sent into described neodymiumIn iron boron permanent-magnet type magnet structure, produce nmr phenomena, also for pointing through tested personnelThe deamplification obtaining after interior hydrogen proton resonance is sent.
Described medical therapeutic equipment comprises: Freescale IMX6 processor, be connected with described probe, and connectReceive described deamplification, analyze the spectral line of described deamplification, and calculate wherein glucose proportion,Thereby obtain tested personnel's blood sugar concentration, described Freescale IMX6 processor is also with described secondThe output of two-way operational amplifier connects to obtain described pulse voltage, and exists when described pulse voltageOutside default pulse range time, send cacosphyxia identification signal, when described blood sugar concentration is at default bloodWhen sugar upper limit concentration, send the too high identification signal of blood sugar concentration, when described blood sugar concentration is at default blood sugarWhen least concentration, send the too low identification signal of blood sugar concentration.
Described medical therapeutic equipment comprises: insulin memory device, and for the pancreas of pre-stored preset capacityIsland element; Liquid level detection device, is positioned at described insulin memory device, for detecting in real time insulinInsulin liquid level in memory device, and in the time that insulin liquid level is equal to or less than preset reference liquid level,Send insufficient insulin alarm signal, described liquid level detection device also with described Freescale IMX6 placeReason device connects described insufficient insulin alarm signal to be sent to described Freescale IMX6 processDevice.
Described medical therapeutic equipment comprises: insulin driving arrangement, process with described Freescale IMX6Device connects, in the time receiving the too high identification signal of described blood sugar concentration, according to described Freescale IMX6The blood sugar concentration that processor forwards and the difference of described default blood sugar upper limit concentration determine that insulin pump drivesMoving signal, value and the speed of supply insulin of insulin pump that described insulin pump has driven signal decidingDegree; Insulin pump, joins respectively with described insulin memory device and injection of insulin equipment, with instituteState insulin driving arrangement and connect, under the control at described insulin driving arrangement, by described pancreasInsulin in the element memory device of island is expelled in tested personnel's body by injection of insulin equipment.
Described medical therapeutic equipment comprises: injection of insulin equipment, the detachable tested personnel's body that is embedded inIn, for to tested personnel's insulin injection; Serial communication circuit, is positioned at Freescale IMX6 placeBetween reason device and Bluetooth matching communication equipment, for by described blood sugar concentration and described insufficient insulin reportAlert signal sends to Bluetooth matching communication equipment.
Described medical therapeutic equipment comprises: Bluetooth matching communication equipment, and for by described blood sugar concentration and instituteState insufficient insulin alarm signal and be wirelessly transmitted to the target bluetooth equipment in connection; Described Bluetooth matchingCommunication equipment comprises the first search subset, the second search subset and coupling connexon equipment.
Wherein, the first search subset, determines bluetooth according to MAC Address concentration in Bluetooth ScatternetThe highest micro bluetooth network of MAC Address concentration is as target piconet, and a Bluetooth Scatternet is by manyIndividual micro bluetooth network composition; The second search subset, is connected with described the first search subset, in instituteState in target piconet, find, quantity preceding by signal strength signal intensity rank and be not more than 7 one or manyIndividual Bluetooth matching communication equipment is as one or more target bluetooth equipments; Equipment connection subset, withDescribed the second search subset connects, and starts with the bluetooth of described one or more target bluetooth equipments logicalLetter connects.
Wherein, when between infrared-emitting diode and infrared receiving diode when pulseless, pulse voltageFor 2.5V, in the time there is the pulse of beating between infrared-emitting diode and infrared receiving diode, bloodMai Shi ear light transmission variation, pulse voltage is greater than 2.5V; Wherein, the first two-way operational amplifier andThe second two-way operational amplifier is all the two-way operational amplifier of TI company.
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, toroidal winding, saddleOne in coil, phased array coil and annulus; Wherein, Direct Digital Frequency Synthesizers instituteThe frequency synthesis adopting selects that Direct Digital is synthetic, one in analog phase-locked look and digital phase-locked loop.
Wherein, when having the quantity of Bluetooth matching communication equipment of signal in described target piconet for being greater thanEqual at 7 o'clock, the quantity of described one or more target bluetooth equipments is 7, when described target slightIn net, there is the quantity of Bluetooth matching communication equipment of signal for being less than at 7 o'clock, described one or more targetsThe quantity of bluetooth equipment is the quantity that has the Bluetooth matching communication equipment of signal in described target piconet.
Alternatively, in described automation blood glucose meter: described serial communication circuit is that RS232 serial is logicalLetter interface; Described Freescale IMX6 processor sending cacosphyxia identification signal, blood sugar is too highWhen identification signal or hypoglycemia identification signal, send abnormality signal simultaneously, otherwise, described in flySi Kaer IMX6 processor sends normal state signal simultaneously; Described medical therapeutic equipment also comprises: nothingLine telecommunication circuit, is connected with described Freescale IMX6 processor, for sending abnormality signalOr normal state signal; Described radio communication circuit is that 3G mobile communication interface or 4G mobile communication connectMouthful; Described medical therapeutic equipment also comprises: FLASH storage chip, and with described Freescale IMX6 placeReason device connects, under pre-stored default pulse range, default blood sugar upper limit concentration and default blood sugarLimit concentration.
In addition, operational amplifier (being called for short " amplifier ") is to have the very circuit unit of high-amplification-factor.In side circuit, conventionally jointly form certain functional module in conjunction with feedback network. He be a kind of withThe amplifier of special Coupling circuit and feedback. Its output signal can be input signal add, subtract or differential,The result of the mathematical operations such as integration. Owing to being applied in early days in simulation computer, in order to realize mathematics fortuneCalculate, therefore gain the name " operational amplifier ".
Amplifier is the circuit unit of a name of the angle from function, can be realized by discrete device,Also can realize in the middle of semiconductor chip. Along with the development of semiconductor technology, most amplifier isForm with single-chip exists. Amplifier of a great variety, is widely used in the middle of electron trade.
Adopt automation blood glucose meter of the present invention, fall behind and nothing for blood sugar apparatus structure in prior artThe technical problem that line communication function is poor, optimizes the structure of existing blood sugar instrument, adds pulse detection to establishStandby and blood sugar concentration automatic control equipment also improves the communication performance of existing bluetooth communication interface simultaneously,Thereby improve the level of its medical services.
Be understandable that, although the present invention disclose as above with preferred embodiment, but above-mentioned enforcementExample is not in order to limit the present invention. For any those of ordinary skill in the art, do not departing fromIn technical solution of the present invention scope situation, all can utilize the technology contents of above-mentioned announcement to the technology of the present inventionScheme is made many possible variations and modification, or is revised as the equivalent embodiment of equivalent variations. Therefore,Every content that does not depart from technical solution of the present invention, foundation technical spirit of the present invention is to above embodimentAny simple modification, equivalent variations and the modification done, all still belong to technical solution of the present invention protectionIn scope.
Claims (7)
1. the blood sugar detecting method based on automation blood glucose meter, the method comprises:
1) provide a kind of automation blood glucose meter, described medical therapeutic equipment comprise insulin driving arrangement,Insulin pump, pulse detection equipment, blood sugar test equipment and Freescale IMX6 processor, described inPulse detection equipment and described blood sugar test equipment be respectively used to extract tested personnel pulse data andBlood glucose level data, described Freescale IMX6 processor and described insulin driving arrangement, described pulseCheckout equipment is connected respectively with described blood sugar test equipment, based on the Pulse Rate of described pulse detection equipmentAccording to determining whether to send cacosphyxia identification signal, the blood glucose level data based on described blood sugar test equipment is trueFixed whether control described insulin driving arrangement to drive described insulin pump to inject pancreas as tested personnelIsland element;
2) use described automation blood glucose meter.
2. the method for claim 1, is characterized in that, described medical therapeutic equipment comprises:
The first resistance, one end is connected with 5V power supply, and the anode of the other end and infrared receiving diode connectsConnect;
The second resistance, one end is connected with 5V power supply, and the other end is connected with one end of the 3rd resistance;
The 3rd resistance, other end ground connection, and there is the resistance identical with the second resistance;
The first two-way operational amplifier, for generation of the reference voltage of 2.5V, its anode and the second resistanceThe other end connect, negative terminal is connected with one end of the first electric capacity, output and infrared-emitting diodeNegative terminal connects, and negative terminal is also connected with the negative terminal of infrared-emitting diode;
The first electric capacity, other end ground connection;
The 4th resistance, one end is connected with the negative terminal of infrared-emitting diode;
The second two-way operational amplifier, anode is connected with the other end of the 4th resistance, negative terminal and infrared connecingThe anode of receiving diode connects, and output is as pulse voltage;
The 5th resistance, is connected in parallel on the second two-way operational amplifier negative terminal and the second two-way operational amplifier is defeatedGo out between end;
The second electric capacity, is connected in parallel on the second two-way operational amplifier negative terminal and the second two-way operational amplifier is defeatedGo out between end;
Infrared-emitting diode, is arranged on tested personnel ear capillary position, infrared for launchingLight, the negative terminal of infrared-emitting diode is connected with the anode of infrared receiving diode;
Infrared receiving diode, is arranged on tested personnel ear capillary position, is positioned at described infraredThe relative position of emitting diode, for receiving infrared after transmission tested personnel ear capillaryLight;
Direct Digital Frequency Synthesizers, the sine wave signal that can adjust for generation of frequency and phase place withUse as mixing as rf frequency source;
Pulse-series generator, for generation of pulse train;
Frequency mixer, connects respectively with described Direct Digital Frequency Synthesizers and described pulse-series generatorConnect, adopt pulse train offset of sinusoidal ripple signal to carry out mixed modulated;
Power amplifier, is connected with described frequency mixer, for the signal after mixed modulated is amplified;
Switching Power Supply, as the interface circuit between probe and power amplifier, by the signal after amplifyingBe loaded in the radio-frequency receiving-transmitting coil of probe;
Nd-Fe-B permanent magnetic type magnet structure produces a field intensity in the space that holds tested personnel's fingerStatic magnetic field uniformly;
Probe, is placed on tested personnel's finger position, is wound around radio-frequency receiving-transmitting coil with by the signal loadingSend in described Nd-Fe-B permanent magnetic type magnet structure, produce nmr phenomena, also for will be through quiltSurvey personnel point the deamplification obtaining after interior hydrogen proton resonance and send;
Freescale IMX6 processor, is connected with described probe, receives described deamplification, analyzesThe spectral line of described deamplification, and calculate wherein glucose proportion, thus obtain tested personnel'sBlood sugar concentration, also defeated with described the second two-way operational amplifier of described Freescale IMX6 processorGo out end and connect to obtain described pulse voltage, and when described pulse voltage is outside default pulse rangeTime, send cacosphyxia identification signal, when described blood sugar concentration is during in default blood sugar upper limit concentration, send outGo out blood sugar excessive concentration identification signal, when described blood sugar concentration is during at default blood sugar least concentration, sendThe too low identification signal of blood sugar concentration;
Insulin memory device, for the insulin of pre-stored preset capacity;
Liquid level detection device, is positioned at described insulin memory device, deposits for detecting in real time insulinInsulin liquid level in storage equipment, and in the time that insulin liquid level is equal to or less than preset reference liquid level, send outGo out insufficient insulin alarm signal, described liquid level detection device is also processed with described Freescale IMX6Device connects described insufficient insulin alarm signal is sent to described Freescale IMX6 processor;
Insulin driving arrangement, is connected with described Freescale IMX6 processor, described in receivingWhen the too high identification signal of blood sugar concentration, the blood sugar forwarding according to described Freescale IMX6 processor is denseThe difference of degree and described default blood sugar upper limit concentration is determined insulin pump drive signal, described insulin pumpValue and the speed of supply insulin of insulin pump that driven signal deciding;
Insulin pump, joins respectively with described insulin memory device and injection of insulin equipment, with instituteState insulin driving arrangement and connect, under the control at described insulin driving arrangement, by described pancreasInsulin in the element memory device of island is expelled in tested personnel's body by injection of insulin equipment;
Injection of insulin equipment, detachable being embedded in tested personnel's body, for noting to tested personnelPenetrate insulin;
Serial communication circuit, between Freescale IMX6 processor and Bluetooth matching communication equipment,Communicate by letter and establish for described blood sugar concentration and described insufficient insulin alarm signal are sent to Bluetooth matchingStandby;
Bluetooth matching communication equipment, for by described blood sugar concentration and described insufficient insulin alarm signalBe wirelessly transmitted to the target bluetooth equipment in connection; Described Bluetooth matching communication equipment comprises the first searchSubset, the second search subset and coupling connexon equipment; Wherein, the first search subset, rootDetermine that according to MAC Address concentration in Bluetooth Scatternet the bluetooth that bluetooth MAC Address concentration is the highest is slightNet is as target piconet, and a Bluetooth Scatternet is made up of multiple micro bluetooth networks; The second searchEquipment, is connected with described the first search subset, and in described target piconet, it is strong that signal is pressed in searchingPreceding, the quantity of degree rank be not more than one or more Bluetooth matching communication equipments of 7 as one orMultiple target bluetooth equipments; Equipment connection subset, is connected with described the second search subset, startsBe connected with the Bluetooth communication of described one or more target bluetooth equipments;
Wherein, when between infrared-emitting diode and infrared receiving diode when pulseless, pulse voltageFor 2.5V, in the time there is the pulse of beating between infrared-emitting diode and infrared receiving diode, bloodMai Shi ear light transmission variation, pulse voltage is greater than 2.5V;
Wherein, the first two-way operational amplifier and the second two-way operational amplifier are all the two-way of TI companyOperational amplifier;
Wherein, the radio-frequency receiving-transmitting coil that described probe is wound around is birdcage coil, toroidal winding, saddleOne in coil, phased array coil and annulus;
Wherein, the frequency synthesis that Direct Digital Frequency Synthesizers adopts selects that Direct Digital is synthetic, mouldIntend the one in phaselocked loop and digital phase-locked loop;
Wherein, when having the quantity of Bluetooth matching communication equipment of signal in described target piconet for being greater thanEqual at 7 o'clock, the quantity of described one or more target bluetooth equipments is 7, when described target slightIn net, there is the quantity of Bluetooth matching communication equipment of signal for being less than at 7 o'clock, described one or more targetsThe quantity of bluetooth equipment is the quantity that has the Bluetooth matching communication equipment of signal in described target piconet.
3. method as claimed in claim 2, is characterized in that:
Described serial communication circuit is RS232 serial communication interface.
4. method as claimed in claim 2, is characterized in that:
Described Freescale IMX6 processor is sending cacosphyxia identification signal, the too high identification of blood sugarWhen signal or hypoglycemia identification signal, send abnormality signal simultaneously, otherwise, described in fly think cardYou send normal state signal by IMX6 processor simultaneously.
5. method as claimed in claim 4, is characterized in that, described medical therapeutic equipment also comprises:
Radio communication circuit, is connected with described Freescale IMX6 processor, for sending abnormal shapeState signal or normal state signal.
6. method as claimed in claim 5, is characterized in that:
Described radio communication circuit is 3G mobile communication interface or 4G mobile communication interface.
7. method as claimed in claim 2, is characterized in that, described medical therapeutic equipment also comprises:
FLASH storage chip, is connected with described Freescale IMX6 processor, for pre-storedDefault pulse range, default blood sugar upper limit concentration and default blood sugar least concentration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510745025.9A CN105607530B (en) | 2015-11-05 | 2015-11-05 | A kind of automatization blood glucose meter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510745025.9A CN105607530B (en) | 2015-11-05 | 2015-11-05 | A kind of automatization blood glucose meter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105607530A true CN105607530A (en) | 2016-05-25 |
| CN105607530B CN105607530B (en) | 2016-12-14 |
Family
ID=55987536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510745025.9A Expired - Fee Related CN105607530B (en) | 2015-11-05 | 2015-11-05 | A kind of automatization blood glucose meter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105607530B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017076103A1 (en) * | 2015-11-05 | 2017-05-11 | 李淑兰 | Automated blood sugar meter |
| CN108619618A (en) * | 2018-05-29 | 2018-10-09 | 北京星辰万有科技有限公司 | A kind of diabetes physical-therapy device |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101107025A (en) * | 2005-01-17 | 2008-01-16 | 诺和诺德公司 | Fluide delivery device with integrated monitoring of physiological characteristics |
| CN101125086A (en) * | 2006-08-18 | 2008-02-20 | 刘胜 | Closed-loop automatic controlling insulin-injecting system |
| US20090312622A1 (en) * | 2006-09-28 | 2009-12-17 | Werner Regittnig | Device And Method For Determining A Value Of A Physiological Parameter Of A Body Fluid |
| CN102016855A (en) * | 2008-04-04 | 2011-04-13 | 海吉雅有限公司 | Apparatus for optimizing a patient's insulin dosage regimen |
| CN103263270A (en) * | 2013-05-02 | 2013-08-28 | 卢世明 | Blood-glucose meter |
| CN204581297U (en) * | 2015-04-23 | 2015-08-26 | 何雷 | A kind of insulin resistant detector based on pulse wave |
| CN105232056A (en) * | 2015-11-05 | 2016-01-13 | 张宏业 | Automated glucometer |
-
2015
- 2015-11-05 CN CN201510745025.9A patent/CN105607530B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101107025A (en) * | 2005-01-17 | 2008-01-16 | 诺和诺德公司 | Fluide delivery device with integrated monitoring of physiological characteristics |
| CN101125086A (en) * | 2006-08-18 | 2008-02-20 | 刘胜 | Closed-loop automatic controlling insulin-injecting system |
| US20090312622A1 (en) * | 2006-09-28 | 2009-12-17 | Werner Regittnig | Device And Method For Determining A Value Of A Physiological Parameter Of A Body Fluid |
| CN102016855A (en) * | 2008-04-04 | 2011-04-13 | 海吉雅有限公司 | Apparatus for optimizing a patient's insulin dosage regimen |
| CN103263270A (en) * | 2013-05-02 | 2013-08-28 | 卢世明 | Blood-glucose meter |
| CN204581297U (en) * | 2015-04-23 | 2015-08-26 | 何雷 | A kind of insulin resistant detector based on pulse wave |
| CN105232056A (en) * | 2015-11-05 | 2016-01-13 | 张宏业 | Automated glucometer |
Non-Patent Citations (2)
| Title |
|---|
| 王显静: "新型智能闭环胰岛素泵系统的研究", 《青岛理工大学硕士学位论文》 * |
| 陈康: "磁共振式无创血糖检测的研究", 《电子科技大学硕士学位论文》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017076103A1 (en) * | 2015-11-05 | 2017-05-11 | 李淑兰 | Automated blood sugar meter |
| CN108619618A (en) * | 2018-05-29 | 2018-10-09 | 北京星辰万有科技有限公司 | A kind of diabetes physical-therapy device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105607530B (en) | 2016-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105193425A (en) | Use method of noninvasive glucometer | |
| CN105193426B (en) | Non-invasive blood glucose meter | |
| CN101553167B (en) | Method of interfacing a detachable display system to a base unit for use in MRI | |
| CN105232056B (en) | medical therapeutic equipment | |
| US9488705B2 (en) | Wireless local transmit coils and array with controllable load | |
| US10185009B2 (en) | Magnetic resonance system and operating method therefor | |
| JP2009072580A (en) | Magnetic resonance apparatus and control method for the same | |
| CN105607530A (en) | Blood glucose detection method based on automatic glucose meter | |
| US10215818B2 (en) | Single coaxial interface for magnetic resonace (MR) coils | |
| US9903926B2 (en) | Determination of communication latency in magnetic resonance tomography systems | |
| CA2339325C (en) | Implantable nuclear magnetic resonance spectrometer | |
| CN104434102B (en) | Method for measuring HF driving pulses | |
| CN105496374B (en) | Strengthen computer aided medicine system | |
| CN103949293B (en) | Liquid metering equipment pipetting instruction parameter rapid setting system and method | |
| CN104689472A (en) | Electromagnetic type magnetic sensitive information feedback method and system | |
| CN210222234U (en) | Radio frequency coil assembly, scanning device and magnetic resonance imaging system | |
| CN209402509U (en) | A kind of external data radio station | |
| CN105678068A (en) | Medical information diagnosis assisting method | |
| WO2021108610A1 (en) | Methods and systems for reducing difference between calculated and measured analyte levels | |
| CN105963827A (en) | Invasive type glucose therapeutic apparatus | |
| CN211478629U (en) | Magnetic resonance equipment of health data supervision platform | |
| US9498127B2 (en) | Data transfer device and data transfer system | |
| CN105411581A (en) | Insulin injection control method based on blood glucose detection | |
| CN105433927A (en) | Multi-functional medical monitor | |
| CN107669335A (en) | Low-temperature plasma scalpel and low-temperature plasma operation device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Huahua Inventor before: Zhang Hongye |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20161010 Address after: 214000 Jiangsu city of Wuxi Province East Pavilion Street Xishan District Yingbin Road No. 1 Applicant after: Wuxi Sani pacifies Science and Technology Ltd. Address before: 18 Box 072152, Baoding, Hebei, Baoding Applicant before: Zhang Hongye |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Gong Fengling Inventor after: Luo Yongwei Inventor after: Chen Weibin Inventor after: Sun Fengtao Inventor after: Ma Chunmei Inventor before: Zhang Huahua |
|
| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20161116 Address after: 063000 Hebei province Tangshan City Xinhua West Road No. 46 North China University of science and technology Applicant after: North China Polytechnics Address before: 214000 Jiangsu city of Wuxi Province East Pavilion Street Xishan District Yingbin Road No. 1 Applicant before: Wuxi Sani pacifies Science and Technology Ltd. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161214 Termination date: 20191105 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |