CN105194182A - Traditional Chinese medicine oral liquid for treating trigeminal neuralgia and preparation method thereof - Google Patents

Traditional Chinese medicine oral liquid for treating trigeminal neuralgia and preparation method thereof Download PDF

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CN105194182A
CN105194182A CN201510765960.1A CN201510765960A CN105194182A CN 105194182 A CN105194182 A CN 105194182A CN 201510765960 A CN201510765960 A CN 201510765960A CN 105194182 A CN105194182 A CN 105194182A
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尹柱良
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Abstract

The invention discloses a traditional Chinese medicine oral liquid for treating trigeminal neuralgia and a preparation method thereof. The traditional Chinese medicine oral liquid is prepared from the following raw materials in parts by weight: 9-15 parts of Chinese angelica, 6-12 parts of grass leaf sweelflag rhizome, 9-15 parts of simple-leaf shrub chastetree fruit, 12-18 parts of Szechuan lovage rhizome, 9-15 parts of dahurian angelica root, 12-18 parts of coastal glehnia root, 1-3 parts of scorpion, 2-8 parts of manchurian wildginger herb, 9-15 parts of stiff silkworms, 12-18 parts of earthworms, 17-23 parts of kudzuvine root, 17-23 parts of danshen root, 12-18 parts of beautiful sweetgum fruit, 3-9 parts of licorice root and 37-43 parts of dragon's blood. The traditional Chinese medicine oral liquid disclosed by the invention has the effects of promoting blood circulation to remove obstruction in collaterals, expelling wind and relieving convulsion, and dispelling cold to relieve pain, and is a safe and reliable traditional Chinese medicine composition which does not have toxic or side effect, and is high in utilization ratio of active ingredients and quick to take effect.

Description

One treats prosopalgic Chinese medicine oral liquid and preparation method
Technical field
The present invention relates to one and treat prosopalgic Chinese medicine oral liquid, belong to the field of Chinese medicines.
Background technology
Trigeminal neuralgia is modal cranial nerve diseases, with the violent pain of the paroxysmal of recurrent exerbation in a side surface part nervi trigeminus areal area for main manifestations, the sickness rate 52.2/10 ten thousand of domestic statistics, female is slightly more than man, sickness rate can increase with the age, trigeminal neuralgia is multiple is born in middle-aged and elderly people, R)L, the feature of this disease is: in Head And Face nervi trigeminus distributed areas, morbidity is rapid to be sent out, all standing, lightning sample, lancinate sample, burn sample, intractable, insufferable severity pain, speak, wash one's face, to brush teeth or mild wind strokes face, having an intense pain when all can cause paroxysmal when even walking, pain lasts several seconds or several minutes, pain is periodical attack, the outbreak intermission is the same with normal person, the western medical treatment Main Means taked this disease at present beats closed treating, this is the prosopalgic conventional method for the treatment of, exactly anhydrous alcohol or other drug are expelled in trifacial branch or semilunar ganglion, cause generation coagulation necrosis, and then block nerves is to the conduction function of pain, although this Therapeutic Method onset is than very fast, but easily recur.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one and treat prosopalgic Chinese medicine oral liquid, it has promoting blood circulation to remove obstruction in the collateral, expellings wind and relieving convulsion, effect of dispersing cold for relieving pain.
The present invention is achieved through the following technical solutions:
One treats prosopalgic Chinese medicine oral liquid, is made up of following raw material: Radix Angelicae Sinensis 9-15 part, Rhizoma Acori Graminei 6-12 part, Fructus Viticis 9-15 part, Rhizoma Chuanxiong 12-18 part, Radix Angelicae Dahuricae 9-15 part, Radix Glehniae 12-18 part, Scorpio 1-3 part, Herba Asari 2-8 part, Bombyx Batryticatus 9-15 part, Pheretima 12-18 part, Radix Puerariae 17-23 part, Radix Salviae Miltiorrhizae 17-23 part, Fructus Liquidambaris 12-18 part, Radix Glycyrrhizae 3-9 part, Sanguis Draxonis 37-43 part.
Preferably, each parts by weight of raw materials is: Radix Angelicae Sinensis 12 parts, Rhizoma Acori Graminei 9 parts, Fructus Viticis 12 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 12 parts, Radix Glehniae 15 parts, Scorpio 2 parts, Herba Asari 5 parts, Bombyx Batryticatus 12 parts, Pheretima 15 parts, Radix Puerariae 20 parts, Radix Salviae Miltiorrhizae 20 parts, Fructus Liquidambaris 15 parts, 6 parts, Radix Glycyrrhizae, Sanguis Draxonis 40 parts.
Pharmacological action:
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm; Return liver, the heart, spleen channel, function with cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow; For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Acori Graminei: nature and flavor with return through: pungent, bitter, temperature; GUIXIN, stomach warp, function with cure mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae; Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.
Fructus Viticis: nature and flavor with return through: pungent, bitter, be slightly cold; Return bladder, liver, stomach warp, function with cure mainly: dispelling wind and heat pathogens, the clear sharp head; For anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
Rhizoma Chuanxiong: nature and flavor with return through: pungent, temperature; Return liver, gallbladder, pericardium channel, function with cure mainly: blood-activating and qi-promoting, wind-expelling pain-stopping; For menoxenia, amenorrhea dysmenorrhea , mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Angelicae Dahuricae: nature and flavor with return through: pungent, temperature; Return stomach, large intestine, lung meridian, function with cure mainly: loose wind dehumidifies, understand things pain-stopping, detumescence and apocenosis; For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Glehniae: nature and flavor with return through: sweet, micro-hardship, is slightly cold; Attach to the lung and stomach meridians, function with cure mainly: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid; For lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound is thirsty.
Scorpio: nature and flavor with return through: pungent, flat; Poisonous; Return Liver Channel, function with cure mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; For infantile convulsion, tic spasm, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Herba Asari: nature and flavor with return through: pungent, temperature; GUIXIN, lung, kidney channel, function with cure mainly: expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention; For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Bombyx Batryticatus: nature and flavor with return through: salty, pungent, flat; Return liver, lung, stomach warp, function with cure mainly: expelling wind for relieving convulsion, dissipating phlegm and resolving masses; For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes is scorching, facial paralysis.
Pheretima: nature and flavor with return through: salty, cold; Return liver, spleen, urinary bladder channel, function with cure mainly: heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis; For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Radix Puerariae: nature and flavor with return through: sweet, pungent, cool; Return spleen, stomach warp; : function with cure mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal; For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Radix Salviae Miltiorrhizae: nature and flavor with return through: bitter, be slightly cold; GUIXIN, Liver Channel, function with cure mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness; For menoxenia, amenorrhea dysmenorrhea, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Fructus Liquidambaris: nature and flavor with return through: bitter, flat; Return liver, kidney channel, function with cure mainly: dispelling, collateral-activating, diuretic stimulates the menstrual flow; For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Radix Glycyrrhizae: nature and flavor with return through: sweet, flat; GUIXIN, lung, spleen, stomach warp, function with cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Sanguis Draxonis: nature and flavor with return through: sweet, salty, flat; GUIXIN, Liver Channel, function with cure mainly: removing blood stasis and relieving pain, hemostasia and promoting granulation; Lose for falling to flutter, ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.
Another technical problem to be solved by this invention is to provide a kind of preparation method preparing above-mentioned Chinese medicine oral liquid.
Another technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a preparation method for prosopalgic Chinese medicine oral liquid, be prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(4) add raw material weight 6-12 soak by water 2-3 hour doubly after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add raw material weight 6-8 soak by water 1.5-2.5 hour doubly again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added above-mentioned raw materials weight and 8-13 water doubly, decoct 1-3 hour, release medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1.5-2.5 hour doubly after being merged by three medicinal residues again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of filtrate weight 1.5-2 times 95% will be added after gained filtrate mixing in middle for step (5) gained filtrate and step (4) fully mixing, 20-24h is left standstill after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
Preferably, a kind of preparation method for the treatment of prosopalgic Chinese medicine oral liquid, is prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;
(4) add the soak by water 2 hours of raw material weight 12 times after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add the soak by water 1.5 hours of raw material weight 8 times again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added the water of above-mentioned raw materials weight and 13 times, decocts 1.5 hours, releasing medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Add the soak by water 1.5 hours of its weight 8 times after three medicinal residues being merged again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of 95% of filtrate weight 1.5 times will be added after gained filtrate mixing in gained filtrate in step (5) and step (4) fully mixing, leave standstill 24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane aperture of described leaf filter is 0.8 μm, in the process of filtering, pressure limit is 0.15MPa, face discharge is 1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane aperture of described leaf filter is 0.8 μm, and in the process of filtering, pressure limit is 0.15MPa, and face discharge is 0.8T/h, obtains filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, when being evaporated to 60 DEG C in thickener, the clear paste of relative density 1.05, obtains clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24 hours under the condition of 6 DEG C, by sodium hydroxide solution adjust ph to 6.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 25min is irradiated in ultraviolet wavelength 254nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
Beneficial effect: the present invention has promoting blood circulation to remove obstruction in the collateral, expellings wind and relieving convulsion, effect of dispersing cold for relieving pain, be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.
The present invention adopts pure Chinese medicine to be raw material, according to prosopalgic pathogenic factor and Clinical symptoms, under instruction of Chinese Medicine theory, carry out prescription be prepared from the basis not being raw-material activity, show through clinical efficacy, this medicine has definite curative effect to trigeminal neuralgia, is a kind of ideal treatment medication of affected nerves of patients with trigeminal neuralgia.
Model case,
Case 1: Mrs Jiang, 42 years old, medical history: trigeminal neuralgia, Face and cheek is very, once to have an injection treatment in hospital, have no improvement, now turn Chinese traditional treatment, take Drug therapy of the present invention three days, after treatment, patient's subjective symptoms obviously alleviates, taking medicine of the present invention one week patient's above-mentioned symptom to disappear, then advise and take medicine of the present invention one week, following up a case by regular visits to 1 year without recurring.
Case 2: Mrs Wang, 53 years old, medical history: trigeminal neuralgia, the ictal pain in patient main suit's right face portion, is difficult to stand, has a meal, too loudly, nervously all can to bring out, examine as trigeminal neuralgia, once to have an injection treatment in hospital, and had no improvement, now turn Chinese traditional treatment, take Drug therapy of the present invention one week, after treatment, patient's subjective symptoms obviously alleviates, and takes medicine of the present invention two weeks patient's above-mentioned symptoms and disappears completely, follows up a case by regular visits to 1 year without recurrence.
Case 3: Mrs Qiu, 60 years old, medical history: the appearance right face severity pain of patient main suit's unknown cause, in sample or the acupuncture sample of lancinating, each outbreak continues several seconds, and for several times, speak, brush teeth, feed etc. all can cause panic attacks in outbreak every day, the gap phase is without any symptom, examine as trigeminal neuralgia, take Drug therapy of the present invention one week, after treatment, patient's subjective symptoms obviously alleviates, take medicine of the present invention two weeks patient's above-mentioned symptoms to disappear completely, follow up a case by regular visits to 1 year without recurrence.
Case 4: Mr. Bi, 47 years old, medical history: patient main suit's left facial part starts paroxysmal pain, transferred thereafter severe pain gradually to, show effect five to ten times everyday, hospital is diagnosed as trigeminal neuralgia, and the pain increased recently, now turns Chinese traditional treatment, take Drug therapy of the present invention one week, after treatment, patient's subjective symptoms obviously alleviates, and takes medicine of the present invention two weeks patient's above-mentioned symptoms and disappears completely, follows up a case by regular visits to 1 year without recurrence.
Case 5: Mrs Wei, women, 44 years old, medical history: on the right side of patient main suit, face is interrupted pain, increase the weight of 1 month, hospital is diagnosed as trigeminal neuralgia, recurs recently, existing Chinese traditional treatment, take Drug therapy of the present invention one week, after treatment, patient's subjective symptoms obviously alleviates, and after taking a course for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.
Case 6: Mr. Qin, 68 years old, medical history: suffered from trigeminal neuralgia before 4 years, so unobvious at first, just sensation right side some slight burn feeling of canthus place, it is heavy when time is light, there is one section of upward swing centre, recur recently, existing Chinese traditional treatment, takes Drug therapy of the present invention one week, after treatment, patient's subjective symptoms obviously alleviates, after taking a course for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears, then advise take two courses for the treatment of of medicine of the present invention after patient's above-mentioned symptom disappear completely, follow up a case by regular visits to 1 year without recurrence.
Case 7: Mr. Zhu, 57 years old, medical history: right side facial area pain, in paroxysmal, severe pain, was difficult to stand.Several seconds persistent period is not to several minutes etc., brush teeth, suffer from cold etc. can be brought out, hospital diagnosis is that trigeminal neuralgia was examined afterwards, take Drug therapy of the present invention one week, after treatment, patient's subjective symptoms obviously alleviates, after taking a course for the treatment of of medicine of the present invention, patient's above-mentioned symptom disappears completely, follows up a case by regular visits to 1 year without recurrence.
Clinical data
Physical data: patient 46 example, man 27 example, female 19 example, age 27-68 year, 47.5 years old mean age.
Diagnostic criteria: the 1) paroxysmal pain of face or forehead, continues several seconds to 2 minutes; 2) pain to have in features 4 at least: 1. along trifacial 1 or several strolls; 2. be characterized as burst, violent, sharp-pointed, shallow table, lancination sample or burn sample; Sharp ache; 3. inspire from trigger point, or bring out, as having a meal, talk, wash one's face or brushing teeth because of some daily routines; 4., after outbreak, patient is completely asymptomatic; 3) impassivity system sign; 4) each patient outbreak of having it mechanical; 5) medical history, body inspection and if desired done special examined can get rid of other reason causing prosopodynia.
Therapeutic Method: take medicine of the present invention every day 2 times, each 30ml one week is a course for the treatment of.
Curative effect determinate standard: recovery from illness: pain stops, the functions such as facial perception are normal, follow up a case by regular visits to more than 3 months without recurrence; Effective: after pain stops, recurring in 3 months, but the comparatively front minimizing more than 50% of the outbreak frequency; Effective: the panic attacks frequency is comparatively front reduces 25%-50%; Invalid: the panic attacks frequency comparatively front minimizing is less than 25%.
Therapeutic outcome: with in this side treatment affected nerves of patients with trigeminal neuralgia 46 example, clinical recovery 35 example, effective 9 examples, effective 2 examples, invalid 0 example, total effective rate 100%.
Detailed description of the invention
Embodiment 1
The present invention treats the preparation of trigeminal neuralgia Chinese medicine oral liquid, and the weight portion of each raw material is: Radix Angelicae Sinensis 15 parts, Rhizoma Acori Graminei 12 parts, Fructus Viticis 15 parts, Rhizoma Chuanxiong 18 parts, the Radix Angelicae Dahuricae 15 parts, Radix Glehniae 18 parts, Scorpio 3 parts, Herba Asari 8 parts, Bombyx Batryticatus 15 parts, Pheretima 18 parts, Radix Puerariae 23 parts, Radix Salviae Miltiorrhizae 23 parts, Fructus Liquidambaris 18 parts, 9 parts, Radix Glycyrrhizae, Sanguis Draxonis 43 parts;
Be prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(4) add raw material weight 6-12 soak by water 2-3 hour doubly after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add raw material weight 6-8 soak by water 1.5-2.5 hour doubly again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added above-mentioned raw materials weight and 8-13 water doubly, decoct 1-3 hour, release medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1.5-2.5 hour doubly after being merged by three medicinal residues again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of filtrate weight 1.5-2 times 95% will be added after gained filtrate mixing in middle for step (5) gained filtrate and step (4) fully mixing, 20-24h is left standstill after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
Usage: oral, every day 2 times, each 30ml.
Embodiment 2
The present invention treats the preparation of trigeminal neuralgia Chinese medicine oral liquid, and the weight portion of each raw material is: Radix Angelicae Sinensis 12 parts, Rhizoma Acori Graminei 9 parts, Fructus Viticis 12 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 12 parts, Radix Glehniae 15 parts, Scorpio 2 parts, Herba Asari 5 parts, Bombyx Batryticatus 12 parts, Pheretima 15 parts, Radix Puerariae 20 parts, Radix Salviae Miltiorrhizae 20 parts, Fructus Liquidambaris 15 parts, 6 parts, Radix Glycyrrhizae, Sanguis Draxonis 40 parts;
Be prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(4) add raw material weight 6-12 soak by water 2-3 hour doubly after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add raw material weight 6-8 soak by water 1.5-2.5 hour doubly again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added above-mentioned raw materials weight and 8-13 water doubly, decoct 1-3 hour, release medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1.5-2.5 hour doubly after being merged by three medicinal residues again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of filtrate weight 1.5-2 times 95% will be added after gained filtrate mixing in middle for step (5) gained filtrate and step (4) fully mixing, 20-24h is left standstill after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
Usage: oral, every day 2 times, each 30ml.
Embodiment 3
The present invention treats the preparation of trigeminal neuralgia Chinese medicine oral liquid, and the weight portion of each raw material is: Radix Angelicae Sinensis 9 parts, Rhizoma Acori Graminei 6 parts, Fructus Viticis 9 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Radix Glehniae 12 parts, Scorpio 1 part, Herba Asari 2 parts, Bombyx Batryticatus 9 parts, Pheretima 12 parts, Radix Puerariae 17 parts, Radix Salviae Miltiorrhizae 17 parts, Fructus Liquidambaris 12 parts, 3 parts, Radix Glycyrrhizae, Sanguis Draxonis 37 parts;
Be prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(4) add raw material weight 6-12 soak by water 2-3 hour doubly after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add raw material weight 6-8 soak by water 1.5-2.5 hour doubly again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added above-mentioned raw materials weight and 8-13 water doubly, decoct 1-3 hour, release medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1.5-2.5 hour doubly after being merged by three medicinal residues again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of filtrate weight 1.5-2 times 95% will be added after gained filtrate mixing in middle for step (5) gained filtrate and step (4) fully mixing, 20-24h is left standstill after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
Usage: oral, every day 2 times, each 30ml.

Claims (6)

1. treat a prosopalgic Chinese medicine oral liquid, it is characterized in that: be made up of following raw material: Radix Angelicae Sinensis 9-15 part, Rhizoma Acori Graminei 6-12 part, Fructus Viticis 9-15 part, Rhizoma Chuanxiong 12-18 part, Radix Angelicae Dahuricae 9-15 part, Radix Glehniae 12-18 part, Scorpio 1-3 part, Herba Asari 2-8 part, Bombyx Batryticatus 9-15 part, Pheretima 12-18 part, Radix Puerariae 17-23 part, Radix Salviae Miltiorrhizae 17-23 part, Fructus Liquidambaris 12-18 part, Radix Glycyrrhizae 3-9 part, Sanguis Draxonis 37-43 part.
2. one according to claim 1 treats prosopalgic Chinese medicine oral liquid, it is characterized in that: the weight portion of each raw material is: Radix Angelicae Sinensis 12 parts, Rhizoma Acori Graminei 9 parts, Fructus Viticis 12 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 12 parts, Radix Glehniae 15 parts, Scorpio 2 parts, Herba Asari 5 parts, Bombyx Batryticatus 12 parts, Pheretima 15 parts, Radix Puerariae 20 parts, Radix Salviae Miltiorrhizae 20 parts, Fructus Liquidambaris 15 parts, 6 parts, Radix Glycyrrhizae, Sanguis Draxonis 40 parts.
3. one according to claim 1 treats prosopalgic Chinese medicine oral liquid, it is characterized in that: the weight portion of each raw material is: Radix Angelicae Sinensis 15 parts, Rhizoma Acori Graminei 12 parts, Fructus Viticis 15 parts, Rhizoma Chuanxiong 18 parts, the Radix Angelicae Dahuricae 15 parts, Radix Glehniae 18 parts, Scorpio 3 parts, Herba Asari 8 parts, Bombyx Batryticatus 15 parts, Pheretima 18 parts, Radix Puerariae 23 parts, Radix Salviae Miltiorrhizae 23 parts, Fructus Liquidambaris 18 parts, 9 parts, Radix Glycyrrhizae, Sanguis Draxonis 43 parts.
4. one according to claim 1 treats prosopalgic Chinese medicine oral liquid, it is characterized in that: the weight portion of each raw material is: Radix Angelicae Sinensis 9 parts, Rhizoma Acori Graminei 6 parts, Fructus Viticis 9 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 9 parts, Radix Glehniae 12 parts, Scorpio 1 part, Herba Asari 2 parts, Bombyx Batryticatus 9 parts, Pheretima 12 parts, Radix Puerariae 17 parts, Radix Salviae Miltiorrhizae 17 parts, Fructus Liquidambaris 12 parts, 3 parts, Radix Glycyrrhizae, Sanguis Draxonis 37 parts.
5. a kind of preparation method for the treatment of prosopalgic Chinese medicine oral liquid according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(4) add raw material weight 6-12 soak by water 2-3 hour doubly after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add raw material weight 6-8 soak by water 1.5-2.5 hour doubly again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added above-mentioned raw materials weight and 8-13 water doubly, decoct 1-3 hour, release medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1.5-2.5 hour doubly after being merged by three medicinal residues again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of filtrate weight 1.5-2 times 95% will be added after gained filtrate mixing in middle for step (5) gained filtrate and step (4) fully mixing, 20-24h is left standstill after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
6. a kind of preparation method for the treatment of prosopalgic Chinese medicine oral liquid according to claim 1 and 2, is characterized in that: be prepared from by following methods:
(1) get raw material Radix Angelicae Sinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;
(2) get raw materials of scorpion, Bombyx Batryticatus, Pheretima cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;
(3) get raw material Fructus Viticis, Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;
(4) add the soak by water 2 hours of raw material weight 12 times after getting the cleaning of raw material Sanguis Draxonis, release medicinal liquid; Add the soak by water 1.5 hours of raw material weight 8 times again, release medicinal liquid; Merge the medicinal liquid of twice decoction, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(5) Radix Angelicae Sinensis after pulverizing in step (1), Rhizoma Acori Graminei, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Glehniae are added the water of above-mentioned raw materials weight and 13 times, decocts 1.5 hours, releasing medicinal liquid; Fructus Viticis after pulverizing in step (3), Herba Asari, Radix Puerariae, Radix Salviae Miltiorrhizae, Fructus Liquidambaris, Radix Glycyrrhizae are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Scorpio after pulverizing in step (2), Bombyx Batryticatus, Pheretima are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Add the soak by water 1.5 hours of its weight 8 times after three medicinal residues being merged again, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;
(6) ethanol of 95% of filtrate weight 1.5 times will be added after gained filtrate mixing in gained filtrate in step (5) and step (4) fully mixing, leave standstill 24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane aperture of described leaf filter is 0.8 μm, in the process of filtering, pressure limit is 0.15MPa, face discharge is 1.5T/h, obtains filtrate, for subsequent use;
(7) filter in step (6) in gained filtrate feeding leaf filter, the filter membrane aperture of described leaf filter is 0.8 μm, and in the process of filtering, pressure limit is 0.15MPa, and face discharge is 0.8T/h, obtains filtrate, for subsequent use;
(8) gained filtrate in step (7) is sent into traditional Chinese drug inspissation machine, when being evaporated to 60 DEG C in thickener, the clear paste of relative density 1.05, obtains clear paste, for subsequent use;
(9) gained clear paste in step (8) is statically placed in 24 hours under the condition of 6 DEG C, by sodium hydroxide solution adjust ph to 6.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 25min is irradiated in ultraviolet wavelength 254nm sterilizing, packs to obtain finished product, must treat prosopalgic Chinese medicine oral liquid.
CN201510765960.1A 2015-11-11 2015-11-11 Traditional Chinese medicine oral liquid for treating trigeminal neuralgia and preparation method thereof Pending CN105194182A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100809A (en) * 2010-11-29 2011-06-22 闫成秀 Chinese medicine preparation for treating trigeminal neuralgia
CN103028018A (en) * 2011-09-29 2013-04-10 刘清友 Preparation method of traditional Chinese medicine prescription for treating prosopalgia
CN103316130A (en) * 2013-06-24 2013-09-25 柳晖 Traditional Chinese medicine composition for treating trigeminal neuralgia
CN104784359A (en) * 2015-05-11 2015-07-22 李汶峰 Traditional Chinese medicine for treating prosopalgia
CN104971236A (en) * 2015-07-28 2015-10-14 青岛蓝盛洋医药生物科技有限责任公司 Traditional Chinese medicine preparation for treating prosopalgia and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100809A (en) * 2010-11-29 2011-06-22 闫成秀 Chinese medicine preparation for treating trigeminal neuralgia
CN103028018A (en) * 2011-09-29 2013-04-10 刘清友 Preparation method of traditional Chinese medicine prescription for treating prosopalgia
CN103316130A (en) * 2013-06-24 2013-09-25 柳晖 Traditional Chinese medicine composition for treating trigeminal neuralgia
CN104784359A (en) * 2015-05-11 2015-07-22 李汶峰 Traditional Chinese medicine for treating prosopalgia
CN104971236A (en) * 2015-07-28 2015-10-14 青岛蓝盛洋医药生物科技有限责任公司 Traditional Chinese medicine preparation for treating prosopalgia and preparation method thereof

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