CN105166835A - Preparation method for water soluble compound cooling agent - Google Patents
Preparation method for water soluble compound cooling agent Download PDFInfo
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- CN105166835A CN105166835A CN201510574732.6A CN201510574732A CN105166835A CN 105166835 A CN105166835 A CN 105166835A CN 201510574732 A CN201510574732 A CN 201510574732A CN 105166835 A CN105166835 A CN 105166835A
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- coolant agent
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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Abstract
The present invention relates to a preparation method for a water soluble compound cooling agent. The preparation method comprises the following steps: step (1) uniformly mixing Tween-80 and poloxamer to obtain solution A; (2) adding poloxamer into the solution A and oscillating the solution A with ultrasound wave to obtain solution B; step (3) dissolving a compound cooling agent in dipropylene glycol, adding the obtained solution into solution B, and uniformly mixing the solution by stirring to obtain the water soluble compound cooling agent. According to the present invention, a plurality of cooling agents are compounded according to a certain ratio, the compounded cooling agent has a gentle and lasting cooling flavor, and has no bitterness. Meanwhile, the problem that the cooling agent is insoluble in water is solved, and the water soluble compound cooling agent can be widely used in foods, daily products, beverages and other products.
Description
Technical field
The invention belongs to coolant agent application, be specifically related to a kind of preparation method of water-soluble compound coolant agent.
Background technology
Coolant agent allly can produce cooling effect and the general name of the not strong chemical substance of the property of medicine.Levorotatory menthol is the most traditional coolant agent, because it can give product refrigerant, fresh sensation, therefore obtains in industries such as food, medicine, daily use chemicals, tobaccos and uses widely.But its shortcoming also clearly: cooling effect not obvious, high volatility when bitter and penetrating odor, consumption are low and act on of short duration, water-soluble and have stronger excitant etc. to eyes hardly.Due to the above-mentioned shortcoming of levorotatory menthol, its use in a lot of product is restricted.In order to overcome the above-mentioned shortcoming of traditional freshener levorotatory menthol, the novel coolant agent obtained by modifying its molecular structure just constantly produces, such as: menthyl lactate, menthone glycerol ketals, WS-3(N-ethyl-to menthyl-3-formamide), WS-23(2-isopropyl-N, 2, 3-trimethylbutyramide), WS-5(acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester) etc., it is active that they have high cool taste mostly, and there is no calcination, numb and stimulation waits side effect, be widely used in food, daily use chemicals, in the product of medicine and other fields.
Menthol and relevant cool taste compound can to the temperature sensor generation effects of human body, make by cold sensor to the cool sensation of people, document is had to show, levorotatory menthol, WS-5(acetic acid (N-ethyl-to menthyl-3-carboxylic acid amides) ethyl ester), WS-23(2-isopropyl-N, 2,3-trimethylbutyramide) be different at intraoral cool feeling site of action.Menthol is mainly attached on mucous membrane of mouth, cold and hot sensor is produced and stimulates, the cool feeling Main Function position of WS-5 is in throat and following, and the cool feeling Main Function position of WS-23 is at the tip of the tongue, therefore three is deployed into composite coolant agent by a certain percentage, the effect of cool feeling amplification can be reached.
Coolant agent itself is all not soluble in water, therefore as needed to be used in water formulation, must add " amphiphile, amphiphilic molecule " with hydrophilic radical and lipophilic group and increase that it is water-soluble, the modal compound containing " amphiphile, amphiphilic molecule " has sapn, tween, propane diols etc.Polyoxyethylene polyoxypropylene (poloxamer, Poloxamer) be polyoxyethylene poly-oxygen propylene aether block copolymer, also be a kind of novel " amphiphile, amphiphilic molecule " compound, its hydrophilic lipophilic balance (HLB value) can reach 20-29, solubilizing effect is good, widely used by as solubilizing agents for drugs at present, it can also reach the object of slowly-releasing, controlled release as adhesive, coating material in addition.
The present invention, by composite for different coolant agent, utilize each coolant agent cool feeling site of action different, realizes the effect of cool feeling amplification, also solve the problem that composite coolant agent is not soluble in water simultaneously, widened the range of application of coolant agent.
Summary of the invention
The invention provides a kind of preparation method of water-soluble compound coolant agent, based on the feature that variety classes coolant agent cool feeling site of action is different, several coolant agent is composite by a certain percentage.The cool taste of coolant agent after composite is soft, lasting, without bitter taste, this invention also solves the water-fast problem of coolant agent simultaneously, can be widely used in the products such as food, daily use chemicals, beverage.
The present invention is achieved through the following technical solutions:
A preparation method for water-soluble compound coolant agent, comprises the following steps:
Step (1): Tween-80, poloxamer are mixed, obtains solution A;
Step (2): cyclodextrin is joined in described solution A, and use ultrasonic oscillation process, obtain solution B;
Step (3): composite coolant agent is joined in dipropylene glycol and dissolves, and join in solution B, be uniformly mixed, obtain final product.
Preferably, the mass ratio of described Tween-80 and poloxamer is 2:1-5:1.
Preferably, described cyclodextrin is the mixture of 2,6-DM-β-CD and HP-β-CD; Preferred further, the mass ratio of described 2,6-DM-β-CDs and HP-β-CD is 1:1-3:1.
Preferably, in described step (2), the instrument of ultrasonic oscillation process is used to shake instrument for numerical control supersonic; Preferred further, the FREQUENCY CONTROL of described supersonic oscillations instrument is at 25-40KHZ, and time controling is at 0.5-3h.
Preferably, described composite coolant agent is the mixture of levorotatory menthol, coolant agent WS-23, WS-5 three; Preferred further, the mass ratio of described levorotatory menthol, coolant agent WS-23, WS-5 three is (3-5): (1-3): (1-3).
Preferably, the mass ratio of described coolant agent and dipropylene glycol is 1:3-1:10.
Beneficial effect of the present invention:
The present invention is composite by a certain percentage by several coolant agent, the cool taste of coolant agent after composite is soft, lasting, without bitter taste, also solve the water-fast problem of coolant agent simultaneously, widened the range of application of coolant agent, can be widely used in the products such as food, daily use chemicals, beverage.
specific embodiment mode
Below in conjunction with specific embodiment, the present invention is described in detail.Following examples will contribute to those skilled in the art and understand the present invention further, but not limit the present invention in any form.It should be pointed out that to those skilled in the art, without departing from the inventive concept of the premise, some distortion and improvement can also be made.These all belong to protection scope of the present invention.
embodiment 1
The present embodiment relates to a kind of preparation method of water-soluble compound coolant agent, comprises the following steps:
Step (1): the ratio being 2:1 according to mass ratio by Tween-80, poloxamer mixes, obtains solution A;
Step (2): 2,6-DM-β-CD and HP-β-CD are mixed with mass ratio 1:1, joins in described solution A, and supersonic oscillations instrument concussion process 0.5h, supersonic frequency controls, at 25KHZ, to obtain solution B;
Step (3): levorotatory menthol, coolant agent WS-23, WS-5 are mixed with mass ratio 3:1:1, join in dipropyleneglycol solution and dissolve, wherein the mass ratio of composite coolant agent and dipropylene glycol is 1:3, joins in solution B until completely dissolved again, be uniformly mixed, obtain final product.
embodiment 2
The present embodiment relates to a kind of preparation method of water-soluble compound coolant agent, comprises the following steps:
Step (1): the ratio being 5:1 according to mass ratio by Tween-80, poloxamer mixes, obtains solution A;
Step (2): 2,6-DM-β-CD and HP-β-CD are mixed with mass ratio 3:1, joins in described solution A, and supersonic oscillations instrument concussion process 3h, supersonic frequency controls, at 40KHZ, to obtain solution B;
Step (3): levorotatory menthol, coolant agent WS-23, WS-5 are mixed with mass ratio 5:3:3, join in dipropyleneglycol solution and dissolve, wherein the mass ratio of composite coolant agent and dipropylene glycol is 1:10, joins in solution B until completely dissolved again, be uniformly mixed, obtain final product.
embodiment 3
The present embodiment relates to a kind of preparation method of water-soluble compound coolant agent, comprises the following steps:
Step (1), the ratio being 3:1 according to mass ratio by Tween-80, poloxamer mix, and obtain solution A;
Step (2), 2,6-DM-β-CD and HP-β-CD to be mixed with mass ratio 2:1, join in described solution A, and supersonic oscillations instrument concussion process 1.5h, supersonic frequency controls, at 35KHZ, to obtain solution B;
Step (3), levorotatory menthol, coolant agent WS-23, WS-5 to be mixed with mass ratio 5:3:1, join in dipropyleneglycol solution and dissolve, wherein the mass ratio of composite coolant agent and dipropylene glycol is 1:5, joins until completely dissolved in solution B, be uniformly mixed, obtain final product.
Claims (9)
1. a preparation method for water-soluble compound coolant agent, is characterized in that, comprises the following steps:
Step (1): Tween-80, poloxamer are mixed, obtains solution A;
Step (2): cyclodextrin is joined in described solution A, and use ultrasonic oscillation process, obtain solution B;
Step (3): composite coolant agent is joined in dipropylene glycol and dissolves, and join in solution B, be uniformly mixed, obtain final product.
2. the preparation method of a kind of water-soluble compound coolant agent according to claim 1, is characterized in that, the mass ratio of described Tween-80 and poloxamer is 2:1-5:1.
3. the preparation method of a kind of water-soluble compound coolant agent according to claim 1, is characterized in that, described cyclodextrin is the mixture of 2,6-DM-β-CD and HP-β-CD.
4. the preparation method of a kind of water-soluble compound coolant agent according to claim 3, is characterized in that, the mass ratio of described 2,6-DM-β-CDs and HP-β-CD is 1:1-3:1.
5. the preparation method of a kind of water-soluble compound coolant agent according to claim 1, is characterized in that, in described step (2), uses the instrument of ultrasonic oscillation process to shake instrument for numerical control supersonic.
6. the preparation method of a kind of water-soluble compound coolant agent according to claim 5, is characterized in that, the FREQUENCY CONTROL of described supersonic oscillations instrument is at 25-40KHZ, and time controling is at 0.5-3h.
7. the preparation method of a kind of water-soluble compound coolant agent according to claim 1, is characterized in that, described composite coolant agent is the mixture of levorotatory menthol, coolant agent WS-23, WS-5 three.
8. the preparation method of a kind of water-soluble compound coolant agent according to claim 7, is characterized in that, the mass ratio of described levorotatory menthol, coolant agent WS-23, WS-5 three is (3-5): (1-3): (1-3).
9. the preparation method of a kind of water-soluble compound coolant agent according to claim 1, is characterized in that, the mass ratio of described coolant agent and dipropylene glycol is 1:3-1:10.
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| CN201510574732.6A CN105166835A (en) | 2015-09-11 | 2015-09-11 | Preparation method for water soluble compound cooling agent |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105686077A (en) * | 2016-03-25 | 2016-06-22 | 湖北中烟工业有限责任公司 | Preparation method of cigarette filter tip rod with blending material controlled-release cool sense essence |
| CN107751522A (en) * | 2017-11-09 | 2018-03-06 | 安徽爱迪香料股份有限公司 | A kind of overlength cool feeling duration pressed candy and preparation method thereof |
| CN107950983A (en) * | 2017-11-27 | 2018-04-24 | 昆山亚香香料股份有限公司 | A kind of compounding coolant agent composition based on menthol and preparation method thereof |
| CN109452523A (en) * | 2018-12-07 | 2019-03-12 | 昆山亚香香料股份有限公司 | Drink coolant agent component and its method for making |
| CN109576099A (en) * | 2018-12-07 | 2019-04-05 | 昆山亚香香料股份有限公司 | For the coolant agent component in beer and its it is made into method |
| CN109593628A (en) * | 2018-12-07 | 2019-04-09 | 昆山亚香香料股份有限公司 | Enhance the cool taste component formula and preparation method thereof of the cool degree of drinks |
| CN112401219A (en) * | 2020-11-30 | 2021-02-26 | 南通亚香食品科技有限公司 | Compound cooling agent composition based on menthol and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105686077A (en) * | 2016-03-25 | 2016-06-22 | 湖北中烟工业有限责任公司 | Preparation method of cigarette filter tip rod with blending material controlled-release cool sense essence |
| CN105686077B (en) * | 2016-03-25 | 2019-10-11 | 湖北中烟工业有限责任公司 | The cigarette mouth stick preparation method of intermingling material controlled release cool feeling essence |
| CN107751522A (en) * | 2017-11-09 | 2018-03-06 | 安徽爱迪香料股份有限公司 | A kind of overlength cool feeling duration pressed candy and preparation method thereof |
| CN107950983A (en) * | 2017-11-27 | 2018-04-24 | 昆山亚香香料股份有限公司 | A kind of compounding coolant agent composition based on menthol and preparation method thereof |
| CN109452523A (en) * | 2018-12-07 | 2019-03-12 | 昆山亚香香料股份有限公司 | Drink coolant agent component and its method for making |
| CN109576099A (en) * | 2018-12-07 | 2019-04-05 | 昆山亚香香料股份有限公司 | For the coolant agent component in beer and its it is made into method |
| CN109593628A (en) * | 2018-12-07 | 2019-04-09 | 昆山亚香香料股份有限公司 | Enhance the cool taste component formula and preparation method thereof of the cool degree of drinks |
| CN112401219A (en) * | 2020-11-30 | 2021-02-26 | 南通亚香食品科技有限公司 | Compound cooling agent composition based on menthol and preparation method thereof |
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