CN105168856A - Traditional Chinese medicine preparation for treating ischemia-reperfusion type slow arrhythmia and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating ischemia-reperfusion type slow arrhythmia and preparation method thereof Download PDFInfo
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- CN105168856A CN105168856A CN201510610403.2A CN201510610403A CN105168856A CN 105168856 A CN105168856 A CN 105168856A CN 201510610403 A CN201510610403 A CN 201510610403A CN 105168856 A CN105168856 A CN 105168856A
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- 239000003814 drug Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 206010003119 arrhythmia Diseases 0.000 title claims abstract description 34
- 230000006793 arrhythmia Effects 0.000 title claims abstract description 33
- 208000028867 ischemia Diseases 0.000 title claims abstract description 27
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 11
- 241000208340 Araliaceae Species 0.000 claims description 9
- 241000180649 Panax notoginseng Species 0.000 claims description 9
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 9
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 11
- 230000008901 benefit Effects 0.000 abstract description 4
- 244000131316 Panax pseudoginseng Species 0.000 abstract 2
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 4
- 208000031225 myocardial ischemia Diseases 0.000 description 4
- 230000002861 ventricular Effects 0.000 description 3
- 206010008479 Chest Pain Diseases 0.000 description 2
- 208000000059 Dyspnea Diseases 0.000 description 2
- 206010013975 Dyspnoeas Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 206010058156 Reperfusion arrhythmia Diseases 0.000 description 2
- 206010063837 Reperfusion injury Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010019280 Heart failures Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010049447 Tachyarrhythmia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 230000036772 blood pressure Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000001951 hemoperfusion Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating ischemia-reperfusion type slow arrhythmia. The traditional Chinese medicine preparation is prepared from, by weight, 9-18 g of cassia twigs, 6-15 g of honey-fried licorice roots, 3-6 g of pseudo-ginseng powder, 8-12 parts of black aconite, 6-12 g of ginseng, 12-18 g of radix ophiopogonis, 6-12 g of schisandra chinensis, 15-30 g of the roots of red-rooted salvia and 10-20 g of angelica sinensis. The traditional Chinese medicine preparation is scientifically prepared, is safe, can be effectively used for treating ischemia-reperfusion type slow arrhythmia patients, and is the innovation of the medicine for treating ischemia-reperfusion type slow arrhythmia. The traditional Chinese medicine preparation is prepared from rich raw materials, is easy to prepare, easy to produce, convenient to take and good in effect, and has huge economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition, relate in particular to a kind of Chinese patent medicine preparation for the treatment of gestation hypertension disease.
Background technology
Myocardial ischemia reperfusion injury refers to the coronary flow imaging of the obturation when coronary heart attack, infarcted region hemoperfusion is rebuild in rear a period of time, former ischemic myocardium to there occurs compared with blood for even more serious damage before recovering, and occurs that blood pressure rapid drawdown, cardiac insufficiency, arrhythmia such as even to be died suddenly at the phenomenon that sb.'s illness took a turn for the worse.Reperfusion arrhythmia is one of main clinical manifestation of myocardial ischemia reperfusion injury, incidence rate can up to more than 80%, comprise slow arrhythmia and tachyarrhythmia, after wherein slow arrhythmia refers to that myocardial ischemia-reperfusion occurs, the class arrhythmia that, Ventricular Rate slow with heart rate is feature lower than 60 beats/min.Tradition arrhythmia chemicals is by directly or indirectly blocking myocardial cell ion passage or receptor exerts antiarrhythmic effect; but the result of famous cardiac arrhythmia inhibition test (CardiacArrhythmiaSuppressionTest, CAST) proposes query to its safety.Chinese medicine prevention myocardial ischemia-reperfusion arrhythmia is clinical and experimentation all achieves significant curative effect, and untoward reaction is few, has unique advantage.Therefore, the medicine developing new treatment ischaemia-reperfusion slow arrhythmia is imperative.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine preparation for the treatment of ischaemia-reperfusion slow arrhythmia, and it can reduce the consumption of arrhythmia chemicals, effectively solves that patient chest is vexed, cardiopalmus, the problem such as to breathe hard.
The present invention is achieved by the following technical solutions:
One treats ischaemia-reperfusion slow arrhythmia Chinese medicine preparation, and it is formulated by weight by following raw material:
Ramulus Cinnamomi 9-18g, Radix Glycyrrhizae Preparata 6-15g, Radix Notoginseng powder 3-6g, Radix Aconiti Lateralis Preparata 8-12g, Radix Ginseng 6-12g, Radix Ophiopogonis 12-18g, Fructus Schisandrae Chinensis 6-12g, Radix Salviae Miltiorrhizae 15-30g, Radix Angelicae Sinensis 10-20g.
Optimum weight proportioning of the present invention is:
Ramulus Cinnamomi 12g, Radix Glycyrrhizae Preparata 9g, Radix Notoginseng powder 4g, Radix Aconiti Lateralis Preparata 10g, Radix Ginseng 9g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 9g, Radix Salviae Miltiorrhizae 22g, Radix Angelicae Sinensis 15g.
The preparation method of described treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation, it comprises the following steps:
Said components Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Radix Notoginseng powder, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis are mixed, decoct with water twice, add the water of its weight 6 to 8 times at every turn, each decoction 1 to 1.5 hour, merge twice decocting liquid, filter, be concentrated into 1/4 to 1/6 of amount of water, obtain medical treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation.
Advantage of the present invention is: the present invention is prepared through science, has warming and activating heart-YANG, effect of invigorating spleen and kidney, and be effective to treatment ischaemia-reperfusion slow arrhythmia, and achieve satisfied effect through clinical trial, pertinent clinical data is as follows:
One, the standard of case is selected
There is typical clinical manifestation (chest distress and palpitation symptoms, shortness of breath and fatigue, extremity are not warm) and electrocardiogram be the patient of dynamic evolution (ST section force down and Ventricular Rate lower than 60 beats/min), all have above-mentioned standard person all as selection case, and treat with Chinese medicine of the present invention.
Two, diagnostic criteria
All have chest distress and palpitation symptoms, shortness of breath and fatigue, the typical clinical manifestation such as extremity are not warm, and electrocardiogram is ST section forces down, and Ventricular Rate is lower than 60 beats/min, and doctor trained in Western medicine is diagnosed as the patient of coronary heart disease.
Three, therapeutic scheme
Allly make a definite diagnosis the ischaemia-reperfusion slow arrhythmia patient meeting case selection standard, all take Chinese medicine of the present invention and treat, every day early, evening is each once, and each serving with 200 ~ 300ml, every 15 days is a course for the treatment of, adds up curative effect after the course for the treatment of.
Four, efficacy assessment standard
Cure: symptom alleged in diagnostic criteria all disappears, and electrocardiogram recovers normal substantially;
Take a turn for the better: symptom alleged in diagnostic criteria has and alleviates or obviously alleviate, and Electrocardioscopy is improved;
Invalid: symptom alleged in diagnostic criteria and Electrocardioscopy, without improvement, even have the gesture increased the weight of.
Five, statistical procedures
Medication treatment is carried out to suffering from ischaemia-reperfusion slow arrhythmia patient 122 people, wherein male 60 people, female 62 people, the oldest 73 years old, minimum 40 years old afterwards according to selecting the standard of case and making a definite diagnosis; The course of disease 1 ~ 20 year.Result effective percentage reaches 95.9%, and concrete statistics is as follows:
During above-mentioned patient consumes, do not find any untoward reaction, show stable curative effect, drug safety.
Six, conclusion
As can be seen from above-mentioned; curative effect of the present invention is high, and curative effect is up to 95.9%, and drug safety; treatment ischaemia-reperfusion slow arrhythmia patient can be effective to; the innovation on treatment ischaemia-reperfusion slow arrhythmia medicine, abundant raw materials of the present invention, preparation method is simple; easy production; taking convenience, effective, economic and social benefit is huge.
Detailed description of the invention
Embodiment 1: treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation of the present invention, it is formulated by weight by following raw material: Ramulus Cinnamomi 12g, Radix Glycyrrhizae Preparata 9g, Radix Notoginseng powder 4g, Radix Aconiti Lateralis Preparata 10g, Radix Ginseng 9g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 9g, Radix Salviae Miltiorrhizae 22g, Radix Angelicae Sinensis 15g.
The preparation method of described treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation, it comprises the following steps:
Said components is mixed, decocts with water twice.Add the water of its weight 8 times for the first time, decoct 1.5 hours, obtain first time decocting liquid, second time adds the water of former drug weight 6 times in medicinal residues, decocts 1 hour, obtains second time decocting liquid, merge twice decocting liquid, filter, be concentrated into 1/4 to 1/6 of amount of water, obtain treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation.
The instructions of taking of Chinese medicine preparation of the present invention is: every day early, evening is each once, and each serving with 200 ~ 300ml, every 15 days is a course for the treatment of, adds up curative effect after the course for the treatment of.
Embodiment 2: treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation of the present invention, it is formulated by weight by following raw material: Ramulus Cinnamomi 9g, Radix Glycyrrhizae Preparata 6g, Radix Notoginseng powder 3g, Radix Aconiti Lateralis Preparata 8g, Radix Ginseng 6g, Radix Ophiopogonis 12g, Fructus Schisandrae Chinensis 6g, Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 10g.
The preparation method of described treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation, it comprises the following steps:
Said components is mixed, decocts with water twice.Add the water of its weight 8 times for the first time, decoct 1.5 hours, obtain first time decocting liquid, second time adds the water of former drug weight 6 times in medicinal residues, decocts 1 hour, obtains second time decocting liquid, merge twice decocting liquid, filter, be concentrated into 1/4 to 1/6 of amount of water, obtain treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation.
The instructions of taking of Chinese medicine preparation of the present invention is: every day early, evening is each once, and each serving with 200 ~ 300ml, every 15 days is a course for the treatment of, adds up curative effect after the course for the treatment of.
Embodiment 3: treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation of the present invention, it is formulated by weight by following raw material: Ramulus Cinnamomi 18g, Radix Glycyrrhizae Preparata 15g, Radix Notoginseng powder 6g, Radix Aconiti Lateralis Preparata 12g, Radix Ginseng 12g, Radix Ophiopogonis 18g, Fructus Schisandrae Chinensis 12g, Radix Salviae Miltiorrhizae 30g, Radix Angelicae Sinensis 20g.
The preparation method of described treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation, it comprises the following steps:
Said components is mixed, decocts with water twice.Add the water of its weight 8 times for the first time, decoct 1.5 hours, obtain first time decocting liquid, second time adds the water of former drug weight 6 times in medicinal residues, decocts 1 hour, obtains second time decocting liquid, merge twice decocting liquid, filter, be concentrated into 1/4 to 1/6 of amount of water, obtain treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation.
The instructions of taking of Chinese medicine preparation of the present invention is: every day early, evening is each once, and each serving with 200 ~ 300ml, every 15 days is a course for the treatment of, adds up curative effect after the course for the treatment of.
Claims (3)
1. treat an ischaemia-reperfusion slow arrhythmia Chinese medicine preparation, it is characterized in that: it is formulated by weight by following raw material:
Ramulus Cinnamomi 9-18g, Radix Glycyrrhizae Preparata 6-15g, Radix Notoginseng powder 3-6g, Radix Aconiti Lateralis Preparata 8-12g, Radix Ginseng 6-12g, Radix Ophiopogonis 12-18g, Fructus Schisandrae Chinensis 6-12g, Radix Salviae Miltiorrhizae 15-30g, Radix Angelicae Sinensis 10-20g.
2. treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation according to claim 1, is characterized in that: it is formulated by weight by following raw material:
Ramulus Cinnamomi 12g, Radix Glycyrrhizae Preparata 9g, Radix Notoginseng powder 4g, Radix Aconiti Lateralis Preparata 10g, Radix Ginseng 9g, Radix Ophiopogonis 15g, Fructus Schisandrae Chinensis 9g, Radix Salviae Miltiorrhizae 22g, Radix Angelicae Sinensis 15g.
3. the preparation method of the treatment ischaemia-reperfusion slow arrhythmia Chinese medicine preparation according to any one of claim 1 to 2, is characterized in that: it comprises the following steps:
It comprises the following steps:
Said components Ramulus Cinnamomi, Radix Glycyrrhizae Preparata, Radix Notoginseng powder, Radix Aconiti Lateralis Preparata, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis are mixed, decoct with water twice, add the water of its weight 6 to 8 times at every turn, each decoction 1 to 1.5 hour, merge twice decocting liquid, filter, be concentrated into 1/4 to 1/6 of amount of water, the Chinese medicine preparation of the chronic heart failure edema that obtains medical treatment.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106880826A (en) * | 2017-03-15 | 2017-06-23 | 付蓉 | A kind of Chinese medicine preparation of chronic heart failure and preparation method thereof |
| CN109490272A (en) * | 2018-12-28 | 2019-03-19 | 上海拉德钫斯生物科技有限公司 | A kind of method of the artery observation attached wall of vascular stem cell in utilization |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101176751A (en) * | 2006-11-09 | 2008-05-14 | 黄振华 | Pharmaceutical composition of red sage root and cassia twig |
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2015
- 2015-09-23 CN CN201510610403.2A patent/CN105168856B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101176751A (en) * | 2006-11-09 | 2008-05-14 | 黄振华 | Pharmaceutical composition of red sage root and cassia twig |
Non-Patent Citations (2)
| Title |
|---|
| 吴玉玲等: "益 气 复 脉 汤 治 疗 室 性 早 搏 临 床 观 察", 《中国中医药现代远程教育》 * |
| 孙博: "益气温阳方药对大鼠心肌缺血再灌注心律失常大鼠模型SOD、MDA的影响", 《中国优秀硕士学位论文全文数据库 医药卫生科技辑》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106880826A (en) * | 2017-03-15 | 2017-06-23 | 付蓉 | A kind of Chinese medicine preparation of chronic heart failure and preparation method thereof |
| CN109490272A (en) * | 2018-12-28 | 2019-03-19 | 上海拉德钫斯生物科技有限公司 | A kind of method of the artery observation attached wall of vascular stem cell in utilization |
| CN109490272B (en) * | 2018-12-28 | 2021-08-27 | 拉德枋斯(广东)生命科学创新研究院有限公司 | Method for observing vessel stem cell wall attachment by using middle artery |
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| CN105168856B (en) | 2018-09-07 |
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Effective date of registration: 20190410 Address after: 450000 people's road, Jinshui District, Zhengzhou, Henan Province, No. 19 Patentee after: The First Affiliated Hospital of Henan University of traditional Chinese Medicine Address before: 450000 No. 19 Renmin Road, Zhengzhou City, Henan Province Patentee before: Gao Yuan |