CN105686077B - The cigarette mouth stick preparation method of intermingling material controlled release cool feeling essence - Google Patents
The cigarette mouth stick preparation method of intermingling material controlled release cool feeling essence Download PDFInfo
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- CN105686077B CN105686077B CN201610177115.7A CN201610177115A CN105686077B CN 105686077 B CN105686077 B CN 105686077B CN 201610177115 A CN201610177115 A CN 201610177115A CN 105686077 B CN105686077 B CN 105686077B
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- Prior art keywords
- essence
- solution
- cool feeling
- mouth stick
- controlled release
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- 239000000463 material Substances 0.000 title claims abstract description 118
- 238000013270 controlled release Methods 0.000 title claims abstract description 53
- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000003756 stirring Methods 0.000 claims abstract description 38
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 37
- 238000000034 method Methods 0.000 claims abstract description 29
- 230000008569 process Effects 0.000 claims abstract description 26
- 238000000465 moulding Methods 0.000 claims abstract description 25
- 239000003205 fragrance Substances 0.000 claims abstract description 16
- 230000035945 sensitivity Effects 0.000 claims abstract description 12
- 239000011159 matrix material Substances 0.000 claims description 30
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 28
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 27
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 27
- 229940041616 menthol Drugs 0.000 claims description 27
- 238000000265 homogenisation Methods 0.000 claims description 19
- 238000005303 weighing Methods 0.000 claims description 13
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 12
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 12
- 229940116229 borneol Drugs 0.000 claims description 12
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 12
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 12
- -1 porphyrin sulfonate Chemical class 0.000 claims description 12
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 150000001412 amines Chemical class 0.000 claims description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- VTJUKNSKBAOEHE-UHFFFAOYSA-N calixarene Chemical class COC(=O)COC1=C(CC=2C(=C(CC=3C(=C(C4)C=C(C=3)C(C)(C)C)OCC(=O)OC)C=C(C=2)C(C)(C)C)OCC(=O)OC)C=C(C(C)(C)C)C=C1CC1=C(OCC(=O)OC)C4=CC(C(C)(C)C)=C1 VTJUKNSKBAOEHE-UHFFFAOYSA-N 0.000 claims description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- GFERWFAWHAQLLF-UHFFFAOYSA-N [N]1C2=CC=C1C=C(N1)C=C(N)C1=CC([N]1)=CC=C1C=C(N1)C=CC1=C2 Chemical class [N]1C2=CC=C1C=C(N1)C=C(N)C1=CC([N]1)=CC=C1C=C(N1)C=CC1=C2 GFERWFAWHAQLLF-UHFFFAOYSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 5
- 229920002554 vinyl polymer Polymers 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- 229960005233 cineole Drugs 0.000 claims description 4
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 claims description 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- XEZNGIUYQVAUSS-UHFFFAOYSA-N 18-crown-6 Chemical compound C1COCCOCCOCCOCCOCCO1 XEZNGIUYQVAUSS-UHFFFAOYSA-N 0.000 claims description 3
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 3
- 239000010642 eucalyptus oil Substances 0.000 claims description 3
- 229940044949 eucalyptus oil Drugs 0.000 claims description 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims description 3
- 150000002729 menthone derivatives Chemical class 0.000 claims description 3
- 235000019477 peppermint oil Nutrition 0.000 claims description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims description 3
- NFLGAXVYCFJBMK-IUCAKERBSA-N (-)-isomenthone Chemical compound CC(C)[C@@H]1CC[C@H](C)CC1=O NFLGAXVYCFJBMK-IUCAKERBSA-N 0.000 claims description 2
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims description 2
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims description 2
- 235000007746 carvacrol Nutrition 0.000 claims description 2
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 claims description 2
- NFLGAXVYCFJBMK-UHFFFAOYSA-N isomenthone Natural products CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 2
- 241000233855 Orchidaceae Species 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 abstract description 4
- 230000036541 health Effects 0.000 abstract description 2
- 238000009210 therapy by ultrasound Methods 0.000 abstract 2
- 230000002045 lasting effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 110
- 210000000214 mouth Anatomy 0.000 description 58
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 18
- 239000003814 drug Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 229920000858 Cyclodextrin Polymers 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 4
- 229920001983 poloxamer Polymers 0.000 description 4
- 229960000502 poloxamer Drugs 0.000 description 4
- 239000011540 sensing material Substances 0.000 description 4
- 244000246386 Mentha pulegium Species 0.000 description 3
- 235000016257 Mentha pulegium Nutrition 0.000 description 3
- 235000004357 Mentha x piperita Nutrition 0.000 description 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 3
- 244000061176 Nicotiana tabacum Species 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000005352 clarification Methods 0.000 description 3
- 235000001050 hortel pimenta Nutrition 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 244000024873 Mentha crispa Species 0.000 description 2
- 235000014749 Mentha crispa Nutrition 0.000 description 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 150000003983 crown ethers Chemical class 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000011557 critical solution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000003546 flue gas Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 230000003694 hair properties Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 description 1
- RKCAIXNGYQCCAL-UHFFFAOYSA-N porphin Chemical compound N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 RKCAIXNGYQCCAL-UHFFFAOYSA-N 0.000 description 1
- 150000004032 porphyrins Chemical class 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/02—Manufacture of tobacco smoke filters
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/061—Use of materials for tobacco smoke filters containing additives entrapped within capsules, sponge-like material or the like, for further release upon smoking
Abstract
The present invention provides a kind of preparation method of the cigarette mouth stick of intermingling material controlled release cool feeling essence.The specific steps are that: supramolecular materials are uniformly mixed according to weight ratio 1:0.5-1:30 ratio to obtain supermolecule solution with the ethanol water of mass fraction 0%-95%；The high molecular material of temperature sensitivity is uniformly mixed according to weight ratio 1:0.5-1:30 ratio to obtain temperature-sensitive macromolecular solution with the ethanol water of mass fraction 0%-95%, then by ultrasonic treatment after the ratio of supramolecular materials solution and the weight ratio 1:0.1-10 of temperature-sensitive macromolecular solution being mixed, add be mixed with ethanol water cool feeling fragrance solution stirring after again pass by ultrasonic treatment after be applied on tow in mouth stick forming process, after mouth stick molding after obtain.The present invention is during smoking cigarettes, the release that essence is slow, lasting, to improve the comfort of smoking cigarettes, reduces harm of the cigarette to human health.
Description
Technical field
The invention belongs to technical field of tobacco, and in particular to a kind of system of the cigarette mouth stick of intermingling material controlled release cool feeling essence
Preparation Method.
Background technique
Since cool taste essence is widely used in daily use chemicals, food, tobacco, medicine and personal hygiene article, so for a long time
Since be constantly subjected to the concern of people.Natural menthol is one in cool taste essence and applies maximum fragrance kind, it because
It is inexpensive, taste is pure, safely, the favor that is easy to get and is constantly subjected to people.With the continuous improvement that people require cool taste product, peppermint
The shortcomings that brain and deficiency are also gradually exposed, and are mainly manifested in two aspects, first is that in terms of high temperature resistant, since menthol is waved
Hair property is stronger, and in food processing process, the loss of fragrance and fragrance is very big especially in the product after high temperature, sternly
The mouthfeel of product is affected again.Second is that cool feeling duration of the menthol in the skin and oral cavity of people is shorter.This two o'clock is not
Foot limits the use of menthol in all respects.
During Modern Pharmaceutics rapidly develop, the important function of high molecular material is increasingly prominent.With certain sky
The supramolecular materials of cavity configuration attract attention because it has the cavity for containing drug molecule, these supramolecular materials have ring paste
Essence, crown ether, porphyrin, calixarenes etc..Temperature sensitivity high molecular material is also one of research hotspot.Temperature sensitivity macromolecule material
Material refers to there is responsiveness to thermal stimulus, has lower critical solution temperature one kind intelligent macromolecule material, as polyvinyl is different
Fourth phthalein amine, polyethylene glycol oxide ether (PEO), polyethylene adjoin pyrrolidone (PVP), poly- isopropyl propylene phthalein amine etc..This temperature is sensitive
Property polymer be used to that gel, microballoon etc. is made, and be widely used in biology, chemicals release, object such as mutually separates at the neck
Domain, high molecular material variation with temperature cause the variation of conformation, so as to be applied to drug as matrix as temperature detect switch (TDS)
Delivery systme.Wherein, temperature sensitivity medicine-carried system can slowly, constantly discharge drug, occur for a long time with site of action tight
Contiguity is touched and is absorbed the drug, and is avoided first pass effect, is improved the bioavilability of drug；Conformational change is controlled using temperature, thus
Promote release, administration number of times can be reduced, extend drug biological half-life, increases curative effect of medication.
It is existing research shows that temperature sensitive controlled-release technology is in drug field comparative maturity, but by temperature sensitive controlled-release
Only the application unit of the technology for tobacco business was attempted, and had applied for patent of invention in 2012, the patent of invention
The preparation method (CN201210544175.X) of the cigarette dripping pill of entitled temperature sensitive controlled-release flavor, the patent are that have
The ethanol water solution that essence is added in the state of the high molecular material substrate melting of temperature sensitivity, which contain, to be made directly
For diameter in the Thermo-sensitive cigarette dripping pill of 3.6-4mm, which is a hard bead, and directly dripping pill is put into mouth stick, due to drop
Belonging to visual and can touching for ball, will affect mouthfeel, and be unable to ensure uniformly shedding for cool taste in sucking process.Except this it
Outside, due to essence be it is readily volatilized, general cool feeling cigarette is easy to volatilize in the cool taste of storage process, is difficult to save.
Summary of the invention
For the deficiencies in the prior art, it is fragrant that the object of the present invention is to provide a kind of intermingling material controlled release cool feelings
The cigarette mouth stick preparation method of essence.Cool feeling essence is wrapped in the matrix that supramolecular materials and Thermo-sensitive material are blended by the present invention
It is interior, intermingling material controlled release cool feeling essence is made, then carry out mouth stick forming step, finally obtains intermingling material controlled release cool feeling essence
Cigarette mouth stick.
Technical solution provided by the invention:
A kind of preparation method of the cigarette mouth stick with intermingling material controlled release cool feeling essence, it is characterised in that specific steps are such as
Under:
(1) supramolecular materials for weighing constant weight add the ethyl alcohol of mass fraction 0%-95% into supramolecular materials
Aqueous solution, stirring is completely dissolved to supramolecular materials under the conditions of 30-60 DEG C reaches clear state, obtains supramolecular materials
Solution, wherein the weight ratio of the ethanol water of supramolecular materials and mass fraction 0%-95% is 1:0.5-1:30, described super
Molecular material be hydroxypropyl cyclodextrin, Amino Porphyrins, porphyrin sulfonate, calixarenes sodium sulfonate, p-sulfonic acid base benzeneazo calixarenes,
One or more of mixtures of 18- crown ether -6；
(2) high molecular material with temperature sensitivity for weighing constant weight, to the macromolecule with temperature sensitivity
The ethanol water of mass fraction 0%-95% is added in material, stirring is completely molten to high molecular material under the conditions of 30-60 DEG C
Solution obtains temperature-sensitive macromolecular solution；The weight ratio of the ethanol water of its mesostroma and mass fraction 0%-95% is 1:0.5-
1:30, the high molecular material with temperature sensitivity are polyethylene glycol, polyvinyl isobutyl phthalein amine, poloxamer, polyoxy
Change vinethene (PEO), polyvinylpyrrolidone (PVP), one or more of mixtures of poly- isopropyl propylene phthalein amine；
(3) step is weighed according to the ratio of supramolecular materials solution and the weight ratio 1:0.1-10 of temperature-sensitive macromolecular solution
(1) the temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and step (2) prepared in, supramolecular materials solution is put
Enter in container and be stirred, weighed whole temperature-sensitive macromolecular solution is added dropwise dropwise in whipping process, until mixed liquor reaches
To clear state；
It (4) is 150-250W/L, supersonic frequency in ultrasonic power by the clear transparent solutions after stirring in step (3)
Ultrasonic homogenation handles 30-120min under conditions of rate is 20-25kHz, obtains matrix solution；
(5) the cool feeling essence for weighing constant weight, by the ethanol water weight of cool feeling essence and mass fraction 50%-95%
The ethanol water of the ratio addition mass fraction 50%-95% than 1:0.5-1:30 is measured, stirring is until cool feeling essence is completely molten
Solution, obtains cool feeling fragrance solution；The cool feeling essence is peppermint oil, menthol, menthones, isomenthone, Cineole, thio eucalyptus
Foline, spearmint, eucalyptus oil, borneol, carvacrol one or more of mixtures；
(6) it is weighed by weight the ratio of 1:0.5-1:30 in the cool feeling fragrance solution and step (4) prepared in step (5)
Whole matrix solutions are put into container and are stirred by the matrix solution of preparation, and weighed cool feeling is added dropwise in whipping process dropwise
Fragrance solution reaches clear state；
It (7) is 150-250W/L, supersonic frequency in ultrasonic power by the clear transparent solutions after stirring in step (6)
Ultrasonic homogenation handles 30-120min under conditions of rate is 20-25kHz, obtains Thermo-sensitive supermolecule controlled release cool feeling essence.
(8) by ultrasonic homogenation in step (7), treated that Thermo-sensitive supermolecule controlled release cool feeling essence is molding in mouth stick
It is applied on tow in the process, the dripping quantity of every mouth stick is 2-20 microlitres, is just obtained after the molding of mouth stick of the present invention
Cigarette mouth stick with intermingling material controlled release cool feeling essence.
The further technical solution of the present invention: when the Thermo-sensitive supermolecule intermingling material controlled release cool feeling prepared in step (7)
When essence dissolves in triacetyl glycerine, before being applied to tow, first the Thermo-sensitive supermolecule prepared in step (7) is blended
Material controlled release cool feeling essence and triacetyl glycerine are mixed by weight the ratio of 1:0.5-1:30, and are stirred to mixed liquor and reached
Uniform state carries out in mouth stick forming process on conventional mouth stick molding equipment, will directly be blended added with Thermo-sensitive supermolecule
The triacetyl glycerine solution of material controlled release cool feeling essence is added on tow, obtains tool of the present invention after the molding of mouth stick
There is the cigarette mouth stick of intermingling material controlled release cool feeling essence；Due to natively needing to add three triacetins in mouth stick forming process
Essence is dissolved in triacetyl glycerine by ester, there is no need to change equipment, using dissolved with Thermo-sensitive supermolecule in forming process
The triacetyl glycerine solution of intermingling material controlled release cool feeling essence is directly appended to tow to replace the triacetyl glycerine of script
On.
When the Thermo-sensitive supermolecule intermingling material controlled release cool feeling essence prepared in step (7) cannot be dissolved in triacetyl glycerine
When, before being applied to tow, after adding perfuming device on conventional mouth stick molding equipment, then mouth stick molding is carried out, and in mouth
Thermo-sensitive supermolecule intermingling material controlled release cool feeling essence, every mouth stick are applied on tow by perfuming device in stick forming process
Dripping quantity be 2-20 microlitres, after mouth stick molding after obtain it is of the present invention with intermingling material controlled release cool feeling essence cigarette use
Mouth stick.The perfuming device is really made of flavoring roller and essence box, and essence box is placed in below flavoring roller, and flavoring roller is mounted on
On rear side of the roll shaft of conventional mouth stick molding equipment addition triacetyl glycerine, after tow adds triacetyl glycerine, it is transmitted to
On flavoring roller, the lower part of flavoring roller is immersed in essence box, and essence can be added on tow during rotation.
The present invention preferably technical solution: the stirring condition in the step (3) and step (6) is 30-60 DEG C of temperature, is stirred
Mixing speed is 100-500rpm.
Beneficial effects of the present invention:
(1) controlled-release flavor of the present invention is supramolecular materials to be dissolved in water or ethyl alcohol or certain density ethyl alcohol is water-soluble
In liquid, then one or more high molecular materials for having temperature sensitivity are dissolved in water or ethyl alcohol or certain density ethyl alcohol is water-soluble
It is miscible according to a certain percentage after liquid, in the state of guarantee system stable and uniform, add the ethanol water of cool feeling essence
It is contained, the entire controlled release cool feeling essence system after containing is the state of stable and uniform, the controlled release cool feeling that then will be prepared
Essence is applied on tow during mouth stick is molding, and the dripping quantity of every mouth stick is 2-20 microlitres, it is ensured that essence it is equal
It is even to distribute, and the appearance common mouth stick of entire mouth stick is the same, has no hard bead that is visual or can touching；
(2) since matrix of the invention is blended by temperature sensing material and supramolecular materials, temperature sensitive matrix can be in 45-
Under conditions of 55 DEG C by solid phase transformation be liquid phase, in cigarette smoking, flue gas reach mouth stick when 45-55 DEG C be critical-temperature,
The matrix for containing cool feeling essence starts to release essence from solid phase to liquid-phase conversion, can control slow during aspirating cigarette
On The Drug Release essence；Meanwhile the supramolecular materials in matrix can play certain protection to fragrance solution, not aspirate cigarette
In the case of, its release time can be extended, and increase the holding time of cool feeling cigarette, there is cool feeling cigarette all in two years
Cool feeling；
(3) solvent that the present invention uses is water and ethyl alcohol, is edible solvent, safer.
Mouth stick prepared by the present invention had both had the release performance of more longlasting cool feeling essence, can be adapted for needing longer guarantor
The cigarette of time is deposited, can also make cigarette in entire aspiration procedure, to the end from first, it may have uniform cool feeling, from
And the comfort of smoking cigarettes is improved, reduce harm of the cigarette to human health.
Specific embodiment
The method of the present invention is described in further detail below with reference to specific embodiment.
Embodiment 1
A kind of preparation method of the cigarette mouth stick with intermingling material controlled release cool feeling essence, it is characterised in that specific steps are such as
Under:
(1) hydroxypropyl cyclodextrin for weighing 100g is added by weight the ratio ratio of 1:5 (hydroxypropyl cyclodextrin: water)
500g water, stirring is completely dissolved to supramolecular materials hydroxypropyl cyclodextrin under the conditions of 30 DEG C reaches clear state, obtains
Supramolecular materials solution；
(2) polyethylene glycol that 100g molecular weight is 5000 is weighed, (polyethylene glycol: 95% ethyl alcohol is water-soluble by weight 1:4
Liquid) ratio the ethanol water of 400g mass fraction 95% is added, stirring is completely dissolved to polyethylene glycol under the conditions of 30 DEG C
Obtain temperature-sensitive macromolecular solution；
(3) 100g is weighed respectively according to the ratio of supramolecular materials solution and the weight ratio 1:2 of temperature-sensitive macromolecular solution
The temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and 200g step (2) prepared in step (1), by supermolecule material
Material solution is put into container, is stirred under the conditions of 30 DEG C by the revolving speed of 100rpm, is added dropwise and is weighed dropwise in whipping process
Whole temperature-sensitive macromolecular solution, until mixed liquor reaches clear state；
(4) by the clear transparent solutions after stirring in step (3), ultrasonic power is 150W/L, supersonic frequency is
Ultrasonic homogenation handles 30min under conditions of 20kHz, obtains matrix solution；
(5) the cool feeling essence of 100g is weighed, the cool feeling essence is by peppermint oil, menthol and menthones according to 1:8:1
Weight ratio be formulated, in the ratio of cool feeling essence and ethanol water weight ratio 1:10 addition 1kg mass fraction 70%
Ethanol water, stirring are completely dissolved up to cool feeling essence, obtain cool feeling fragrance solution；
(6) it is weighed by weight the ratio of 1:8 in the cool feeling fragrance solution and 400g step (4) prepared in 50g step (5)
Whole matrix solutions are put into container by the matrix solution of preparation, under the conditions of 30 DEG C, are stirred directly according to 200rpm revolving speed
It is completely dissolved to material, weighed whole cool feeling fragrance solutions is added dropwise in whipping process dropwise, reach clear state；
It (7) is 150-250W/L, supersonic frequency in ultrasonic power by the clear transparent solutions after stirring in step (6)
Ultrasonic homogenation handles 30-120min under conditions of rate is 20-25kHz, obtains Thermo-sensitive supermolecule controlled release cool feeling essence；
(8) by ultrasonic homogenation in step (7), treated that Thermo-sensitive supermolecule controlled release cool feeling essence is molding in mouth stick
It is applied on tow by perfuming device in the process, the dripping quantity of every mouth stick is 2 microlitres, just obtains this hair after the molding of mouth stick
The bright cigarette mouth stick with intermingling material controlled release cool feeling essence.
Embodiment 2
A kind of preparation method of the cigarette mouth stick with intermingling material controlled release cool feeling essence, it is characterised in that specific steps are such as
Under:
(1) Amino Porphyrins for weighing 100g add by weight the ratio of 1:10 (Amino Porphyrins: 20% ethanol water)
The ethanol water for entering 1kg mass fraction 20%, stirring is completely dissolved to supramolecular materials under the conditions of 40 DEG C reaches clarification thoroughly
Bright state obtains supramolecular materials solution；
(2) the polyvinyl isobutyl phthalein amine that 100g molecular weight is 10000 is weighed, by weight 1:10 (polyvinyl isobutyl
Phthalein amine: 50% ethanol water) ethanol water of 1kg 50% is added, stirring is to until material is complete under the conditions of 40 DEG C
Dissolution, obtains temperature-sensitive macromolecular solution；
(3) 100g step is weighed according to the ratio of supramolecular materials solution and the weight ratio 1:5 of temperature-sensitive macromolecular solution
(1) the temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and 500g step (2) prepared in, supramolecular materials are molten
Liquid is put into container, is stirred under the conditions of 40 DEG C according to the revolving speed of 200rpm, is added dropwise dropwise in whipping process weighed
Whole temperature-sensitive macromolecular solution, until mixed liquor reaches clear state；
(4) by the clear transparent solutions after stirring in step (3), ultrasonic power is 200W/L, supersonic frequency is
Ultrasonic homogenation handles 60min under conditions of 25kHz, obtains matrix solution；
(5) the cool feeling essence of 100g is weighed, the cool feeling essence is by menthol, Cineole, spearmint, eucalyptus oil, dragon
Brain is formed according to the weight ratio mixed preparing of 5:2:1.5:1.5, water-soluble by cool feeling essence and the ethyl alcohol of mass fraction 50%-95%
The ethanol water of the ratio addition 1kg mass fraction 50%-95% of liquid weight ratio 1:10, stirring is until cool feeling essence is completely molten
Solution, obtains cool feeling fragrance solution；
(6) the cool feeling fragrance solution prepared in 100g step (5) and 600g step (4) are weighed by weight the ratio of 1:6
Whole matrix solutions are put into container by the matrix solution of middle preparation, are stirred directly under the conditions of 40 DEG C according to the revolving speed of 300rpm
It is completely dissolved to material, weighed cool feeling fragrance solution is added dropwise in whipping process dropwise, reaches clear state；
(7) by the clear transparent solutions after stirring in step (6), ultrasonic power is 200W/L, supersonic frequency is
Ultrasonic homogenation handles 60min under conditions of 25kHz, obtains Thermo-sensitive supermolecule controlled release cool feeling essence.
(8) first that the Thermo-sensitive supermolecule intermingling material controlled release cool feeling prepared in step (7) is fragrant before being applied to tow
Essence and triacetyl glycerine weigh the Thermo-sensitive supermolecule control prepared in 100g step (4) by weight the ratio of 1:10 respectively
Menthol and 1kg triacetyl glycerine are released, is mixed and stirred for reaching uniform state to mixed liquor, on conventional mouth stick molding equipment
It carries out in mouth stick forming process, will directly be added with the triacetyl glycerine of Thermo-sensitive supermolecule intermingling material controlled release cool feeling essence
Solution is added on tow, obtains the cigarette mouth of the present invention with intermingling material controlled release cool feeling essence after the molding of mouth stick
Stick.
Embodiment 3
A kind of preparation method of the cigarette mouth stick with intermingling material controlled release cool feeling essence, it is characterised in that specific steps are such as
Under:
(1) the calixarenes sodium sulfonate for weighing 100g, by the weight ratio of 1:15, (calixarenes sodium sulfonate: 60% ethyl alcohol is water-soluble
Liquid) ethanol water that 1.5kg mass fraction is 60% is added, stirring to supramolecular materials are completely dissolved under the conditions of 50 DEG C,
Obtain supramolecular materials solution；
(2) poloxamer that 200g molecular weight is 8000 is weighed, by weight the ratio of 1:12 (poloxamer: aqueous solution)
Be added 2.4kg aqueous solution, under the conditions of 50 DEG C stirring until material be completely dissolved, obtain temperature-sensitive macromolecular solution；
(3) 100g step is weighed according to the ratio of supramolecular materials solution and the weight ratio 1:8 of temperature-sensitive macromolecular solution
(1) the temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and 800g step (2) prepared in, supramolecular materials are molten
Liquid is put into container, is stirred under the conditions of 50 DEG C according to the revolving speed of 400rpm, is added dropwise dropwise in whipping process weighed
Whole temperature-sensitive macromolecular solution, until mixed liquor reaches clear state；
(4) by the clear transparent solutions after stirring in step (3), ultrasonic power is 250W/L, supersonic frequency is
Ultrasonic homogenation handles 100min under conditions of 25kHz, obtains matrix solution；
(5) menthol for weighing 100g is added by weight the ratio of 1:15 (menthol: 70% ethanol water)
The ethanol water of 1.5kg mass fraction 70% obtains menthol solutions until menthol is completely dissolved；
(6) ratio by weight 1:10 (menthol solutions: matrix solution) weighs the peppermint prepared in 100g step (5)
The matrix solution prepared in alcoholic solution and 1kg step (4), whole matrix solutions are put into container, under the conditions of 50 DEG C according to
The revolving speed stirring of 400rpm is completely dissolved up to material, and weighed menthol solutions are added dropwise in whipping process dropwise, reach clarification
Pellucidity；
(7) by the clear transparent solutions after stirring in step (6), ultrasonic power is 250W/L, supersonic frequency is
Ultrasonic homogenation handles 100min under conditions of 25kHz, obtains Thermo-sensitive supermolecule controlled release menthol.
(8) by treated the Thermo-sensitive supermolecule controlled release menthol of ultrasonic homogenation in step (7) in the molding mistake of mouth stick
It is applied on tow in journey by perfuming device, the dripping quantity of every mouth stick is 8 microlitres, just obtains the present invention after the molding of mouth stick
The cigarette mouth stick with intermingling material controlled release menthol.
Embodiment 4
A kind of preparation method of the cigarette mouth stick with intermingling material controlled release cool feeling essence, it is characterised in that specific steps are such as
Under:
(1) crown ether -6 supramolecular materials 18- for weighing 100g, by weight the 1:20 (ethanol water of 18- crown ether -6:50%
Solution) ratio be added 2kg mass fraction 50% ethanol water, under the conditions of 60 DEG C stirring until material be completely dissolved,
Obtain supramolecular materials solution；
(2) weigh 100g molecular weight be 15000 polyvinylpyrrolidone, by weight 1:20 (polyvinylpyrrolidone:
50% ethanol water) ratio be added 2kg mass fraction be 50% ethanol water, under the conditions of 60 DEG C stirring until
Material is completely dissolved, and obtains temperature-sensitive macromolecular solution；
(3) 200g step is weighed according to the ratio of supramolecular materials solution and the weight ratio 1:8 of temperature-sensitive macromolecular solution
(1) the temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and 1.6kg step (2) prepared in, by supramolecular materials
Solution is put into container, is stirred under the conditions of 60 DEG C according to the revolving speed of 500rpm, is added dropwise and is weighed dropwise in whipping process
Whole temperature-sensitive macromolecular solution, until mixed liquor reaches clear state；
(4) by the clear transparent solutions after stirring in step (3), ultrasonic power is 250W/L, supersonic frequency is
Ultrasonic homogenation handles 120min under conditions of 25kHz, obtains matrix solution；
(5) borneol for weighing 100g is added in the ratio of borneol and the ethanol water weight ratio 1:20 of mass fraction 95%
Add the ethanol water of 2kg mass fraction 95%, stirring is completely dissolved up to borneol, obtains borneol solution；
(6) it is molten to weigh the borneol prepared in 50g step (5) for the ratio by weight 1:20 (borneol solution: matrix solution)
The matrix solution prepared in liquid and 1kg step (4), whole matrix solutions are put into container and are carried out, under the conditions of 60 DEG C according to
The revolving speed of 500rpm stirs, and weighed borneol solution is added dropwise dropwise in whipping process, reaches clear state；
(7) by the clear transparent solutions after stirring in step (6), ultrasonic power is 250W/L, supersonic frequency is
Ultrasonic homogenation handles 120min under conditions of 25kHz, obtains Thermo-sensitive supermolecule controlled release borneol；
(8) by treated the Thermo-sensitive supermolecule controlled release borneol of ultrasonic homogenation in step (7) in the molding process of mouth stick
In be applied on tow by perfuming device, the dripping quantity of every mouth stick is 15 microlitres, just obtains the present invention after the molding of mouth stick
The cigarette mouth stick with intermingling material controlled release borneol.
Embodiment 5
A kind of preparation method of the cigarette mouth stick with intermingling material controlled release cool feeling essence, it is characterised in that specific steps are such as
Under:
(1) supramolecular materials of 100g are weighed, the supramolecular materials are hydroxypropyl cyclodextrin, Amino Porphyrins, sulfonic acid porphin
Quinoline, calixarenes sodium sulfonate are formed according to the weight ratio mixed preparing of 6:2:1:1, by 1:20 weight ratio (supramolecular materials:
60% ethanol water, weight ratio) ethanol water that 1.5kg mass fraction is 60% is added, it is stirred under the conditions of 40 DEG C
It is completely dissolved to supramolecular materials, obtains supramolecular materials solution；
(2) temperature sensing material of 200g is weighed, the temperature sensing material is by poloxamer, polyethylene glycol, polyvinylpyrrolidine
Ketone is formed according to the weight ratio mixed preparing of 2:5:3, and 2.4kg is added by weight the ratio of 1:12 (temperature sensing material: aqueous solution)
Aqueous solution, under the conditions of 40 DEG C stirring until material be completely dissolved, obtain temperature-sensitive macromolecular solution；
(3) 200g step is weighed according to the ratio of supramolecular materials solution and the weight ratio 1:10 of temperature-sensitive macromolecular solution
(1) the temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and 2kg step (2) prepared in, supramolecular materials are molten
Liquid is put into container, is stirred under the conditions of 40 DEG C according to the revolving speed of 400rpm, is added dropwise dropwise in whipping process weighed
Whole temperature-sensitive macromolecular solution, until mixed liquor reaches clear state；
(4) by the clear transparent solutions after stirring in step (3), ultrasonic power is 250W/L, supersonic frequency is
Ultrasonic homogenation handles 100min under conditions of 25kHz, obtains matrix solution；
(5) menthol for weighing 100g is added by weight the ratio of 1:15 (menthol: 70% ethanol water)
The ethanol water of 1.5kg mass fraction 70% obtains menthol solutions until menthol is completely dissolved；
(6) ratio by weight 1:10 (menthol solutions: matrix solution) weighs the peppermint prepared in 100g step (5)
The matrix solution prepared in alcoholic solution and 1kg step (4), whole matrix solutions are put into container, under the conditions of 40 DEG C according to
The revolving speed stirring of 400rpm is completely dissolved up to material, and weighed menthol solutions are added dropwise in whipping process dropwise, reach clarification
Pellucidity；
(7) by the clear transparent solutions after stirring in step (6), ultrasonic power is 250W/L, supersonic frequency is
Ultrasonic homogenation handles 100min under conditions of 25kHz, obtains Thermo-sensitive supermolecule controlled release menthol；
(8) by treated the Thermo-sensitive supermolecule controlled release menthol of ultrasonic homogenation in step (7) in the molding mistake of mouth stick
It is applied on tow in journey by perfuming device, the dripping quantity of every mouth stick is 8 microlitres, just obtains the present invention after the molding of mouth stick
The cigarette mouth stick with intermingling material controlled release menthol.
It needs to add on conventional mouth stick molding equipment in embodiment one, embodiment three, example IV and embodiment five
The cool feeling essence dripping quantity of flavoring equipment, every mouth stick of control reaches requirement.It is set in embodiment two using conventional mouth stick molding
Standby direct flavoring.
Claims (2)
1. a kind of preparation method of the cigarette mouth stick of intermingling material controlled release cool feeling essence, it is characterised in that specific step is as follows:
(1) supramolecular materials for weighing constant weight add the ethanol water of mass fraction 0%-95% into supramolecular materials,
Stirring is completely dissolved to supramolecular materials under the conditions of 30-60 DEG C reaches clear state, obtains supramolecular materials solution,
The weight ratio of the ethanol water of middle supramolecular materials and mass fraction 0%-95% is 1:0.5-1:30, and the supramolecular materials are
Amino Porphyrins, porphyrin sulfonate, calixarenes sodium sulfonate, p-sulfonic acid base benzeneazo calixarenes, the one or more of of 18- crown ether -6 mix
It closes；
(2) high molecular material with temperature sensitivity for weighing constant weight, to the high molecular material with temperature sensitivity
The ethanol water of middle addition mass fraction 0%-95%, stirring is completely dissolved to obtain to high molecular material under the conditions of 30-60 DEG C
Temperature-sensitive macromolecular solution；The weight ratio of the ethanol water of its mesostroma and mass fraction 0%-95% is 1:0.5-1:30, institute
Stating the high molecular material with temperature sensitivity is polyethylene glycol, polyvinyl isobutyl phthalein amine, polyethylene glycol oxide ether, poly- isopropyl
One or more of mixing of propylene phthalein amine；
(3) step (1) is weighed according to the ratio of supramolecular materials solution and the weight ratio 1:0.1-10 of temperature-sensitive macromolecular solution
The temperature-sensitive macromolecular solution prepared in the supramolecular materials solution and step (2) of middle preparation, supramolecular materials solution is put into
It is stirred in container, and weighed whole temperature-sensitive macromolecular solution is added dropwise dropwise in whipping process, until mixed liquor reaches
To clear state；
(4) by the clear transparent solutions after stirring in step (3), ultrasonic power is 150-250W/L, supersonic frequency is
Ultrasonic homogenation handles 30-120min under conditions of 20-25kHz, obtains matrix solution；
(5) the cool feeling essence for weighing constant weight, by the ethanol water weight ratio 1 of cool feeling essence and mass fraction 50%-95%:
The ethanol water of the ratio addition mass fraction 50%-95% of 0.5-1:30, stirring are completely dissolved up to cool feeling essence, obtain cool
Feel fragrance solution；The cool feeling essence is peppermint oil, menthol, menthones, isomenthone, Cineole, thio Cineole, stays orchid
One or more of mixing of perfume, eucalyptus oil, borneol, carvacrol；
(6) preparation in the cool feeling fragrance solution prepared in step (5) and step (4) is weighed by weight the ratio of 1:0.5-1:30
Matrix solution, whole matrix solutions are put into container and are stirred, and it is fragrant that weighed cool feeling is added dropwise in whipping process dropwise
Smart solution reaches clear state；
(7) by the clear transparent solutions after stirring in step (6), ultrasonic power is 150-250W/L, supersonic frequency is
Ultrasonic homogenation handles 30-120min under conditions of 20-25kHz, obtains Thermo-sensitive supermolecule intermingling material controlled release cool feeling essence；
(8) the Thermo-sensitive supermolecule intermingling material controlled release cool feeling essence that will be prepared in step (7), passes through before being applied to tow
It adds perfuming device on conventional mouth stick molding equipment to be uniformly added on tow, the perfuming device is by flavoring roller and essence
Box composition, essence box are placed in below flavoring roller, and flavoring roller is mounted on the roller of conventional mouth stick molding equipment addition triacetyl glycerine
On rear side of axis, Thermo-sensitive supermolecule intermingling material controlled release cool feeling essence is placed in essence box, adds triacetyl glycerine in tow
Later, it is transmitted on flavoring roller, the lower part of flavoring roller is immersed in essence box, during rotation by Thermo-sensitive supermolecule
Intermingling material controlled release cool feeling essence is added on tow, and the dripping quantity of every mouth stick is 2-20 microlitres, is total to after the molding of mouth stick
The cigarette mouth stick of mixed material controlled release cool feeling essence.
2. a kind of preparation method of the cigarette of intermingling material controlled release cool feeling essence according to claim 1 with mouth stick, feature
Be: the stirring condition in the step (3) and step (6) is 30-60 DEG C of temperature, mixing speed 100-500rpm.
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| CN1672600A (en) * | 2005-04-19 | 2005-09-28 | 张鹰 | Delayed releasing mint filter tip for cigarette and its production process |
| CN101390657A (en) * | 2007-09-21 | 2009-03-25 | 武汉烟草(集团)有限公司 | Cigarette filter tip rod capable of sustained releasing mint and production technique thereof |
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