CN105168567A - Maca health care composition - Google Patents

Maca health care composition Download PDF

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Publication number
CN105168567A
CN105168567A CN201510433841.6A CN201510433841A CN105168567A CN 105168567 A CN105168567 A CN 105168567A CN 201510433841 A CN201510433841 A CN 201510433841A CN 105168567 A CN105168567 A CN 105168567A
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China
Prior art keywords
meyenii walp
lepidinm meyenii
parts
health composition
mice
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CN201510433841.6A
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Chinese (zh)
Inventor
贾国华
屈集平
吴治军
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Suzhou Aladdin Biotechnology Co Ltd
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Suzhou Aladdin Biotechnology Co Ltd
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Priority to CN201510433841.6A priority Critical patent/CN105168567A/en
Publication of CN105168567A publication Critical patent/CN105168567A/en
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Abstract

The invention relates to a composition, in particular to a maca health care composition, which is characterized by mainly being formed by mixing the following ingredients in parts by weight: 42 to 68 parts of maca, 5 to 25 parts of black fruit Chinese wolfberries and 3 to 15 parts of herba cistanches. The composition has the advantages that all ingredients supplement each other; and the synergistic effects on resisting the fatigue, improving the immunity, delaying the human body senescence, resisting tumor and lowering the blood pressure are achieved.

Description

Lepidinm meyenii Walp health composition
Technical field
The present invention relates to compositions, particularly relate to a kind of Lepidinm meyenii Walp health composition.
Background technology
Lepidinm meyenii Walp is a kind of plant of Cruciferae separate row Vegetable spp, originates in mountain area, Peru Andean, locals mainly with it as food, also as conventional medicament use, introduce a fine variety in a large number in Yunnan Province at present.Lepidinm meyenii Walp has resisting fatigue, improvement function, improves the several functions such as fertility.By zoopery and human experimentation research, demonstrate it and there is resisting fatigue, improvement function, antioxidation, minimizing prostatic hyperplasia really, improve the effects such as fertility.
Lycium ruthenicum Murr., be the perennial shrub of Lycium section, Lycium ruthenicum Murr. contains 17 seed amino acids, 13 kinds of trace element, and wherein the content of calcium, magnesium, copper, zinc, ferrum is also higher than red Fructus Lycii.It is the most effective natural free radical scavenger that wild Lycium ruthenicum Murr. contains a large amount of anthocyanin elements, and delaying human body cell tissue is old and feeble.Keep younger state, life lengthening.It is medicinal, and health value is far away higher than common red Fructus Lycii.Be described as " soft gold ".Drink with wild Lycium ruthenicum Murr. bubble for a long time, tool obviously protects vision protection effect, prevents and treats diabetes effect preferably in addition.There is obvious resisting fatigue, protect the liver, antitumor, dredging vascellum, blood pressure lowering, protection Cardiovascular System.
Herba Cistanches, Herba Cistanches is used as medicine, long-standing.It is sweet and warm in nature, and salty and matter profit, has YANG invigorating not dry, and the logical kidney yang the kidney invigorating of temperature is empty; Nourishing YIN is oiliness, and the feature that abdomen treats constipation is led in intestine moistening.Asthenia internal injury controlled by Chinese medicine, chills and pain of the waist and kness, sexual impotence, and spermatorrhea is infertile, the empty constipation of body.In recent years, the world of medicine's application modern scientific method carries out assay to Herba Cistanches, result shows, Herba Cistanches contains Alkaloid and crystallinity neutral substance, truly have effect for the treatment of chills and pain of the waist and kness, woman infertility, neurasthenia, auditory dysesthesia, also there is the effect reduced blood pressure, and can be used as the hemorrhage use of cystitis, bladder hemorrhage, kidney hemorrhagic disease.
Current above-mentioned various raw material all has folk prescription or the finished product processed with other raw material compound recipe or patent, and dosage form has tablet, but has no the product and reported in literature that are made up of above three kinds of raw materials.
Summary of the invention
The object of this invention is to provide a kind of Lepidinm meyenii Walp health composition, it is characterized in that, be mainly grouped into by the one-tenth of following weight portion: Lepidinm meyenii Walp 42-68 part, Lycium ruthenicum Murr. 5-25 part, Herba Cistanches 3-15 part are obtained by mixing.
Further, be grouped into by the one-tenth of following weight portion: Lepidinm meyenii Walp 50-65 part, Lycium ruthenicum Murr. 8-22 part, Herba Cistanches 6-12 part are obtained by mixing.
Further, also comprise probiotic bacteria, account for 60-90 part by weight.
Further, also comprise probiotic bacteria, account for 70-80 part by weight.
Further, described compositions also comprises inulin, starch, oligomeric xylose or cellulose.
Further, described compositions may be used for preparing electuary, capsule, oral liquid or tablet.
Compositions of the present invention is that the functional characteristics respectively had according to Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches carries out matched combined, and Lepidinm meyenii Walp has resisting fatigue, improvement function, antioxidation, minimizing prostatic hyperplasia, improves the effects such as fertility; Lycium ruthenicum Murr. has delaying human body cell ageing, has obvious resisting fatigue, protects the liver, antitumor, dredging vascellum, blood pressure lowering, protection Cardiovascular System; Herba Cistanches has the effect having and control asthenia internal injury, treatment chills and pain of the waist and kness, woman infertility, neurasthenia, auditory dysesthesia, also there is the effect reduced blood pressure, three supplements and complements each other, and has synergism for resisting fatigue, raising immunity, delaying human body caducity, antitumor, blood pressure lowering.
Detailed description of the invention
Technical scheme of the present invention is described in detail below in conjunction with embodiment.
Embodiment 1:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches, the weight of each component: Lepidinm meyenii Walp 68 parts, Lycium ruthenicum Murr. 5 parts, Herba Cistanches 3 parts are obtained by mixing.Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches can be all crude drug or the compositions for extract.Described extract extracts by the method for prior art with crude drug and obtains.
Embodiment 2:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches, the weight of each component: Lepidinm meyenii Walp 42 parts, Lycium ruthenicum Murr. 25 parts, Herba Cistanches 15 parts are obtained by mixing.All the other conditions are identical with embodiment 1.
Embodiment 3:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches, the weight of each component: Lepidinm meyenii Walp 50 parts, Lycium ruthenicum Murr. 22 parts, Herba Cistanches 6 parts.All the other conditions are identical with embodiment 1.
Embodiment 4:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches, the weight of each component: Lepidinm meyenii Walp 65 parts, Lycium ruthenicum Murr. 22 parts, Herba Cistanches 12 parts.All the other conditions are identical with embodiment 1.
Embodiment 5:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches and probiotic bacteria, the weight of each component: Lepidinm meyenii Walp 35 parts, Lycium ruthenicum Murr. 22 parts, Herba Cistanches 7 parts, probiotic bacteria 60 parts.All the other conditions are identical with embodiment 1.
Embodiment 6:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches and probiotic bacteria, the weight of each component: Lepidinm meyenii Walp 35 parts, Lycium ruthenicum Murr. 22 parts, Herba Cistanches 7 parts, probiotic bacteria 90 parts.All the other conditions are identical with embodiment 1.
Embodiment 7:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches and probiotic bacteria, the weight of each component: Lepidinm meyenii Walp 35 parts, Lycium ruthenicum Murr. 22 parts, Herba Cistanches 7 parts, probiotic bacteria 70 parts.All the other conditions are identical with embodiment 1.
Embodiment 8:
Lepidinm meyenii Walp health composition, containing Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches and probiotic bacteria, the weight of each component: Lepidinm meyenii Walp 35 parts, Lycium ruthenicum Murr. 22 parts, Herba Cistanches 7 parts, probiotic bacteria 80 parts.All the other conditions are identical with embodiment 1.
Below the Application Example of said composition, when compositions be crude drug or solid extract time, first pulverize, cross after 50 mesh sieves and prepare burden again.
Embodiment 9:
The preparation of Lepidinm meyenii Walp health composition tablet: Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches compositions 80%, starch 5%, cellulose 15% drop into mixing 10-30 minute in mixer, add ethanol as wetting agent, mixing 10-30 minute, mixed material 12-20 mesh sieve is granulated, and puts into drying equipment inner drying, adds 1% magnesium stearate (or in prior art conventional amount used) of dried particles total amount, granulate, tabletting, packaging, namely makes tablet of the present invention.
Embodiment 10:
The preparation of Lepidinm meyenii Walp health composition tablet: Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches, Herba Leonuri bacteria composition 70%, starch 10%, cellulose 20%, following steps are with embodiment 9.
Embodiment 11:
The preparation of Lepidinm meyenii Walp health care composition capsule: Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches compositions 50%, starch 50%, drops into mixing 10-30 minute in mixer, adds ethanol as wetting agent, mixing 5-10 minute, mixed material 12-20 mesh sieve is granulated, and puts into drying equipment inner drying, adds 1% magnesium stearate (or in prior art conventional amount used) of dried particles total amount, granulate, capsule charge, packaging, namely making content is heavily the capsule of 0.3g.
Embodiment 12:
The preparation of electuary: Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches compositions 10%, add 80% dextrin, 10% white sugar, (compositions and white sugar are pulverized, crossed 80 mesh sieves), drops into mixing 10-30 minute in mixer, adds ethanol as wetting agent, mixing 5-10 minute, mixed material 12-20 mesh sieve is granulated, and puts into drying equipment inner drying, dry with the screening of 10-60 eye mesh screen, pack after removing coarse granule and fine powder, be packaged into every bag of 3g.
Embodiment 13:
The preparation of oral liquid: Lepidinm meyenii Walp, Lycium ruthenicum Murr., Herba Cistanches compositions, add 5 times amount purified water and obtain oral liquid, add the potassium sorbate (or in prior art conventional amount used) of oral liquid measure 0.1%, filtration, subpackage, sterilizing, packaging, obtain oral liquid of the present invention.
In sum, described health composition can be used for preparing tablet, capsule, electuary, oral liquid.
Embodiment 14:
Experimental conditions is as follows:
(1) Lepidinm meyenii Walp health composition (embodiment 4) (embodiment 4) impact on mice muscle power:
Only choose Male Kunming strain mice 20-24g40, be divided at random 4 groups (often organizing 10 mices), wherein establish normal saline negative control group and 3 Lepidinm meyenii Walp health composition various dose groups of the present invention, little, in, the extract of large three dosage component gavage Lepidinm meyenii Walp other every day health-care combination compositions, dosage is respectively 0.5g/kg, 1.0g/kg, 1.5g/kg, successive administration 40d, carries out mice heavy burden test after last gavage 30min.Mouse tail is born a heavy burden 5%, is placed in 100cm × 80cm × 40cm pond went swimming, depth of water 30cm, water temperature 25 DEG C ± 0.5 DEG C, 10, every pond mice, record mice swimming beginning is the mice burden swimming time to the death time.Experiment shows, 1.0g/kg, 1.5g/kg group can obviously extend the mice burden swimming time, compares have significance (P < 0.01) with negative group.The results are shown in Table 1.
Table 1 physical exertion is tested
Group Dosage (g/Kg) Swimming time (S)
Negative control group Normal saline 320.5±126.4
Small dose group 0.5 379.8±173.1
Middle dosage group 1.0 589.4±226.9
Heavy dose of group 1.5 648.7±284.3
(2) containing activity of fighting against senium impact in Lepidinm meyenii Walp health composition (embodiment 4) Mice:
1. grouping and modeling
Mice is divided into 5 groups at random according to body weight: the basic, normal, high dosage group of normal group, model group, health composition group.Often organize 10, raise by 5 cages, normal diet.
Except normal group, the D-galactose normal saline solution of each group mice neck in morning every day dorsal sc injection 0.15g/kg, normal group injection equal-volume normal saline.After injection terminates, each administration group mice is all by 0.1mL/kg body weight dose gavage, and Lepidinm meyenii Walp health composition dosage is: dosage group (0.5g/kg), health composition group high dose group (1g/kg) in health composition group low dose group (0.1g/kg), health composition group.Normal group and model group mice give equal-volume distilled water.
Observe the situations such as mice activity, outward appearance, feces every day and record, according to body weight adjustment dosage, successive administration 56d.
2.1 defying age indexs
The activity of fighting against senium of the health composition of embodiment 4 characterizes with the aging of the outside of model mice and inside aging sign is weighed.Wherein, outside old and feeble sign comprises Body Mass Index and the behavioral indexes of mice, and internal representation comprises shoot formation and the Antioxidant Indexes of mice.
2.2 Body Mass Index
Claim a body weight to for every 3 days each group of mice, record and observe modeling situation, each mensuration before all selections are fed with the time morning is weighed.
2.3 behavioral indexes
Behavioral indexes comprises three parts: autonomic activities ability measures, step down test, the mobility of examination mice, learning capacity.
(1) autonomic activities ability measures
Within every two weeks, survey autonomic activities once.Under dark, micro-acoustic environment, mice is put into respectively the independent activities case of autonomic activities instrument, wait for 1min, make it to adapt to.Automatically record mice active situation by computer after laundering period terminates, measure the movable number of times in every mice 5min.Each Simultaneously test is with 5 mices of cage.
(2) learning capacity test
Under dark, micro-acoustic environment, put into respectively by 5 of same cage mices and independently measure case, mice is shocked by electricity in bottom, jumps onto platform and can escape electric shock, and obtains memory.Old and feeble or amnemonic animal, ability of learning and memory within a certain period of time can decline, and jumping off number of times increases.Redeterminate after 24h, record mice is electrically shocked number of times lower mice and jumps off the time (incubation period) of platform for the first time in 5min, if mice does not jump off from platform in 5min, then presses 300s incubation period and calculates.Duration of test carries out a diving tower test for every two weeks, observes the improvement result of each group of health composition to mouse aging non-space inquiry learning memory ability.
3. experimental result
After mouse subcutaneous injection D-galactose, engender the situation that body weight increasess slowly.Within 4th week, start in modeling, compared with normal group, the body weight of model mice has started to present significant difference, and increases gradually with the prolongation difference of time, reaches pole significant difference to the 5th Zhou Shiyi.In modeling at the beginning of the 4th week, the Mouse Weight of compositions high dose group and model aging are organized mice and are presented significant difference.And in last week of modeling, compositions low dose group Mouse Weight still remains good ascendant trend, illustrate that the health composition giving low dosage can intervene the situation of the weight loss of the mouse aging of D-galactose induction.
After mouse subcutaneous injection D-galactose, engender that motion frequency declines, be slow in action, the situation such as bradykinesia.By measuring its autonomic activities ability discovery, the autonomic activities number of times in model group mice 5min shows a process obviously declined for 2 weeks after modeling.When modeling 2 weeks, the autonomic activities frequency giving compositions basic, normal, high dosage group mice produced significant difference with model group, and within the 6th week, expanded gap (table 2) further in modeling.Show that Lepidinm meyenii Walp health composition has the effect of the old and feeble mobility decline caused of opposing, and this effect is steady in a long-term.
Table 2 health composition is on the impact of D-galactose Aging mice autonomic activities ability
Result with represent, n=10.Compared with model group: * p < 0.05, * * p < 0.01.
Modeling the 4th week, model mice showed the diving tower errors number and the remarkable incubation period lower than normal mouse that are significantly higher than normal mouse.Show to compare normal mouse, model mice memory ability significantly declines, and possesses old and feeble outside and characterizes.Health composition mice shows significantly lower than diving tower errors number and the duration incubation period (table 3) being significantly higher than model mice of model mice in modeling on the 4th week.The performance of health composition high dose group reaches extremely significant level of difference.Show that health composition has the effect improving mouse aging non-NULL intersexuality Term Learning memory ability.
Table 3 health composition is on the impact of D-galactose Aging mice non-NULL intersexuality Term Learning memory ability
Result with represent, n=10.Compared with model group: * p < 0.05, * * p < 0.01.
The result of this research shows, Lepidinm meyenii Walp health composition all has stronger activity of fighting against senium in vivo, the situation of the weight loss of the mice of D-galactose induction can be intervened, the situation of the mice mobility decline of opposing D-galactose induction, improve mice non-NULL intersexuality Term Learning memory ability, make it to keep the memory to stimulating, there is the learning capacity of good avoidance harm.Therefore, Lepidinm meyenii Walp health composition can improve outside and the inside aging sign of mice.

Claims (6)

1. a Lepidinm meyenii Walp health composition, is characterized in that, is mainly grouped into by the one-tenth of following weight portion: Lepidinm meyenii Walp 42-68 part, Lycium ruthenicum Murr. 5-25 part, Herba Cistanches 3-15 part are obtained by mixing.
2. Lepidinm meyenii Walp health composition according to claim 1, is characterized in that, is to be grouped into by the one-tenth of following weight portion: Lepidinm meyenii Walp 50-65 part, Lycium ruthenicum Murr. 8-22 part, Herba Cistanches 6-12 part are obtained by mixing.
3. Lepidinm meyenii Walp health composition according to claim 1, is characterized in that, also comprise probiotic bacteria, accounts for 60-90 part by weight.
4. Lepidinm meyenii Walp health composition according to claim 1, is characterized in that, also comprise probiotic bacteria, accounts for 70-80 part by weight.
5. the Lepidinm meyenii Walp health composition according to claim 1 or 3, is characterized in that, also comprises inulin, starch, oligomeric xylose or cellulose.
6. the Lepidinm meyenii Walp health composition according to claim 1 or 2 or 3 or 4, is characterized in that: described compound may be used for preparing electuary, capsule, oral liquid or tablet.
CN201510433841.6A 2015-07-23 2015-07-23 Maca health care composition Pending CN105168567A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596013A (en) * 2017-10-14 2018-01-19 云南钰腾生物科技有限公司 A kind of extracting method of maca and its male health-care product of preparation
CN114209064A (en) * 2021-12-24 2022-03-22 智酷生物科技(广州)有限公司 Composition with effects of resisting fatigue, resisting oxidation and improving immunity
CN114762510A (en) * 2021-01-11 2022-07-19 漠中泉内蒙古餐饮管理有限责任公司 Maca yang-tonifying tea and making method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596013A (en) * 2017-10-14 2018-01-19 云南钰腾生物科技有限公司 A kind of extracting method of maca and its male health-care product of preparation
CN114762510A (en) * 2021-01-11 2022-07-19 漠中泉内蒙古餐饮管理有限责任公司 Maca yang-tonifying tea and making method thereof
CN114209064A (en) * 2021-12-24 2022-03-22 智酷生物科技(广州)有限公司 Composition with effects of resisting fatigue, resisting oxidation and improving immunity

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Application publication date: 20151223