CN105194419B - Resisiting influenza virus herbal composite - Google Patents
Resisiting influenza virus herbal composite Download PDFInfo
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- CN105194419B CN105194419B CN201510744503.4A CN201510744503A CN105194419B CN 105194419 B CN105194419 B CN 105194419B CN 201510744503 A CN201510744503 A CN 201510744503A CN 105194419 B CN105194419 B CN 105194419B
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Abstract
The invention discloses a kind of resisiting influenza virus herbal composite, raw material components include: 12-30 parts of screwtree root, 6-15 parts of sweet wormwood, 5-15 parts of mulberry leaf, 2-6 parts of rhizoma imperatae, 6-15 parts of whiteflower cacalia seed, 3-8 parts of radix scutellariae, 3-8 parts of Radix Rhapontici seu Radix Echinopsis according to parts by weight.The present invention, as raw material, does not add any additive using natural Chinese medicinal herb, and infected by influenza has unique curative effect, and fever caused by infected by influenza, headache, bodily pain, pharyngalgia, cough, asthma therapy effect are rapid, without side-effects to human body.
Description
Technical field
The present invention relates to a kind of resisiting influenza virus herbal composites.
Background technique
Influenza (Influenza) is a kind of Acute respiratory infectious disease as caused by influenza virus, and infectiousness is strong, disease incidence
It is high.Eighties of last century 4 times large-scale influenza virus has attacked the mankind, brings very grave disaster.Into after the new century, H5N1 people fowl stream
The prevalence of Influenza Virus and H1N1virus brings great harm to the mankind.In recent years influenza has that Epidemic Scope is wide, passes
The features such as fast, the period is long, easy to recur after drug withdrawal is broadcast, brings huge difficulty to prevention and treatment.Safe and efficient Tamiflu exists
Medical field is concerned.Virus is the small biology of nature, and by the research progress in more than 100 years of the mankind, the mankind are gradually disclosed
The characteristic of virus and the correlation of virus and the mankind, nature.But, the mankind are still seldom to the understanding of virus, right
5,000 kinds viral 95% of natural boundary treaty, still know nothing.This is mainly due to the variability of virus to allow mankind's unpredictable.It is existing
There is being widely used for chemicals, influenza virus is made to produce drug resistance, therapeutic effect is unsatisfactory, can also generate to human body secondary
Effect.
Summary of the invention
The object of the present invention is to provide a kind of resisiting influenza virus herbal composite, the present invention uses natural Chinese medicinal herb conduct
Raw material, does not add any additive, and infected by influenza has a unique curative effect, fever caused by infected by influenza, headache, bodily pain,
Pharyngalgia, cough, asthma therapy effect are rapid, without side-effects to human body.Technical solution provided by the invention are as follows:
A kind of resisiting influenza virus herbal composite, which is characterized in that its raw material components includes: mountain sesame according to parts by weight
It is 12-30 parts numb, 6-15 parts of sweet wormwood, 5-15 parts of mulberry leaf, 2-6 parts of rhizoma imperatae, 6-15 parts of whiteflower cacalia seed, 3-8 parts of radix scutellariae, 3-8 parts of Radix Rhapontici seu Radix Echinopsis.
Preferably, in resisiting influenza virus herbal composite, the screwtree root is serration screwtree root.
Preferably, in resisiting influenza virus herbal composite, the rhizoma imperatae is to remove fibrous root and film quality leaf sheath
Rhizoma imperatae.
Preferably, in resisiting influenza virus herbal composite, the mulberry leaf, which are selected, grows 1 year diameter for 1.5-2cm
Branch on the mulberry leaf that grow.
Preferably, in resisiting influenza virus herbal composite, the whiteflower cacalia seed uses diameter 0.7-1.2cm, surface
Corvinus, it is glossy, it is seen that the whiteflower cacalia seed of horizontal ring grain or transverse crack.
A kind of preparation method of resisiting influenza virus herbal composite, comprising the following steps:
Rhizoma imperatae and radix scutellariae are cleaned 2-3 after with warm water to thinly slice, then with screwtree root, sweet wormwood, mulberry leaf, whiteflower cacalia seed and
Radix Rhapontici seu Radix Echinopsis mixing is put into grinding vessel in, after pulverizing be added want 10 times of medicinal powder amount water decoct 40-60 minutes after extracted
Liquid, extracting solution are cooled to room temperature, and 95% ethyl alcohol is added and stirs evenly, and standing precipitates solution 20-30 minutes, add 75%
Ethyl alcohol continue to staticly settle 20-30 minutes, pour out supernatant, by sediment concentration medicinal extract is made, be put into refrigerator and save backup.
Technical solution of the present invention has the outstanding advantages present invention, as raw material, not add using natural Chinese medicinal herb compared with the prior art
Add any additive, infected by influenza has a unique curative effect, fever caused by infected by influenza, headache, bodily pain, pharyngalgia, cough,
Asthma therapy effect is rapid, without side-effects to human body.
Specific embodiment
The present invention is described again below with reference to embodiment, but should not be limited the scope of the invention with this.
Embodiment one
A kind of resisiting influenza virus herbal composite, which is characterized in that its raw material components includes: mountain sesame according to parts by weight
12 parts, 6 parts of sweet wormwood, 5 parts of mulberry leaf, 2 parts of rhizoma imperatae, 6 parts of whiteflower cacalia seed, 3 parts of radix scutellariae, 3 parts of Radix Rhapontici seu Radix Echinopsis of fiber crops.Wherein screwtree root is serration mountain
Sesame, rhizoma imperatae are the rhizoma imperatae for removing fibrous root and film quality leaf sheath, and mulberry leaf, which are selected, grows 1 year diameter on the branch of 1.5-2cm
The mulberry leaf of growth, whiteflower cacalia seed use diameter 0.7-1.2cm, and surface corvinus is glossy, it is seen that the bitter stone of horizontal ring grain or transverse crack
Lotus.
The resisiting influenza virus herbal composite the preparation method comprises the following steps: rhizoma imperatae and radix scutellariae are cleaned 2-3 after with warm water
It thinly slices, then mixes and be put into grinding vessel with screwtree root, sweet wormwood, mulberry leaf, whiteflower cacalia seed and Radix Rhapontici seu Radix Echinopsis, be added and want after pulverizing
The water that 10 times of medicinal powder amount obtains extracting solution after decocting 40-60 minutes, and extracting solution is cooled to room temperature, and the ethyl alcohol for being added 95% stirs
Even, standing precipitates solution 20-30 minutes, and the ethyl alcohol for adding 75% continues to staticly settle 20-30 minutes, pours out supernatant,
Medicinal extract is made in sediment concentration, refrigerator is put into and saves backup.
Embodiment two
A kind of resisiting influenza virus herbal composite, which is characterized in that its raw material components includes: mountain sesame according to parts by weight
30 parts, 13 parts of sweet wormwood, 8 parts of mulberry leaf, 5 parts of rhizoma imperatae, 10 parts of whiteflower cacalia seed, 5 parts of radix scutellariae, 5 parts of Radix Rhapontici seu Radix Echinopsis of fiber crops.Wherein screwtree root is serration
Screwtree root, rhizoma imperatae are the rhizoma imperatae for removing fibrous root and film quality leaf sheath, and mulberry leaf, which are selected, grows 1 year diameter for the branch of 1.5-2cm
The mulberry leaf of upper growth, whiteflower cacalia seed use diameter 0.7-1.2cm, and surface corvinus is glossy, it is seen that the hardship of horizontal ring grain or transverse crack
Encrinite.
The resisiting influenza virus herbal composite the preparation method comprises the following steps: rhizoma imperatae and radix scutellariae are cleaned 2-3 after with warm water
It thinly slices, then mixes and be put into grinding vessel with screwtree root, sweet wormwood, mulberry leaf, whiteflower cacalia seed and Radix Rhapontici seu Radix Echinopsis, be added and want after pulverizing
The water that 10 times of medicinal powder amount obtains extracting solution after decocting 40-60 minutes, and extracting solution is cooled to room temperature, and the ethyl alcohol for being added 95% stirs
Even, standing precipitates solution 20-30 minutes, and the ethyl alcohol for adding 75% continues to staticly settle 20-30 minutes, pours out supernatant,
Medicinal extract is made in sediment concentration, refrigerator is put into and saves backup.
Embodiment three
A kind of resisiting influenza virus herbal composite, which is characterized in that its raw material components includes: mountain sesame according to parts by weight
30 parts of fiber crops, 15 parts of sweet wormwood, 15 parts of mulberry leaf, 6 parts of rhizoma imperatae, 15 parts of whiteflower cacalia seed, 8 parts of radix scutellariae, wherein screwtree root is serration to 8 parts of Radix Rhapontici seu Radix Echinopsis
Screwtree root, rhizoma imperatae are the rhizoma imperatae for removing fibrous root and film quality leaf sheath, and mulberry leaf, which are selected, grows 1 year diameter for the branch of 1.5-2cm
The mulberry leaf of upper growth, whiteflower cacalia seed use diameter 0.7-1.2cm, and surface corvinus is glossy, it is seen that the hardship of horizontal ring grain or transverse crack
Encrinite.
The resisiting influenza virus herbal composite the preparation method comprises the following steps: by the rhizoma imperatae of above-mentioned components by weight percent and radix scutellariae temperature
Water cleaning 2-3 is thinly sliced after, then is mixed and be put into grinding vessel with screwtree root, sweet wormwood, mulberry leaf, whiteflower cacalia seed and Radix Rhapontici seu Radix Echinopsis, is ground
After grinds be added want 10 times of medicinal powder amount water decoct 40-60 minute after obtain extracting solution, extracting solution is cooled to room temperature, addition
95% ethyl alcohol stirs evenly, and standing precipitates solution 20-30 minutes, and the ethyl alcohol for adding 75% continues to staticly settle 20-30
Minute, supernatant is poured out, medicinal extract is made in sediment concentration, refrigerator is put into and saves backup.
Using CPE method research embodiment 1, the inhibition of embodiment 2 and 3 herbal composite of embodiment to influenza Alphavirus
Effect: MD-CK cell is pressed 2 × 106/ mL is inoculated in 96 well culture plates, 200 holes μ L/, in 5%CO2, 37 DEG C of cultures for 24 hours, be added
Various concentration sample and RBV, while cell controls are set, continue to cultivate 48h, cytopathy degree is observed, using Reed-Muench
Half toxic concentration (the TC of method calculating drug50) and maximal non-toxic concentration (TC50).Mdck cell is pressed 4 × 106/ mL is inoculated in
96 well culture plates, 100 holes μ L/, in 5%CO2, 37 DEG C of cultures for 24 hours.Influenza Alphavirus 0.2 × 10 is added-4(93×TCID50),
100 holes μ L/, 37 DEG C of absorption 2h abandon virus liquid, are separately added into various concentration sample and RBV.Cell normal control and disease are set simultaneously
Poison control, observes cytopathy degree for 24 hours, and the half-inhibitory concentration (IG of drug is calculated using Reed-Muench method50), and tie
Close the result meter drug therapeutic indices (Treatment Index, TI=TC50/IC50) of cell toxicity test.As the result is shown such as
Under:
The herbal composite of 1 embodiment 1,2,3 of table is to anti-influenza A virus determination of activity result
The results show that the herbal composite of embodiment 1,2,3 has apparent inhibition to make influenza Alphavirus in vitro
With.
Although the embodiment of invention has been disclosed as above, listed fortune not only in the description and the implementation
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily real
Now other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is not limited to
Specific details and proportion example shown and described herein.
Claims (6)
1. a kind of resisiting influenza virus herbal composite, which is characterized in that its raw material components is calculated by weight as: screwtree root
12-30 parts, 6-15 parts of sweet wormwood, 5-15 parts of mulberry leaf, 2-6 parts of rhizoma imperatae, 6-15 parts of whiteflower cacalia seed, 3-8 parts of radix scutellariae, 3-8 parts of Radix Rhapontici seu Radix Echinopsis.
2. resisiting influenza virus herbal composite as described in claim 1, which is characterized in that the screwtree root is serration mountain sesame
Fiber crops.
3. resisiting influenza virus herbal composite as described in claim 1, which is characterized in that the rhizoma imperatae is to remove fibrous root
With the rhizoma imperatae of film quality leaf sheath.
4. resisiting influenza virus herbal composite as described in claim 1, which is characterized in that the mulberry leaf select growth 1 year
The mulberry leaf grown on the branch that diameter is 1.5-2cm.
5. resisiting influenza virus herbal composite as described in claim 1, which is characterized in that the whiteflower cacalia seed uses diameter
0.7-1.2cm, surface corvinus is glossy, it is seen that the whiteflower cacalia seed of horizontal ring grain or transverse crack.
6. a kind of preparation method of resisiting influenza virus herbal composite as claimed in any one of claims 1 to 5, feature exist
In, comprising the following steps:
Rhizoma imperatae and radix scutellariae are cleaned 2-3 after with warm water to thinly slice, then with screwtree root, sweet wormwood, mulberry leaf, whiteflower cacalia seed and Radix Rhapontici seu Radix Echinopsis
Mixing be put into grinding vessel in, after pulverizing be added want 10 times of medicinal powder amount water decoct 40-60 minutes after obtain extracting solution, mention
It takes liquid to be cooled to room temperature, 95% ethyl alcohol is added and stirs evenly, standing precipitates solution 20-30 minutes, adds 75% second
Alcohol continues to staticly settle 20-30 minutes, pours out supernatant, and medicinal extract is made in sediment concentration, refrigerator is put into and saves backup.
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| CN201510744503.4A CN105194419B (en) | 2015-11-05 | 2015-11-05 | Resisiting influenza virus herbal composite |
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| CN201510744503.4A CN105194419B (en) | 2015-11-05 | 2015-11-05 | Resisiting influenza virus herbal composite |
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| CN105194419B true CN105194419B (en) | 2019-03-12 |
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| CN107279501A (en) * | 2017-08-04 | 2017-10-24 | 哈尔滨千合动物药品制造有限公司 | A kind of feed for animals with resisiting influenza virus and preparation method thereof |
| CN115463125B (en) * | 2022-08-26 | 2024-01-26 | 高州市人民医院 | Application of 5-methoxy flavone in preparing medicine for preventing or treating influenza virus infection |
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