CN105194663A - 聚乙二醇化磷脂为载体的胶束多肽疫苗 - Google Patents
聚乙二醇化磷脂为载体的胶束多肽疫苗 Download PDFInfo
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- CN105194663A CN105194663A CN201510701659.4A CN201510701659A CN105194663A CN 105194663 A CN105194663 A CN 105194663A CN 201510701659 A CN201510701659 A CN 201510701659A CN 105194663 A CN105194663 A CN 105194663A
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Abstract
Description
脂类/肽(mol/mol) | 脂类/MPLA(mass/mass) | PEG-PE溶液浓度 | MPLA溶液浓度 | E7-20溶液浓度 |
44:1 | 79:1 | 5mg/mL | 40μg/mL | 100μg/mL |
脂:肽(w/w) | 50:1 | 20:1 | 10:1 | 5:1 | 2:1 | 1:1 |
脂:MPLA(w/w) | 100:1 | 100:1 | 100:1 | 100:1 | 100:1 | 100:1 |
包封率(%) | 100.00 | 100.00 | 100.00 | 97.99 | 67.76 | 25.48 |
脂:肽(w/w) | 50:1 | 20:1 | 10:1 | 5:1 | 2:1 | 1:1 |
脂:MPLA(w/w) | 100:1 | 100:1 | 100:1 | 100:1 | 100:1 | 100:1 |
包封率(%) | 100.00 | 100.00 | 100.00 | 91.76 | 40.10 | 27.91 |
Claims (5)
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CN108254348A (zh) * | 2018-01-31 | 2018-07-06 | 国家烟草质量监督检验中心 | 一种高通量检测活性微生物的pH敏感型荧光传感器及构建方法 |
CN108938568A (zh) * | 2018-08-07 | 2018-12-07 | 中国医学科学院生物医学工程研究所 | 基于共包载抗原和双免疫激动剂的磷脂杂化聚合物囊泡的DCs疫苗及其制备方法与应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN108254348A (zh) * | 2018-01-31 | 2018-07-06 | 国家烟草质量监督检验中心 | 一种高通量检测活性微生物的pH敏感型荧光传感器及构建方法 |
CN108254348B (zh) * | 2018-01-31 | 2020-11-17 | 国家烟草质量监督检验中心 | 一种高通量检测活性微生物的pH敏感型荧光传感器及构建方法 |
CN108938568A (zh) * | 2018-08-07 | 2018-12-07 | 中国医学科学院生物医学工程研究所 | 基于共包载抗原和双免疫激动剂的磷脂杂化聚合物囊泡的DCs疫苗及其制备方法与应用 |
CN108938568B (zh) * | 2018-08-07 | 2021-01-05 | 中国医学科学院生物医学工程研究所 | 基于共包载抗原和双免疫激动剂的磷脂杂化聚合物囊泡的DCs疫苗及其制备方法与应用 |
CN112426537A (zh) * | 2020-11-16 | 2021-03-02 | 国家纳米科学中心 | 一种多肽纳米胶束及其制备方法和应用 |
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