CN105219738A - 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 - Google Patents
重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 Download PDFInfo
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- CN105219738A CN105219738A CN201510603311.1A CN201510603311A CN105219738A CN 105219738 A CN105219738 A CN 105219738A CN 201510603311 A CN201510603311 A CN 201510603311A CN 105219738 A CN105219738 A CN 105219738A
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- herpes simplex
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编号 | 给药类型 | 第1周 | 第2周 | 第4周 | 第7周 | 第10周 |
第1组 | PBS | 25 | 20 | 22 | 21 | 20 |
第2组 | 实施例1 | 37 | 45 | 40 | 35 | 30 |
第3组 | 实施例2 | 39 | 41 | 38 | 35 | 29 |
第4组 | 对比例1 | 34 | 37 | 35 | 31 | 25 |
第5组 | 对比例2 | 35 | 36 | 32 | 30 | 24 |
第6组 | 空白载体 | 24 | 21 | 22 | 20 | 19 |
第7组 | 正常大鼠 | 52 | 45 | 40 | 39 | 38 |
给药类型 | 给药第2天 | 给药第7天 | 给药第11天 |
实施例3 | 17.8% | 20.8% | 90% |
实施例4 | 17.0% | 22.2% | 78% |
对比例3 | 14.1% | 18.3% | 72.5% |
对比例4 | 14.5% | 15.9% | 56.6% |
空白载体 | -- | 1.0% | -0.8% |
Claims (10)
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CN201510603311.1A CN105219738A (zh) | 2015-09-21 | 2015-09-21 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
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CN201510603311.1A CN105219738A (zh) | 2015-09-21 | 2015-09-21 | 重组单纯疱疹病毒及它感染和制备它的宿主细胞以及它们的应用 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106318915A (zh) * | 2016-09-21 | 2017-01-11 | 重庆宇珩生物科技有限公司 | 重组单纯疱疹病毒HSV‑hTERTp_ICP4_LungCA‑GFP及诊断试剂盒 |
CN107541527A (zh) * | 2017-10-25 | 2018-01-05 | 陕西省眼科研究所 | 一种治疗复发性hsk的双基因靶向治疗系统 |
WO2021175293A1 (zh) | 2020-03-05 | 2021-09-10 | 北京唯源立康生物科技有限公司 | 一种单纯疱疹病毒及其用途 |
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2015
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CN1295612A (zh) * | 1998-01-29 | 2001-05-16 | 拜奥维克斯有限公司 | 突变型单纯疱疹病毒及其用途 |
CN1242426A (zh) * | 1998-07-22 | 2000-01-26 | 中国医科大学 | Hsv-1病毒载体系统及构建和快速导入方法 |
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CN1439056A (zh) * | 2000-04-12 | 2003-08-27 | 拜奥维克斯有限公司 | 用于免疫调节的疱疹病毒 |
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CN101203530A (zh) * | 2004-10-28 | 2008-06-18 | 匹兹堡大学高等教育联邦体系 | 关于脊髓损伤疼痛的外周递送的谷氨酸脱羧酶基因治疗 |
Non-Patent Citations (4)
Title |
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CAROLINE E. LILLEY, ET AL.: "Multiple Immediate-Early Gene-Deficient Herpes Simplex Virus Vectors Allowing Efficient Gene Delivery to Neurons in Culture and Widespread Gene Delivery to the Central Nervous System In Vivo", 《JOURNAL OF VIROLOGY》 * |
JOAO BRAZ, ET AL.: "Therapeutic Efficacy in Experimental Polyarthritis of Viral-Driven Enkephalin Overproduction in Sensory Neurons", 《THE JOURNAL OF NEUROSCIENCE》 * |
LAILA SAMADY, ET AL.: "Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs- HSV Vectors for Dendritic Cell-Mediated Immunotherapy", 《JOURNAL OF VIROLOGY》 * |
王锷 等: "表达脑啡肽基因的单纯疤疹病毒I型扩增子载体的构建、包装和扩增", 《中华麻醉学杂志》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106318915A (zh) * | 2016-09-21 | 2017-01-11 | 重庆宇珩生物科技有限公司 | 重组单纯疱疹病毒HSV‑hTERTp_ICP4_LungCA‑GFP及诊断试剂盒 |
CN106318915B (zh) * | 2016-09-21 | 2020-02-18 | 重庆宇珩生物科技有限公司 | 重组单纯疱疹病毒HSV-hTERTp_ICP4_LungCA-GFP及诊断试剂盒 |
CN107541527A (zh) * | 2017-10-25 | 2018-01-05 | 陕西省眼科研究所 | 一种治疗复发性hsk的双基因靶向治疗系统 |
WO2021175293A1 (zh) | 2020-03-05 | 2021-09-10 | 北京唯源立康生物科技有限公司 | 一种单纯疱疹病毒及其用途 |
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Inventor after: Li Xiaopeng Inventor after: Tian Chao Inventor after: Zhao Jingshu Inventor after: Zhou Hua Inventor after: Li Jinfeng Inventor after: Yu Geng Inventor before: Yu Geng Inventor before: Li Jinfeng |
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Effective date of registration: 20170401 Address after: 100085 Haidian District open road, Beijing, No. 3, layer A315, 5 Applicant after: Beijing Wei Kang source Biotechnology Co. Ltd. Address before: 100085 Beijing, Haidian District on the road to open on the ground floor, room 5, No. 508 Applicant before: BEIJING SOURCE OF GOD'S BIOLOGICAL TECHNOLOGY CO., LTD. |
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Application publication date: 20160106 |