CN105168034A - Skin irritation reliever and skin whitening cosmetic composition comprising the same - Google Patents
Skin irritation reliever and skin whitening cosmetic composition comprising the same Download PDFInfo
- Publication number
- CN105168034A CN105168034A CN201510333841.9A CN201510333841A CN105168034A CN 105168034 A CN105168034 A CN 105168034A CN 201510333841 A CN201510333841 A CN 201510333841A CN 105168034 A CN105168034 A CN 105168034A
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- CN
- China
- Prior art keywords
- skin
- green tea
- skin irritation
- nicotiamide
- tea tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The invention relates to a skin irritation reliever containing a green tea tree root extract as an effective ingredient and a skin whitening cosmetic composition comprising the same.
Description
Technical field
The present invention relates to a kind of skin irritation-reducing agent and the whitening that comprises it to apply some make up compositions.
This application claims the interests of the applying date of No. 10-2014-0072766th, the korean patent application submitted on June 16th, 2014 to Koran Office, its content is all contained in this description.
Background technology
As standard of beauty, women wants to have the not only young but also white colour of skin, in order to reach this requirement, in current cosmetic industry, also more and more pays close attention to whitening function cosmetics.
Recently, along with most of mechanism of melanin pigmentation is disclosed, the whitening agent of various kind is just being developed at present.The color of skin is determined by the amount of the skin pigments such as melanin and distribution.When Dermal exposure under ultraviolet light time, in the melanosome of melanocyte (melanocyte), tyrosine (tyrosine) by tryrosinase (tyrosinase) oxidation and generate melanin.The melanin generated thus is delivered to keratinocyte by melanocytic dendron (dendrite).Melanin plays the important function making skin from ultraviolet injury, but, when making growing amount increase due to specific factor, a large amount of melanin generated thus can be delivered to keratinocyte and make melanin accumulate in skin epidermis, thus causes the pigmentations such as black speck.
Nicotiamide (Niacinamide) is as the physiologically active amide of vitamin B3 being known as pyridine 3 carboxylic acid, by hindering the movement of melanosome, it stops that the melanin of synthesis moves to keratinocyte.Reduce cutaneous pigmentation thus, thus improve whitening function.
But when the nicotiamide with whitening function is for skin, exists and cause skin irritant problem, therefore, when the composition as cosmetics uses, being subject to can not containing restriction more than finite concentration.
Usually, when applying from outside to stimulate, keratinocyte (keratinocyte) or langerhans' cells (Langerhan'scell) can be prepared cytokine profiles (Cytokine) and discharge, and must discharge the cytokine of interleukin 8 (Interleukin-8:IL-8) etc. in the irritant reaction or local inflammation course of reaction of skin.
Known hydrocortisone is alleviated effectively scytitis and skin irritation, but it can cause the side effect such as atrophoderma and vasodilation as steroid dose.
Therefore, need to develop a kind of can with while more than the concentration with abundant whitening effect containing nicotiamide, again not containing steroid doses such as hydrocortisone, by reducing or suppressing the free of the cytokines such as interleukin 8, thus the skin irritant cosmetics caused by nicotiamide can be reduced.
[prior art document]
[patent documentation]
(patent documentation 1) No. 10-2009-0091511st, Korea S's Publication (2009.08.28)
Summary of the invention
The technical problem solved
The invention provides a kind of skin irritation-reducing agent and cosmetic composition, described skin irritation-reducing agent is for having abirritant effect during skin, described cosmetic composition comprises described skin irritation-reducing agent, thus while there is skin whitening effects, few for stimulating during skin.
Technical scheme
The invention provides a kind of containing the skin irritation-reducing agent of green tea tree root extract as effective ingredient.
In addition, the invention provides and a kind ofly to apply some make up compositions as the skin-whitening of effective ingredient containing green tea tree root extract and nicotiamide.
Beneficial effect
Skin irritation-reducing agent according to the present invention has suppression or reduces the skin irritant effect caused by nicotiamide.Skin-whitening according to the present invention applies some make up compositions due to containing nicotiamide, and while therefore having excellent skin whitening effects, the skin irritation caused by nicotiamide is little.
In addition, contain green tea root extract as natural extract according to skin irritation-reducing agent of the present invention and the skin-whitening compositions that applies some make up, thus the skin irritation remission effect of the excellence of the side effect not having steroid material is provided.
Accompanying drawing explanation
Fig. 1 illustrates the result of the described green tea root extract powder of embodiment 1 being carried out nuclear magnetic resonance, NMR (NMR) and FAB/MS analysis as test portion.Transverse axis is the quantity of electric charge (unit: m/z), and the longitudinal axis is relative intensity (relativeintensity, 100 benchmark).
Detailed description of the invention
" skin " in the present invention represents the tissue covering animal body surface, and it be the body surface organization not only comprising covering face or health etc., also comprises the concept of the most broad sense of scalp and hair.In addition, in the present invention, " sensitive skin " can be defined as, and due to low to the repellence of outside stimulus, therefore with outside stimulus, heat easily occur, itches, burns the skin of the abnormal responses such as sense, burning sensation, blush, drying, inflammation.The reason of this sensitive skin can comprise abuse, the living environment or pressure etc. of the characteristic, family history, medical history, cosmetics etc. of congenital cutaneous." extract " in the present invention refers to and to have nothing to do with the form of extracting method, Extraction solvent, composition that extraction obtains or extract, and the material obtained by the composition extracting natural materials includes concept widely wherein.
In the present invention, the wild Camellia sinensis (CamelliaSinensis) of green tea tree representation Camellia sinensis section.
The invention provides a kind of containing the skin irritation-reducing agent of green tea tree root extract as effective ingredient.
For one embodiment of the invention, described green tea tree root extract (GreenTeaRootExtract) is obtained by the step to green tea tree root enforcement cleaning step, pulverising step, use solvent extraction, filtration step, concentration step and drying steps.
The step of described use solvent extraction can be extracted with the ethanol water of 70%.
Described filtration step can use the diameter of filter pore to be that the filter of 5 μm, 1 μm, 0.5 μm and/or 0.2 μm filters.
For one embodiment of the invention, described green tea tree root extract contains rogchapoinin
Described rogchapoinin can represent with following chemical formula 1.
[chemical formula 1]
For one embodiment of the invention, described skin irritation is for alleviating the skin irritation of being brought out by nicotiamide.More specifically, described skin irritation can for the skin irritation caused by nicotiamide when the skin preparations for extenal use comprising nicotiamide being used for skin.
Described skin irritation-reducing agent contains described green tea tree root extract as effective ingredient, thus can suppress the interleukin 8 secreted by skin when nicotiamide composition is contacted with skin, thus has sensitive-skinned people and also nicotiamide composition can be used for skin.
For one embodiment of the invention, with described skin irritation-reducing agent total weight, the content of described green tea tree root extract is more than 6.25ppm, below 3000ppm.When the content of described green tea tree root extract with described skin irritation-reducing agent total weight for more than 6.25ppm time, the interleukin 8 secreted by skin can be suppressed when then nicotiamide composition being used for skin, thus there is the effect alleviating the stimulation caused by nicotiamide.When more than more than 3000ppm, then remission effect is stimulated no longer to improve.
The invention provides and a kind ofly to apply some make up compositions as the whitening of effective ingredient containing green tea tree root extract and nicotiamide.
Whitening according to the present invention applies some make up compositions simultaneously containing reducing the skin irritant green tea tree root extract caused by nicotiamide, thus compared with the cosmetic composition separately containing nicotiamide, even if contain nicotiamide with high concentration, when described cosmetic composition is used for skin, also suitably skin irritation can be suppressed.Thus, the nicotiamide of high concentration can be contained, when therefore described cosmetic composition being used for skin, can powerfully hinder the melanin synthesized on skin to move to keratinocyte, thus whitening effect can be improved further by reducing cutaneous pigmentation.
For one embodiment of the invention, to apply some make up composition total weight in described skin-whitening, the content of described green tea tree root extract is more than 6.25ppm, below 3000ppm.When described green tea tree root extract content with skin-whitening apply some make up composition total weight count more than 6.25ppm time, the interleukin 8 secreted by skin can be suppressed when then nicotiamide composition being used for skin, thus there is the effect alleviating the stimulation caused by nicotiamide.When more than 3000ppm, then remission effect is stimulated no longer to improve.
For one embodiment of the invention, the weight ratio of described green tea tree root extract and described nicotiamide is 1:3000 to 1:6.When the weight ratio of described green tea tree root extract and described nicotiamide is less than 1:3000, does not then have and effectively stimulate remission effect, when being greater than 1:6, then stimulating remission effect no longer to improve.
Skin-whitening according to the present invention applies some make up compositions can containing acceptable carrier on cosmeceutical or Dermatology or substrate by dosage form.Its whole dosage forms that can use as applicable local provide, and such as, can be provided as solution, gel, solid, the anhydrous product of slurry
oil phase is scattered in obtain in aqueous phase emulsion, suspension, microemulsion, microcapsule, subparticle ball or ion-type (liposome) and nonionic folliculus dispersant form, or can be the form of frost, astringent, lotion, powder, ointment, spray or screening flaw rod.In addition, can with foam (foam) form or comprise further compression propellant aerosol combination form use.Described cosmetics can obtain according to the method that this area is conventional.
In addition, described cosmetics can contain fatty material, organic solvent, lytic agent, concentrating agents, gellant, softening agent, antioxidant, suspending agent, stabilizing agent, foaming agent (foamingagent), aromatic, surfactant, water, ion-type or nonionic emulsifier, filler, chelating agen, chelating agent, preservative agent, vitamin, blocker, wetting agent, quintessence oil, dyestuff, pigment, hydrophilic or lipophile activating agent, the adjuvant that lipid folliculus or other composition any etc. being usually used in cosmetics are commonly used in cosmeceutical or Dermatology field.Described adjuvant imports with amount normally used in cosmeceutical or Dermatology field.
Below, structure of the present invention and effect will be further illustrated by test example and dosage form example.But only in order to help to understand the present invention, object illustratively provides for these test examples and dosage form example, and category of the present invention and scope are not limited to following embodiment.
< embodiment 1>
After water cleaning green tea tree root, pulverize by a certain size.The green tea tree root of pulverizing is put into 70% ethanol water (1:8), extracts 24 hours at the temperature of 60 DEG C.The diameter of filter pore is used by green tea tree root extracting solution to be that the filter of 5 μm, 1 μm, 0.5 μm and 0.2 μm filters in order.By the green tea tree root extract of filtration after the temperature of 60 DEG C goes down to desolventize, vacuum drying 24 hours at the temperature of 70 DEG C, thus prepare green tea tree root extract powder.
Using described green tea root extract powder as test portion, utilize nuclear magnetic resonance, NMR (Varian500MHz, Inova500 spectroscope (Spectrometer), VARIAN Oncology Systems (VarianInc.,) U.S.) and FAB/MS (JMS700, Japan of Jeol Ltd. (JeolLtd.)), the composition confirming to contain in green tea root extract is rogchaponin, and its result as shown in fig. 1.
< comparative example 1>
The green tea of drying is put into 70% ethanol water (1:8), carry out extracting for 24 hours at the temperature of 60 DEG C.The diameter of filter pore is used by green tea extracting solution to be that the filter of 5 μm, 1 μm, 0.5 μm and 0.2 μm filters in order.By the green tea extracting solution filtered, after the temperature of 60 DEG C go down to desolventize, vacuum drying 24 hours at the temperature of 70 DEG C, thus prepare green tea extract powder.
< test example 1> to dissociate suppression ratio evaluation for the IL-8 that nicotiamide stimulates
Using keratinocyte (the cell line name: HaCaT as test cell, purchased from Dr.N.E.Fusenig, DeutschesKrebsforschungszentrum, Heidelberg, Germany), utilize the hyclone (Fetalbovinesereum containing 10%, FBS, purchased from Lonza, U.S.) and 1% Pen .-Strep (Penicillin-Streptomycin, purchased from Lonza, the U.S.) DMEM culture medium (Dulbecco'sModifiedEagleMedium, purchased from Lonza, USA), with 2x10
4after the density in cell number/hole is inoculated in 96-orifice plate (48wellplate), at 37 DEG C, the CO of 5%
2cultivate 24 hours under condition.After removing culture fluid, clean 1 time with 200 μ l phosphate buffered solution (Phosphatebufferedsaline, PBS), add 200 μ l not containing the cell culture medium of hyclone, and cultivate 6 hours.Afterwards, by the DMEM culture medium containing 1% hyclone, after 10 minutes, the nicotiamide (purchased from DSM) of 500ppm concentration is used to process cultivation 16 hours by the concentration process mentioned in following table 1 to embodiment 1, comparative example 1 and positive controls (hydrocortisone).50 μ l supernatant are taken out from culture fluid, and the free inhibition by utilizing the enzyme-linked immunosorbent assay (ELISA) of interleukin 8 enzyme linked immunological kit (ELISAkit) (purchased from BDpharmigen, the U.S.) to evaluate interleukin 8.Particularly, based on the rhIL-8 as standard substance (purchased from BDpharmigen, USA) absorbance draws standard curve, and after obtaining the reaction equation between absorbance and standard substance, substitute into the absorbance of treated substance, thus obtain the secretory volume as the interleukin 8 of its inflammatory mediator.Afterwards, obtain the free suppression ratio (%) of interleukin 8 according to following formula, and the results are shown in following table 1.
Free suppression ratio (%)=[1-(processing the interleukin 8 secretory volume of the interleukin 8 secretory volume-non-processor group of the group of this experimental concentration)/(the interleukin 8 secretory volume of the group of process 500ppm nicotiamide)-(IL-8 secretory volume of non-processor group)] × 100
[table 1]
As described in table 1 result shown in, according to the green tea tree root extract of embodiments of the invention 1 compared with the green tea extract of comparative example 1, the free suppression ratio of interleukin 8 is high, thus can determine to stimulate that to alleviate usefulness excellent.
In addition, although the green tea tree root extract of embodiment 1 is for deriving from crude, but it illustrates the stimulation remission effect of the hydrocortisone closer to positive controls, therefore, expect its using become can replace as one of steroid, the effective candidate substances that is known as the hydrocortisone with bringing out property of steroid diabetes, osteoporosis, the side effect such as blood pressure increases, body weight increases.
Claims (6)
1. a skin irritation-reducing agent, described skin irritation-reducing agent contains green tea tree root extract as effective ingredient.
2. skin irritation-reducing agent according to claim 1, is characterized in that, green tea tree root extract contains rogchaponin.
3. skin irritation-reducing agent according to claim 1, is characterized in that, described skin irritation is the stimulation caused by nicotiamide.
4. skin irritation-reducing agent according to claim 1, is characterized in that, with described skin irritation-reducing agent total weight, the content of described green tea tree root extract is more than 6.25ppm, below 3000ppm.
5. skin-whitening applies some make up a compositions, and the described skin-whitening compositions that applies some make up contains green tea tree root extract and nicotiamide as effective ingredient.
6. skin-whitening according to claim 5 applies some make up compositions, and it is characterized in that, the weight ratio of described green tea tree root extract and described nicotiamide is 1:3000 to 1:6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2014-0072766 | 2014-06-16 | ||
| KR1020140072766A KR102224350B1 (en) | 2014-06-16 | 2014-06-16 | Agent for reducing skin irritation and cosmetic composition for skin whitening containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105168034A true CN105168034A (en) | 2015-12-23 |
Family
ID=54890818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510333841.9A Pending CN105168034A (en) | 2014-06-16 | 2015-06-16 | Skin irritation reliever and skin whitening cosmetic composition comprising the same |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR102224350B1 (en) |
| CN (1) | CN105168034A (en) |
| HK (1) | HK1213196A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070196318A1 (en) * | 2006-02-22 | 2007-08-23 | Marini Jan L | Cosmetic herbal compositions |
| CN101048134A (en) * | 2004-12-22 | 2007-10-03 | 雅芳产品公司 | The use of plant extracts to prevent and/or reduce the signs of subjective discomfort and/or irritation in the topical application of cosmetic products |
| US20110262505A1 (en) * | 2010-04-22 | 2011-10-27 | Gina Athwal | Seaweed-derived cosmetic compositions |
| KR20130035325A (en) * | 2011-09-30 | 2013-04-09 | (주)아모레퍼시픽 | External composition for skin containing saponin derived from the root of camellia sinensis |
| KR20130108853A (en) * | 2012-03-26 | 2013-10-07 | (주)아모레퍼시픽 | Composition containing triterpenoid saponin extracted from the root of camellia sinensis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101444689B1 (en) | 2008-02-25 | 2014-09-26 | (주)아모레퍼시픽 | Whitening cosmetic composition |
-
2014
- 2014-06-16 KR KR1020140072766A patent/KR102224350B1/en active IP Right Grant
-
2015
- 2015-06-16 CN CN201510333841.9A patent/CN105168034A/en active Pending
-
2016
- 2016-02-03 HK HK16101232.8A patent/HK1213196A1/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101048134A (en) * | 2004-12-22 | 2007-10-03 | 雅芳产品公司 | The use of plant extracts to prevent and/or reduce the signs of subjective discomfort and/or irritation in the topical application of cosmetic products |
| US20070196318A1 (en) * | 2006-02-22 | 2007-08-23 | Marini Jan L | Cosmetic herbal compositions |
| US20110262505A1 (en) * | 2010-04-22 | 2011-10-27 | Gina Athwal | Seaweed-derived cosmetic compositions |
| KR20130035325A (en) * | 2011-09-30 | 2013-04-09 | (주)아모레퍼시픽 | External composition for skin containing saponin derived from the root of camellia sinensis |
| KR20130108853A (en) * | 2012-03-26 | 2013-10-07 | (주)아모레퍼시픽 | Composition containing triterpenoid saponin extracted from the root of camellia sinensis |
Non-Patent Citations (2)
| Title |
|---|
| P. CHATTOPADHYAY ET AL: "Anti-inflammatory activity of tea (Camellia sinensis) root extract", 《LIFE SCIENCES》 * |
| VARUGHESE,T ET AL: "Tea Triterpenoidal Saponins from the Roots of Camellia sinensis Have Inhibitory Effects against Alcohol Dehydrogenase", 《PLANTA MEDICA》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| HK1213196A1 (en) | 2016-06-30 |
| KR20150144094A (en) | 2015-12-24 |
| KR102224350B1 (en) | 2021-03-09 |
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