CN105194068A

CN105194068A - Raynaud's disease and therapeutic drug thereof

Info

Publication number: CN105194068A
Application number: CN201510644592.5A
Authority: CN
Inventors: 吕小萍; 李先强
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-10-09
Filing date: 2015-10-09
Publication date: 2015-12-30

Abstract

The invention relates to a Raynaud's disease and a therapeutic drug thereof, belonging to the technical field of medical science and solving the problem that the Raynaud's disease is easy to recur when being treated by using western medicines. By virtue of analysis, the symptoms of the Raynaud's disease appear on the skin surface but the pathogenesis is caused by the internal factors of a human body; the Raynaud's disease belongs to excess of yin due to yang insufficiency, qi asthenia as well as qi stagnation and blood stasis; and the Raynaud's disease is treated by adopting a traditional Chinese medicine combination with the effects of nourishing yin and strengthening yang, nourishing qi and blood as well as promoting blood circulation to remove meridian obstruction. The therapeutic drug is prepared from the following ingredients in parts by weight: 15 parts of safflower, 15 parts of forsythia, 15 parts of isatis leaf, 15 parts of felwort, 15 parts of honeysuckle, 15 parts of radix rehmanniae, 10 parts of seaweed, 10 parts of kelp, 15 parts of achyranthes root, 15 parts of dangshen, 10 parts of leech, 10 parts of fiveleaf akebia, 10 parts of peach kernel and 7 parts of licorice. The therapeutic effect is obvious and stable.

Description

Raynaud disease and medicine thereof

Technical field

The present invention relates to Raynaud disease and medicine thereof, particularly with the medicine of traditional Chinese medical herbal treatment, belong to medicine technology field.

Background technology

Raynaud disease (English: Raynauddisease) also claims Reynolds syndrome, is the acra arteriolospasm disease being nervus vasculairs dysfunction and causing.Be its Clinical symptoms with Raynaud's phenomenons such as paroxysmal extremity distal symmetrical skin whitening, cyanosis, flushing.This disease is more common in women, and man, female's disease rates are about 1: 10.Age of onset is many between 20 ~ 30 years old, absolutely less more than 40 years old.Great majority see cold area.Send out cold season well.Raynaud disease is vascular function disease, most typical Symptoms be both hands both feet when meeting cold or excited after there is pale, cyanosis, flushing episode process, recover normal after warming gradually.Mostly be women's morbidity.Their early stage both hands Symptoms is obvious, and the course of disease can involve biped for a long time Symptoms.Have the women of this Symptoms, generally will check immune system, show as Raynaud's phenomenon at first because of what have a disease of immune system, disease of immune system comprises systemic lupus erythematosus vasculitis or rheumatic vasculitis etc.In this way simple Raynaud's phenomenon or Raynaud's syndrome treatment and more after all better, if delay treatment can not recover normal.As delay treatment, final development final result is similar to three phases of thromboangiitis obliterans, there will be ulcer that finger (toe) holds, necrosis.The main clinical manifestation of Raynaud disease is when cold stimulation or psychentonia, and typical Raynaud phenomenon appears in finger skin, i.e. pale, cyanosis, flushing, normal intermittent color of the leather change.When finger presents pale and cyanosis, finger tips can with numbness, twinge, send out cool and insensitive.

After taking warming measure. hand color of the leather just becomes flushing color, and Pi Wenchang rises, and now can have slight to burn sample distending pain.Then color of the leather is normal, and above-mentioned symptom disappears thereupon.At the initial stage of morbidity, have obvious seasonality, namely outbreak cold season is frequent and the arteriospasm persistent period is longer, and the number of times minimizing shown effect in warm season, the arteriospasm persistent period is shorter, or seldom shows effect.The state of an illness comparatively severe one is more responsive to cold, therefore in the winter time can not in outdoor activity and work.

Raynaud disease complication: it is cold that Raynaud disease can make thin vessels close, result causes digit ischemic downright bad.Severe patient can occur referring to that (toe) end refers to that abdomen flattens, gangrene, phalangette can downright bad because of ischemia, absorbed, dissolved, occurring shortening or section finger phenomenon.The patient that some are had a low resistance, digit ischemic and ulcer occurs likely cause the disease such as osteomyelitis, septicemia, this is also the most serious complication of primary disease, correctly and in time applies the generation that anti-infectives contributes to preventing these complication.

The Raynaud disease cause of disease is still not exclusively clear and definite at present.Cold stimulation, emotion hormone or psychentonia are main motivating factors.Other inducements are as infection, fatigue etc.Because state of an illness menstrual phase of being everlasting increases the weight of, alleviate in trimester of pregnancy, therefore, someone thinks that this disease may be relevant with gonad function.

The treatment of Raynaud disease: Drug therapy has (1) calcium ion antagonist, nifedipine, diltiazem; (2) reserpine; (3) α receptor antagonist, prazosin etc., western medicine is obviously effective, but is easy to recurrence.Operative treatment: can sympathectomy be considered to medicine nonresponder, but curative effect needs to be observed further.

Summary of the invention

chinese medicine fundamentally can analyze the cause of disease, thus suits the remedy to the case, to reach the object for the treatment of both the principal and secondary aspects of a disease.Analyze Raynaud disease with Chinese medicine, the symptom of Raynaud disease is at skin surface, but the cause of disease is at inside of human body, belongs toexcess of YIN due to YANG-insufficiency, healthy energy are failed, qi depression to blood stasis, and treatment should with YIN nourishing and YANG strengthening, invigorating qi and benefiting blood, and the Chinese medicine composition of promoting blood circulation to remove obstruction in the collateral is taken as treating scheme.

Raynaud disease and medicine thereof taked technical scheme of dealing with problems combines by each Chinese medicine quality part ratio below: 15 parts, Flos Carthami, Fructus Forsythiae 15 parts, Folium Isatidis 15 parts, Radix Gentianae 15 parts, Flos Lonicerae 15 parts, 15 parts, the Radix Rehmanniae, Sargassum 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Achyranthis Bidentatae 15 parts, Radix Codonopsis 15 parts, Hirudo 10 parts, Caulis Akebiae 10 parts, 10 parts, Semen Persicae, 7 parts, Radix Glycyrrhizae.

Property of medicine effect of each Chinese medicine in lower surface analysis Raynaud disease and medicine thereof.Chinese medicine safflower effect: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving, control amenorrhea ， mass in the abdomen, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.Fructus Forsythiae effect: heat clearing away, removing toxic substances, eliminating stagnation, detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Folium Isatidis effect: heat clearing away, removing toxic substances, removing heat from blood, hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.The function of Radix Gentianae is: heat clearing and damp drying, eliminating pathogen in the liver gallbladder excess-fire, for jaundice due to damp-heat, leukorrhagia, eczema scrotum, and the puckery pain of pyretic stranguria oliguria with reddish urine; Liver flaming-up of gallbladder-fire causes conjunctival congestion and swelling pain, and deaf ear is swollen, costalgia; Acute infantile convulsion, the diseases such as high fever tic.One of conventional rare Chinese medicine of Flos Lonicerae system, has the effects such as heat-clearing and toxic substances removing, dredge the meridian passage, broad-spectrum antiseptic and antiviral, all contains Flos Lonicerae, have " Chinese medicine antibiotic " laudatory title in the flu of more than 70%, antiinflammatory Chinese patent medicine.Radix Rehmanniae clearing away heat and cooling blood, promote the production of body fluid and invigorate blood circulation, stop blooding.Sargassum energy Tumor suppression, has effect of health care, enhancing immunity, anticancer, antitumor, anticoagulation, thrombosis of losing weight, prevent.Thallus Laminariae (Thallus Eckloniae): hard masses softening and resolving, expectorant, diuretic, for goiter, scrofula, painful and swollen testis, phlegm retention edema.Radix Achyranthis Bidentatae effect: eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards, for amenorrhea, dysmenorrhea, soreness of waist and knee joint.Radix Codonopsis is put down, and sweet in the mouth, micro-acid, return spleen, lung meridian, invigorating the spleen and replenishing QI, and spleen invigorating lung benefiting can strengthen the immunity of people; For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.Hirudo effect: removing blood stasis, removing blood stasis, stimulates the menstrual flow, and control blood-retention ， mass in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, and order is pain also, nebula.Caulis Akebiae pathogenic fire purging row water, promoting blood circulation, controls hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Semen Persicae can improve hemodynamic situation, promotes bile secretion, has inhibitory action, and have fiber facilitation, be beneficial to defecation to external thrombus, can promote primipara's uterine contraction and hemorrhage have analgesia, antiinflammatory, antibacterial, anti-allergic effects.Radix Glycyrrhizae is relieving cough and expelling phlegm medicine, and effect is rather extensive, in Chinese medicine decoction and Chinese patent medicine compatibility, and effect of its QI invigorating strengthening the spleen conventional and middle emergency, coordinating the actions of various ingredients in a prescription.

Raynaud disease and the medicine beneficial effect of the invention thereof are: Raynaud disease and medicine thereof are by analyzing Raynaud disease with tcm theory symptom at skin surface, but the cause of disease is at inside of human body, belongs toexcess of YIN due to YANG-insufficiency, healthy energy are failed, qi depression to blood stasis, and with YIN nourishing and YANG strengthening, invigorating qi and benefiting blood, the Chinese medicine composition of promoting blood circulation to remove obstruction in the collateral takes the scheme for the treatment of, and curative effect is obvious, treating both the principal and secondary aspects of a disease, solves the problem that external Western medicine repeats to show effect.

Detailed description of the invention

Raynaud disease and medicine thereof combine by each Chinese medicine quality part ratio below: 15 parts, Flos Carthami, Fructus Forsythiae 15 parts, Folium Isatidis 15 parts, Radix Gentianae 15 parts, Flos Lonicerae 15 parts, 15 parts, the Radix Rehmanniae, Sargassum 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Achyranthis Bidentatae 15 parts, Radix Codonopsis 15 parts, Hirudo 10 parts, Caulis Akebiae 10 parts, 10 parts, Semen Persicae, 7 parts, Radix Glycyrrhizae.By said medicine usage ratio, being suitable for a dosage dose that a Raynaud disease patient takes is combine by each Chinese medicine quality below: 15 grams, Flos Carthami, Fructus Forsythiae 15 grams, Folium Isatidis 15 grams, Radix Gentianae 15 grams, Flos Lonicerae 15 grams, 15 grams, the Radix Rehmanniae, Sargassum 10 grams, Thallus Laminariae (Thallus Eckloniae) 10 grams, Radix Achyranthis Bidentatae 15 grams, Radix Codonopsis 15 grams, Hirudo 10 grams, Caulis Akebiae 10 grams, 10 grams, Semen Persicae, 7 grams, Radix Glycyrrhizae.Using method: decoct soup and take medicinal liquid orally, day takes dose, serve on and is almost recovered in a week.

Claims

1. Raynaud disease and medicine thereof, is characterized in that combining by each Chinese medicine quality part ratio below: 15 parts, Flos Carthami, Fructus Forsythiae 15 parts, Folium Isatidis 15 parts, Radix Gentianae 15 parts, Flos Lonicerae 15 parts, 15 parts, the Radix Rehmanniae, Sargassum 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Radix Achyranthis Bidentatae 15 parts, Radix Codonopsis 15 parts, Hirudo 10 parts, Caulis Akebiae 10 parts, 10 parts, Semen Persicae, 7 parts, Radix Glycyrrhizae.