CN105194495A - Preparation for treating osteoarticular tuberculosis and preparation method - Google Patents

Preparation for treating osteoarticular tuberculosis and preparation method Download PDF

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CN105194495A
CN105194495A CN201510661566.3A CN201510661566A CN105194495A CN 105194495 A CN105194495 A CN 105194495A CN 201510661566 A CN201510661566 A CN 201510661566A CN 105194495 A CN105194495 A CN 105194495A
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不公告发明人
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Abstract

The invention discloses a preparation for treating osteoarticular tuberculosis and a preparation method. The preparation is prepared from the following main raw materials in parts by weight: 9-16 parts of rhodiola rosea, 7-15 parts of salvia chinensis, 8-14 parts of melastoma dodecandrum roots, 6-15 parts of apium graveolens, 8-12 parts of cortex juglandis mandshuricae, 9-14 parts of Chinese rose flowers, 8-13 parts of fructus alpiniae oxyphyllae, 10-16 parts of hibiscus rosa-sinensis, 9-15 parts of embelia parviflora, 8-16 parts ofmanyflower supplejack stems and leaves, 10-15 parts of cistanche salsa, 7-14 parts of crossostephium chinense and 6-13 parts of kirilow rhodiola rhizome and roots. According to the preparation, the functions of body tissues and organs can be adjusted; and the organism immunity is improved, so that the target of curing osteoarticular tuberculosis is reached; the preparation is capable of treating both symptoms and root causes, and is free of recurrence and free of a side effect; and the drug resistance is not generated.

Description

The preparation for the treatment of tuberculosis of bone and joint and method for making
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation and method for making for the treatment of tuberculosis of bone and joint.
Background technology
Tuberculosis of bone and joint is the chronic disease based on bone destruction and osteoporosis, is multiplely born in child and youth.Be secondary tuberculosis, primary lesion is mainly in pulmonary.Tulase enters lymph hematogenous spread to each internal organs of whole body at primary tumor, particularly reticuloendothelial system comprises osteoarthrosis, majority send out stove eliminate by phagocyte, and only a few is sent out and is early hidden, once resistance of human body reduces, tulase breeding in latent infection stove, breaks through the tissue of encirclement and falls ill.Tuberculosis of bone and joint is generally single-shot, often occurs in vertebra, is secondly knee joint, hip and elbow joint etc.Morbidity slowly, can have low grade fever in afternoon, affected part pain, tenderness, kowtows pain and muscle spasm, and joint motion is limited.Slightly not red, the not hot abscess of late origin, is called cold abscess; After ulceration, forming sinus tract, can there is ankylosis in secondary mixed infection.Active pathological process period erythrocyte sedimentation rate speeds, and in leukocyte differential count, lymph corpuscle increases; May find tubercule bacillus in pus, pathologic finding contributes to making a definite diagnosis.The visible osteoporosis of X-ray examination and bone destruction, intervertebral space or joint space is narrow and abscess shade.
Treatment: 1. constitutional treatment.Comprise rest trophotherapy and antituberculotics.Sufficient nutrition is the primary condition of building up one's resistance to disease.Suitable nutrition is that the auxiliary tone of good appetite and meals is proper.Preferably select numerous food, note the cooking, change style, to stimulate appetite more.Conventional antituberculotics has amino Shui Yang Suan ﹑ ethamine Ding Chun ﹑ that Mei Su ﹑ rifampicin of Ka of Yi Yan Jing ﹑ Lian Mei Su ﹑ Dui and than carboxamide dihydrochloride etc.In order to avoid Resistant strain produces, usual use in conjunction 2 kinds or 3 kinds of medicines, be a course for the treatment of with 3 months, various medicine can be used alternatingly.2. topical therapeutic.Comprise local braking, abscess Chuan Ci ﹑ local injection Yao Wu ﹑ focal cleaning Shu ﹑ joint fusion Shu ﹑ osteotomy and arthroplasty etc.
Application publication number CN103800865A(application number 201210547395.8) Chinese patent literature disclose a kind of Chinese herbal medicine for the treatment of bone tuberculosis, make 20-30 parts, Radix Rehmanniae Preparata by following weight in grams medicine; Semen Sinapis Albae 20-30 parts; Colla cornus cervi 20-30 parts; Carbonized Rhizoma Zingiberis (processed) 5-20 parts; 6-9 parts, Herba Ephedrae; 5-20 parts, Radix Glycyrrhizae; The Radix Astragali 20-30 parts; Radix Angelicae Sinensis 20-30 parts; Squama Manis 20-30 parts; Flos Lonicerae 20-30 parts; Drymoglossum Herba Drymoglossi 20-30 parts.The price of the Squama Manis used in this patent documentation is more expensive, adds the financial burden of patient.Application publication number CN103638499A(application number 201310671533.8) Chinese patent literature disclose a kind of medicine for the treatment of tuberculosis of bone and joint and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Herba Artemisiae Annuae, Cauliset Folium Piperis Hancei, Radix vitis viniferae, Rhizoma Cibotii, Caulis Spatholobi, Lignum Sappan, Radix Asteris, Eupolyphaga Seu Steleophaga, Lignum Aquilariae Resinatum, Herba Verbenae.The Chinese medicine kind used in this patent documentation is more.Application publication number CN104547814A(application number 201510039469.0) Chinese patent literature disclose a kind of Chinese medicine preparation for the treatment of tuberculosis of bone and joint, described Chinese medicine preparation comprises Squama Manis, Nidus Vespae, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Colla cornus cervi, Radix Ginseng, Rhizoma Dioscoreae, the Radix Stemonae, Cortex Cinnamomi, Fructus Hordei Germinatus, Radix Salviae Miltiorrhizae, the Cortex Eucommiae, Semen Persicae, Radix Achyranthis Bidentatae, Radix Notoginseng powder, Radix Dipsaci, Rhizoma Drynariae.The Squama Manis used in this patent documentation and the price of Radix Ginseng more expensive, add the financial burden of patient.
At present, antituberculotics and operative treatment are the methods for the treatment of tuberculosis of bone and joint routine, and antituberculotics effectively can control, kill tubercule bacillus, but long-term edible meeting have side effects to Liver and kidney vitals, even cause producing fastbacteria in body; Operation can mitigate the disease at short notice, but cures the symptoms, not the disease, and just remove the pathogenic bacterium of patient part, once resistance declines, pathogenic bacteria is easy to again cause a disease.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of preparation and method for making for the treatment of tuberculosis of bone and joint.The present invention can the function of reconditioner soma organ, and improve immunity of organisms, thus reach the object of curing bone tuberculosis, treating both the principal and secondary aspects of a disease, does not recur, and has no side effect, and can not produce drug resistance.
Technical scheme of the present invention is:
The preparation for the treatment of tuberculosis of bone and joint, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Rhodiolae 9-16, Herba Salviae Chinensis 7-15; Herba Melastomatis dodecandri 8-14, Herba Apii graveolentis 6-15, Cortex Juglandis mandshuricae 8-12; Flos Rosae Chinensis 9-14; Fructus Alpiniae Oxyphyllae 8-13, Flos Hibisci Rosae-Sinensis 10-16, Radix seu Caulis Embeliae Parviflorae 9-15; Ramulus et folium berchemiae floribundae 8-16; Herba Cistanches 10-15, Coagulum Opuntiae sucus 7-14, Rhizoma Rhodiolae kirilowii 6-13.
The preparation for the treatment of tuberculosis of bone and joint, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Rhodiolae 11-14; Herba Salviae Chinensis 9-13, Herba Melastomatis dodecandri 10-12, Herba Apii graveolentis 9-12; Cortex Juglandis mandshuricae 9-11, Flos Rosae Chinensis 10-13, Fructus Alpiniae Oxyphyllae 10-12; Flos Hibisci Rosae-Sinensis 11-14; Radix seu Caulis Embeliae Parviflorae 10-14, Ramulus et folium berchemiae floribundae 10-13, Herba Cistanches 11-13; Coagulum Opuntiae sucus 9-13, Rhizoma Rhodiolae kirilowii 8-12.
The preparation for the treatment of tuberculosis of bone and joint, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Rhodiolae 13; Herba Salviae Chinensis 11, Herba Melastomatis dodecandri 11, Herba Apii graveolentis 10; Cortex Juglandis mandshuricae 10, Flos Rosae Chinensis 12, Fructus Alpiniae Oxyphyllae 11; Flos Hibisci Rosae-Sinensis 13; Radix seu Caulis Embeliae Parviflorae 12, Ramulus et folium berchemiae floribundae 11, Herba Cistanches 12; Coagulum Opuntiae sucus 11, Rhizoma Rhodiolae kirilowii 10.
Present invention also offers the preparation method preparation of aforementioned therapies tuberculosis of bone and joint being made pharmaceutically acceptable thick paste agent, powder, pill and granule.
The preparation method of described thick paste agent is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be condensed into the clear paste (being preferably condensed into the clear paste that relative density is 1.23) that relative density is 1.2-1.24, add step (2) gained, stir, add refined honey, continue heating to temper to relative density to be the thick paste of 1.38, to obtain final product.
The preparation method of described powder is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 180 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.34) that relative density is 1.33-1.35,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 180 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, with 5g often bag subpackage, sterile packaged and get final product.
The preparation method of described pill is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 150 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.34) that relative density is 1.33-1.35,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 150 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, make for binding agent is general the pill (preferably making for binding agent is general the pill that particle diameter is 5mm with the ethanol of 55%) that particle diameter is 5mm with the ethanol of 45%-65%, dry, to obtain final product.
The preparation method of described granule is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be condensed into the clear paste (being preferably condensed into the clear paste that relative density is 1.23) that relative density is 1.2-1.24, drying under reduced pressure, pulverize, add step (2) gained, stir, add cane sugar powder, the amount of cane sugar powder is 1.6-2.4 times (amount of preferably sucrose powder is 2.2 times of gained clear paste weight) of gained clear paste weight, 12% starch slurry is granulated, drying, granulate, to obtain final product.
The preparation recipe for the treatment of tuberculosis of bone and joint provided by the invention is scientific and reasonable, and the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, there is blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, kidney-replenishing, reducing swelling and alleviating pain, enrich and benefit essence and blood, strong waist knee joint, expelling wind and removing dampness
Effect, can the function of reconditioner soma organ, improve immunity of organisms, thus reach the object of curing tuberculosis of bone and joint;
2, treating both the principal and secondary aspects of a disease, does not recur;
3, have no side effect, can not drug resistance be produced;
4, medicine source is easy to get and price is comparatively cheap.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the preparation for the treatment of tuberculosis of bone and joint, the primary raw material medicine getting following weight parts is prepared from (every part is 360g): Radix Rhodiolae 9 parts, Herba Salviae Chinensis 7 parts; Herba Melastomatis dodecandri 8 parts, Herba Apii graveolentis 6 parts, Cortex Juglandis mandshuricae 8 parts; Flos Rosae Chinensis 9 parts; Fructus Alpiniae Oxyphyllae 8 parts, Flos Hibisci Rosae-Sinensis 10 parts, Radix seu Caulis Embeliae Parviflorae 9 parts; Ramulus et folium berchemiae floribundae 8 parts; Herba Cistanches 10 parts, Coagulum Opuntiae sucus 7 parts, Rhizoma Rhodiolae kirilowii 6 parts.
The preparation method of the preparation powder of above-mentioned treatment tuberculosis of bone and joint is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water every day 2 times, stripping and slicing, dries, for subsequent use;
(2) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/3 of Fructus Alpiniae Oxyphyllae weight, moistening 2 hours, puts to steam in container and steams 3 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 180 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add the water of two taste crude drug 4 times, decoct 25 minutes, leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add the water of 9 taste crude drug 5.3 times, decoct 50 minutes, leach medicinal liquid, add the water of 9 taste crude drug 4.5 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste that relative density is 1.33,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 180 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, with 5g often bag subpackage, sterile packaged and get final product.
The instructions of taking of the preparation powder of gained treatment tuberculosis of bone and joint of the present invention is: oral, one day twice, each 5g, boiled water was taken after mixing it with water.
embodiment 2the preparation for the treatment of tuberculosis of bone and joint, the primary raw material medicine getting following weight parts is prepared from (every part is 360g): Radix Rhodiolae 16 parts, Herba Salviae Chinensis 15 parts; Herba Melastomatis dodecandri 14 parts, Herba Apii graveolentis 15 parts, Cortex Juglandis mandshuricae 12 parts; Flos Rosae Chinensis 14 parts; Fructus Alpiniae Oxyphyllae 13 parts, Flos Hibisci Rosae-Sinensis 16 parts, Radix seu Caulis Embeliae Parviflorae 15 parts; Ramulus et folium berchemiae floribundae 16 parts; Herba Cistanches 15 parts, Coagulum Opuntiae sucus 14 parts, Rhizoma Rhodiolae kirilowii 13 parts.
The preparation method of the preparation thick paste agent of above-mentioned treatment tuberculosis of bone and joint is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water every day 3 times, stripping and slicing, dries, for subsequent use;
(2) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight, moistening 3 hours, puts to steam in container and steams 4.5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add the water of two taste crude drug 5.2 times, decoct 34 minutes, leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add the water of 9 taste crude drug 6.3 times, decoct 50 minutes, leach medicinal liquid, add the water of 9 taste crude drug 4.8 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be condensed into the clear paste that relative density is 1.23, add step (2) gained, stir, add refined honey, continue heating and temper to relative density to be the thick paste of 1.38, to obtain final product.
model case one:what XX, female, 40 years old.Before more than 3 years, without obvious inducement, patient occurs that left foot first slaps toe joint place pain, and the symptoms such as swelling, to local hospital inspection, are examined as tuberculosis of bone and joint.Take antituberculosis drugs treat, without being clearly better.Once many places diagnosis and treatment, all do not cure.Under the introduction of friend, carry out here diagnosis and treatment.Patient's fatigue and weakness, pale tongue with thin fur is white, and deficient and weak pulse is unable.You Yilou road, affected part, pus is oozed out in bottom, edge taupe, and inner edge of instep has two place's fistula mouths.Take the preparation thick paste agent of the present embodiment gained treatment tuberculosis of bone and joint, three times on the one, each 8g, boiled water is taken after mixing it with water.After taking 2 months, symptom is obviously improved.Continue to take 1 month, recovery from illness.Follow up a case by regular visits to without recurrence.
embodiment 3the preparation for the treatment of tuberculosis of bone and joint, the primary raw material medicine getting following weight parts is prepared from (every part is 360g): Radix Rhodiolae 11 parts, Herba Salviae Chinensis 9 parts; Herba Melastomatis dodecandri 10 parts, Herba Apii graveolentis 9 parts, Cortex Juglandis mandshuricae 9 parts; Flos Rosae Chinensis 10 parts; Fructus Alpiniae Oxyphyllae 10 parts, Flos Hibisci Rosae-Sinensis 11 parts, Radix seu Caulis Embeliae Parviflorae 10 parts; Ramulus et folium berchemiae floribundae 10 parts; Herba Cistanches 11 parts, Coagulum Opuntiae sucus 9 parts, Rhizoma Rhodiolae kirilowii 8 parts.
The preparation method of the preparation pill of above-mentioned treatment tuberculosis of bone and joint is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water every day 3 times, stripping and slicing, dries, for subsequent use;
(2) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight, moistening 3 hours, puts to steam in container and steams 4.5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 150 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add the water of two taste crude drug 5.2 times, decoct 34 minutes, leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add the water of 9 taste crude drug 6.3 times, decoct 50 minutes, leach medicinal liquid, add the water of 9 taste crude drug 4.8 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste that relative density is 1.34,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 150 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, the pill that particle diameter is 5mm made by the ethanol with 55% for binding agent is general, dry, to obtain final product.
model case two:high XX, female, 32 years old.Before more than 1 year, there is the left hip arthralgia without obvious inducement in patient, to local hospital inspection, is diagnosed as left coxodynia.Use antituberculosis drugs treat, without taking a turn for the better.Then to our hospital.Patient's left lower extremity Limb Shortening 3 centimetres, amyotrophy, has limping on foot, and the activity rear left hip arthralgia increases the weight of.Left hip joint portion tenderness, kowtow pain obviously.Take the preparation pill of the present embodiment gained treatment tuberculosis of bone and joint, three times on the one, each 2 balls, warm water takes.Take 1 month, affected part tenderness, kowtow pain all have clear improvement.Continue to take 2 months, recovery from illness, functional rehabilitation.Follow up a case by regular visits to without recurrence.
embodiment 4the preparation for the treatment of tuberculosis of bone and joint, the primary raw material medicine getting following weight parts is prepared from (every part is 360g): Radix Rhodiolae 14 parts, Herba Salviae Chinensis 13 parts; Herba Melastomatis dodecandri 12 parts, Herba Apii graveolentis 12 parts, Cortex Juglandis mandshuricae 11 parts; Flos Rosae Chinensis 13 parts; Fructus Alpiniae Oxyphyllae 12 parts, Flos Hibisci Rosae-Sinensis 14 parts, Radix seu Caulis Embeliae Parviflorae 14 parts; Ramulus et folium berchemiae floribundae 13 parts; Herba Cistanches 13 parts, Coagulum Opuntiae sucus 13 parts, Rhizoma Rhodiolae kirilowii 12 parts.
The preparation method of the preparation granules agent of above-mentioned treatment tuberculosis of bone and joint is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water every day 3 times, stripping and slicing, dries, for subsequent use;
(2) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight, moistening 3 hours, puts to steam in container and steams 4.5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add the water of two taste crude drug 5.2 times, decoct 34 minutes, leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add the water of 9 taste crude drug 6.3 times, decoct 50 minutes, leach medicinal liquid, add the water of 9 taste crude drug 4.8 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be condensed into the clear paste that relative density is 1.23, drying under reduced pressure, pulverize, add step (2) gained, stir, add cane sugar powder, the amount of cane sugar powder is 2.2 times of gained clear paste weight, 12% starch slurry is granulated, drying, granulate, to obtain final product.
model case three:open XX, man, 15 years old.Before 2 years, there is swelling pain without obvious inducement in the right knee of patient, the symptoms such as local skin heating.Examination in hospital nearby, examines as right tuberculosis of knee joint, and parallel operative treatment, leaves hospital after disease amelioration, but You Xi popliteal nest place surgical wound fails to heal always, repeatedly suppurates, and tunnel, delay is so far.Then to our hospital.Patient's hectic fever in the afternoon, night sweat, body of the tongue are light red, thin fur, deep-thready pulse.The two lower limb of patient are isometric, right knee swelling deformity, respectively there is an operative scar front and back, heal not good enough, there is 1cm × 1cm sinus tract, deeply about a 3cm at slightly rubescent popliteal nest place, local, inside has a small amount of faint yellow purulence to ooze out, the thick odorless of matter, right knee Pi Wenlvegao, local organization elasticity is slightly poor, and right knee bends and stretches limited.Right knee joint diseased region biopsy: diagnosis of tuberculosis granulation tissue, acid-fast stain (+).Be diagnosed as right tuberculosis of knee joint.Take the preparation granules agent of the present embodiment gained treatment tuberculosis of bone and joint, three times on the one, each 10g, boiled water is taken after mixing it with water.Take 1 month, symptom is obviously improved.Continue to take 2 months, sinus tract heals, functional rehabilitation.Follow up a case by regular visits to without recurrence.
embodiment 5the preparation for the treatment of tuberculosis of bone and joint, the primary raw material medicine getting following weight parts is prepared from (every part is 360g): Radix Rhodiolae 13 parts, Herba Salviae Chinensis 11 parts; Herba Melastomatis dodecandri 11 parts, Herba Apii graveolentis 10 parts, Cortex Juglandis mandshuricae 10 parts; Flos Rosae Chinensis 12 parts; Fructus Alpiniae Oxyphyllae 11 parts, Flos Hibisci Rosae-Sinensis 13 parts, Radix seu Caulis Embeliae Parviflorae 12 parts; Ramulus et folium berchemiae floribundae 11 parts; Herba Cistanches 12 parts, Coagulum Opuntiae sucus 11 parts, Rhizoma Rhodiolae kirilowii 10 parts.
The preparation method of the preparation powder of above-mentioned treatment tuberculosis of bone and joint is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water every day 3 times, stripping and slicing, dries, for subsequent use;
(2) get Fructus Alpiniae Oxyphyllae, poach, amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight, moistening 3 hours, puts to steam in container and steams 4.5 hours, take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 180 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add the water of two taste crude drug 5.2 times, decoct 34 minutes, leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add the water of 9 taste crude drug 6.3 times, decoct 50 minutes, leach medicinal liquid, add the water of 9 taste crude drug 4.8 times, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste that relative density is 1.34,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 180 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, with 5g often bag subpackage, sterile packaged and get final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Rhodiolae: base is former: be the herb of crassulaceae plants Rhodiola sachalinensis, Radix Rhodiolae, Rhodiola Crassulaceae etc.The property of medicine: cold; Sweet; Puckery.Return lung meridian.Function cures mainly: QI invigorating lung heat clearing; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Main deficiency of vital energy and physically weak; Fear of cold after being ill; Shortness of breath and fatigue; Cough due to lung-heat; Spitting of blood; Leucorrhea is suffered from diarrhoea; Traumatic injury; Burn and scald; Neurosis; Altitude sickness.
Herba Salviae Chinensis: base is former: be the herb of labiate Herba Salviae Chinensis.Chemical analysis: herb is containing sterol, Triterpenoid, aminoacid.Root is containing stachyose.The property of medicine: pungent, bitter, is slightly cold.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating.Main menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, has blood in stool, jaundice due to damp-heat, hot toxic-heat and blood stasis, drenches pain, leukorrhagia, rheumatic ostalgia, scrofula, and skin ulcer swells, acute mastitis, herpes zoster, leprosy, and traumatic injury wound is swollen.
Herba Melastomatis dodecandri: base is former: the root of Melastomateae plants Herba Melastomatis Dodecandri.The property of medicine: bitter in the mouth; Micro-sweet; Property is put down.Return liver, spleen, lung meridian.Function cures mainly: invigorate blood circulation; Hemostasis; Dampness removing; Removing toxic substances.Main dysmenorrhea; Difficult labour; Puerperal abdonimal pain; Retention of placenta; Metrorrhagia; Leucorrhea; Cough; Spit blood; Dysentery; Jaundice; Drench pain; Chronic malaria; Rheumatalgia; Toothache; Scrofula; Hernia; Traumatic injury impairment caused by overstrain; Venom.
Herba Apii graveolentis: base is former: be the whole herb with root of samphire Herba Apii graveolentis.The property of medicine: sweet in the mouth; Pungent; Micro-hardship; Cool in nature.Return liver, stomach, lung meridian.Function cures mainly: suppressing the hyperactive liver; Heat clearing away; Dispel the wind; Diuretic; Hemostasis; Removing toxic substances.Main dizziness due to hyperactivity of liver-YANG; Headache due to pathogenic wind-heat; Cough; Jaundice; Urine leaching pain; Hematuria; Metrorrhagia; Leukorrhagia; Skin infection toxic swelling.
Cortex Juglandis mandshuricae: base is former: be the bark of juglandaceae plant Juglans mandshurica.The property of medicine: bitter; Pungent; Cold nature.Function cures mainly: heat clearing and damp drying; Eliminating pathogen in the liver improving eyesight.Main damp-heat diarrhea; Normal lower yellow thick; Conjunctival congestion and swelling pain; Hordeolum; Epiphora induced by wind; Bone tuberculosis.
Flos Rosae Chinensis: base is former: be the flower of rosaceous plant Flos Rosae Chinensis.The property of medicine: sweet; Temperature; Nontoxic.Return liver, kidney channel.Function cures mainly: promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Main menoxenia, dysmenorrhea, amenorrhea, traumatic injury, swelling and pain due to blood stasis, scrofula, carbuncle, scalds.
Fructus Alpiniae Oxyphyllae: base is former: be the fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae.The property of medicine: pungent, temperature.Return spleen, kidney channel.Function cures mainly: warming spleen and stopping diarrhaly take the photograph saliva, warming the kidney reducing urination controlling nocturnal emission with astringent drugs.Main Deficiency and coldness of spleen and stomach, vomit, have loose bowels, coldly in abdomen to educate, the many salivas of mouth, enuresis due to deficiency of the kidney, frequent micturition, seminal emission, nebulousurine.
Flos Hibisci Rosae-Sinensis: base is former: be the flower of Malvaceae plant Hibiscus rosasinensis.The property of medicine: sweet; Light; Flat.GUIXIN, lung, liver, spleen channel.Function cures mainly: lung heat clearing; Removing heat from blood; Removing dampness; Removing toxic substances.Main cough due to lung-heat; Spitting of blood; Epistaxis; Metrorrhagia; Leucorrhea; Dysentery; Reddish and whitish turbid urine; Carbuncle skin infection.
Radix seu Caulis Embeliae Parviflorae: base is former: be root and the old stem of Myrsinacea plant Radix seu Caulis Embeliae Parviflorae.The property of medicine: bitter; Puckery; Warm in nature.Return liver, kidney channel.Function cures mainly: enrich blood, and invigorates blood circulation, strong waist knee joint.The all cards of main blood deficiency, menoxenia, amenorrhea, puerperal asthenia, waist and leg ache, injury and bone fracture.
Ramulus et folium berchemiae floribundae: base is former: for Rhamnaceae plant spends more the stem of Radix Berchemiae Giraldianae, leaf or root.The property of medicine: sweet; Puckery; Tepor.Return liver, gallbladder meridian.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Stomachache; Dysmenorrhea; Puerperal abdonimal pain; Traumatic injury; Tuberculosis of bone and joint; Osteomyelitis; Infantile malnutrition; Hepatitis; Liver cirrhosis.
Herba Cistanches: base is former: be the fleshy stem of orobanchaceae plant cistanche.The property of medicine: sweet in the mouth; Salty; Warm in nature.Return kidney, large intestine channel.Function cures mainly: kidney-replenishing, benefiting essence-blood, intestine moistening road.Main kidney yang deficiency, the sexual impotence of asthenia of essence and blood, seminal emission, nebulousurine, the frequent micturition heeltap, lumbago flaccidity of the lower limbs, tinnitus order flower, menstruation is spread out the phase, infertility, dryness of the intestine constipation.
Coagulum Opuntiae sucus: base is former: be the juice concretion flowed out in the fleshy stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.The property of medicine: sweet; Cold in nature.Function cures mainly: clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Main hemorrhoidal bleeding; Have blood in stool; Furuncle swells; Scald; Palpitation with a distress feeling; Acute infantile convulsion wind.
Rhizoma Rhodiolae kirilowii: base is former: be the root and rhizome of Crassulaceae Rhodida plant Rhodiola kirilowii (Regel) Maxim..Composition: herb is containing butyl alcohol, and daucosterol, rhodioside, hundred arteries and veins are with glycosides.The property of medicine: bitter, puckery, temperature.Return lung, the heart, liver, large intestine channel.Function cures mainly: tranquilizing by nourishing the heart, blood stasis dispelling, hemostasis.Cure mainly deficiency of vital energy and physically weak, weak palpitation and insomnia of losing heart, dizzy dizzy, pain uncomfortable in chest, traumatic injury, menoxenia, metrorrhagia, spits blood, dysentery, diarrhoea.
test example 1the clinical practice of the preparation (embodiment 5) of gained treatment tuberculosis of bone and joint of the present invention: in JIUYUE, 2009 in JIUYUE ,-2011, screens 278 routine tuberculosis of bone and joint patients in 3 hospitals.Wherein, male 155 example, women 123 example, at 15 ~ 56 years old age, average 28 years old, the course of disease was the longest 8 years, the shortest 5 months.Spinal tuberculosis 165 example, coxodynia 70 example, tuberculosis of knee joint 28 example, tuberculosis of elbow joint 15 example.All make a definite diagnosis through x-ray or CT examination and laboratory inspection.Be divided into two groups at random, experimental group and matched group (often organizing 139 people).Two groups of patients compare in the physical data such as sex, age, the course of disease, the state of an illness, and there was no significant difference, has comparability.Experimental group uses gained of the present invention to treat the preparation of tuberculosis of bone and joint, and using method: oral, one day twice, each 5g, boiled water was taken after mixing it with water.Matched group uses the Drug therapys such as isoniazid, rifampicin, pyrazinamide, ethambutol.After two groups of patients all treat three months, carry out Comparison of therapeutic.
Curative effect situation criterion: cure: systemic conditions is good, local symptom, sign disappear, wound healing, functional rehabilitation or substantially recover, and x-ray inspection display knitting is good, and joint space is clear or merge at functional position; Take a turn for the better: systemic conditions and local symptom, sign take a turn for the better, x-ray checks that pathological changes heals not yet completely, and joint deformity is not corrected completely; Invalid: whole body and local symptom are only slightly improved, x-ray inspection is without being clearly better.Total effectively comprising cures and takes a turn for the better.Result is as shown in table 1.
Table 1: the preparation compliance test result [example (%)] of gained treatment tuberculosis of bone and joint of the present invention
Therapeutic effect: cure 105 examples in 139 routine patients of experimental group, account for 75.54%; Take a turn for the better 32 examples, accounts for 23.02%; Invalid 2 examples, account for 1.44%; Total effective rate reaches 98.56%.In 139 routine patients of matched group, cure 35 examples, account for 25.18%; Take a turn for the better 70 examples, accounts for 50.36%; Invalid 34 examples, account for 24.46%; Total effective rate is 75.54%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.
The present invention is primary raw material medicine with Radix Rhodiolae, Herba Salviae Chinensis, Herba Melastomatis dodecandri and Herba Apii graveolentis etc., makes the preparation for the treatment of tuberculosis of bone and joint.Radix Rhodiolae QI invigorating lung heat clearing in side; Fructus Alpiniae Oxyphyllae is nourished heart; Hemostasis with astringents; Dissipating blood stasis for subsidence of swelling.Herba Salviae Chinensis blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, mass dissipating and swelling eliminating.Herba Melastomatis dodecandri is invigorated blood circulation; Hemostasis; Dampness removing; Removing toxic substances.Herba Apii graveolentis suppressing the hyperactive liver; Heat clearing away; Dispel the wind; Diuretic; Hemostasis; Removing toxic substances.
Cortex Juglandis mandshuricae heat clearing and damp drying; Eliminating pathogen in the liver improving eyesight.Flos Rosae Chinensis promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Fructus Alpiniae Oxyphyllae is warming spleen and stopping diarrha takes the photograph saliva, warming the kidney reducing urination controlling nocturnal emission with astringent drugs.Flos Hibisci Rosae-Sinensis lung heat clearing; Removing heat from blood; Removing dampness; Removing toxic substances.Radix seu Caulis Embeliae Parviflorae is enriched blood, and invigorates blood circulation, strong waist knee joint.Ramulus et folium berchemiae floribundae expelling wind and removing dampness; Promoting blood circulation and stopping pain.Herba Cistanches kidney-replenishing, benefiting essence-blood, intestine moistening road.Coagulum Opuntiae sucus clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Rhizoma Rhodiolae kirilowii tranquilizing by nourishing the heart, blood stasis dispelling, hemostasis.All medicines share, and play the effect of blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, kidney-replenishing, reducing swelling and alleviating pain, enrich and benefit essence and blood, strong waist knee joint, expelling wind and removing dampness altogether, can the function of reconditioner soma organ, improve immunity of organisms, thus reach the object of curing tuberculosis of bone and joint.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the preparation of tuberculosis of bone and joint, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Rhodiolae 9-16; Herba Salviae Chinensis 7-15, Herba Melastomatis dodecandri 8-14, Herba Apii graveolentis 6-15; Cortex Juglandis mandshuricae 8-12, Flos Rosae Chinensis 9-14, Fructus Alpiniae Oxyphyllae 8-13; Flos Hibisci Rosae-Sinensis 10-16; Radix seu Caulis Embeliae Parviflorae 9-15, Ramulus et folium berchemiae floribundae 8-16, Herba Cistanches 10-15; Coagulum Opuntiae sucus 7-14, Rhizoma Rhodiolae kirilowii 6-13.
2. the preparation for the treatment of tuberculosis of bone and joint as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Rhodiolae 11-14; Herba Salviae Chinensis 9-13, Herba Melastomatis dodecandri 10-12, Herba Apii graveolentis 9-12; Cortex Juglandis mandshuricae 9-11, Flos Rosae Chinensis 10-13, Fructus Alpiniae Oxyphyllae 10-12; Flos Hibisci Rosae-Sinensis 11-14; Radix seu Caulis Embeliae Parviflorae 10-14, Ramulus et folium berchemiae floribundae 10-13, Herba Cistanches 11-13; Coagulum Opuntiae sucus 9-13, Rhizoma Rhodiolae kirilowii 8-12.
3. the preparation for the treatment of tuberculosis of bone and joint as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Rhodiolae 13; Herba Salviae Chinensis 11, Herba Melastomatis dodecandri 11, Herba Apii graveolentis 10; Cortex Juglandis mandshuricae 10, Flos Rosae Chinensis 12, Fructus Alpiniae Oxyphyllae 11; Flos Hibisci Rosae-Sinensis 13; Radix seu Caulis Embeliae Parviflorae 12, Ramulus et folium berchemiae floribundae 11, Herba Cistanches 12; Coagulum Opuntiae sucus 11, Rhizoma Rhodiolae kirilowii 10.
4. the preparation of the treatment tuberculosis of bone and joint as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment tuberculosis of bone and joint is made pharmaceutically acceptable thick paste agent, and the preparation method of described thick paste agent is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be condensed into the clear paste (being preferably condensed into the clear paste that relative density is 1.23) that relative density is 1.2-1.24, add step (2) gained, stir, add refined honey, continue heating to temper to relative density to be the thick paste of 1.38, to obtain final product.
5. the preparation of the treatment tuberculosis of bone and joint as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment tuberculosis of bone and joint is made pharmaceutically acceptable powder, and the preparation method of described powder is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, every day changes water 2-4 time, stripping and slicing, dries, for subsequent use;
(2) get Fructus Alpiniae Oxyphyllae, poach, amount of water is the 1/3-2/3 of Fructus Alpiniae Oxyphyllae weight, moistening 2-4 hour, puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 180 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.34) that relative density is 1.33-1.35,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 180 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, with 5g often bag subpackage, sterile packaged and get final product.
6. the preparation of the treatment tuberculosis of bone and joint as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment tuberculosis of bone and joint is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 150 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid merged, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.34) that relative density is 1.33-1.35,60 DEG C of dryings 14 hours, take out, are ground into fine powder, cross 150 mesh sieves;
(6) by step (2) and the mixing of step (5) gained, make for binding agent is general the pill (preferably making for binding agent is general the pill that particle diameter is 5mm with the ethanol of 55%) that particle diameter is 5mm with the ethanol of 45%-65%, dry, to obtain final product.
7. the preparation of the treatment tuberculosis of bone and joint as described in as arbitrary in claims 1 to 3, it is characterized in that, the preparation of this treatment tuberculosis of bone and joint is made pharmaceutically acceptable granule, and the preparation method of described granule is:
(1) get Cortex Juglandis mandshuricae, be soaked in water 2 days, change water 2-4 time every day (preferred every day changes water 3 times), stripping and slicing, dries, for subsequent use;
(2) Fructus Alpiniae Oxyphyllae is got, poach, amount of water is the preferred amount of water of 1/3-2/3(of Fructus Alpiniae Oxyphyllae weight is 1/2 of Fructus Alpiniae Oxyphyllae weight), moistening 2-4 hour (preferred moistening 3 hours), puts to steam in container and steams 3-5.5 hour (preferably put to steam in container and steam 4.5 hours), take out, spread out in porcelain dish, dry in the shade, smash to pieces, cross 160 mesh sieves;
(3) Flos Rosae Chinensis and Flos Hibisci Rosae-Sinensis are put into pot, add two taste crude drug 4-6 water (preferably adding the water of two taste crude drug 5.2 times) doubly, decoct 25-40 minute (preferably decocting 34 minutes), leach medicinal liquid;
(4) step (1) gained and all the other the 9 taste crude drug except Cortex Juglandis mandshuricae, Flos Rosae Chinensis, Fructus Alpiniae Oxyphyllae and Flos Hibisci Rosae-Sinensis are together put into the pot that step (3) fills medicinal residues, add 9 taste crude drug 5.3-6.6 water (preferably adding the water of 9 taste crude drug 6.3 times) doubly, decoct 50 minutes, leach medicinal liquid, add 9 taste crude drug 4.5-5.6 water (preferably adding the water of 9 taste crude drug 4.8 times) doubly, continue decoction 40 minutes, leach medicinal liquid, merge twice medicinal liquid;
(5) step (3) and step (4) gained medicinal liquid are merged, be condensed into the clear paste (being preferably condensed into the clear paste that relative density is 1.23) that relative density is 1.2-1.24, drying under reduced pressure, pulverize, add step (2) gained, stir, add cane sugar powder, the amount of cane sugar powder is 1.6-2.4 times (amount of preferably sucrose powder is 2.2 times of gained clear paste weight) of gained clear paste weight, 12% starch slurry is granulated, drying, granulate, to obtain final product.
8. the preparation method of the preparation powder for the treatment of tuberculosis of bone and joint as claimed in claim 5, it is characterized in that, in step (1), every day changes water 3 times.
9. the preparation method of the preparation powder for the treatment of tuberculosis of bone and joint as claimed in claim 5, it is characterized in that, in step (2), amount of water is 1/2 of Fructus Alpiniae Oxyphyllae weight.
10. the preparation method of the preparation powder for the treatment of tuberculosis of bone and joint as claimed in claim 5, is characterized in that, moistening 3 hours in step (2).
CN201510661566.3A 2015-10-15 2015-10-15 Preparation for treating osteoarticular tuberculosis and preparation method Withdrawn CN105194495A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103638499A (en) * 2013-12-12 2014-03-19 苏振华 Medicament for treating osteoarticular tuberculosis and preparation method of medicament
CN103800865A (en) * 2012-12-17 2014-05-21 唐焱华 Chinese herbal medicine for treating osteoarticular tuberculosis
CN104606352A (en) * 2015-02-12 2015-05-13 黄永刚 Bone tuberculosis treating compound pill

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103800865A (en) * 2012-12-17 2014-05-21 唐焱华 Chinese herbal medicine for treating osteoarticular tuberculosis
CN103638499A (en) * 2013-12-12 2014-03-19 苏振华 Medicament for treating osteoarticular tuberculosis and preparation method of medicament
CN104606352A (en) * 2015-02-12 2015-05-13 黄永刚 Bone tuberculosis treating compound pill

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Application publication date: 20151230