CN105213430A - A kind of method reducing Hirudinaria manillensis lyophilized powder fishy smell - Google Patents
A kind of method reducing Hirudinaria manillensis lyophilized powder fishy smell Download PDFInfo
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- CN105213430A CN105213430A CN201510724737.2A CN201510724737A CN105213430A CN 105213430 A CN105213430 A CN 105213430A CN 201510724737 A CN201510724737 A CN 201510724737A CN 105213430 A CN105213430 A CN 105213430A
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- lyophilized powder
- hirudinaria manillensis
- fishy smell
- sodium hydroxide
- hydroxide solution
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Abstract
The invention provides a kind of method reducing Hirudinaria manillensis lyophilized powder fishy smell, it comprises the steps: a, prepares mass fraction is the sodium hydroxide solution of 0.25 ~ 2.0%; B, get Hirudinaria manillensis lyophilized powder, add the sodium hydroxide solution of step a, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, mixing, 50 DEG C of reaction 1h; C, to dry, pulverize.Present invention also offers Hirudinaria manillensis medicine or the health product of Hirudinaria manillensis lyophilized powder that said method is prepared from and preparation.Method provided by the invention, effectively can reduce the fishy smell in Hirudinaria manillensis lyophilized powder, and method is harmless, pollution-free, safety is good, has a good application prospect.
Description
Technical field
The present invention relates to a kind of method reducing Hirudinaria manillensis lyophilized powder fishy smell.
Background technology
Hirudinaria manillensis lyophilized powder is the Preparata of the fresh entirety of Yi Zhi section animal Hirudinaria manillensis (PoecilobdellamanillensisLesson), its primary efficacy is that removing blood stasis stimulates the menstrual flow, Zhu Yu Xiao Disorder, and modern clinic is used for the treatment of the cardiovascular and cerebrovascular diseases such as hypertension, hyperlipidemia, cerebral hemorrhage, cerebral thrombosis.For Hirudo medical material, " Chinese Pharmacopoeia ", though do not include wherein by Hirudinaria manillensis, Hirudinaria manillensis is as common class Hirudo kind of sucking blood, and not only widely distributed, aboundresources, and antithrombin activity is far away higher than pharmacopeia kind.
Hirudinaria manillensis lyophilized powder is processed by modern freezing mode, farthest save the anticoagulating active active substance of medical material, but because it has strong fishy smell, patient's receiving degree is low, take difficulty, had a strong impact on using and selling of Hirudinaria manillensis lyophilized powder, therefore, Hirudinaria manillensis lyophilized powder eliminating sargassum smell is urgently to be resolved hurrily.
There is no bibliographical information Hirudinaria manillensis lyophilized powder being carried out to defishying at present, how effectively reducing Hirudinaria manillensis lyophilized powder fishy smell is current this area urgent problem.
Summary of the invention
The object of the present invention is to provide a kind of method that effectively can reduce Hirudinaria manillensis lyophilized powder fishy smell.
The invention provides a kind of method reducing Hirudinaria manillensis lyophilized powder fishy smell, it comprises the steps:
A, preparation mass fraction are the sodium hydroxide solution of 0.25 ~ 2.0%;
B, get Hirudinaria manillensis lyophilized powder, add the sodium hydroxide solution of step a, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, mixing, 50 DEG C of reaction 1h;
C, to dry, pulverize.
Wherein, in step a, the mass fraction of described sodium hydroxide solution is 1%.
Wherein, in step c, the temperature of described drying is 45 DEG C.
Present invention also offers the Hirudinaria manillensis lyophilized powder that said method is prepared from.The Hirudinaria manillensis lyophilized powder that said method prepares can be used as the raw material producing medicine or health product.
Present invention also offers a kind of Hirudinaria manillensis medicine or health product, it is the Hirudinaria manillensis lyophilized powder be prepared from by above-mentioned any one method is active component, adds the oral formulations that on medicine or health product, acceptable adjuvant or complementary composition are prepared from.
Wherein, described oral formulations is granule, capsule, pill, tablet.
Method provided by the invention, effectively can reduce the fishy smell in Hirudinaria manillensis lyophilized powder; And simple to operate, cost is low.Hirudinaria manillensis lyophilized powder fishy smell through the inventive method process is low, and the impression of patient's oral medication better, is easy to accept.
Obviously, according to foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
The detailed description of the invention of form by the following examples, is described in further detail foregoing of the present invention again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Accompanying drawing explanation
The different naoh concentration of Fig. 1 is on the impact of fishy smell, and abscissa is naoh concentration.
Detailed description of the invention
Be described further with embodiment below, but the present invention is not limited to these embodiments.
The experiment reagent that the present invention is used and instrument as follows:
The experiment reagent that table 1 the present invention is used and instrument
Embodiment 1 the present invention reduces the method for Hirudinaria manillensis lyophilized powder fishy smell
1, experimental technique
Take Hirudinaria manillensis lyophilized powder 5g, the sodium hydroxide solution of preparation mass fraction 0.25%;
In Hirudinaria manillensis lyophilized powder, add sodium hydroxide solution, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, water-bath 1h at 50 DEG C, 45 DEG C of oven dry, pulverizes, to obtain final product.
2, hedonic scoring system evaluates fishy smell degree
Hedonic scoring system's evaluation ideas the inventive method reduces the fishy smell degree of the Hirudinaria manillensis lyophilized powder after fishy smell.
The evaluation group be made up of 6 assessment officers (22 ~ 26 years old, each 3 of men and women) carries out subjective appreciation to this experiment.The evaluation of this experiment fishy smell adopts ten point system, and the distilled water without fishy smell counts 0 point, is 10 points with the former powder of Hirudinaria manillensis lyophilized powder that fishy smell is the strongest.
Scoring 0 ~ 2: substantially without fishy smell; 2 ~ 4: micro-have fishy smell; 4 ~ 6: have fishy smell; 6 ~ 8: fishy smell is obvious; 8 ~ 10: have serious fishy smell.
During evaluation, 1g sample is loaded specimen cup, and add 50 DEG C of water, stir, assessment officer carries out sensory evaluation according to above-mentioned code of points, finally gets it and is equally divided into final score.
3, experimental result:
6 assessment officer's evaluation results are as shown in table 2.
Table 2
| Assessment officer one | Assessment officer two | Assessment officer three | Assessment officer four | Assessment officer five | Assessment officer six | Average |
| 7.0 | 6.3 | 6.5 | 6.8 | 6.5 | 7.1 | 6.7 |
Embodiment 2 the present invention reduces the method for Hirudinaria manillensis lyophilized powder fishy smell
1, experimental technique
Take Hirudinaria manillensis lyophilized powder 5g, the sodium hydroxide solution of preparation mass fraction 0.5%;
In Hirudinaria manillensis lyophilized powder, add sodium hydroxide solution, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, water-bath 1h at 50 DEG C, 45 DEG C of oven dry, pulverizes, to obtain final product.
2, hedonic scoring system evaluates fishy smell degree, and method is with described in embodiment 1.
3, experimental result:
6 assessment officer's evaluation results are as shown in table 3.
Table 3
| Assessment officer one | Assessment officer two | Assessment officer three | Assessment officer four | Assessment officer five | Assessment officer six | Average |
| 7.0 | 5.9 | 6.0 | 6.8 | 6.5 | 6.8 | 6.5 |
Embodiment 3 the present invention reduces the method for Hirudinaria manillensis lyophilized powder fishy smell
1, experimental technique
Take Hirudinaria manillensis lyophilized powder 5g, the sodium hydroxide solution of preparation mass fraction 1.0%;
In Hirudinaria manillensis lyophilized powder, add sodium hydroxide solution, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, water-bath 1h at 50 DEG C, 45 DEG C of oven dry, pulverizes, to obtain final product.
2, hedonic scoring system evaluates fishy smell degree, and method is with described in embodiment 1.
3, experimental result:
6 assessment officer's evaluation results are as shown in table 4.
Table 4
| Assessment officer one | Assessment officer two | Assessment officer three | Assessment officer four | Assessment officer five | Assessment officer six | Average |
| 7.0 | 5.9 | 6.0 | 6.8 | 6.5 | 5.0 | 6.2 |
Embodiment 4 the present invention reduces the method for Hirudinaria manillensis lyophilized powder fishy smell
1, experimental technique
Take Hirudinaria manillensis lyophilized powder 5g, the sodium hydroxide solution of preparation mass fraction 1.5%;
In Hirudinaria manillensis lyophilized powder, add sodium hydroxide solution, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, water-bath 1h at 50 DEG C, 45 DEG C of oven dry, pulverizes, to obtain final product.
2, hedonic scoring system evaluates fishy smell degree, and method is with described in embodiment 1.
3, experimental result:
6 assessment officer's evaluation results are as shown in table 5.
Table 5
| Assessment officer one | Assessment officer two | Assessment officer three | Assessment officer four | Assessment officer five | Assessment officer six | Average |
| 7.5 | 7.2 | 7.2 | 6.8 | 6.5 | 6.8 | 7.0 |
Embodiment 5 the present invention reduces the method for Hirudinaria manillensis lyophilized powder fishy smell
1, experimental technique
Take Hirudinaria manillensis lyophilized powder 5g, the sodium hydroxide solution of preparation mass fraction 2.0%;
In Hirudinaria manillensis lyophilized powder, add sodium hydroxide solution, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, water-bath 1h at 50 DEG C, 45 DEG C of oven dry, pulverizes, to obtain final product.
2, hedonic scoring system evaluates fishy smell degree, and method is with described in embodiment 1.
3, experimental result:
6 assessment officer's evaluation results are as shown in table 6.
Table 6
| Assessment officer one | Assessment officer two | Assessment officer three | Assessment officer four | Assessment officer five | Assessment officer six | Average |
| 8.0 | 7.8 | 7.5 | 7.5 | 7.7 | 6.7 | 7.7 |
Naoh concentration different in embodiment 1-5 is mapped on the impact of Hirudinaria manillensis lyophilized powder fishy smell, sees Fig. 1.
As seen from Figure 1, naoh concentration is 0.25 ~ 2.0% time, and the inventive method all has the effect reducing Hirudinaria manillensis lyophilized powder fishy smell, and the inventive method effectively can reduce Hirudinaria manillensis lyophilized powder fishy smell.Especially under 1% sodium hydroxide solution, the effect that the inventive method reduces Hirudinaria manillensis lyophilized powder fishy smell is best, Hirudinaria manillensis lyophilized powder fishy smell can be reduced by 38%, and sodium hydroxide concentration is relatively less, achieves unexpected technique effect.
To sum up, method provided by the invention, effectively can reduce the fishy smell in Hirudinaria manillensis lyophilized powder, the Hirudinaria manillensis lyophilized powder fishy smell of the inventive method process is low, and the impression of patient's oral medication better, is easy to accept, and safe and reliable, the inventive method has a good application prospect.
Claims (6)
1. reduce a method for Hirudinaria manillensis lyophilized powder fishy smell, it is characterized in that: it comprises the steps:
A, preparation mass fraction are the sodium hydroxide solution of 0.25 ~ 2.0%;
B, get Hirudinaria manillensis lyophilized powder, add the sodium hydroxide solution of step a, the ratio (g/mL) making Hirudinaria manillensis lyophilized powder and sodium hydroxide solution is 1:5, mixing, 50 DEG C of reaction 1h;
C, to dry, pulverize.
2. method according to claim 1, is characterized in that: in step a, and the mass fraction of described sodium hydroxide solution is 1%.
3. method according to claim 1, is characterized in that: in step c, and the temperature of described drying is 45 DEG C.
4. the Hirudinaria manillensis lyophilized powder that is prepared from of claim 1-3 any one method.
5. a Hirudinaria manillensis medicine or health product, it is characterized in that: it is the Hirudinaria manillensis lyophilized powder be prepared from by claim 1-3 any one method is active component, adds the oral formulations that on medicine or health product, acceptable adjuvant or complementary composition are prepared from.
6. Hirudinaria manillensis medicine according to claim 5 or health product, is characterized in that: described oral formulations is granule, capsule, pill, tablet.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101253960A (en) * | 2008-04-10 | 2008-09-03 | 山东鲁研食品技术有限公司 | Flour quality modifying agent preparation taking bean dregs as principal raw material |
| CN102160620A (en) * | 2011-03-10 | 2011-08-24 | 湖南农业大学 | Method for processing fish head soup noodles |
| CN102823879A (en) * | 2012-08-22 | 2012-12-19 | 陕西科技大学 | Donkey penis balanus black matter removal method |
| CN103783581A (en) * | 2013-10-17 | 2014-05-14 | 华隆（乳山）食品工业有限公司 | Processing method of fishskin peanuts |
-
2015
- 2015-10-30 CN CN201510724737.2A patent/CN105213430A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101253960A (en) * | 2008-04-10 | 2008-09-03 | 山东鲁研食品技术有限公司 | Flour quality modifying agent preparation taking bean dregs as principal raw material |
| CN102160620A (en) * | 2011-03-10 | 2011-08-24 | 湖南农业大学 | Method for processing fish head soup noodles |
| CN102823879A (en) * | 2012-08-22 | 2012-12-19 | 陕西科技大学 | Donkey penis balanus black matter removal method |
| CN103783581A (en) * | 2013-10-17 | 2014-05-14 | 华隆（乳山）食品工业有限公司 | Processing method of fishskin peanuts |
Non-Patent Citations (1)
| Title |
|---|
| 章超桦等: "《水产风味化学》", 30 September 2012 * |
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Application publication date: 20160106 |
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