KR101326376B1 - Cosmetic Compositon Using Nano Capsule Containing Azelaic Acid And Skim Milk for Treating Acne Skin and Its Manufacturing Method Thereof - Google Patents

Abstract

According to the present invention, a method for preparing cosmetics for treating acne using nanocapsules of azelaic acid and skim milk powder is a step of freeze-drying a mixture composed of 15 to 25 parts by weight of azelaic acid and 75 to 85 parts by weight of skim milk powder (S110). ), Pulverizing the freeze-dried mixture in the step S110 with a nano grinding classifier (S120), extracting the nanopowder into the fluidized bed process, pre-drying and spraying the coating liquid at a predetermined fluidization pressure after pre-drying It characterized in that it comprises a step of coating the powder (S130).
According to the present invention, it is easy to penetrate into the skin to obtain the desired pharmacological effect at low concentration, and has excellent skin affinity, so that there is no side effect even when used daily, and it does not precipitate even when stored for a long time.

Description

Cosmetic Compositon Using Nano Capsule Containing Azelaic Acid And Skim Milk for Treating Acne Skin and Its Manufacturing Method Thereof}

The present invention relates to a cosmetic composition and a manufacturing method for treating acne, and to a cosmetic composition and a method for preparing acne treatment using nanocapsules formed by coating nanoparticles of azelaic acid and skim milk powder with corn protein.

The medical name of acne is vulgar acne, which increases the production of sebum in the pores, abnormally keratinizes the skin epithelial cells and blocks the openings of the pores, and is caused by the growth of acne-causing bacteria and inflammation.

Acne is a skin disease that occurs mainly in adolescents with secondary sexual maturity, and it is reported that about 80% occur between 11 and 30 years of age, and about 6% of patients are in their 30s and later. Acne may occur after 20s.

The causes of acne can be largely divided into three, the first is the production of sebum overproduction. Early acne is triggered by increased hormones during sexual maturation, especially testosterone is recognized as the most important hormone, which stimulates sebaceous glands to increase sebum production. Sebum is composed of triglycerol at initial secretion, but is gradually broken down into free fatty acids and glycerol by lipase, one of the extracellular enzymes of Propionibacterium acnes. 95% of the free fatty acids in the skin are caused by this bacterium and induce microvesicle formation and inflammatory reactions. The extracellular enzymes of propionibacterium acnes include lipase, protease, hyaluronidase, etc., which have an important effect on the progression of acne.

Second is the closure of the pores. The nipple is closed due to the hyperkeratosis of the skin affected by the free fatty acids and hormones produced by the action of propionibacterium acnes and the excessive secretion of sebum, thereby facilitating the propagation of the anaerobic bacterium propionibacterium acnes. do.

Third is the increase in the number of anaerobic bacteria, Propionibacterium acnes. When sebum accumulates as a white mass or as a bonded black mass of melanin, propionibacterium acnes increases.

The three factors mentioned above are the biggest factors causing acne, but other factors such as the action of neuroproteins due to stress, genetic factors, cosmetics, heat, moisture and ultraviolet rays that cause extinction are also related to the occurrence of acne.

On the other hand, the therapeutic agent for acne is divided into a topical treatment to be directly applied to lesions and a systemic treatment to take medicines. Local or systemic treatments are used singly or in combination according to the type of acne and each step. Topical treatments include synthetic vitamin A ointment, benzoyl peroxide, antibiotic ointment, steroid ointment, azelaic acid, and the like. Systemic treatments include oral antibiotics, hormones, and synthetic vitamin A preparations.

Recently, cosmetics that solve these acne have become popular. However, the materials such as salicylic acid, tricholic acid, retinol, nisin, etc. used in these cosmetics, although the raw material itself has excellent antibacterial effect, there are disadvantages in the formulation restrictions and effective application in cosmetic formulations. In order to improve this drawback, azelaic acid derivatives having a high acne treatment effect may be added to the formulation, but azelaic acid has many problems when used because of its structural properties when applied to cosmetic formulations. In other words, it has properties that are insoluble in water and oil, and when the microemulsion is made and dispersed, it is precipitated at low temperatures and skin irritation occurs when used at high concentrations.

Currently, products using azelaic acid are products made by dispersing in a polyhydric alcohol such as polyethylene glycol (PEG) and then preparing a microemulsion formulation. Because of their large particle size, these products often lead to precipitation during long-term storage, poor skin affinity, tingling and tingling, and even severe inflammation. In addition, there is a problem of low efficacy despite low concentration of absorption into the skin.

The present invention has been devised in view of the above point, and formulated a thermodynamic and kinetically stable azelaic acid water-dispersible nanoemulsion, which has excellent penetrating power even at low concentrations, and has excellent efficacy and good affinity for skin. It is an object of the present invention to provide a cosmetic composition and a method for preparing acne using nanocapsules.

Acne treatment cosmetic composition according to the present invention provided to achieve the above object is a mixture consisting of 15 to 25 parts by weight of azelaic acid, 75 to 85 parts by weight of skim milk powder after lyophilization and pulverized, the ground nanopowder corn It is characterized in that the nano-encapsulated by coating with a protein coating solution. Wherein the nanocapsule is preferably a size of 100 ~ 300nm.

In addition, the method for preparing a cosmetic treatment for acne using nanocapsules of azelaic acid and skim milk powder according to the present invention is a step of freeze-drying a mixture consisting of 15 to 25 parts by weight of azelaic acid and 75 to 85 parts by weight of skim milk powder at -70 ° C (S110). ); Extracting the nanopowder by pulverizing the mixture lyophilized in the step S110 with a nano grinding classifier (S120); And injecting the nanopowder into a fluidized bed process to pre-dry and spraying the coating liquid at a predetermined fluidization pressure to coat the nanopowder (S130).

Here, the nanopowder and the coating liquid in the step S130 may be a ratio of 1: 2.

In addition, the coating solution in the step S130 is preferably corn protein (10% Zein-DP).

In step S130, the nanopowder is pre-dried for 30 minutes at inlet air temperature 60 ℃, outlet air temperature 40 ℃, the fluidization pressure is preferably 0.4kg / ㎠.

In addition, the optimum conditions of the fluidized bed process in the step S130 is preferably inlet air temperature 67 ~ 73 ℃, spray rate 0.6 ~ 0.8 mL / min, spray pressure 1.8 ~ 2.0 Kg / ㎠.

According to the present invention, a cosmetic composition and a method for preparing acne using nanocapsules of azelaic acid and skim milk powder can be easily penetrated into the skin to obtain a desired pharmacological effect at low concentrations, and have excellent skin-affinity, and thus have side effects. It does not precipitate even when stored for a long time.

1 is a view showing the chemical structural formula of azelaic acid,
2 is a flowchart showing a method for preparing acne treatment cosmetic using nanocapsules of azelaic acid and skim milk powder according to an embodiment of the present invention;
3 is a view showing the intake air temperature, spraying rate, yield, particle size, elution rate, water content, water activity for nanocapsules of azelaic acid and skim milk powder,
4 is a view showing an image of the nanocapsules of azelaic acid and skim milk powder,
5 is a view showing the mechanical chromaticity for the nanocapsules of azelaic acid and skim milk powder, and
6 is a view showing the optimum conditions of particle size, dissolution rate, water content according to inlet air temperature, spray rate, spray pressure for the nanocapsules of azelaic acid and skim milk powder.

These and other objects, features and other advantages of the present invention will become more apparent by describing in detail preferred embodiments of the present invention with reference to the accompanying drawings. Hereinafter, with reference to the accompanying drawings it will be described in detail the cosmetic composition and preparation method for treating acne using nanocapsules of azelaic acid and skim milk powder according to an embodiment of the present invention. For purposes of this specification, like reference numerals in the drawings denote like elements unless otherwise indicated.

1 is a view showing the chemical structural formula of azelaic acid, Figure 2 is a flow chart showing a method for preparing acne treatment cosmetics using nanocapsules of azelaic acid and skim milk powder according to an embodiment of the present invention, Figure 3 is azelaic acid and degreasing Figure 4 shows the yield, particle size, elution rate, water content, water activity according to the inlet air temperature, spray rate, spray pressure for the nanocapsules of milk powder, Figure 4 is a view showing the image of the nanocapsules of azelaic acid and skim milk powder, 5 is a view showing the mechanical color for the nanocapsules of azelaic acid and skim milk powder, and Figure 6 is a particle size, elution rate, moisture according to the inlet air temperature, spray rate, spray pressure for the nanocapsules of azelaic acid and skim milk powder The figure which shows the optimum condition of content.

The cosmetic composition for treating acne according to the present invention is formed by pulverizing a mixture consisting of 15 to 25 parts by weight of azelaic acid and 75 to 85 parts by weight of skim milk powder, and then encapsulating the powdered nanopowder with a corn protein coating solution to form nanocapsule. . Here, the nanocapsules are preferably in the size of 100 ~ 300nm.

Azelaic acid represented by the chemical structural formula of FIG. 1 is dicarboxylic acid having two carboxyl groups (-COOH) in one molecule, and is contained in wheat, rye, and barley. It is a natural substance that is produced by Pytirosporum ovale, a kind of fungus that resides on the skin. Applying a cream containing 20% of this substance on the affected area is effective for skin diseases such as acne. This substance is also known to promote hair growth. Azelaic acid inhibits the growth of bacteria such as acne bacteria (Propionibacterium acnes) and Staphylococcus epidermidis in hair follicles. It also removes unnecessary keratin that is thickened by abnormal keratolytic and acne-free complications of keratinocytes, and removes dead skin cells that cover the acne to help acne heal, remove peroxides, and inflame It alleviates In addition, it is especially effective for patients with spots such as spots on the skin due to abnormal pigmentation by relieving the coloring of the skin, and is effective in brown spots remaining on the skin due to acne sequelae.

Encapsulation technology is the technology of encapsulating solid, liquid, or gaseous substances or packaging inside a substance or tissue to release its contents at a controlled rate under certain conditions. Nano-sized packaging units are called nanocapsule and the size is defined as 100nm or less in nanocosmetics. The shape is ideal but the sphere is largely influenced by the original material structure before it is encapsulated. The material that is coated inside is called core material, payload, active, internal phase, fill, etc. This coating area is classified by thickness and layer part.

Nano-encapsulation technology protects unstable substances such as functional ingredients or drugs from the external environment such as light, oxygen, and moisture to reduce losses, isolates highly reactive substances, hides toxicity, odors, tastes, and solidifies to simplify handling. It is used for the purpose of adjusting the dissolution rate of the contents. However, in the field of nano cosmetics, the use of nanocapsules is limited to coating materials and solvents used in nanocosmetics, and it is important to select an appropriate process in consideration of treatment costs and possibilities.

Recently, the products mainly composed of azelaic acid are microemulsified formulations dispersed in synthetic polymers such as polyethylene glycol (PEG) or biopolymers such as ribosomes. Existing commercial products are also easily oxidized, leading to deterioration in shelf life. As a result, it is still not widely used as a suitable product material.

In the present invention, the nano-encapsulation technology was applied to the skimmed milk powder, which is a natural ingredient and has good skin-friendliness and penetration. The present invention improves the physicochemical properties of azelaic acid while maintaining the functional properties of the azelaic acid- skim milk powder material, which is effective for acne, and improves the quality of nanocosmetics and removes rejection or foreign body feeling when using the core synthesis. Utilizing the central composite design and response surface methodology (RSM), the conditions of the fluid-bed processor (Miniglatt, Glatt, Germany), namely inlet air temperature, spray rate and spray pressure By monitoring the quality characteristics of the nanocapsules, the present invention relates to a cosmetic composition for acne treatment using the new azelaic acid- skim milk powder.

Referring to Figure 2, when looking at the cosmetic preparation method for treating acne using nanocapsules of azelaic acid and skim milk powder according to the present invention, a mixture consisting of 15 to 25 parts by weight of azelaic acid, 75 to 85 parts by weight skim milk powder -70 ℃ Freeze-drying step (S110), pulverizing the freeze-dried mixture in step S110 with a nano grinding classifier to extract the nanopowder (S120), the nanopowder is put into a fluidized bed process to pre-dry and then the coating liquid at a predetermined fluidization pressure Spraying the nano-powder is composed of a step (S130). In the step S130, the nanopowder and the coating solution have a good ratio of 1: 2, the coating solution is corn protein (10% Zein-DP), and the nanopowder is pre-dried for 30 minutes at an inlet air temperature of 60 ° C and an outlet air temperature of 40 ° C. The fluidization pressure is preferably 0.4 kg / cm 2. In addition, the optimum conditions of the fluidized bed process machine is inlet air temperature 67 ~ 73 ℃, spray rate 0.6 ~ 0.8 mL / min, spray pressure 1.8 ~ 2.0 Kg / ㎠ it is good.

[Example]

The sample used in the experiment of the cosmetic composition for treating acne using azelaic acid according to the present invention is skim milk (skim milk, Seoul milk, Korea) against azelaic acid (azelaic acid, Sichuan Huamai Technology Co., Ltd, China). 1: 5 (g / g) mixed in a ratio of lyophilized and dried at -70 ℃ and pulverized to an average particle size of 29.72 ± 0.3nm and selected by azelaic acid-milk powder (azelaic acid-milk nano powder) Samples were used to nanoencapsulate.

, Netzsch-Condux Mahltechnik GmbH, German)로 분쇄한 후 나노캡슐화 하는데 필요한 실험재료로 사용하였다.The powdered skim milk powder was first made into skim milk powder to increase the density of the milk powder, and then swelled larger than the particles of skim milk powder to remove lactose. Specifically, the calcium milk solution was added while heating and stirring the milk liquid, and then the coagulated milk grains And the supernatant were separated and the supernatant was removed using lactose membrane separation technology. The skim milk powder of the lactose-free porous structure is adsorbed and dried secondarily to azelaic acid suspension, and then freeze-dried to form an irregular, coarse and swollen state as much as possible. Secondary processed lyophilized powder was prepared by nano grinding machine (ZetaBeads).

, Netzsch-Condux Mahltechnik GmbH, German) and used as experimental material for nanoencapsulation.

Next, the nanoencapsulation process of azelaic acid- skim milk powder nanopowder is examined.

50 g of azelaic acid- skim milk powder nanopowder manufactured in a fluid-bed processor (Miniglatt, Glatt, German) for nanoencapsulation of azelaic acid- skim milk powder nanopowder was added and the inlet air temperature was 60 ° C for preliminary drying. After preliminary drying of the fine powder for 30 min at the outlet air temperature of 40 ℃, the coating liquid was sprayed by each manufacturing process at a fluidization pressure of 0.4kg / ㎠ to encapsulate. At this time, the coating solution was corn protein (10% Zein-DP, Poonglim Chemical Co., Ltd., Korea), the ratio of azelaic acid- skim milk powder and powder solution was 1: 2 (g / g).

Here, the experimental plan for the optimization of nanoencapsulation process of azelaic acid- skim milk powder nanopowder is examined.

Central synthesis using the inlet air temperature, the feeding speed of the coating solution, and the atomizing pressure as independent variables (Xn), which are important variables for nanoencapsulation of azelaic acid- skim milk powder nanopowders According to the plan, the code was encoded into five stages, -2, -1, 0, 1, and 2, as shown in Table 1. In addition, as shown in Table 2, the yield (Yield, Y1), particle size (Y2), elution ratio (Y3), Moisture content (Y4), water activity (Y5) and mechanical color (Hunter's color values, Y6) were measured. A SAS (statistical analysis system) program was used for the response surface regression analysis, and a mathematical model was used for the 4D response surface methodology (RSM) for each experimental condition.

TABLE 1

<Table 2>

<Table 3>

TABLE 4

<Table 5>

<Table 6>

Yield is the percentage of the weight of the prepared nanocapsules relative to the amount of azelaic acid- skim milk powder nanopowder and coating liquid used to prepare the nanocapsules.

Particle size of the sample was measured using a particle size analyzer (LS 13320, Berkman, USA). At this time, the solvent used for analysis is isopropyl alcohol (isopropyl alcohol). Morphological characteristics of the sample particles were observed using FE SEM (Field Emission-Scanning Electron Microscopy, LEO 1530, Carazeiss, Germany).

The elution ratio of the prepared nanocapsules was measured by adding 1 g of sample to 20 mL of physiological saline solution, stirring and leaving it at 37 ° C. for 2 h, taking the supernatant, and measuring the absorbance at 420 nm. Indicated.

Moisture contents of the prepared nanocapsules were measured using an infrared moisture meter (MA100, Satorius, Germany), and water activity was measured at 25 ° C using a water activity meter (TH-500, Novasina, Swizerland). It is shown.

The mechanical color (Hunter's color values) of the sample was expressed as L, a and b values of the Hunter method using a color difference meter (JS555, Color Techo Co., Japan). At this time, the L, a, and b values of the standard white plate were 97.7, -0.03, and 1.95.

Fluidized bed process machine to show the four-dimensional reaction surface for yield, particle size, dissolution rate and water content which are considered important quality factors of nanocapsules for the prediction of optimal manufacturing process and optimization of nanocapsule encapsulation process The optimum process conditions were estimated. In addition, after setting arbitrary points in the predicted range and substituting them into the regression equation, the reliability was verified by comparing experimental values obtained through actual experiments under the same conditions with respect to the predicted optimal values. The results are as follows.

Yield

The results of measuring the yield according to the encapsulation process conditions of the nanocapsules are shown in Table 2. In other words, the yield of the nanocapsules ranged from 46.67 to 69.60%, and the difference in loss due to adhesion in the device was large depending on the inlet air temperature, spray rate and spray pressure. In addition, the results of this carry out the reaction surface regression while preparing the nanocapsules to the experimental conditions designed by the central composite design, R ² of the regression formula for the yield is the significance to 0.9071 was recognized at the significance level of 5% (see Table 3 ). The maximum value for yield was 70.97% at inlet air temperature 69.33 ℃, spray rate 0.71mL / min, spray pressure 1.63kg / ㎠, minimum value was inlet air temperature 63.18 ℃, spray rate 0.62mL / min, spray pressure It was predicted to be 38.58% at 1.36 kg / cm 2 (see Table 4). This is the value predicted by the reaction surface analysis, and the yield was greatly affected by the inlet air temperature, the spraying speed and the spraying pressure. The conditions of the highest yield were the inlet air temperature 65 ~ 75 ℃, spraying rate 0.6 ~ 0.8mL / min and It can be predicted in the range of the spray pressure 1.4 ~ 1.9 kg / ㎠ (see Figure 3-A). These results indicate that the coating liquid is not dried properly under the conditions of excessively low or high inlet air temperature, and the droplet size of the coating liquid increases and the fine powder flow is not adequately entangled under conditions of high spraying speed and low spray pressure. It is believed that the yield is reduced by the occurrence of the phenomenon.

2. Particle size and shape

The particle size of the nanocapsules according to inlet air temperature, spray rate and spray pressure is shown in Table 5, and the reaction surface regression equation is shown in Table 3. The particle size of each experimental condition was measured in the range of 63.00 ~ 98.86nm, and R ² of the response surface regression equation was 0.9027, and the significance was recognized at the significance level within 5%. The predicted peak point was the saddle point, and the maximum particle size was 98.56 nm at the inlet air temperature of 75.01 ° C, the spray rate of 0.83 mL / min, and the spray pressure of 1.37 kg / cm 2 (see Table 4). .

The particle size was greatly influenced by the spraying speed and the spraying pressure, and there was little effect on the inlet air temperature (see Table 6).

As shown in Fig. 3-B, the particle size of the sample is high inlet air temperature, high spraying speed, and low spray pressure, the large droplets of coating liquid surrounds the surface of the nanocapsule in a state where the flow of the nanopowder is small. It is thought to increase in size. As shown in the FE SEM image of FIG. 4, the nanocapsule is composed of uniform nanoparticles having a size of 100 to 200 nm, has excellent aqueous dispersibility, has a uniform particle size distribution, and has a physiological activity such as azelaic acid in the inner hollow. There is an effect to support the material. In addition, the azelaic acid-defatted milk powder nanopowder manufactured by the present optimal process has a large surface area of 100 m 2 / g or more and has a meso pore of narrow distribution, so that it is possible to support the bioactive substance. Therefore, it has excellent component stability against azelaic acid, so physical properties such as skin absorption rate, yield, moisture content, and dissolution rate are expected to be superior to those of existing formulations and are expected to further improve product quality and function for various cosmetic compositions.

3. Elution ratio

The zein-DP used as a coating material is a corn protein that is not soluble in water but soluble in hydrous ethanol. It has a characteristic of being dissolved in surfactants such as alkaline aqueous solution having a pH of about 11 or higher, SDS, and high concentration urea solution. Therefore, nanocapsules were prepared according to inlet air temperature, spray rate and spray pressure using zein-DP as a coating material, and the coating efficiency was investigated by measuring the dissolution rate in physiological saline. As a result of showing the dissolution rate of the nanocapsules, the absorbance was in the range of 0.238 to 0.887, and it can be seen that the absorbance may vary by about 4 times depending on the method of preparing the nanocapsules (see Table 5). R ² of the response surface regression equation for the dissolution rate of nanocapsules in physiological saline was 0.9158, and the significance was recognized at the significance level within 5% (see Table 3). In physiological saline conditions similar to human skin, the dissolution rate of nanocapsules was most affected by the inlet air temperature and spray rate, and the inlet air temperature range was 65 ~ 75 ℃ and the spray rate was around 0.7mL / min. Since it is hardly eluted, it was possible to make safe nanocapsules in physiological saline, and since the coating material of the nanocapsules was protein, it would not have a great effect on skin cells (Table 6, see Fig. 3-C).

4. Moisture contents and Water activity

Changes in water content and water activity of nanocapsules according to inlet air temperature, spray rate and spray pressure are shown in Table 2. That is, in the case of water content, it appeared in the range of 2.72 ~ 4.04%, and in the case of water activity, it appeared in the range of 0.136 ~ 0.199. The regression equation by response surface analysis is shown in Table 3, and R ² for water content and water activity was 0.9122 and 0.9077, and the significance was recognized at a significance level within 5%. The water content according to the inlet air temperature, the spraying speed and the spraying pressure was shown to be most affected by the spraying speed, and it was found that the moisture content increases as the spraying speed increases and the spraying pressure increases (Table 6). , See FIG. 3-D). The water activity was most affected by the spray pressure, and the water activity increased as the spray rate increased and the spray pressure increased. This tendency was similar to that of the water content (Table 6, Figure 3-E). At higher spray pressures and faster spray rates, the spray rate of the coating solution is faster than that of the drying rate. However, the maximum moisture content is low at 4.04%, which may not affect the quality of nanocapsules.

5. Hunter's color values

The change in mechanical chromaticity for each experimental condition is shown in Table 5. The response surface regression equation is shown in Table 3, and R ² of the regression equation for the L, a, and b values is 0.9032, 0.8068, and 0.8204. L value was significant at the significance level within 5%, b value was significant at the significance level within 10%, but a value was not significant. Looking at the reaction surface for the mechanical chromaticity, the L value was increased as the inlet air temperature was increased, it was found to increase before and after the spray pressure 1.6kg / ㎠ (see Figure 5-A). The value of a tended to decrease as the inlet air temperature and the spray pressure increased, and the value of b increased as the inlet air temperature increased (see FIGS. 5-B and 5-C). As a result, when the zein-DP is coated in large quantities, the color of the nanocapsules becomes slightly darker in translucent. The higher the spray pressure, the smaller the droplet size of the sprayed coating liquid is, resulting in a thinner coating layer. As the inflow air increases, the value of b is considered to increase due to the browning reaction.

6. Prediction and demonstration of optimal manufacturing process

The yield, particle size, elution rate, water content, water activity and mechanical chromaticity of the nanocapsules were investigated in order to set the optimum manufacturing conditions of the nanocapsules according to the inlet air temperature, spray rate and spray pressure. As a result, the optimum manufacturing conditions of the nanocapsules were predicted by showing the reaction surface of yield, particle size, dissolution rate and water content. As shown in Figure 6, the yield, particle size, dissolution rate and water content were all satisfied with the range of inlet air temperature 67 ~ 73 ℃, spray rate 0.6 ~ 0.8mL / min and spray pressure 1.8 ~ 2.0kg / ㎠. Therefore, the physicochemical properties were predicted by substituting arbitrary conditions, inlet air temperature 70 ℃, spray rate 0.7mL / min and spray pressure 1.9kg / cm2, within the predicted optimum conditions. As a result, yield 62.08%, particle size 101.40 nm, elution rate 0.368, water content 3.59%, water activity 0.19, mechanical chromaticity L value 67.39, a value 5.74 and b value 30.51 (see Table 7).

<Table 7>

The reliability of the regression equation was verified by verifying the manufacturing efficiency of the nanocapsules with experimental values obtained through actual experiments under the same conditions as the predicted values of the quality characteristics of the nanocapsules. At this time, the manufacturing conditions of the production efficiency was confirmed by the inlet air temperature 70 ℃, spray rate 0.7mL / min and spray pressure 1.9kg / ㎠, as shown in Table 7 of the nanocapsules obtained through the actual experiment under the arbitrary conditions Yield, particle size, dissolution rate, water content, water activity, and mechanical chromaticity were found to be similar trends compared to the values predicted by the reaction surface analysis method.

The present invention is to develop a skin compatible acne nano-cosmetics that can be absorbed and eluted slowly without skin irritation. Therefore, in order to solve the problems and difficulties of penetration and skin affinity, which have been the most problematic problems in acne cosmetic formulations, it is possible to maintain the functional characteristics of azelaic acid and modify the physical and chemical properties to make optimized azelaic acid- skim milk powder nanocapsule As a result, excellent results in quality characteristics, ie, yield, particle size, dissolution rate, moisture content, water activity, and mechanical chromaticity, were achieved. The nanocapsules were prepared by changing the inlet air temperature (60 ~ 80 ℃), spray rate (0.5 ~ 0.9mL / min) and spray pressure (1.2 ~ 2.0kg / ㎠) according to the central synthesis plan as a fluidized bed process , Regression analysis was performed by examining the quality characteristics of nanocapsules. The maximum predicted yield of nanocapsules was 70.97%, which was strongly influenced by the inlet air temperature, spray rate and spray pressure. The particle size of the sample was increased as the inlet air temperature was high, the spray rate was fast, and the spray pressure was low.In the physiological saline condition similar to human skin, the dissolution rate of nanocapsules was most affected by the inlet air temperature and spray rate. I was receiving. The water content increased as the spraying speed increased and the spraying pressure increased, and the water activity showed a tendency similar to the water content. The mechanical chromaticities L and b increased with increasing inlet air temperature. The high yield, small particle size, and optimum conditions for the preparation of skin-friendly nanocapsules were estimated in the range of inlet air temperature 67 ~ 73 ℃, spray rate 0.6 ~ 0.8 mL / min and spray pressure 1.8 ~ 2.0 Kg / ㎠. The experimental values actually tested at any point within the above prediction range showed similar trends to those predicted by the response surface methodology, which could verify the reliability of the regression equation.

According to the present invention, a cosmetic composition and a method for preparing acne using nanocapsules of azelaic acid and skim milk powder can be easily penetrated into the skin to obtain a desired pharmacological effect at low concentrations, and have excellent skin-affinity, and thus have side effects. It does not precipitate even when stored for a long time.

Although the preferred embodiments of the present invention have been described, the present invention is not limited to the specific embodiments described above. It will be apparent to those skilled in the art that numerous modifications and variations can be made in the present invention without departing from the spirit or scope of the appended claims. And equivalents should also be considered to be within the scope of the present invention.

Claims (7)

A composition comprising 15 to 25 parts by weight of azelaic acid and 75 to 85 parts by weight of skim milk powder, lyophilized and pulverized, and a nanocapsule of azelaic acid and skim milk powder, which is encapsulated and coated with a corn protein coating solution. . The method of claim 1,
The nanocapsules are a cosmetic composition using the nanocapsules of azelaic acid and skim milk powder, characterized in that the size of 100 ~ 300nm. 15 to 25 parts by weight of azelaic acid, 75 to 85 parts by weight of skim milk powder, freeze-drying at -70 ° C. (S110);
Extracting the nanopowder by pulverizing the mixture lyophilized in the step S110 with a nano grinding classifier (S120);
Putting the nanopowder into a fluidized bed process, preliminarily drying for 30 minutes at an inlet air temperature of 60 ° C. and an outlet air temperature of 40 ° C., and then spraying the coating liquid at a fluidization pressure of 0.4 kg / cm 2 to coat the nanopowder (S130); Cosmetic preparation using nanocapsules of azelaic acid and skim milk powder comprising a. 4. The method of claim 3, wherein in step S130
The nano powder and the coating liquid is a cosmetic preparation method using the nano-capsule of azelaic acid and skim milk powder, characterized in that 1: 1 ratio. The method of claim 4, wherein in step S130
The coating solution is a method for producing a cosmetic using nanocapsules of azelaic acid and skim milk powder, characterized in that the corn protein. delete 4. The method of claim 3, wherein in step S130
The optimum condition of the fluidized bed process is the preparation of cosmetics using nanocapsules of azelaic acid and skim milk powder, characterized in that the inlet air temperature 67 ~ 73 ℃, spray rate 0.6 ~ 0.8 mL / min, spray pressure 1.8 ~ 2.0 Kg / ㎠ Way.

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