CN105194193A - Traditional Chinese medicine oral liquid for treating polycystic ovary syndromes and preparation method - Google Patents
Traditional Chinese medicine oral liquid for treating polycystic ovary syndromes and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine oral liquid for treating polycystic ovary syndromes and a preparation method. The traditional Chinese medicine oral liquid is prepared from the following raw materials in parts by weight: 12-18 parts of Chinese angelica, 7-13 parts of safflower, 12-18 parts of beautiful sweetgum fruit, 9-15 parts of Szechuan lovage rhizome, 5-11 parts of leech, 12-18 parts of glossy privet fruit, 27-33 parts of chingma abutilon seed, 27-33 parts of cowherb seed, 37-43 parts of hawthorn fruit, 17-23 parts of India madder root, 9-15 parts of prepared nutgrass galingale rhizome, 12-18 parts of ricepaperplant pith, 27-33 parts of motherwort herb and 4-10 parts of liquorice root. The traditional Chinese medicine oral liquid has the functions of promoting blood circulation to remove blood stasis, nourishing kidney yin and nourishing and generating blood and is a safe and reliable traditional Chinese medicine composition which does not have any toxic or side effect, has high active ingredient usage rate and takes effect quickly.
Description
Technical field
The present invention relates to a kind of Chinese medicine oral liquid for the treatment of polycystic ovary syndrome, belong to the field of Chinese medicines.
Background technology
Polycystic ovarian syndrome (PCOS) be rarely to send a manuscript to the compositor ovum or anovulation, excessive androgen or insulin resistant, the syndrome of endocrine regulation that polycystic ovary is feature, symptom comprises hypomenorrhea or amenorrhea, chronic anovulation, infertile, hirsutism and acne etc., because of chronic anovulation, endometrium hyperplasia can be made under serious conditions, increase the risk of carcinoma of endometrium, atypical case can show as: 1. pure amenorrhea is without obesity, hirsutism and ovary enlargement, get rid of other various diseases, and progesterone test positive, PCOS must be thought of as; 2. ovulation type hemorrhage of functional disorder; 3. irregular menstruation merges hirsutism; 4. irregular menstruation accompanies manlike symptom, without obviously fat; 5. dysfunctional uterine bleeding companion is sterile; Need the relevant medical history of inquiry in detail for the case that is not true to type, as onset age, growth promoter situation, onset process, medication history, family history, personal lifestyle is accustomed to, previously with or without systemic disease.In conjunction with auxiliary examination, get rid of other diseases, and clarify a diagnosis through inspections such as B ultrasonic, most scholar raises according to adolescence morbidity, menstruation and abnormal ovulation, hirsutism, blood LH and (or) LH/FSH ratio, too high in conjunction with androgen levels, ultrasonic examination has polycystic ovary sign, after getting rid of other similar diseases, can determine the diagnosis of this disease.The western medical treatment Main Means taked this disease is at present that the western medical treatment such as drug-induced ovulation, gonadotropin releasing hormone easily causes side effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of polycystic ovary syndrome, it has effect of blood circulation promoting and blood stasis dispelling, nourishing kidney yin, blood-nourishing blood-generating.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine oral liquid for polycystic ovary syndrome, be made up of following raw material: Radix Angelicae Sinensis 12-18 part, Flos Carthami 7-13 part, Fructus Liquidambaris 12-18 part, Rhizoma Chuanxiong 9-15 part, Hirudo 5-11 part, Fructus Ligustri Lucidi 12-18 part, Semen Abutili 27-33 part, Semen Vaccariae 27-33 part, Fructus Crataegi 37-43 part, Radix Rubiae 17-23 part, Rhizoma Cyperi (processed) 9-15 part, Medulla Tetrapanacis 12-18 part, Herba Leonuri 27-33 part, Radix Glycyrrhizae 4-10 part.
Preferably, each parts by weight of raw materials is: Radix Angelicae Sinensis 15 parts, 10 parts, Flos Carthami, Fructus Liquidambaris 15 parts, Rhizoma Chuanxiong 12 parts, Hirudo 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Abutili 30 parts, Semen Vaccariae 30 parts, Fructus Crataegi 40 parts, 20 parts, Radix Rubiae, Rhizoma Cyperi (processed) 12 parts, Medulla Tetrapanacis 15 parts, Herba Leonuri 30 parts, 7 parts, Radix Glycyrrhizae.
Pharmacological action:
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm; Return liver, the heart, spleen channel, function with cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow; For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Flos Carthami: nature and flavor with return through: pungent, temperature; GUIXIN, Liver Channel, function with cure mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; For amenorrhea, dysmenorrhea, lochia, note of the ancient Chinese abdominal mass mass in the abdomen, injury from falling down, skin infection swells and ache.
Fructus Liquidambaris: nature and flavor with return through: bitter, flat; Return liver, kidney channel, function with cure mainly: dispelling, collateral-activating, diuretic stimulates the menstrual flow; For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Rhizoma Chuanxiong: nature and flavor with return through: pungent, temperature; Return liver, gallbladder, pericardium channel, function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping; For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Hirudo: nature and flavor with return through: salty, bitter, flat; Slightly poisonous; Return Liver Channel, function with cure mainly: removing blood stasis, removing blood stasis, stimulates the menstrual flow; Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down.
Fructus Ligustri Lucidi: nature and flavor with return through sweet, bitter, cold; Return liver, kidney channel, function with cure mainly: nourishing the liver and kidney, improving eyesight black hair; For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Semen Abutili: property is put down, bitter in the mouth; Effect diuretic, laxation, stimulating milk secretion; Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances, nebula removing; For dysentery, the puckery pain of gonorrhea. carbuncle, corneal nebula.
Semen Vaccariae: nature and flavor with return through: bitter, flat; Return liver, stomach warp, function with cure mainly: promoting blood circulation to restore menstrual flow, stimulating milk secretion subside a swelling; For agalactia, amenorrhea, dysmenorrhea, acute mastitis swells and ache.
Fructus Crataegi: nature and flavor with return through sour, sweet, tepor; Return spleen, stomach, Liver Channel, function with cure mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis; For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia; The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens; For meat stagnation, dysentery is not well.
Radix Rubiae: nature and flavor with return through: bitter, cold; Return Liver Channel, function with cure mainly: removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow; For spitting blood, epistaxis, metrorrhagia, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.
Rhizoma Cyperi (processed): meridian distribution of property and flavor: pungent, micro-hardship, micro-sweet, flat, returns Liver Channel, spleen channel, tri-jiao channel; Effect: depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving; Function cures mainly: resolving depression of regulating the flow of vital energy, pain relieving regulating menstruation; Treating the liver discomfort in the stomach, depression of QI, breast abdomen distending pain over the hypochondrium, phlegm retention feeling of fullness, menoxenia, bleeding not during menses.
Medulla Tetrapanacis: nature and flavor with return through: sweet, light, be slightly cold; Attach to the lung and stomach meridians, function with cure mainly: clearing away heat and promoting diuresis, ventilation stimulating milk secretion; For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.
Herba Leonuri: nature and flavor with return through: bitter, pungent, be slightly cold; Return liver, pericardium channel; Function with cure mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema; For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Radix Glycyrrhizae: nature and flavor with return through: sweet, flat; GUIXIN, lung, spleen, stomach warp, function with cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Another technical problem to be solved by this invention is to provide a kind of preparation method preparing above-mentioned Chinese medicine oral liquid.
Another technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a preparation method for the Chinese medicine oral liquid of polycystic ovary syndrome, be prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
Preferably, a kind of preparation method for the treatment of the Chinese medicine oral liquid of polycystic ovary syndrome, is prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 18000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 80% is added by volume, leave standstill 48 hours, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size of the filter membrane of described ultrafilter is 40nm, and the pressure limit crossed in filter fly is 0.3MPa, and the scope of the crossflow velocity in filter process is 3.5m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, when being evaporated to 60 DEG C in receiver, the extractum of relative density 1.10, obtains extractum, for subsequent use;
(6) by gained clear paste sodium hydroxide solution adjust ph to 7.0 in step (5), embedding is in clean vial again, steam sterilization 35min sterilizing under 100 DEG C of conditions after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
Beneficial effect: the present invention has effect of blood circulation promoting and blood stasis dispelling, nourishing kidney yin, blood-nourishing blood-generating, be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.
The present invention adopts pure Chinese medicine to be raw material, according to pathogenic factor and the Clinical symptoms of polycystic ovary syndrome, under instruction of Chinese Medicine theory, carry out prescription be prepared from the basis not being raw-material activity, show through clinical efficacy, this medicine has definite curative effect to polycystic ovary syndrome, is the ideal treatment medication of a kind of polycystic ovary syndrome patient.
Model case
Case 1: Mrs Ou Yang, 26 years old, medical history: existing two wheat harvesting periods of menolipsis, urine examination unpregnancy, examines as polycystic ovary syndrome, not feels at ease, transfer the traditional Chinese medical science and see a doctor, with Drug therapy 6 Nikkei of the present invention extremely, stomachache unbearably, with clot, follows up a case by regular visits to 1 year without recurrence.
Case 2: Mrs Duan, 36 years old, medical history: the bodily form is fat, lip hair, shank-feathering was many and grow, and hospital diagnosis is polycystic ovary syndrome.Take medicine of the present invention, all are normal to remove examination in hospital after taking four courses for the treatment of continuously, within after drug withdrawal 4th month, become pregnant successfully.
Case 3: Mrs Fan, 25 years old, medical history: come about half a year once, be diagnosed as: polycystic ovary syndrome, not feel at ease, carried out the traditional Chinese medical science and sees a doctor, and all are normal to remove examination in hospital after taking four courses for the treatment of continuously, within after drug withdrawal 2nd month, become pregnant successfully.
Case 4: Mrs Yin, 31 years old, medical history: hypomenorrhea, obesity, existing six wheat harvesting periods of menolipsis, urine examination unpregnancy, hospital examine into: polycystic ovary syndrome, all are normal to remove examination in hospital after taking four courses for the treatment of continuously, within after drug withdrawal 6th month, become pregnant successfully.
Case 5: Mrs Zuo, 37 years old, medical history: patient menstrual is 7 months non-row, urine examination unpregnancy, hospital examines as polycystic ovary syndrome, not feels at ease, transfer the traditional Chinese medical science to see a doctor, all are normal to remove examination in hospital after taking four courses for the treatment of continuously, within after drug withdrawal 2nd month, become pregnant successfully.
Case 6: Mrs Fang, 35 years old, medical history: marry 3 years so far conceived, existing two wheat harvesting periods of menolipsis, urine examination unpregnancy, hospital examine into: polycystic ovary syndrome, all are normal to remove examination in hospital after taking four courses for the treatment of continuously, within after drug withdrawal 3rd month, become pregnant successfully.
Clinical data
Physical data: polycystic ovary syndrome patient totally 45 example, the age 22-45 year.
Diagnostic criteria: 1, clinical manifestation: patient has one or more in following symptom: 1) menoxenia: amenorrhea, infrequent menstruation before amenorrhea, very few, minority ischemia or inadequate luteal function; 2) hirsutism: chaeta, pubes are dense; 3) fat: moderate obesity; 4) infertile: caused by anovulation; 2, sign: detect abnormal uterine, bilateral ovaries increases; 3, B ultrasonic detects: typical person can show the polycystic ovary image of multiple follicles that bilateral ovaries increases.
Therapeutic Method: take oral liquid of the present invention, every day 3 times, each 30ml 7th is a course for the treatment of.
Curative effect determinate standard: recovery from illness: menstrual cycle is normal, hormonal readiness measures normal, and B ultrasonic detects normal ovulation, and B ultrasonic ovary many cystic sign disappears.Take a turn for the better: menstrual cycle is normal, hormonal readiness measures LH/FSH ratio to be reduced, and T value reduces, and B ultrasonic detects have superiority ovarian follicular growth but anovulation, and the many cystic of B ultrasonic ovary reduce or singly survey disappearance.Invalid: clinical symptoms is without improvement, and hormonal readiness measures without changing, and B ultrasonic detects without dominant follicle growth, and B ultrasonic ovary many cystic sign is unchanged.
Therapeutic outcome: by this side treatment polycystic ovary syndrome patient 45 example, wherein clinical recovery 42 example, take a turn for the better 2 examples, and invalid 0 example, total effective rate is 100%.
Detailed description of the invention
Embodiment 1
The present invention treats the preparation of polycystic ovary syndrome Chinese medicine oral liquid, and the weight portion of each raw material is: Radix Angelicae Sinensis 18 parts, 13 parts, Flos Carthami, Fructus Liquidambaris 18 parts, Rhizoma Chuanxiong 15 parts, Hirudo 11 parts, Fructus Ligustri Lucidi 18 parts, Semen Abutili 33 parts, Semen Vaccariae 33 parts, Fructus Crataegi 43 parts, 23 parts, Radix Rubiae, Rhizoma Cyperi (processed) 15 parts, Medulla Tetrapanacis 18 parts, Herba Leonuri 33 parts, 10 parts, Radix Glycyrrhizae;
Be prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
Usage: oral, every day 3 times, each 30ml.
Embodiment 2
The present invention treats the preparation of polycystic ovary syndrome Chinese medicine oral liquid, and the weight portion of each raw material is: Radix Angelicae Sinensis 15 parts, 10 parts, Flos Carthami, Fructus Liquidambaris 15 parts, Rhizoma Chuanxiong 12 parts, Hirudo 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Abutili 30 parts, Semen Vaccariae 30 parts, Fructus Crataegi 40 parts, 20 parts, Radix Rubiae, Rhizoma Cyperi (processed) 12 parts, Medulla Tetrapanacis 15 parts, Herba Leonuri 30 parts, 7 parts, Radix Glycyrrhizae;
Be prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
Usage: oral, every day 3 times, each 30ml.
Embodiment 3
The present invention treats the preparation of polycystic ovary syndrome Chinese medicine oral liquid, and the weight portion of each raw material is: Radix Angelicae Sinensis 12 parts, 7 parts, Flos Carthami, Fructus Liquidambaris 12 parts, Rhizoma Chuanxiong 9 parts, Hirudo 5 parts, Fructus Ligustri Lucidi 12 parts, Semen Abutili 27 parts, Semen Vaccariae 27 parts, Fructus Crataegi 37 parts, 17 parts, Radix Rubiae, Rhizoma Cyperi (processed) 9 parts, Medulla Tetrapanacis 12 parts, Herba Leonuri 27 parts, 4 parts, Radix Glycyrrhizae;
Be prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
Usage: oral, every day 3 times, each 30ml.
Claims (6)
1. treat a Chinese medicine oral liquid for polycystic ovary syndrome, it is characterized in that: be made up of following raw material: Radix Angelicae Sinensis 12-18 part, Flos Carthami 7-13 part, Fructus Liquidambaris 12-18 part, Rhizoma Chuanxiong 9-15 part, Hirudo 5-11 part, Fructus Ligustri Lucidi 12-18 part, Semen Abutili 27-33 part, Semen Vaccariae 27-33 part, Fructus Crataegi 37-43 part, Radix Rubiae 17-23 part, Rhizoma Cyperi (processed) 9-15 part, Medulla Tetrapanacis 12-18 part, Herba Leonuri 27-33 part, Radix Glycyrrhizae 4-10 part.
2. a kind of Chinese medicine oral liquid for the treatment of polycystic ovary syndrome according to claim 1, is characterized in that: the weight portion of each raw material is: Radix Angelicae Sinensis 15 parts, 10 parts, Flos Carthami, Fructus Liquidambaris 15 parts, Rhizoma Chuanxiong 12 parts, Hirudo 8 parts, Fructus Ligustri Lucidi 15 parts, Semen Abutili 30 parts, Semen Vaccariae 30 parts, Fructus Crataegi 40 parts, 20 parts, Radix Rubiae, Rhizoma Cyperi (processed) 12 parts, Medulla Tetrapanacis 15 parts, Herba Leonuri 30 parts, 7 parts, Radix Glycyrrhizae.
3. a kind of Chinese medicine oral liquid for the treatment of polycystic ovary syndrome according to claim 1, is characterized in that: the weight portion of each raw material is: Radix Angelicae Sinensis 18 parts, 13 parts, Flos Carthami, Fructus Liquidambaris 18 parts, Rhizoma Chuanxiong 15 parts, Hirudo 11 parts, Fructus Ligustri Lucidi 18 parts, Semen Abutili 33 parts, Semen Vaccariae 33 parts, Fructus Crataegi 43 parts, 23 parts, Radix Rubiae, Rhizoma Cyperi (processed) 15 parts, Medulla Tetrapanacis 18 parts, Herba Leonuri 33 parts, 10 parts, Radix Glycyrrhizae.
4. a kind of Chinese medicine oral liquid for the treatment of polycystic ovary syndrome according to claim 1, is characterized in that: the weight portion of each raw material is: Radix Angelicae Sinensis 12 parts, 7 parts, Flos Carthami, Fructus Liquidambaris 12 parts, Rhizoma Chuanxiong 9 parts, Hirudo 5 parts, Fructus Ligustri Lucidi 12 parts, Semen Abutili 27 parts, Semen Vaccariae 27 parts, Fructus Crataegi 37 parts, 17 parts, Radix Rubiae, Rhizoma Cyperi (processed) 9 parts, Medulla Tetrapanacis 12 parts, Herba Leonuri 27 parts, 4 parts, Radix Glycyrrhizae.
5. a kind of preparation method for the treatment of the Chinese medicine oral liquid of polycystic ovary syndrome according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10-30 minute is got, then put into decocting machine and decoct with water twice, first time adds above-mentioned raw material weight and 6-10 soak by water 1-2 hour doubly, second time adds above-mentioned raw materials weight and 5-8 soak by water 1-2 hour doubly, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 10000-30000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 60-90% is added by volume, leave standstill 24-48 hour, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size scope of the filter membrane of described ultrafilter is 20-500nm, and the pressure limit crossed in filter fly is 0.05-0.7MPa, and the scope of the crossflow velocity in filter process is 1-6m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, in receiver, be evaporated to the extractum of relative density 1.10-1.15 during 60-70 DEG C, obtain extractum, for subsequent use;
(6) by gained clear paste in step (5) by sodium hydroxide solution adjust ph to 6.0-8.0, embedding is in clean vial again, steam sterilization 25-35min sterilizing under 100-103 DEG C of condition after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
6. a kind of preparation method for the treatment of the Chinese medicine oral liquid of polycystic ovary syndrome according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) raw material Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Hirudo, Fructus Crataegi cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(2) raw material Fructus Liquidambaris, Fructus Ligustri Lucidi, Semen Abutili, Semen Vaccariae, Radix Rubiae, Rhizoma Cyperi (processed), Medulla Tetrapanacis, Herba Leonuri, Radix Glycyrrhizae cold water soak 10 minutes is got, then put into decocting machine and decoct with water twice, first time adds the soak by water 1 hour of above-mentioned raw material weight and 10 times, second time adds the soak by water 1 hour of above-mentioned raw materials weight and 8 times, collecting decoction, filters, and collects filtrate, obtain filtrate, for subsequent use;
(3) admixing medical solutions is obtained by putting into high speed centrifuge centrifugalize under rotating speed is 18000r/min after gained filtrate mixing in gained filtrate in step (1) and step (2), then the ethanol of 80% is added by volume, leave standstill 48 hours, filter, filtrate recycling ethanol, refilter, obtain admixing medical solutions, for subsequent use;
(4) gained admixing medical solutions in step (3) is put into ultrafilter to filter, the average pore size of the filter membrane of described ultrafilter is 40nm, and the pressure limit crossed in filter fly is 0.3MPa, and the scope of the crossflow velocity in filter process is 3.5m/s, obtain filtrate, for subsequent use;
(5) gained filtrate in step (4) is sent into receiver, when being evaporated to 60 DEG C in receiver, the extractum of relative density 1.10, obtains extractum, for subsequent use;
(6) by gained clear paste sodium hydroxide solution adjust ph to 7.0 in step (5), embedding is in clean vial again, steam sterilization 35min sterilizing under 100 DEG C of conditions after lid is rolled in fill, and warehouse-in is finished product, must treat the Chinese medicine oral liquid of polycystic ovary syndrome.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104162057A (en) * | 2014-08-26 | 2014-11-26 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating obese polycystic ovarian syndrome and applications thereof |
| CN104906183A (en) * | 2015-06-16 | 2015-09-16 | 郭前进 | Traditional Chinese medicine pill for treating female infertility and preparation method of traditional Chinese medicine pill |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104162057A (en) * | 2014-08-26 | 2014-11-26 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating obese polycystic ovarian syndrome and applications thereof |
| CN104906183A (en) * | 2015-06-16 | 2015-09-16 | 郭前进 | Traditional Chinese medicine pill for treating female infertility and preparation method of traditional Chinese medicine pill |
Non-Patent Citations (2)
| Title |
|---|
| 凌沛学: "《中药学概论》", 31 August 2007, 中国轻工业出版社 * |
| 牛建昭: "《现代中西医妇科学》", 31 March 1996, 中国科学技术出版社 * |
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