CN105194502A - Traditional Chinese medicine preparation for treating habitual abortion - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicine formulas, in particular to a traditional Chinese medicine preparation for treating habitual abortion. The traditional Chinese medicine preparation is characterized by being prepared from raw materials in parts by weight as follows: 15-20 parts of south dodder seeds, 10-15 parts of marshmallow roots, 8-12 parts of Siberian nitraria fruits, 10-12 parts of cortex Lycii, 10-15 parts of sharpleaf galangal fruits, 6-10 parts of malaytea scurfpea fruits, 20-25 parts of bamboo shavings, 6-8 parts of ramie roots, 10-12 parts of hairyvein agrimonia herb and buds, 12-15 parts of argy wormwood leaves, 15-20 parts of ears of common selfheal fruit-spike, 8-10 parts of herb of dindygulen peperomia, 12-16 parts of sappan wood, 6-10 parts of astragalus membranaceus, 15-20 parts of palmleaf raspberry fruits, 16-18 parts of eclipta prostrata, 12-16 parts of glossy privet fruits, 3-5 parts of root-bark of Omei Linden and 3-5 parts of herba gynostemmatis pentaphylli. The nineteen raw materials are soaked in water, decocted and deslagged, and filter liquor is obtained. The traditional Chinese medicine preparation has the efficacy of qi replenishment, spleen invigoration, kidney tonification and miscarriage prevention, has a better curative effect on spleen-kidney deficiency type habitual abortion and does not have any toxic and side effect.

Description

The Chinese medicine preparation for the treatment of habitual abortion

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine preparation for the treatment of habitual abortion.

Background technology

As everyone knows, habitual abortion is TCM-related Terms, refers to that induced abortion or abortion recur more than 3 times or 3 times, also known as " pregnant repeatly fall repeatly " or " number induced abortion ", be one of common disease of pregnancy, belong to the category of infertility.Disease name general is in the world the habitual abortion (recurrent spontaneous abortion) that doctor trained in Western medicine is said at present.Habitual abortion can experience threatened abortion, inevitable abortion, incomplete or artificial abortion several stage usually.Only can show as vagina in early days hemorrhage a little, or have the hidden pain of slight lower abdomen, the bleeding time can last for days or several weeks, and blood volume is less.Once vaginal hemorrhage is increased, abdomen pain increases the weight of, and checks the existing expansion of cervix uteri mouth, during even visible foetal sac blocking eck, miscarries inevitable.As pregnant thing is all discharged, be called artificial abortion; Only the pregnant thing of part is discharged, and when still having part to remain in cavity of uterus, is called incomplete abortion, needs clearing heat in the pericardium process immediately.

Patient often experiences gestation repeatedly and repeatedly miscarries, and some patients generation abortion times, even up to 7-8 time, is brought considerable distress not only to sufferers themselves's body and mind, and may be caused breaking of family friction and marriage thus.Habitual abortion sickness rate is in increasing trend in recent years, and its cause of disease and correlative factor complexity, cause this disease and comprise many-sided factors such as heredity, dissection, endocrine, immunity, infection.Currently western medicine there is no desirable therapy to primary disease, clinical treatment many employings low dosage aspirin, corticosteroid hormone, heparin or said method R. concomitans, but above therapy exists shortcomings such as side effect is large, clinical effectiveness is not obvious, patient not easily accepts.

Summary of the invention

Object of the present invention is exactly to overcome above-mentioned existing technical deficiency, provides a kind of Chinese medicine preparation for the treatment of habitual abortion, has effect that relatively outstanding air making-up and spleen enlivening, kidney tonifying are antiabortive, has good curative effect, and have no side effect to spleen kidney both deficiency type habitual abortion.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine preparation for the treatment of habitual abortion, it is characterized in that being made up of the crude drug of following weight portion, Semen Cuscutae 15 ~ 20, Radix althaeae roseae 10 ~ 15, Herba Carlinae biebersteinii 8 ~ 12, Cortex Lycii 10 ~ 12, Fructus Alpiniae Oxyphyllae 10 ~ 15, Fructus Psoraleae 6 ~ 10, Caulis Bambusae In Taenia 20 ~ 25, Radix Boehmeriae 6 ~ 8, Herba Agrimoniae 10 ~ 12, Folium Artemisiae Argyi 12 ~ 15, XIAKUQIU 15 ~ 20, Herba Peperomiae Dindygulensis 8 ~ 10, Lignum Sappan 12 ~ 16, the Radix Astragali 6 ~ 10, Fructus Rubi 15 ~ 20, Eclipta prostrata 16 ~ 18, Fructus Ligustri Lucidi 12 ~ 16, Cortex Tiliae omeiensis Radicis 3 ~ 5, Herb Gynostemmae Pentaphylli 3 ~ 5, above-mentioned 19 taste crude drug are soaked in water, to remove slag after decocting to obtain filtrate.

The invention has the beneficial effects as follows to there is effect that relatively outstanding air making-up and spleen enlivening, kidney tonifying are antiabortive, have good curative effect to spleen kidney both deficiency type habitual abortion, and have no side effect.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Semen Cuscutae, Radix althaeae roseae, Herba Carlinae biebersteinii, Cortex Lycii, Fructus Alpiniae Oxyphyllae, Fructus Psoraleae, Caulis Bambusae In Taenia, Radix Boehmeriae, Herba Agrimoniae, Folium Artemisiae Argyi, XIAKUQIU, Herba Peperomiae Dindygulensis, Lignum Sappan, the Radix Astragali, Fructus Rubi, Eclipta prostrata, Fructus Ligustri Lucidi, Cortex Tiliae omeiensis Radicis, Herb Gynostemmae Pentaphylli is adopted to be that crude drug is prepared from.The every auxiliary medicine of its component (weight portion) is Semen Cuscutae 18, Radix althaeae roseae 13, Herba Carlinae biebersteinii 10, Cortex Lycii 11, Fructus Alpiniae Oxyphyllae 12, Fructus Psoraleae 8, Caulis Bambusae In Taenia 22, Radix Boehmeriae 7, Herba Agrimoniae 11, Folium Artemisiae Argyi 13, XIAKUQIU 17, Herba Peperomiae Dindygulensis 9, Lignum Sappan 14, the Radix Astragali 8, Fructus Rubi 17, Eclipta prostrata 17, Fructus Ligustri Lucidi 14, Cortex Tiliae omeiensis Radicis 4, Herb Gynostemmae Pentaphylli 4.Getting above-mentioned 19 taste crude drug gross weights is 230 grams, add water 1100-1200ml, soaks 4-5 hour, then boil slow fire with high heat and decoct to about 60 minutes, remove slag to obtain filtrate about 200ml, medicinal residues add water about 300-400ml again, and decoct about 30 minutes, remove slag to obtain filtrate about 100ml, be total to obtain about 300ml medicine juice, i.e. obtained decoction of the present invention, load in sterile glass vials, seal bottle cap is for subsequent use.Every day 1 dose point sooner or later 2 times oral.

Effect of Semen Cuscutae energy the kidney invigorating and essence nourishing of the present invention, nourishing the liver to improve visual acuity, solid tire stopping leak; Radix althaeae roseae root can make lubricant, for mucosal inflammation, plays protection, abirritant effect; Herba Carlinae biebersteinii strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood.Control asthenic body, deficiency of both QI and blood, incoordination between the spleen and stomach, dyspepsia, menoxenia; Cortex Lycii heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma; Fructus Alpiniae Oxyphyllae cures mainly: Deficiency and coldness of spleen and stomach, and vomiting, has loose bowels, and coldly in abdomen educates, the many salivas of mouth, enuresis due to deficiency of the kidney; Fructus Psoraleae kidney invigorating and YANG supporting, controlling nocturnal emission with astringent drugs reducing urination, lumbago due to renal deficiency, frequent micturition, bed-wetting; Caulis Bambusae In Taenia has removing heat-phlegm, relieving restlessness, effect of preventing or arresting vomiting.Hold expectorant under the arm for gallbladder fire, palpitation with fear is not peaceful, vexed insomnia, pregnancy reactions, frequent fetal movement; Radix Boehmeriae has heat clearing away, hemostasis, removing toxic substances, dissipating blood stasis, to erysipelas, and carbuncle, traumatic injury, the effects such as snake bite and insect sting; Herba Agrimoniae astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, control epistaxis and have specially good effect; Folium Artemisiae Argyi warming the meridian for stopping bleeding, dispersing cold for relieving pain, external removing dampness to relieve itching; XIAKUQIU has clearing away liver-fire, effect of dissipating blood stasis knot; Herba Peperomiae Dindygulensis clearing heat and moistening lung, invigorating the spleen and replenishing QI; Lignum Sappan blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.As married woman's amenorrhea due to stagnation of blood, dysmenorrhea, postpartum stagnation cardiac and abdominal pain, puerperal blood faints; The function that the Radix Astragali has tonifying Qi and lifting yang, benefit defends consolidating superficial resistance; Fructus Rubi has supplementing the kidney to control the nocturnal reducing urination, effect of nourishing the liver to improve visual acuity.Be usually used in emission and spermatorrhea, enuresis frequent micturition; Eclipta prostrata nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the diseases such as enterorrhagia; The Chinese medicine of Fructus Ligustri Lucidi replenishing kidney-YIN, nourishing the liver to improve visual acuity, can treating the liver kidney deficiency, dizzy ear toot, the disease such as early whitening of hair and two blurred vision pastes; Cortex Tiliae omeiensis Radicis promoting of the circulation of QI and removing the obstruction in the collaterals.Control traumatic injury and infirmities and diseases; Herb Gynostemmae Pentaphylli replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing.

The each raw material of the present invention also can the embodiment that mixes of ratio (weight portion) listed by according to the form below realize, and its processing method is identical with embodiment one.

Clinical efficacy is summed up:

1, case-data: that selects hospital ward and outpatient clinic meets spleen kidney both deficiency type habitual abortion patient 60 example.The method of employing random packet, parallel control is studied.Treatment group 30 example, at 25 years old ~ 39 years old age, average 31 years old, gravity flow parity mostly was 4 person 9 examples most, and all the other have been miscarried 2 times; Matched group 30 example, age 26-37 year, average 28 years old, gravity flow parity mostly was 3 persons 6 example most, and all the other have been miscarried 2 times.During first visit two groups pregnant age reckling be all pregnant 3 weeks, treatment group is pregnant 10 weeks to the maximum, and matched group is pregnant 12 weeks to the maximum.Two groups of Genders, age, the course of disease and abortion times, disease integration through statistical analysis no difference of science of statistics, equal tool comparability (P > 0.05).

2, diagnosis basis:

(1) Western medicine diagnose standard:

According to the 7th edition, People's Health Publisher " obstetrics and gynecology ", ACA is positive, and recurrent spontaneous abortion diagnostic criteria is as follows:

1) the continuous spontaneous abortion of Women of Childbearing Age is more than twice or twice;

2) anticardiolipin antibody (ACA) is positive;

3) uterus shape position normal in size, tubal patency, luteal function is normal, causes the pathological factor of spontaneous abortion except the ACA positive without other;

4) bridegroom's or husband's side semen efamination is normal.

(2) tcm diagnosis standard:

1) pregnantly repeatly fall repeatly, the bridegroom's or husband's side checks normal person;

2) chromosome examination, gets rid of caused by inherited genetic factors;

3) gynecologial examination, understands uterus with or without deformity;

(3) TCM syndrome CM syndrome differentiation criterion: (drafting with reference to " new Chinese medicine guideline of clinical investigations ", " Gynecology of Chinese Medicine " related content)

Asthenia of both the spleen and kidney is demonstrate,proved: dizziness and tinnitus, soreness of waist and knee, fatigue in both spirit and physical strength, and lazy speech of breathing hard, anorexia loose stool, nocturia, there is dim speckle in eye socket darkness or face.Pale tongue, thin fur, deep and weak pulse.

Main symptom: more than 2 tires of previously having miscarried, phenolics has threatened abortion (occur the tenesmus of lumbago, lower abdomen, vaginal hemorrhage etc. after menolipsis, possess wherein at least 1 person) for the third time;

Secondary card: 1. spiritlessness and weakness; 2. shallow complexion or dark and gloomy; 3. dizziness and tinnitus; 4. nocturia; 5. there is skin dark stain in the black dull or face of eye socket; 6. light red tongue, or have indentation, white and moist fur, deep pulse is thin and delicate.

Above main symptom is indispensable, when secondary card possesses at least 3, can examine as clinical plan.

3, case standard is included in:

(1) Women of Childbearing Age, age 22-40 year, healthy, without intrauterine device;

(2) spontaneous abortion recurs more than twice or twice;

(3) anticardiolipin antibody (ACA) is positive;

(4) except the ACA positive, cause the pathological factor of spontaneous abortion without other, require that treatment is normally to become pregnant voluntarily;

(5) men and women's chromosome examination is normal;

(6) bridegroom's or husband's side semen efamination is normal.

4, Excluded cases standard:

(1) genitals organic disease is got rid of in gynecologial examination, ultrasound diagnosis;

(2) Reproductive Endocrine Hormones measures and gets rid of endocrine factors;

(3) cervical secretions detects and gets rid of genital system infection;

(4) severe cardiac cerebrovascular is merged, primary disease and the psychotics such as liver, kidney and hemopoietic system;

(5) age is below 22 years old or more than 40 years old person.

5, case standard is rejected:

(1) rear discovery is included in exclusion standard disease patient;

(2) case of medication is not specified by testing program;

(3) drug administration process data logging is incomplete, cannot judge curative effect person.

6, to come off and termination criteria:

(1) naturally come off and person lost to follow-up in observing;

(2) there is the person that should not continue reception test such as complication or special physiological change in experimenter.

(3) serious adverse reaction occurs person in test, should stop clinical trial in time.

Come off and answer itemized record reason with the case stopped, and the switching of its last curative effect testing result is added up for final result.

7, usage and dosage:

Treatment group: take the embodiment of the present invention one Chinese medicine preparation treatment, every day 1 dose point morning and evening 2 times oral.Take 4 weeks at least continuously, eliminate as principle with clinical symptoms after taking medicine, symptom is not eliminated and is taken drug withdrawal after 3 months.

Matched group: zishenyutai pill (the accurate word Z44020008 of traditional Chinese medicines) eats three times in one day, and light salt brine is oral after meal, patient need take medicine 1-3 month, eliminates as principle with clinical symptoms after taking medicine, but clothes are to drug withdrawal after 3 months.Patient's pregnancy period prohibits sexual life, avoids overworked, and special vaginal hemorrhage person lies up.After treatment in 3 months terminates, follow up a case by regular visits to and carry out efficacy evaluation to normal labor.

8, curative effect determinate standard: (formulating with reference to " disease of tcm Standardization of diagnosis and curative effect ")

Effective: normal labor; Invalid: after treatment, abortion of still having an abortion.

9, therapeutic effect:

Without rejecting and coming off and stop case in therapeutic process, all complete clinical observation.

Two groups of patient treatment total effectses compare, and treatment group is successfully prevented miscarriage to normal labor person and is reached for 96.7%, and matched group is successfully prevented miscarriage to normal labor person and is reached for 90.0%, and total effective rate compares, and treatment group is apparently higher than matched group.

The comparitive study of table 1. treatment group and matched group

Group	Effectively	Invalid	Total effective rate
				Treatment group	28	1	93.3％
Matched group	26	4	86.7％

Routine blood test, routine urinalysis, electrocardiogram change without exception before and after treatment group patient treatment, in therapeutic process, vital sign steadily and without the untoward reaction such as nausea and vomiting, allergy, illustrate that our clinical application is safe and reliable.Therapeutic outcome shows that treatment group cure rate and effective percentage are obviously better than matched group, has significant difference.

Illustrate thus and use Chinese medicine preparation of the present invention treatment habitual abortion particularly to treat the habitual abortion belonging to asthenia of both the spleen and kidney and cause, achieve significant curative effect, clinical practice is safe and reliable.

Claims (1)

1. treat the Chinese medicine preparation of habitual abortion for one kind, it is characterized in that being made up of the crude drug of following weight portion: Semen Cuscutae 15 ~ 20, Radix althaeae roseae 10 ~ 15, Herba Carlinae biebersteinii 8 ~ 12, Cortex Lycii 10 ~ 12, Fructus Alpiniae Oxyphyllae 10 ~ 15, Fructus Psoraleae 6 ~ 10, Caulis Bambusae In Taenia 20 ~ 25, Radix Boehmeriae 6 ~ 8, Herba Agrimoniae 10 ~ 12, Folium Artemisiae Argyi 12 ~ 15, XIAKUQIU 15 ~ 20, Herba Peperomiae Dindygulensis 8 ~ 10, Lignum Sappan 12 ~ 16, the Radix Astragali 6 ~ 10, Fructus Rubi 15 ~ 20, Eclipta prostrata 16 ~ 18, Fructus Ligustri Lucidi 12 ~ 16, Cortex Tiliae omeiensis Radicis 3 ~ 5, Herb Gynostemmae Pentaphylli 3 ~ 5, above-mentioned 19 taste crude drug are soaked in water, filtrate of removing slag after decocting to obtain.