CN105229168B - 纳米流体中分子的表征 - Google Patents
纳米流体中分子的表征 Download PDFInfo
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- CN105229168B CN105229168B CN201480009730.6A CN201480009730A CN105229168B CN 105229168 B CN105229168 B CN 105229168B CN 201480009730 A CN201480009730 A CN 201480009730A CN 105229168 B CN105229168 B CN 105229168B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767219P | 2013-02-20 | 2013-02-20 | |
| US61/767,219 | 2013-02-20 | ||
| PCT/US2014/017226 WO2014130589A1 (en) | 2013-02-20 | 2014-02-19 | Characterization of molecules in nanofluidics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105229168A CN105229168A (zh) | 2016-01-06 |
| CN105229168B true CN105229168B (zh) | 2020-07-17 |
Family
ID=51391777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480009730.6A Active CN105229168B (zh) | 2013-02-20 | 2014-02-19 | 纳米流体中分子的表征 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9809855B2 (enExample) |
| EP (1) | EP2959015B1 (enExample) |
| JP (2) | JP6542676B2 (enExample) |
| CN (1) | CN105229168B (enExample) |
| AU (1) | AU2014219001A1 (enExample) |
| CA (1) | CA2901460A1 (enExample) |
| WO (1) | WO2014130589A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10844424B2 (en) | 2013-02-20 | 2020-11-24 | Bionano Genomics, Inc. | Reduction of bias in genomic coverage measurements |
| CN105229168B (zh) | 2013-02-20 | 2020-07-17 | 生物纳米基因有限公司 | 纳米流体中分子的表征 |
| CN106164295B (zh) | 2014-02-25 | 2020-08-11 | 生物纳米基因公司 | 减小基因组覆盖测量中的偏差 |
| WO2018148903A1 (zh) * | 2017-02-16 | 2018-08-23 | 上海亿康医学检验所有限公司 | 泌尿系统肿瘤的辅助诊断方法 |
| DE102019200929A1 (de) * | 2019-01-25 | 2020-07-30 | Robert Bosch Gmbh | Verfahren und Vorrichtung zum optischen Erfassen einer Länge eines Makromoleküls |
| JP2023554621A (ja) * | 2020-12-15 | 2023-12-28 | クアンタム-エスアイ インコーポレイテッド | 超高感度バイオセンサ法 |
| WO2024145268A2 (en) | 2022-12-25 | 2024-07-04 | Bionano Genomics, Inc. | Optical genome mapping cartridges |
| EP4639178A1 (en) | 2022-12-25 | 2025-10-29 | Bionano Genomics, Inc. | Optical genome mapping system |
| EP4639177A1 (en) | 2022-12-25 | 2025-10-29 | Bionano Genomics, Inc. | Instrumentation of optical genome mapping systems |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101765462A (zh) * | 2007-03-28 | 2010-06-30 | 生物纳米芯股份有限公司 | 使用纳米通道阵列的大分子分析方法 |
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| US20030104428A1 (en) | 2001-06-21 | 2003-06-05 | President And Fellows Of Harvard College | Method for characterization of nucleic acid molecules |
| SG169225A1 (en) * | 2001-07-25 | 2011-03-30 | Univ Princeton | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
| AU2003243691A1 (en) | 2002-06-20 | 2004-01-06 | Primera Biosystems, Inc. | Apparatus for polynucleotide detection and quantitation |
| US8346482B2 (en) * | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| US20100216153A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20060063184A1 (en) | 2004-09-09 | 2006-03-23 | Felix Carolyn A | Compositions and methods for the detection of DNA topoisomerase II complexes with DNA |
| JP2009529887A (ja) * | 2006-03-13 | 2009-08-27 | イコニシス インコーポレーテッド | 胎児細胞およびガン細胞を診断する非侵襲的方法 |
| EP3978121A1 (en) | 2006-07-19 | 2022-04-06 | BioNano Genomics, Inc. | Nanonozzle device arrays: their preparation and use for macromolecular analysis |
| EP3892736A1 (en) * | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US20090076345A1 (en) | 2007-09-14 | 2009-03-19 | Corventis, Inc. | Adherent Device with Multiple Physiological Sensors |
| JP4831236B2 (ja) | 2007-11-12 | 2011-12-07 | 株式会社村田製作所 | 操作位置検出器およびその応用装置 |
| KR20110016479A (ko) | 2008-06-06 | 2011-02-17 | 바이오나노매트릭스, 인크. | 통합 나노유체 분석 장치, 제작 방법 및 분석 기술 |
| US8628919B2 (en) * | 2008-06-30 | 2014-01-14 | Bionano Genomics, Inc. | Methods and devices for single-molecule whole genome analysis |
| WO2011050147A1 (en) | 2009-10-21 | 2011-04-28 | Bionanomatrix, Inc . | Methods and related devices for single molecule whole genome analysis |
| JP5846703B2 (ja) | 2008-11-18 | 2016-01-20 | バイオナノ ジェノミックス、インク. | ポリヌクレオチドのマッピング及び配列決定 |
| US20100137154A1 (en) * | 2008-12-01 | 2010-06-03 | Ach Robert A | Genome analysis using a methyltransferase |
| US20120097835A1 (en) | 2009-05-19 | 2012-04-26 | BioNano Geneomics, Inc. | Devices and methods for dynamic determination of sample position and orientation and dynamic repositioning |
| US9725315B2 (en) | 2009-09-28 | 2017-08-08 | Bionano Genomics, Inc. | Nanochannel arrays and near-field illumination devices for polymer analysis and related methods |
| SG189778A1 (en) * | 2009-10-20 | 2013-05-31 | Agency Science Tech & Res | Microfluidic system for trapping and detection of a biological entity in a sample |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
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| EP2547795B1 (en) | 2010-03-16 | 2015-01-14 | Nanostring Technologies, Inc | Compositions and methods for the detection of genomic features |
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| CN105143462A (zh) | 2013-02-05 | 2015-12-09 | 生物纳米基因有限公司 | 用于单分子分析的方法 |
| CN105229168B (zh) | 2013-02-20 | 2020-07-17 | 生物纳米基因有限公司 | 纳米流体中分子的表征 |
-
2014
- 2014-02-19 CN CN201480009730.6A patent/CN105229168B/zh active Active
- 2014-02-19 CA CA2901460A patent/CA2901460A1/en active Pending
- 2014-02-19 JP JP2015558929A patent/JP6542676B2/ja active Active
- 2014-02-19 US US14/768,422 patent/US9809855B2/en active Active
- 2014-02-19 EP EP14753475.4A patent/EP2959015B1/en active Active
- 2014-02-19 WO PCT/US2014/017226 patent/WO2014130589A1/en not_active Ceased
- 2014-02-19 AU AU2014219001A patent/AU2014219001A1/en not_active Abandoned
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2017
- 2017-10-27 US US15/795,847 patent/US10669586B2/en active Active
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2019
- 2019-06-13 JP JP2019110164A patent/JP6928032B2/ja active Active
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2020
- 2020-05-29 US US16/887,679 patent/US11359244B2/en active Active
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2022
- 2022-05-11 US US17/741,708 patent/US12275992B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101765462A (zh) * | 2007-03-28 | 2010-06-30 | 生物纳米芯股份有限公司 | 使用纳米通道阵列的大分子分析方法 |
Non-Patent Citations (1)
| Title |
|---|
| Genome mapping on nanochannel arrays for structural variation analysis and sequence assembly;Ernest T Lam等;《Nature Biotechnology》;20120801;第30卷(第8期);第771-776页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2959015A1 (en) | 2015-12-30 |
| US20200362413A1 (en) | 2020-11-19 |
| US10669586B2 (en) | 2020-06-02 |
| JP6928032B2 (ja) | 2021-09-01 |
| US20220340973A1 (en) | 2022-10-27 |
| US20180223361A1 (en) | 2018-08-09 |
| JP2019205434A (ja) | 2019-12-05 |
| EP2959015B1 (en) | 2020-11-04 |
| US20160046992A1 (en) | 2016-02-18 |
| US9809855B2 (en) | 2017-11-07 |
| EP2959015A4 (en) | 2016-08-17 |
| AU2014219001A1 (en) | 2015-10-08 |
| HK1219511A1 (zh) | 2017-04-07 |
| US12275992B2 (en) | 2025-04-15 |
| JP2016510590A (ja) | 2016-04-11 |
| WO2014130589A1 (en) | 2014-08-28 |
| CA2901460A1 (en) | 2014-08-28 |
| CN105229168A (zh) | 2016-01-06 |
| US11359244B2 (en) | 2022-06-14 |
| JP6542676B2 (ja) | 2019-07-10 |
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