CN105223181A - A kind of fluorescence detection device - Google Patents
A kind of fluorescence detection device Download PDFInfo
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- CN105223181A CN105223181A CN201510703414.5A CN201510703414A CN105223181A CN 105223181 A CN105223181 A CN 105223181A CN 201510703414 A CN201510703414 A CN 201510703414A CN 105223181 A CN105223181 A CN 105223181A
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Abstract
The invention discloses a kind of fluorescence detection device, comprise light source, excitation fiber, light-splitting device, detection optical fiber, launching fiber and photodetector; One end of excitation fiber connects light source, and the other end of excitation fiber is connected to the first end of light-splitting device; One end of detection optical fiber is connected to the second end of light-splitting device, and the other end of detection optical fiber is for connecting testing sample; One end of launching fiber connects photodetector, and the other end is connected to the 3rd end of light-splitting device; Light source produces exciting light, and be transferred to light-splitting device through excitation fiber, after light-splitting device light splitting, enter detection optical fiber, exciting light is irradiated on testing sample by detection optical fiber; After detection optical fiber is entered in the optically-coupled that testing sample returns, launching fiber is entered again through light-splitting device, the illumination of launching fiber transmission is mapped on photodetector, and photodetector detects the light signal that launching fiber sends, and realizes the detection to the fluorescence signal that sample sends.The present invention has that volume is little, the feature of good stability.
Description
Technical field
The invention belongs to fluoroscopic examination field, more specifically, relate to a kind of fluorescence detection device.
Background technology
Fluoroscopic examination is widely used in the fields such as material detection, life science, medical research.Fluorescence detection device comprises light source, monochromator or optical filter and photo-detector.The exciting light that light source sends is radiated at after on testing sample, and the light that sample returns incides on photo-detector after monochromator or optical filter, can qualitative or quantitative detecting the fluorescence signal of sample by the measured value detecting photo-detector.Its exciting light of conventional fluorescent pick-up unit and utilizing emitted light are propagated all in free space, and need the optical element for free space to carry out the structure of light path, its volume is larger.In free space light path, once the locus of certain optical element changes, all can there is deviation in its subsequent optical path, cause the decline of effect, and the usual volume of Free Space Optics part is also difficult to accomplish very high mechanical stability comparatively greatly.When detecting for fluorescence signal in the body of living body biological, the volume of the interior pry head of conventional fluorescent pick-up unit is comparatively large, is difficult to accomplish Wicresoft.
Summary of the invention
For the defect of prior art, the object of the present invention is to provide a kind of fluorescence detection device, be intended to solve fluorescence detection device of the prior art and cause owing to needing the optical element for free space to carry out light path structure the problem that volume is large, light stability is poor.
The invention provides a kind of fluorescence detection device, comprise light source, excitation fiber, light-splitting device, detection optical fiber, launching fiber and photodetector; One end of described excitation fiber connects described light source, and the other end of described excitation fiber is connected to the first end of described light-splitting device; One end of described detection optical fiber is connected to the second end of described light-splitting device, and the other end of described detection optical fiber is for connecting testing sample; One end of described launching fiber connects described photodetector, and the other end is connected to the 3rd end of described light-splitting device; Described light source produces exciting light, and be transferred to described light-splitting device through described excitation fiber, after light-splitting device light splitting, enter detection optical fiber, exciting light is irradiated on testing sample by detection optical fiber; After detection optical fiber is entered in the optically-coupled that testing sample returns, launching fiber is entered again through light-splitting device, the illumination of launching fiber transmission is mapped on photodetector, and photodetector detects the light signal that launching fiber sends, and realizes the detection to the fluorescence signal that sample sends.
Further, described light source is fiber coupled laser, and described photodetector is photomultiplier.
Further, described fluorescence detection device also comprises the first optical fiber collimator between one end and described photomultiplier and the first optical filter that are connected to described launching fiber in turn; The optical alignment that described first optical fiber collimator is used for described launching fiber to transmit is to free space; Described first optical filter is used for carrying out filtering process to the light of free space.
Further, described light-splitting device comprises the second optical fiber collimator, the first fiber coupler, dichroic sheet and the second fiber coupler; Described second optical fiber collimator is arranged in the input path of described dichroic sheet, and the input end of described second optical fiber collimator is as the first end of described light-splitting device, the light that the output terminal of described second optical fiber collimator exports is as the incident light of described dichroic sheet; Described first fiber coupler is arranged on the reflected light path of described dichroic sheet, and one end of described first fiber coupler is as the second end of described light-splitting device, and the other end of described first fiber coupler is for receiving the light through described dichroic sheet reflection; Described second fiber coupler is arranged on the transmitted light path of described dichroic sheet, and one end of described second fiber coupler is as the 3rd end of described light-splitting device, and the other end of described second fiber coupler is for receiving the light through the transmission of described dichroic sheet.
Further, described light-splitting device also comprises the second optical filter be arranged between described second optical fiber collimator and described dichroic sheet.
Further, described light-splitting device comprises the 3rd optical filter also comprising and being arranged between described dichroic sheet and described second fiber coupler.
Present invention also offers a kind of fluorescence detection device, comprise fiber coupled laser, excitation fiber, the second optical fiber collimator, the first fiber coupler, dichroic sheet, the 3rd optical filter, detection optical fiber and photomultiplier; Described second optical fiber collimator is arranged in the input path of described dichroic sheet, and the input end of described second optical fiber collimator connects described fiber coupled laser by described excitation fiber; Described first fiber coupler is arranged on the reflected light path of described dichroic sheet, and one end of described first fiber coupler connects testing sample by described detection optical fiber; Described 3rd optical filter and described photomultiplier are successively set on the transmitted light path of described dichroic sheet.
The present invention utilizes the beam splitter in the optical fibre light splitting element replacement free space of Highgrade integration, the luminous energy transmitted in free space and light signal is limited in the optical device of optical fiber and Highgrade integration in conventional fluorescent pick-up unit; Make the volume of whole fluorescence detection device little and be not afraid of bending and vibration, achieving miniaturization and the high stability of fluorescence detection device.
Accompanying drawing explanation
Fig. 1 is the structural representation of the fluorescence detection device that the embodiment of the present invention provides.
Fig. 2 is the structural representation of the fluorescence detection device that first embodiment of the invention provides.
Fig. 3 is the structural representation of the fluorescence detection device that second embodiment of the invention provides.
Fig. 4 is the structural representation of the fluorescence detection device that third embodiment of the invention provides.
Fig. 5 is the structural representation of the fluorescence detection device that fourth embodiment of the invention provides.
Fig. 6 is the structural representation of the fluorescence detection device that fifth embodiment of the invention provides.
1 is light source, and 2 is excitation fiber, and 3 is light-splitting device, and 4 is detection optical fiber, 5 is testing sample, and 6 is launching fiber, and 7 is photodetector, and 8 is fiber coupled laser, 9 is y-type optical fiber, and 10 is the first optical fiber collimator, and 11 is the first optical filter, 12 is photomultiplier, and 13 is the second optical fiber collimator, and 14 is filter set shell, 15 is the first fiber coupler, and 16 is dichroic sheet, and 17 is the second fiber coupler, 18 is coupling fiber LED, and 19 is the second optical filter, and 20 is the 3rd optical filter.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
The fluorescence detection device that the embodiment of the present invention provides utilizes optical fiber to carry out luminous energy and optical signal transmission.Fig. 1 shows the structure of this fluorescence detection device, and for convenience of explanation, illustrate only the part relevant to the embodiment of the present invention, details are as follows:
Fluorescence detection device comprises light source 1, optical fiber and photodetector 7; Wherein light source 1 is for generation of exciting light, and optical fiber is used for the exciting light of transmission light source 1 generation and the fluorescence of testing sample transmitting, and photodetector 7 detects for the fluorescence launched testing sample 5.
The present invention utilizes the beam splitter in the optical fibre light splitting element replacement free space of Highgrade integration, the luminous energy transmitted in free space and light signal is limited in the optical device of optical fiber and Highgrade integration in conventional fluorescent pick-up unit.Optical fiber, as a kind of optical waveguide components of softness, has volume little and the feature of not being afraid of bending and vibrating, is beneficial to the miniaturization and high stability that realize fluorescence detection device.
Light source can be the light source that light emitting diode (LED), semiconductor laser, solid state laser, fiber laser or other forms of laser instrument etc. can realize coupling fiber.
Optical fiber can be single-mode fiber or multimode optical fiber, also can be the optical fiber of glass optical fiber, silica fibre, plastic optical fiber or other core materials.
Photodetector can be photodiode, temperature-sensitive power meter, pyroelectricity meter, avalanche diode, photomultiplier or other photodetectors.
The exciting light that light source 1 produces is coupled in excitation fiber 2 by optical fiber coupling device, and the light in excitation fiber 2 enters detection optical fiber 4 through light-splitting device 3, and exciting light is irradiated on testing sample 5 by detection optical fiber 4.After detection optical fiber 4 is entered in the optically-coupled that testing sample 5 returns, then enter launching fiber 6 through light-splitting device 3, the illumination of launching fiber 6 is mapped on photodetector 7.Photodetector 7 detects the light signal that launching fiber sends, and realizes the detection to the fluorescence signal that sample sends.
In order to further description fluorescence detection device provided by the invention, existing details are as follows with instantiation by reference to the accompanying drawings:
The structure of the fluorescence detection device that first embodiment of the invention provides as shown in Figure 2, is made up of fiber coupled laser 8, y-type optical fiber 9, first optical fiber collimator 10, first optical filter 11, photomultiplier 12.Y-type optical fiber 9 comprises and being made up of four parts, comprises excitation fiber 2, optical splitter 13, detection optical fiber 4 and launching fiber 6, and wherein excitation fiber 2, detection optical fiber 4 and launching fiber 6 are respectively three ends of y-type optical fiber 9.Excitation fiber 2 is entered in the optically-coupled that described fiber coupled laser 8 sends, then enters into detection optical fiber 4 through optical splitter 13, is then irradiated on sample 5.The light that sample 5 sends is coupled into detection optical fiber 4 again, enters launching fiber 6 through optical splitter 13, then is collimated to free space through the first optical fiber collimator 10, is irradiated on photomultiplier 12 after the first optical filter 11.
Y-type optical fiber 8 is a kind of optical fibre device having three interfaces.Y-type optical fiber 8 of the present invention, its three interfaces can be divided into two groups, and one of them interface is one group, and another two interfaces are in another group.Suppose that the interface index of y-type optical fiber 8 is respectively A, B and C, wherein A is one group, B and C is another group.Y-type optical fiber 8 of the present invention has following function: can export from C port from the light of A port input, can export from the light of C port input from B port.
First embodiment is simple structure of the present invention, compact conformation, and stability is high, and extendability is strong.
The structure of the fluorescence detection device that second embodiment of the invention provides as shown in Figure 3, by fiber coupled laser 8, excitation fiber 2, second optical fiber collimator 13, filter set shell 14, dichroic sheet 16, first fiber coupler 15, detection optical fiber 4, launches the first optical filter 11 and photomultiplier 12 forms.The optically-coupled that described fiber coupled laser 8 exports enters in excitation fiber 2, then free space is collimated to through the second optical fiber collimator 13, enter into the first fiber coupler 15 through dichroic sheet 16 reflection, then be coupled into detection optical fiber 4 through the first fiber coupler 15, be irradiated on sample 5.The light that sample 5 sends is coupled into detection optical fiber 4 again, is oppositely collimated to free space through the first fiber coupler 15, is irradiated on photomultiplier 12 through dichroic sheet 16 and transmitting the first optical filter 11.
Second embodiment uses dichroic sheet as light-splitting device, and spectroscopical effeciency is higher, but structure is comparatively complicated.
The structure of the fluorescence detection device that third embodiment of the invention provides as shown in Figure 4, by fiber coupled laser 8, excitation fiber 2, second optical fiber collimator 13, filter set shell 14, dichroic sheet 16, first fiber coupler 15, second fiber coupler 17, detection optical fiber 4, is launched the first optical filter 11, launching fiber 6 and photomultiplier 12 and is formed.The optically-coupled that described fiber coupled laser 8 exports enters in excitation fiber 2, then free space is collimated to through the second optical fiber collimator 13, enter into the first fiber coupler 15 through dichroic sheet 16 reflection, then be coupled into detection optical fiber 4 through the first fiber coupler 15, be irradiated on sample 5.The light that sample 5 sends is coupled into detection optical fiber 4 again, oppositely free space is collimated to through the first fiber coupler 15, be irradiated on the second fiber coupler 17 through dichroic sheet 16 and transmitting the first optical filter 11, then be coupled into launching fiber 6, be then irradiated on photomultiplier 12.
3rd embodiment introduces launching fiber on the basis of the second embodiment, the beam-splitting structure comprising dichroic sheet can be made more compact, higher than the second embodiment in miniaturization and stability.
The structure of the fluorescence detection device that fourth embodiment of the invention provides as shown in Figure 5, is made up of fiber coupled laser 8, excitation fiber 2, second optical fiber collimator 13, first optical fiber collimator 10, filter set shell 14, dichroic sheet 16, first fiber coupler 15, second fiber coupler 17, detection optical fiber 4, launching fiber 6, first optical filter 11 and photomultiplier 12.The optically-coupled that fiber coupled laser 8 exports enters in excitation fiber 2, then free space is collimated to through the second optical fiber collimator 13, enter into the first fiber coupler 15 through dichroic sheet 16 reflection, then be coupled into detection optical fiber 4 through the first fiber coupler 15, be irradiated on sample 5.The light that sample 5 sends is coupled into detection optical fiber 4 again, oppositely free space is collimated to through the first fiber coupler 15, be irradiated on the second fiber coupler 17 through dichroic sheet 16, be coupled into launching fiber 6 again, then be collimated to free space through the first optical fiber collimator 10, be irradiated on photomultiplier 12 after launching the first optical filter 11.
4th embodiment introduces transmitting optical filter on the basis of the 3rd embodiment, can improve signal to noise ratio (S/N ratio).
The structure of the fluorescence detection device that fifth embodiment of the invention provides as shown in Figure 6, by coupling fiber LED18, excitation fiber 2, second optical fiber collimator 13, first optical fiber collimator 10, filter set shell 14, second optical filter 19, dichroic sheet 16, first fiber coupler 15, second fiber coupler 17, detection optical fiber 4, launching fiber 6, launches the first optical filter 11 and photomultiplier 12 forms.The optically-coupled that described fiber coupled laser 8 exports enters in excitation fiber 2, then free space is collimated to through the second optical fiber collimator 13, through the second optical filter 19, the first fiber coupler 15 is entered into through dichroic sheet 16 reflection, be coupled into detection optical fiber 4 through the first fiber coupler 15 again, be irradiated on sample 5.The light that sample 5 sends is coupled into detection optical fiber 4 again, oppositely free space is collimated to through the first fiber coupler 15, be irradiated on the second fiber coupler 17 through dichroic sheet 16, be coupled into launching fiber 6 again, then be collimated to free space through the first optical fiber collimator 10, be irradiated on photomultiplier 12 after launching the first optical filter 11.
5th embodiment introduces exciter filter on the basis of the 4th embodiment, can stray light in filtering wideband light source, can improve signal to noise ratio (S/N ratio) using the occasion (such as using LED illumination) of wideband light source.
Those skilled in the art will readily understand; the foregoing is only preferred embodiment of the present invention; not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. a fluorescence detection device, it is characterized in that, comprise light source (1), excitation fiber (2), light-splitting device (3), detection optical fiber (4), launching fiber (6) and photodetector (7);
One end of described excitation fiber (2) connects described light source (1), and the other end of described excitation fiber (2) is connected to the first end of described light-splitting device (3);
One end of described detection optical fiber (4) is connected to the second end of described light-splitting device (3), and the other end of described detection optical fiber (4) is for connecting testing sample (5);
One end of described launching fiber (6) connects described photodetector (7), and the other end is connected to the 3rd end of described light-splitting device (3);
Described light source (1) produces exciting light, described light-splitting device (3) is transferred to through described excitation fiber (2), after light-splitting device (3) light splitting, enter detection optical fiber (4), exciting light is irradiated on testing sample (5) by detection optical fiber (4); After detection optical fiber (4) is entered in the optically-coupled that testing sample (5) returns, launching fiber (6) is entered again through light-splitting device (3), the illumination that launching fiber (6) transmits is mapped on photodetector (7), photodetector (7) detects the light signal that launching fiber sends, and realizes the detection to the fluorescence signal that sample sends.
2. fluorescence detection device as claimed in claim 1, it is characterized in that, described light source (1) is fiber coupled laser (8), and described photodetector (7) is photomultiplier (12).
3. fluorescence detection device as claimed in claim 2, it is characterized in that, described fluorescence detection device also comprises the first optical fiber collimator (10) between one end and described photomultiplier (12) and the first optical filter (11) that are connected to described launching fiber (6) in turn;
Described first optical fiber collimator (10) for optical alignment that described launching fiber (6) is transmitted to free space; Described first optical filter (11) is for carrying out filtering process to the light of free space.
4. fluorescence detection device as claimed in claim 3, it is characterized in that, described light-splitting device (3) comprises the second optical fiber collimator (13), the first fiber coupler (15), dichroic sheet (16) and the second fiber coupler (17);
Described second optical fiber collimator (13) is arranged in the input path of described dichroic sheet (16), and the input end of described second optical fiber collimator (13) is as the first end of described light-splitting device (3), the light that the output terminal of described second optical fiber collimator (13) exports is as the incident light of described dichroic sheet (16);
Described first fiber coupler (15) is arranged on the reflected light path of described dichroic sheet (16), and one end of described first fiber coupler (15) is as the second end of described light-splitting device (3), the other end of described first fiber coupler (15) is used for receiving the light reflected through described dichroic sheet (16);
Described second fiber coupler (17) is arranged on the transmitted light path of described dichroic sheet (16), and one end of described second fiber coupler (17) is as the 3rd end of described light-splitting device (3), the other end of described second fiber coupler (17) is used for receiving the light through the transmission of described dichroic sheet (16).
5. fluorescence detection device as claimed in claim 4, it is characterized in that, described light-splitting device (3) also comprises the second optical filter (19) be arranged between described second optical fiber collimator (13) and described dichroic sheet (16).
6. fluorescence detection device as claimed in claim 4, it is characterized in that, described light-splitting device (3) comprises the 3rd optical filter (20) also comprising and being arranged between described dichroic sheet (16) and described second fiber coupler (17).
7. a fluorescence detection device, it is characterized in that, comprise fiber coupled laser (8), excitation fiber (2), the second optical fiber collimator (13), the first fiber coupler (15), dichroic sheet (16), the 3rd optical filter (20), detection optical fiber (4) and photomultiplier (12);
Described second optical fiber collimator (13) is arranged in the input path of described dichroic sheet (16), and the input end of described second optical fiber collimator (13) connects described fiber coupled laser (8) by described excitation fiber (2);
Described first fiber coupler (15) is arranged on the reflected light path of described dichroic sheet (16), and one end of described first fiber coupler (15) connects testing sample (5) by described detection optical fiber (4);
Described 3rd optical filter (20) and described photomultiplier (12) are successively set on the transmitted light path of described dichroic sheet (16).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105806526A (en) * | 2016-04-29 | 2016-07-27 | 重庆大学 | Quantum dot stress gage |
| CN105928645A (en) * | 2016-04-29 | 2016-09-07 | 重庆大学 | Three-directional stressometer based on quantum dots |
| CN105953957A (en) * | 2016-04-29 | 2016-09-21 | 重庆大学 | Dodecahedral three-dimensional stress gage based on quantum dots |
| CN106018278A (en) * | 2016-07-11 | 2016-10-12 | 上海爱涛信息科技有限公司 | Miniaturized photoelectric module for fluorescence detection |
| CN110221051A (en) * | 2019-05-23 | 2019-09-10 | 南京航空航天大学 | A kind of double scale nanometer drug detection in vivo systems of dual wavelength and sequential control method |
| CN110702264A (en) * | 2019-10-31 | 2020-01-17 | 浙江光塔节能科技有限公司 | Detection system for quantum dot optical fiber illumination |
| CN112485734A (en) * | 2020-09-27 | 2021-03-12 | 中国电子科技集团公司第十三研究所 | Method for improving fluorescence collection efficiency of NV color centers of diamonds |
| CN112683869A (en) * | 2020-12-25 | 2021-04-20 | 中国科学院苏州生物医学工程技术研究所 | Fluorescent quantitative detection method |
| CN113670470A (en) * | 2021-08-13 | 2021-11-19 | 西安和其光电科技股份有限公司 | Novel optical fiber temperature measurement module |
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| CN105806526A (en) * | 2016-04-29 | 2016-07-27 | 重庆大学 | Quantum dot stress gage |
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| CN110221051A (en) * | 2019-05-23 | 2019-09-10 | 南京航空航天大学 | A kind of double scale nanometer drug detection in vivo systems of dual wavelength and sequential control method |
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| CN112485734A (en) * | 2020-09-27 | 2021-03-12 | 中国电子科技集团公司第十三研究所 | Method for improving fluorescence collection efficiency of NV color centers of diamonds |
| CN112683869A (en) * | 2020-12-25 | 2021-04-20 | 中国科学院苏州生物医学工程技术研究所 | Fluorescent quantitative detection method |
| CN112683869B (en) * | 2020-12-25 | 2023-03-14 | 中国科学院苏州生物医学工程技术研究所 | Fluorescent quantitative detection method |
| CN113670470A (en) * | 2021-08-13 | 2021-11-19 | 西安和其光电科技股份有限公司 | Novel optical fiber temperature measurement module |
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Application publication date: 20160106 |
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| WD01 | Invention patent application deemed withdrawn after publication |