CN107233217A - A kind of lyophilized formulations containing surfactant and its wash shield product - Google Patents
A kind of lyophilized formulations containing surfactant and its wash shield product Download PDFInfo
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- CN107233217A CN107233217A CN201610180366.0A CN201610180366A CN107233217A CN 107233217 A CN107233217 A CN 107233217A CN 201610180366 A CN201610180366 A CN 201610180366A CN 107233217 A CN107233217 A CN 107233217A
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- lyophilized formulations
- binding agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
Abstract
The present invention relates to a kind of lyophilized formulations containing surfactant and its shield product is washed, especially a kind of lyophilized formulations product being made up of binding agent and surfactant, and can be applied to wash protector for collar domain.
Description
Technical field
The present invention relates to a kind of lyophilized formulations containing surfactant and its shield product is washed, especially one kind is by binding agent and surfactant
The lyophilized formulations product of composition, and can be applied to wash protector for collar domain.
Background technology
Lyophilized figuration technology refers to addition skeleton supporting agent and binding agent in the active component of flowable liquid, semisolid or solid,
Or itself contains binding agent and skeleton supporting agent in the flowable liquid, semisolid or solid, is then filled into mould,
The technology for being able to be molded by freeze drying process, the preparation prepared by freezing figuration technology is referred to as lyophilized excipient.
Because such preparation uses freeze drying process, thermally sensitive composition can be protected not to be destroyed, while being produced by water sublimed a large amount of
Micropore and duct, can have disintegration and dissolution velocity quickly, therefore receive extensive use, can apply to oral disnitegration tablet, speed
Release the multiple fields such as piece, chewable tablets, novel cosmetic, health food, solid beverage, medical dressing.
The content of the invention
The invention provides the lyophilized formulations containing surfactant and its shield product is washed, the product is made up of surfactant and binding agent,
Wherein surfactant is than binding agent：Surfactant：Binding agent=1:1000 to 100:1.
The weight proportion of surfactant and binding agent can further preferably 1:900 to 900:1,1:800 to 800:1,1:700 to
700:1,1:600 to 600:1,1:500 to 500:1,1:400 to 400:1,1:300 to 300:1, more preferably 1:200 to 200:1,
1:100 to 100:1,1:90 to 90:1,1:80 to 80:1,1:70 to 70:1, most preferably 1：60 to 60:1,1:50 to 50:1.
The surfactant of the lyophilized formulations be nonionic surface active agent, anion surfactant, cationic surfactant and
One or more combinations in zwitterionic surfactant.
The nonionic surface active agent is natural surfactant, Determination of Polyoxyethylene Non-ionic Surfactants and polyol type nonionic
One or more combinations in surfactant；Wherein described natural surfactant is to have surface from animals and plants or derivatives thereof
The material of living property, including sapindoside, soapberry extract, Fructus Gleditsiae Abnormalis extract, lanolin, lecithin, Tea Saponin, cholesteric
Alcohol, alkyl polyglycoside, mucoprotein, phosvitin, lipoprotein, triterpenoid saponin, steroid saponin, carrageenan, alginic acid, cyclodextrin,
One or more combinations in fatty acid mono glycidol, konjaku powder.
Described binding agent be glue class, cellulose ethers, modified starch series, PVP, carbomer, PVA, hyalomitome acids, albumin,
Chitosan, dextran, agar, polyaminoacid, glycan or combinations thereof.
Described glue class binding agent is collagen, gelatin, gelatin hydrolysate, Arabic gum, xanthans, carragheen, pectin, konjac glucomannan, angle
Pitch dish glue, locust bean gum, natural gum, locust bean gum；Described cellulose ethers binding agent is carboxymethyl cellulose, carboxyethyl cellulose, hydroxyl
Ethylmethylcellulose, hydroxypropyl methyl cellulose；Described modified starch series binding agent is selected from pulullan, hydroxypropul starch, hydroxypropyl
Ylmethyl starch, pregelatinized starch, amylose, CMS, HES, hydroxypropul starch etc.；Described polyaminoacid
Selected from polyglutamic acid, polyalanine, polylysine etc.；Affiliated glycan is selected from fucoidin, synanthrin etc..
Described lyophilized formulations, can also further add active component, include but is not limited to the chemicals of human body and animal health into
Point, traditional Chinese medicine ingredients, natural extract, bioactive ingredients, biological products, disinfectant, nutritious supplementary pharmaceutical and have to skin nursing
One or more kinds of combinations in beneficial composition.
Described lyophilized formulations, also containing other auxiliary materials, other auxiliary materials are antioxidant, flavouring and essence, Transdermal absorption promotion
One or more in agent, PH conditioning agents.
The one kind or number of described antioxidant in vitamin C, anthocyanidin, resveratrol, the polyhydric phenols of plant origin
The mixture planted；The flavouring and essence be selected from mint flavored, chocolate flavoured, vanilla flavored, caf, tea flavour, corn taste, lemon,
The mixture of essence such as milk flavor or more one or more fragrance；Described skin penetration enhancer is in lecithin, tween, sapn
Any or several mixture；Described PH conditioning agents are selected from any one of citric acid, tartaric acid, sodium acid carbonate, sodium carbonate
Or several mixtures.
Its mode of production of lyophilized formulations containing surfactant, includes direct sessile drop method, lyophilized figuration method, three kinds of modes of pressing.
The mode of production of wherein direct sessile drop method, comprises the following steps：
A) by the solution or suspension of the formation of water, binding agent, surfactant and other auxiliary materials, constant volume, degassing；
B) quantitative filling pump is used, internally temperature is in the nacelle below solution eutectic point and instiled, and makes to freeze rapidly during its dropping liquid；
C) frozen solution is freeze-dried, obtains including the lyophilized formulations of surfactant.
The mode of production for wherein freezing figuration method comprises the following steps：
A) by the solution or suspension of the formation of water, binding agent, surfactant and other auxiliary materials, constant volume；
B) quantitative filling pump is used, will a) be injected into quantitative mould, be de-gassed；
C) will b) be freeze-dried, and remove solvent, obtain including the lyophilized formulations of surfactant, and lyophilized formulations can with break away from moulds,
Dress is wrapped inside.
Wherein the mode of production of pressing, comprises the following steps：
A) configuration of water, binding agent, surfactant and other auxiliary materials or part are configured to solution or suspension, constant volume；
B) it will a) freeze and physical crushing be into ice particle or ice powder；
C) will to be formulated remaining supplementary material dry-mixed；
D) it will b) and c) carry out being sufficiently mixed progress being fitted into quantitative mould and suppressed；
E) it will e) be freeze-dried, remove solvent, obtain lyophilized formulations.
The lyophilized formulations containing surfactant can be used alone, and can also be used cooperatively with conventional shield product of washing.
Embodiment
The present invention is further illustrated by the following examples, but the present invention is not restricted to this.
Embodiment 1：
By 3g soapberry extracts, 2g Fructus Gleditsiae Abnormalis extracts, 5% mixed solution, deaeration, constant volume are configured to；Mixed solution is freezed simultaneously
Using pulverizer physical crushing into ice particle or ice powder；After being well mixed with 1g Sodium Hyaluronates, progress is fitted into quantitative mould, is pressed
Spheroidal is made；It is freeze-dried, removes solvent, obtain hair washing lyophilized formulations.
In use, hair is thoroughly drenched, once used amount lyophilized excipient is taken out as the palm of the hand, is added 10ml or so water and is rubbed dissolving,
The hair for being applied to moistening is used.
Example 2：
2g lanolin is configured to 3% solution, constant volume；Using quantitative filling pump, solution is injected into quantitative mould, carried out
Degassing；It is freeze-dried under -196 DEG C of environment, removes solvent, obtains wrapping lanolated lyophilized formulations, and lyophilized formulations can be with
Break away from moulds, is wrapped inside dress.
In use, once used amount lyophilized excipient is uniformly dissolved using toner, skin surface is applied to.
Example 3：
1g ascorbic acid, 3g trehaloses, 2g lanolin are configured to 2% mixed solution, constant volume, degassing；Using quantitative filling pump,
Internally temperature is in the nacelle below solution eutectic point and instiled, and makes to freeze rapidly during its dropping liquid；Frozen mixed solution is entered
- 196 DEG C of freeze-dryings of row, obtain including the lyophilized formulations of surfactant.
In use, once used amount lyophilized excipient is uniformly sprinkling upon into moistening facial mask surface, gently rub, excipient preparation to be freezed is completely molten
Xie Hou, is removed after facial mask is spread on into facial 20min.
Example 4：
5g sodium glutamates, 1g white pond lily flower extracts are configured to 3% mixed solution, constant volume, degassing；Using quantitative filling pump,
Internal temperature is in the nacelle below solution eutectic point and instiled, and makes to freeze rapidly during its dropping liquid；Frozen mixed solution is carried out
- 196 DEG C of freeze-dryings, obtain including the lyophilized formulations of surfactant.
In use, extrusion mildy wash, once used amount lyophilized excipient is uniformly sprinkling upon on mildy wash, gently rubbed, excipient system to be freezed
After agent is completely dissolved, it is applied to face and rubs to foaming and rinsed with clear water.
Example 5：
2g sodium lauroyl glutamates, 1g Sodium Hyaluronates, 5g Propirams are configured to 4% mixed solution, constant volume；Use quantitative filling
Pump, mixed solution is injected into quantitative mould, is de-gassed；It is freeze-dried, removes solvent, obtains including surface-active
The lyophilized formulations of agent, and dress can be wrapped inside with break away from moulds in lyophilized formulations.
In use, taking out once used amount lyophilized excipient is placed in the palm of the hand, dissolved, rubbed to abundant dissolving using suitable quantity of water, it is uniform to apply
Smear and rinsed in face to after bubbling with clear water.
Example 6：
Prepare phytosterol：Tween-80=3:2 mixed solution, constant volume；Mixed solution is freezed and physical crushing is into ice particle or ice powder；
Progress be sufficiently mixed progress be fitted into quantitative mould carry out be pressed into petal shape；It is freeze-dried, removes solvent, obtain lyophilized formulations.
In use, taking out once used amount lyophilized excipient is placed in the palm of the hand, dissolved, rubbed to abundant dissolving using appropriate eye make-up remover,
Uniformly it is applied near the eyes, is rinsed well after massage using clear water.
The occupation mode of the present invention is not limited to form cited in embodiment, and embodiment is only presently preferred embodiments of the present invention, no
Protection domain can be limited with this.All simple or equivalent changes and modification with described in scope of the presently claimed invention, come under this hair
Bright protection domain.
Claims (13)
1. a kind of lyophilized formulations containing surfactant and its wash shield product, it is characterised in that the product by being constituted with surfactant and binding agent,
Wherein surfactant is than binding agent：Surfactant：Binding agent=1:1000 to 100:1.
2. the lyophilized formulations described in claim 1, it is characterised in that the surfactant is nonionic surface active agent, anion surface active
One or more combinations in agent, cationic surfactant and zwitterionic surfactant.
3. the lyophilized formulations described in claim 1,2, it is characterised in that the nonionic surface active agent is natural surfactant, polyoxyethylene
One or more combinations in type nonionic surfactant and polyol-based non-ionic surfactant；Wherein described natural surfactant is source
In the material with surface-active property of animals and plants or derivatives thereof, including sapindoside, soapberry extract, Fructus Gleditsiae Abnormalis extract, lanolin,
Lecithin, Tea Saponin, cholesterine, alkyl polyglycoside, mucoprotein, phosvitin, lipoprotein, triterpenoid saponin, steroid saponin, carrageenan,
One or more combinations in alginic acid, cyclodextrin, fatty acid mono glycidol, konjaku powder.
4. the lyophilized formulations described in claim 1-3, it is characterised in that described binding agent be glue class, cellulose ethers, modified starch series, PVP,
Carbomer, PVA, hyalomitome acids, albumin, chitosan, dextran, agar, polyaminoacid, glycan or combinations thereof.
5. the lyophilized formulations described in claim 1-4, it is characterised in that described glue class binding agent be collagen, gelatin, gelatin hydrolysate, Arabic gum,
Xanthans, carragheen, pectin, konjac glucomannan, carrageenan, locust bean gum, natural gum, locust bean gum；Described cellulose ethers binding agent is carboxylic first
Base cellulose, carboxyethyl cellulose, hydroxyethylmethylcellulose, hydroxypropyl methyl cellulose；Described modified starch series binding agent is selected from Propiram
Sugar, hydroxypropul starch, hydroxypropyl methyl starch, pregelatinized starch, amylose, CMS, HES, hydroxypropul starch etc.；
Described polyaminoacid is selected from polyglutamic acid, polyalanine, polylysine etc.；Affiliated glycan is selected from fucoidin, synanthrin etc..
6. the lyophilized formulations described in claim 1-5, it is characterised in that it can also further add active component, include but is not limited to human body and
Chemicals composition, traditional Chinese medicine ingredients, natural extract, bioactive ingredients, biological products, disinfectant, the nutritious supplementary pharmaceutical of animal health
With to one or more kinds of combinations in skin nursing beneficiating ingredient.
7. the lyophilized formulations described in claim 1-6, it is characterised in that it also contains other auxiliary materials, other auxiliary materials are antioxidant, flavouring
And the one or more in essence, skin penetration enhancer, PH conditioning agents.
8. the lyophilized formulations described in claim 1-7, it is characterised in that described antioxidant, which is selected from vitamin C, anthocyanidin, resveratrol, plant, to be come
One or several kinds of mixtures in the polyhydric phenols in source；The flavouring and essence are selected from mint flavored, chocolate flavoured, vanilla flavored, coffee
The mixture of essence such as taste, tea flavour, corn taste, lemon, milk flavor or more one or more fragrance；Described skin penetration enhancer is selected from
Any of lecithin, tween, sapn or several mixtures；Described PH conditioning agents are selected from citric acid, tartaric acid, sodium acid carbonate, carbon
Any one of sour sodium or several mixtures.
9. the lyophilized formulations described in claim 1-8, it is characterised in that the mode of production, include direct sessile drop method, lyophilized figuration method, three kinds of sides of pressing
Formula.
10. the mode of production of the direct sessile drop method described in claim 9, it is characterised in that comprise the following steps：
A) by the solution or suspension of the formation of water, binding agent, surfactant and other auxiliary materials, constant volume, degassing；
B) quantitative filling pump is used, internally temperature is in the nacelle below solution eutectic point and instiled, and makes to freeze rapidly during its dropping liquid；
C) frozen solution is freeze-dried, obtains including the lyophilized formulations of surfactant.
11. the mode of production of the lyophilized figuration method described in claim 9, it is characterised in that comprise the following steps：
A) by the solution or suspension of the formation of water, binding agent, surfactant and other auxiliary materials, constant volume；
B) quantitative filling pump is used, will a) be injected into quantitative mould, be de-gassed；
C) it will b) be freeze-dried, remove solvent, obtain including the lyophilized formulations of surfactant, and dress can be wrapped inside with break away from moulds in lyophilized formulations.
12. the mode of production of the pressing described in claim 9, it is characterised in that comprise the following steps：
A) configuration of water, binding agent, surfactant and other auxiliary materials or part are configured to solution or suspension, constant volume；
B) it will a) freeze and physical crushing be into ice particle or ice powder；
C) will to be formulated remaining supplementary material dry-mixed；
D) it will b) and c) carry out being sufficiently mixed in the progress loading amount of ordering mould being suppressed；
E) it will e) be freeze-dried, remove solvent, obtain lyophilized formulations.
13. wash shield product described in claim 1-12, it is characterised in that the lyophilized formulations containing surfactant can be used alone, and also may be used
To be used cooperatively with conventional shield product of washing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610180366.0A CN107233217A (en) | 2016-03-25 | 2016-03-25 | A kind of lyophilized formulations containing surfactant and its wash shield product |
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| CN201610180366.0A CN107233217A (en) | 2016-03-25 | 2016-03-25 | A kind of lyophilized formulations containing surfactant and its wash shield product |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019073362A1 (en) * | 2017-10-12 | 2019-04-18 | Solyplus Berlin Gmbh | Methods of fabrication of concentrated and homogeneously wetted massive polymers and applications thereof |
| WO2020186747A1 (en) * | 2019-03-21 | 2020-09-24 | 李和伟 | Freeze-dried formulation, preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340079A (en) * | 1999-02-10 | 2002-03-13 | 苏韦拉克皮肤和健康护理股份公司 | Freeze-dried agent containing paramylon, production and utilization thereof |
| CN1473562A (en) * | 2003-06-27 | 2004-02-11 | 辉 刘 | Mouth cavity quick dissolving quick disintegrating freeze-dried tablet and its preparing method |
| CN101010067A (en) * | 2004-07-29 | 2007-08-01 | 塞弗伦法国公司 | Modafinil oral lyophilizate |
| CN102869363A (en) * | 2010-01-15 | 2013-01-09 | 利赛拉公司 | Lyophilized cake formulations |
| CN103893133A (en) * | 2012-12-26 | 2014-07-02 | 李和伟 | Formula and preparing method of freeze-dried excipient preparation |
| CN103961283A (en) * | 2014-04-04 | 2014-08-06 | 广州舒泰生物技术有限公司 | Acne-repairing freeze-drying preparation as well as preparation and application thereof |
| CN104208029A (en) * | 2013-05-30 | 2014-12-17 | 上海医药工业研究院 | Vaccine composition powder preparation used for nose and preparation method thereof |
-
2016
- 2016-03-25 CN CN201610180366.0A patent/CN107233217A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340079A (en) * | 1999-02-10 | 2002-03-13 | 苏韦拉克皮肤和健康护理股份公司 | Freeze-dried agent containing paramylon, production and utilization thereof |
| CN1473562A (en) * | 2003-06-27 | 2004-02-11 | 辉 刘 | Mouth cavity quick dissolving quick disintegrating freeze-dried tablet and its preparing method |
| CN101010067A (en) * | 2004-07-29 | 2007-08-01 | 塞弗伦法国公司 | Modafinil oral lyophilizate |
| CN102869363A (en) * | 2010-01-15 | 2013-01-09 | 利赛拉公司 | Lyophilized cake formulations |
| CN103893133A (en) * | 2012-12-26 | 2014-07-02 | 李和伟 | Formula and preparing method of freeze-dried excipient preparation |
| CN104208029A (en) * | 2013-05-30 | 2014-12-17 | 上海医药工业研究院 | Vaccine composition powder preparation used for nose and preparation method thereof |
| CN103961283A (en) * | 2014-04-04 | 2014-08-06 | 广州舒泰生物技术有限公司 | Acne-repairing freeze-drying preparation as well as preparation and application thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019073362A1 (en) * | 2017-10-12 | 2019-04-18 | Solyplus Berlin Gmbh | Methods of fabrication of concentrated and homogeneously wetted massive polymers and applications thereof |
| WO2020186747A1 (en) * | 2019-03-21 | 2020-09-24 | 李和伟 | Freeze-dried formulation, preparation method and application thereof |
| JP2022526687A (en) * | 2019-03-21 | 2022-05-25 | 和偉 李 | Lyophilized preparation and its preparation method and application |
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