CN104257624A - Novel effervescent and disintegrative premix and preparation method thereof - Google Patents
Novel effervescent and disintegrative premix and preparation method thereof Download PDFInfo
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- CN104257624A CN104257624A CN201410455835.6A CN201410455835A CN104257624A CN 104257624 A CN104257624 A CN 104257624A CN 201410455835 A CN201410455835 A CN 201410455835A CN 104257624 A CN104257624 A CN 104257624A
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- acid
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Abstract
The invention belongs to the technical field of producing food, healthcare food and medicines, and relates to a novel effervescent and disintegrative premix and a preparation method thereof. According to the novel effervescent and disintegrative premix, an acid source and a carbon dioxide source are isolated through such technical means as coating; under a circumstance of little moisture absorption, acid-base neutralization is avoided; the premix effectively improves shortcomings that bag bulging, pipe boosting and like are easy to occur, and a stability is improved.
Description
Technical field
The invention belongs to food, health food and pharmaceutical production technical field, relate to a kind of new effervescent disintegrate pre-mixing agent and preparation method thereof.
Background technology
Effervescent tablet is a kind of tablet made for gas-producing disintegrant with suitable bronsted lowry acids and bases bronsted lowry, and its technology of preparing is widely used in the production of food, health food and medicine.Effervescent tablet drops in water can produce great amount of carbon dioxide gas, impels whole tablet to dissolve at short notice, and drug effect is rapid, and bioavailability is high.And compared with liquid preparation, carry more convenient.Oral effervescent tablet is specially adapted to the patient of child, old people and solid preparation of can not swallowing.According to some clinical needs, special effervescent tablet can also be prepared into.As vagina effervescence etc., can drug effect be improved for topical therapeutic, reduce the side effect of some drugs.The acid source that effervescent tablet is conventional has citric acid, tartaric acid, fumaric acid, adipic acid, malic acid, water-soluble amino acid, rare ore deposit acid (example hydrochloric acid), acid salt (citric acid potassium dihydrogen, potassium hydrogen tartrate, fumaric acid sodium etc.) etc.Carbon dioxide source: sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate etc.The most frequently used acid source is citric acid, the most frequently used carbon dioxide source is sodium bicarbonate, sodium carbonate and potassium carbonate, the dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react, but after water put into by effervescent tablet, two kinds of material generation acid-base reactions, produce a large amount of bubble (carbon dioxide), make the rapid disintegrate of tablet and thawing, the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.
Prior art weak point is:
Gas-producing disintegrant is a large amount of bronsted lowry acids and bases bronsted lowry, therefore easily moisture absorption and acid-base neutralization reaction occurs, produce the phenomenons such as swollen bag, booster, material impact is produced to the stability of tablet.
Summary of the invention
In order to solve problems of the prior art, the present invention is directed to above problem, through lot of experiments, a kind of new effervescent disintegrate pre-mixing agent of independent research, adopt technological means isolation acid source and the carbon dioxide sources such as parcel, when a small amount of moisture absorption, acid-base neutralization reaction can not occur, effectively improve and easily the shortcomings such as swollen bag, booster occur, improve its stability.
In order to realize object of the present invention, the technical scheme of employing is summarized as follows:
A new effervescent disintegrate pre-mixing agent, is characterized in that, primarily of acid source, carbon dioxide source and wrappage composition, acid source and carbon dioxide source are wrapped in wrappage respectively.
Described a kind of new effervescent disintegrate pre-mixing agent, it is characterized in that, preparation technology is: 1. wrappage be heated to liquid state or be dissolved in a small amount of anhydrous organic solvent; 2. 1. will walk and obtain product and mix homogeneously with acid source and carbon dioxide source respectively, dry; 3. will 2. walk the product mix homogeneously obtained, to obtain final product.
Described a kind of new effervescent disintegrate pre-mixing agent, is characterized in that, described wrappage is the hydrophilic film coating material that the art is commonly used, and comprises one or several mixture in hydroxypropyl emthylcellulose, Polyethylene Glycol and sodium carboxymethyl cellulose.
Described a kind of new effervescent disintegrate pre-mixing agent, is characterized in that, described wrappage can containing the plasticizer under hydrophilic plasticizer or normal temperature condition being liquid state.
Described a kind of new effervescent disintegrate pre-mixing agent, it is characterized in that, described acid source is the acid source that the art is commonly used, and comprises one or several mixture in citric acid, tartaric acid, fumaric acid, adipic acid, malic acid, water-soluble amino acid, rare ore deposit acid (example hydrochloric acid), acid salt (citric acid potassium dihydrogen, potassium hydrogen tartrate, fumaric acid sodium etc.) etc.
Described a kind of new effervescent disintegrate pre-mixing agent, is characterized in that, described carbon dioxide source is the carbon dioxide source that the art is commonly used, and comprises one or more mixture in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate etc.
Described a kind of new effervescent disintegrate pre-mixing agent, it is characterized in that, described acid source and the mass ratio range of carbon dioxide source are acid source: carbon dioxide source=1 ~ 4: 2.
Compared with prior art, the good effect that the present invention has is: acid source and carbon dioxide source, after wrappage parcel, are effectively isolated, added stability.
Detailed description of the invention
Demonstration example 1
(1) prescription
(acid source) citric acid: 10g
(carbon dioxide source) sodium bicarbonate: 13g
(wrappage) polyethylene glycol 6000: 2g
(2) preparation technology
1. the polyethylene glycol 6000 heating in water bath of recipe quantity molten condition, be divided into two parts, for subsequent use; 2. the sodium bicarbonate of recipe quantity and citric acid are joined respectively the portion 1., mix homogeneously, is cooled to room temperature; 3. will 2. walk product mix homogeneously, to obtain final product.
Demonstration example 2
(1) prescription
(acid source) tartaric acid: 10g
Citric acid: 1g
(carbon dioxide source) potassium bicarbonate: 8g
(wrappage) polyethylene glycol 6000: 2g
(2) preparation technology
1. the polyethylene glycol 6000 of recipe quantity is dissolved in a small amount of dehydrated alcohol, for subsequent use; 2. the potassium bicarbonate of recipe quantity is joined 1., mix homogeneously, drying at room temperature; 3. 2. will walk product to mix homogeneously with recipe quantity tartaric acid and citric acid, to obtain final product.
Demonstration example 3
(1) prescription
(acid source) fumaric acid: 12g
(carbon dioxide source) sodium bicarbonate: 8g
(wrappage) copolyvidone: 2g
(plasticizer) triethyl citrate: 0.2g
(2) preparation technology
1. the copolyvidone of recipe quantity is dissolved in a small amount of dehydrated alcohol, adds recipe quantity triethyl citrate, mix homogeneously, for subsequent use; 2. the fumaric acid of recipe quantity is joined 1., mix homogeneously, drying at room temperature; 3. 2. will walk product to mix homogeneously with recipe quantity sodium bicarbonate, to obtain final product.
Exemplary scenario described here is only the explanation to the principle of the invention, and preferred embodiment of the present invention, should not by any way, utilizes describing and limit the scope of the invention above.The professional person of this area, can utilize principle of the present invention, designs various different embodiment, and does not exceed scope of the present invention.
Claims (7)
1. a new effervescent disintegrate pre-mixing agent, comprise acid source, carbon dioxide source and wrappage, it is characterized in that, acid source and carbon dioxide source are wrapped in wrappage respectively.
2. a kind of new effervescent disintegrate pre-mixing agent as claimed in claim 1, it is characterized in that, preparation technology is: 1. wrappage be heated to liquid state or be dissolved in a small amount of anhydrous organic solvent; 2. 1. will walk and obtain product and mix homogeneously with carbon dioxide source, dry; 3. mixing homogeneously 2. walking the product obtained with acid source, obtaining final product.
3. a kind of new effervescent disintegrate pre-mixing agent as claimed in claim 1, it is characterized in that, described wrappage is the hydrophilic film coating material that the art is commonly used, and comprises one or several mixture in copolyvidone, hydroxypropyl emthylcellulose, Polyethylene Glycol and sodium carboxymethyl cellulose.
4. a kind of new effervescent disintegrate pre-mixing agent as claimed in claim 1, is characterized in that, described wrappage is liquid plasticizer under containing hydrophilic plasticizer or normal temperature condition.
5. a kind of new effervescent disintegrate pre-mixing agent as claimed in claim 1, it is characterized in that, described acid source is the acid source that the art is commonly used, and comprises one or several mixture of citric acid, tartaric acid, fumaric acid, adipic acid, malic acid, water-soluble amino acid, the acid of rare ore deposit, acid salt apoplexy due to endogenous wind.
6. a kind of new effervescent disintegrate pre-mixing agent as claimed in claim 1, it is characterized in that, described carbon dioxide source is the carbon dioxide source that the art is commonly used, and comprises one or more mixture in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate, calcium carbonate.
7. a kind of new effervescent disintegrate pre-mixing agent as claimed in claim 1, it is characterized in that, described acid source and the mass ratio range of carbon dioxide source are acid source: carbon dioxide source=1 ~ 4: 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410455835.6A CN104257624A (en) | 2014-09-10 | 2014-09-10 | Novel effervescent and disintegrative premix and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410455835.6A CN104257624A (en) | 2014-09-10 | 2014-09-10 | Novel effervescent and disintegrative premix and preparation method thereof |
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| CN104257624A true CN104257624A (en) | 2015-01-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410455835.6A Pending CN104257624A (en) | 2014-09-10 | 2014-09-10 | Novel effervescent and disintegrative premix and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875170A (en) * | 2017-11-10 | 2018-04-06 | 江苏扬新生物医药有限公司 | A kind of effervescent agent containing calcium carbonate |
| CN109232108A (en) * | 2018-11-23 | 2019-01-18 | 福建农林大学 | A kind of preparation method as the compound fertilizer spread fertilizer over the fields |
| CN110292566A (en) * | 2019-07-08 | 2019-10-01 | 上海中医药大学 | A method of reducing effervescent tablet sticking amount in actual production |
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| CN101406463A (en) * | 2008-02-28 | 2009-04-15 | 王世锋 | Method for preparing metronidazole, clotrimazole and chlorhexidime vaginal acetate effervescent tablet and quality control method |
| CN101416952A (en) * | 2008-11-28 | 2009-04-29 | 崔学龙 | Contain gas-producing disintegrant of sodium bicarbonate microcapsule and preparation method thereof |
| CN102048708A (en) * | 2010-12-08 | 2011-05-11 | 赵磊 | Tinidazole vaginal effervescent tablet and preparation method thereof |
| CN102600473A (en) * | 2012-04-06 | 2012-07-25 | 安徽山河药用辅料股份有限公司 | Preparation method of premix adjuvant for effervescent tablet |
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2014
- 2014-09-10 CN CN201410455835.6A patent/CN104257624A/en active Pending
Patent Citations (5)
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| WO2002042407A2 (en) * | 2000-10-31 | 2002-05-30 | The Procter & Gamble Company | Multi-phase detergent tablets and method of reblending these tablets |
| CN101406463A (en) * | 2008-02-28 | 2009-04-15 | 王世锋 | Method for preparing metronidazole, clotrimazole and chlorhexidime vaginal acetate effervescent tablet and quality control method |
| CN101416952A (en) * | 2008-11-28 | 2009-04-29 | 崔学龙 | Contain gas-producing disintegrant of sodium bicarbonate microcapsule and preparation method thereof |
| CN102048708A (en) * | 2010-12-08 | 2011-05-11 | 赵磊 | Tinidazole vaginal effervescent tablet and preparation method thereof |
| CN102600473A (en) * | 2012-04-06 | 2012-07-25 | 安徽山河药用辅料股份有限公司 | Preparation method of premix adjuvant for effervescent tablet |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875170A (en) * | 2017-11-10 | 2018-04-06 | 江苏扬新生物医药有限公司 | A kind of effervescent agent containing calcium carbonate |
| CN107875170B (en) * | 2017-11-10 | 2020-07-07 | 江苏扬新生物医药有限公司 | Calcium carbonate-containing effervescent agent |
| CN109232108A (en) * | 2018-11-23 | 2019-01-18 | 福建农林大学 | A kind of preparation method as the compound fertilizer spread fertilizer over the fields |
| CN110292566A (en) * | 2019-07-08 | 2019-10-01 | 上海中医药大学 | A method of reducing effervescent tablet sticking amount in actual production |
| CN110292566B (en) * | 2019-07-08 | 2022-03-29 | 上海中医药大学 | Method for reducing sticking quantity of effervescent tablets in actual production |
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