CN105165882B - A kind of miticide composition containing acequinocyl - Google Patents
A kind of miticide composition containing acequinocyl Download PDFInfo
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- CN105165882B CN105165882B CN201510562455.7A CN201510562455A CN105165882B CN 105165882 B CN105165882 B CN 105165882B CN 201510562455 A CN201510562455 A CN 201510562455A CN 105165882 B CN105165882 B CN 105165882B
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Abstract
The invention discloses a kind of miticide composition containing acequinocyl, the miticide composition containing active components A and active component B, wherein active components A are selected from acequinocyl, and active component B is selected from any one following compound：Clofentezine, azacyclotin, fenbutatin oxide, flufenzine, fenisobromolate, and active components A and active component B weight ratio are the ︰ 1 of 1 ︰ 80~80.The present composition has synergistic effect to a variety of evil mites for endangering agricultural production, reduces pesticide usage amount, reduces agricultural chemicals and stay residual on crop, alleviate environmental pollution, to person poultry safety, Environmental compatibility is good, and evil mite is not likely to produce the resistance to the action of a drug.
Description
The application is divisional application, and original application is " a kind of to contain acequinocyl for the patent application of Shaanxi Meibang Pesticide Co., Ltd.
Miticide composition ", the application Wei ︰ 201210215651.3 of original application, original application day is 2012.06.27.
Technical field
The invention belongs to technical field of pesticide, it is related to a kind of miticide composition containing acequinocyl answering in crops evil mite
With.
Background technology
Acequinocyl (acequinocyl) chemical name：2- (acetoxyl group) 3- dodecyls -1,4-naphthoquinone, molecular formula：
C24H32O4.Acequinocyl is naphthoquinone derivatives, predominantly contact killing type acaricide, has toxicity of ingesting concurrently.2- ten is hydrolyzed into mite body
Dialkyl group -3- hydroxyls -1,4-naphthoquinone, and be combined with the Qo sites on the electron transfer pathways in mitochondria, so as to suppress electricity
Son transmission.
Clofentezine (Clofentezine) chemical name：3,6- double (2- chlorphenyls) -1,2,4,5- tetrazines, molecular formula：
C14H8Cl2N4.Clofentezine is special efficacy acaricide, lasting medicine.To occurring the full pawl of apple on fruit tree, cotton, ornamental plant
Mite, the ovum of congo red spider and deutonymph are effectively, harmless to Predatory Mites, natural enemy.
Azacyclotin (Azocyclotin) chemical name：1- (three cyclohexyl stannyls) -1- hydrogen -1,2,4- triazoles,
Molecular formula：C20H35N3Sn.Azacyclotin is the stronger broad spectrum activity acaricide of action of contace poison, can kill deutonymph, into mite and summer egg, to the winter
Ovum is invalid.There is preferable stability to light and rainwater, the longevity of residure is longer.To crop safety under typical concentrations.
Fenbutatin oxide (Fenbutatin oxide) chemical name：Double [three 2- methylphenyls propyl group) tin] oxide, molecule
Formula：C60H78OSn2.Fenbutatin oxide is a kind of non-interior suction acaricide, and the evil mite resistant to organophosphor and organochlorine does not produce friendship to it
Mutual resistance, to evil mite based on tagging.
Flufenzine (diflovidazin) chemical name：3- (2- chlorphenyls) -6- (2,6- difluorophenyls) -1,2,4,5- four
Piperazine, molecular formula：C14H7ClF2N4.Flufenzine accessible go out ovum and percutaneous activity, attract mite into mite to take food, also prevent and treat the pupa stage
Mite mite.The compound effects mechanism is unique, not only there is excellent activity to ovum and into mite, and it is unsound to produce female mite
Ovum, causes destroying the evidence for mite, while the evil mites such as pear sucker, oystershell scale, leafhopper can be also prevented, and to natural enemy and Environmental security.
Fenisobromolate (bromopropylate) chemical name：4,4'- dibromo benzoin isopropyl propionates, molecular formula
C17H16Br2O3, fenisobromolate be a kind of mite killing spectrum wide, lasting period length, toxicity it is low, to natural enemy, honeybee and crop is safer kills
Mite agent.It is contact relatively strong, no absorbability, to having certain lethal effect into, deutonymph and ovum, temperature change influences not on drug effect
Greatly.
However, in the real process of agricultural production, preventing and treating evil mite and being easiest to generate the problem that the drug-fast production of evil mite
It is raw.Different cultivars composition is compounded, and is to prevent and treat resistance evil mite very common method.Heterogeneity is compounded, according to reality
Application effect, to judge that certain compounding is synergy plus and or antagonism.In most cases, the compounding effect of agricultural chemicals
All it is additive effect, really has the compounding of synergistic effect seldom, especially synergistic effect is clearly, co-toxicity coefficient is very high answers
With just less.Study, find acequinocyl and clofentezine, azacyclotin, fenbutatin oxide, flufenzine, fenisobromolate is multiple by inventor
Good synergistic effect can be produced after matching somebody with somebody, and it is multiple on acequinocyl and clofentezine, azacyclotin, fenbutatin oxide, flufenzine, fenisobromolate
The relevant report matched somebody with somebody not yet is disclosed.
The content of the invention
Have that synergistic function, use cost be low, preventive effect is good containing acequinocyl the purpose of the present invention is to propose to a kind of
Miticide composition.
Miticide composition proposed by the present invention containing acequinocyl contains active components A and active component B, active components A with
Active component B weight ratio is the ︰ 1 of 1 ︰ 80~80, and described active components A is selected from acequinocyl, and active component B is selected from clofentezine, three
One of azoles tin, fenbutatin oxide, flufenzine, fenisobromolate are planted, and active components A is the ︰ of 1 ︰ 50~50 with weight ratio preferred active component B
1；The more preferably weight ratio of acequinocyl and clofentezine is the ︰ 1 of 1 ︰ 30~30, the weight ratio of acequinocyl and azacyclotin for 1 ︰ 30~
The weight ratio of 15 ︰ 1, acequinocyl and fenbutatin oxide is the ︰ 1 of 1 ︰ 30~15, and the weight ratio of acequinocyl and flufenzine is the ︰ 1 of 1 ︰ 10~30, is gone out
The weight ratio of mite quinone and fenisobromolate is the ︰ 1 of 1 ︰ 30~10；More preferably the weight ratio of acequinocyl and clofentezine is the ︰ 1 of 1 ︰ 10~10,
The weight ratio of acequinocyl and azacyclotin is the ︰ 1 of 1 ︰ 15~5, and the weight ratio of acequinocyl and fenbutatin oxide is the ︰ 1 of 1 ︰ 15~5, acequinocyl with
The weight ratio of flufenzine is the ︰ 1 of 1 ︰ 5~15, and the weight ratio of acequinocyl and fenisobromolate is the ︰ 1 of 1 ︰ 15~5.
Miticide composition proposed by the present invention containing acequinocyl is used for the purposes for preventing and treating evil mite on crops, described farming
Thing includes cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby
Crop, root crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop；Described evil mite bag
Include red spider, yellow spider, rust mite, Panonychus citri, goitre mite, tetranychus viennensis, yellow tea mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid,
Shenmu-Yanan railway.
Active components A, active component B weight ratio are the ︰ 1 of 1 ︰ 80~80.The weight hundred of active component in usual composition
It is the 0.5%~90% of gross weight, preferably 5%~80% to divide content.According to different preparation types, active component content
Scope is different.Generally, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%；
Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
At least contain a kind of surfactant in the miticide composition of the present invention, active component is in water during in favor of applying
It is scattered.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
Surfactant selected by the miticide composition of the present invention is known in those skilled in the art：It can be selected from
One or more in dispersant, wetting agent, binding agent or defoamer.It can also contain capable according to different dosage forms, in preparation
Disintegrant, antifreeze well known to field technique personnel etc..
The present invention miticide composition can by user using it is preceding through dilute or directly use.Its preparation can be by usual
Processing method known in those skilled in the art prepare, i.e., after active material is mixed with liquid flux or solid carrier,
The one or more added in surfactant such as dispersant, stabilizer, wetting agent, binding agent, defoamer.
The miticide composition of the present invention, acceptable formulation on any agricultural chemicals can be processed on demand, wherein more preferably
Formulation for wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, micro-capsule hang
Floating-suspending agent.
Composition includes following constituent content when wettable powder is made：Active components A 1%~80%, active component
B1%~80%, dispersant 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 1%~80%, active component
B1%~80%, dispersant 3%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binding agent 0~8%, more than filler
Amount.
Composition includes following constituent content when suspending agent is made：Active components A 0.5%~50%, active component
B0.5%~50%, dispersant 2%~10%, wetting agent 2%~10%, defoamer 0.01%~2%, thickener 0~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when suspension emulsion is made：Active components A 0.5%~50%, active component
B0.5%~50%, dispersant 2%~10%, defoamer 0.01%~2%, solvent 1%~15%, thickener 0~2%, breast
Agent 2%~12%, antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when aqueous emulsion is made：Active components A 0.5%~50%, active component
B0.5%~50%, solvent 1%~30%, emulsifying agent 1%~15%, antifreeze 0~8%, thickener 0~2%, defoamer
0.01%~2%, deionized water supplies surplus.
Composition includes following constituent content when microemulsion is made：Active components A 0.5%~50%, active component
B0.5%~50%, solvent 1%~30%, emulsifying agent 3%~25%, antifreeze 0~8%, defoamer 0.01%~2%, go
Ionized water supplies surplus.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.5%~50%, active component
B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~10%, organic solvent 1%~10%, emulsifying agent
1%~7%, defoamer 0.01%~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
It is composition B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~12%, wetting agent 1%~8%, organic
Solvent 1%~15%, emulsifying agent 1%~6%, defoamer 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~
5%th, deionized water adds to 100%；
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
(1) after acequinocyl and clofentezine, azacyclotin, fenbutatin oxide, flufenzine, fenisobromolate compounding, with obvious synergy and
Lasting effect；(2) to cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit
Crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop, on green manure pasture crop
Evil mite has greater activity；(3) pesticide usage amount is reduced, residual quantity of the agricultural chemicals on crop is reduced, environment is alleviated dirty
Dye；(4) to person poultry safety, Environmental compatibility is good；And preparation adhesion strength strengthens, resistance of rainwater washing against.
Embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The invention is not limited in this.
Application Example one
The wettable powder of example 1~14
Acequinocyl, active component B, dispersant, wetting agent, filler are well mixed in mixed cylinder, through airslide disintegrating mill
Remixed after crushing uniform, you can wettable powder product of the present invention is made, 1 is specifically shown in Table.
The each component of 1 embodiment of table 1~14 and parts by weight
The water dispersible granules of example 15~28
Acequinocyl, active component B, dispersant, wetting agent, disintegrant, filler etc. are needed through air-flow crushing together
Particle diameter, add other auxiliary agents such as binding agent (can add to be not added with), obtain pelletize materials.Item is quantified into feeding fluid bed system
In grain drying machine after granulation and drying, you can water dispersible granules product of the present invention is made, 2 are specifically shown in Table.
The each component of 2 embodiment of table 15~28 and parts by weight
The suspending agent of example 29~42
By dispersant, wetting agent, defoamer, thickener (can add to be not added with), antifreeze (can add to be not added with), by a high speed
Shear-mixed is uniform, adds acequinocyl, active component B, ball milling 2~3 hours in ball mill make diameter of particle all at 5 μm
Hereinafter, surplus is supplied with deionized water, you can suspending agent product of the present invention is made, 3 are specifically shown in Table.
The each component of 3 embodiment of table 29~42 and parts by weight
The suspension emulsion of example 43~51
Dispersant, defoamer, thickener (can add to be not added with), antifreeze (can add to be not added with) are mixed by high speed shear
Uniformly, acequinocyl is added, ball milling 2~3 hours in ball mill make diameter of particle all below 5 μm, acequinocyl is made and suspends
Agent, then directly emulsifies active component B, solvent, emulsifying agent and various auxiliary agents in suspending agent with high speed agitator, and surplus is used
Deionized water is supplied, and suspension emulsion product of the present invention is made, 4,5 are specifically shown in Table.
The each component of 4 embodiment of table 43~48 and parts by weight
The each component of 5 embodiment of table 49~51 and parts by weight
The aqueous emulsion of example 52~60
Acequinocyl, active component B, solvent, emulsifying agent are added together, make to be dissolved into homogeneous oil phase；By deionized water, resist
Jelly agent (can add to be not added with), thickener (can add to be not added with), defoamer are mixed, into homogeneous aqueous phase.Under high velocity agitation,
Aqueous phase is added into oil phase, surplus is supplied with deionized water；Aqueous emulsion product of the present invention is can be prepared by, 6 are specifically shown in Table.
The each component of 6 embodiment of table 52~60 and parts by weight
Clofentezine, azacyclotin, fenbutatin oxide, flufenzine, fenisobromolate in table 1~6 are exchanged, novel formulation can be made.
The microemulsion of example 61~63
Acequinocyl, active component B, solvent, emulsifying agent, antifreeze (can add to be not added with), defoamer are sufficiently mixed into equal
Even transparent oil phase, is slowly added into deionized water under agitation, forms WO emulsion, then agitated heating, is allowed to fast
Fast phase inversion is cooled to room temperature and makes up to balance into oil-in-water type, and through filtering, surplus is supplied with deionized water；It can be prepared by this hair
Bright described microemulsion product, is specifically shown in Table 7.
The each component of 7 embodiment of table 61~63 and parts by weight
Example 64,65 microcapsule suspending agents
Acequinocyl, active component B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, in shearing bar
Under part, oil phase is added to containing in emulsifying agent, pH adjusting agent, the aqueous phase solution of dispersant, surplus is supplied with deionized water, two
Plant material to react in oil-water interfaces, form high score ascus wall, the well dispersed microcapsule suspending agent of the present composition is made
Product.Specifically it is shown in Table 8.
The embodiment 64 of table 8,65 each components and parts by weight
Example 66,67 microcapsule suspension-suspendinagent agents
Active component B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing in emulsifying agent, the aqueous phase solution of pH adjusting agent, well dispersed microcapsule suspending agent is made.By dispersant, wet
Profit agent, defoamer, thickener (can add to be not added with) are well mixed by high speed shear, add acequinocyl, ball milling 2 in ball mill
~3 hours, make diameter of particle all below 5 μm, suspending agent is made, then suspending agent is added to the water of micro-capsule suspension
In phase solution, deionized water supplies surplus, the well dispersed microcapsule suspension-suspendinagent agent product of the present composition is made, specifically
It is shown in Table 9.
The embodiment 66 of table 9,67 each components and parts by weight
The embodiment of the present invention is the method being combined using Toxicity Determination and field test.First pass through indoor virulence survey
Calmly, the co-toxicity coefficient (CTC) after clear and definite two kinds of medicaments are compounded by a certain percentage, CTC ＜ 80 are antagonism, 80≤CTC≤120
For summation action, CTC ＞ 120 are synergistic effect, on this basis, then carry out field test.
Test method：The mother liquor of each mixed agent is diluted to five series concentrations respectively during experiment, is respectively placed in beaker
It is standby.Using the first leaching leaf method that is followed by mite, by not in contact with the blade of the same size of any medicament in the decoction configured
Take out, dry naturally after immersion 5s, be put into foster mite box, then connect for the young mite of examination, raised under the conditions of 25 DEG C, often handle 3
Secondary repetition, it is 50 often to repeat examination mite number used, while setting blank control, dead mite number is checked in 72h, the death rate and correction is calculated
The death rate, tries to achieve virulence regression equation and calculates LC50Value.If compareing the death rate is more than 10%, it is considered as invalid experiment.Calculate public
Formula is as follows：
Evil mite corrected mortality is converted into probit value (y), concentration for the treatment of (μ g/ml) is converted into logarithm value (x), with minimum
Square law draws virulence regression equation, and thus calculates the value of every kind of medicament, and calculating common poison according to the abundant equations of Sun Yun is
Number CTC.Calculation formula is following, and (using acequinocyl as standard agent, 100) its toxicity index is：
TI × P of M theoretical toxicity index (TTI)=acequinocylAcequinocyl+Effective active composition B TI × PEffective active composition B
In formula：M is the mixture of different ratio
PEffective active composition BFor effective active composition B shared ratios in the composition
PAcequinocylFor acequinocyl shared ratio in the composition
B is selected from one of clofentezine, azacyclotin, fenbutatin oxide, flufenzine, fenisobromolate and planted.
Application Example two：
For examination evil mite：Mandarin tree red spider
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Effective cause of acequinocyl and clofentezine active compound and the two different ratio mixture is determined by pilot study
Dead concentration range.
Toxicity test result
The acequinocyl of table 10 compounds the toxicity test analysis of results table to mandarin tree red spider with clofentezine
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient (CTC) |
| Acequinocyl | — | 1.65 | — |
| Clofentezine | — | 1.53 | — |
| Go out Man Kun ︰ clofentezines | 80:1 | 0.92 | 179.17 |
| Go out Man Kun ︰ clofentezines | 50:1 | 0.90 | 183.05 |
| Go out Man Kun ︰ clofentezines | 40:1 | 0.85 | 193.75 |
| Go out Man Kun ︰ clofentezines | 30:1 | 0.76 | 216.56 |
| Go out Man Kun ︰ clofentezines | 20:1 | 0.72 | 228.31 |
| Go out Man Kun ︰ clofentezines | 10:1 | 0.69 | 237.44 |
| Go out Man Kun ︰ clofentezines | 5:1 | 0.66 | 246.78 |
| Go out Man Kun ︰ clofentezines | 1:1 | 0.59 | 269.11 |
| Go out Man Kun ︰ clofentezines | 1:5 | 0.63 | 245.84 |
| Go out Man Kun ︰ clofentezines | 1:10 | 0.66 | 233.37 |
| Go out Man Kun ︰ clofentezines | 1:20 | 0.69 | 222.52 |
| Go out Man Kun ︰ clofentezines | 1:30 | 0.70 | 219.09 |
| Go out Man Kun ︰ clofentezines | 1:40 | 0.79 | 194.02 |
| Go out Man Kun ︰ clofentezines | 1:50 | 0.82 | 186.86 |
| Go out Man Kun ︰ clofentezines | 1:80 | 0.87 | 176.03 |
As shown in Table 10, acequinocyl is matched in 1 80~80 ︰ 1 of ︰ with clofentezine to mandarin tree red spider, and co-toxicity coefficient is equal
More than 120, illustrate that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~80, when the proportioning of acequinocyl and clofentezine
In 1 30~30 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and co-toxicity coefficient is all higher than 215.Wherein when acequinocyl and clofentezine weight
Amount is than being 1:Co-toxicity coefficient is maximum when 1, and synergistic effect is the most obvious.Find that acequinocyl is with clofentezine proportioning through applicant's experiment
30：1、25：1、20：1、15：1、10：1、8：1、6：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：8、
1：10、1：12、1：14、1：15、1：20、1：25、1：To the red spider in various crop, yellow spider, rust mite, full pawl when 30
Mite, goitre mite, tetranychus viennensis, yellow tea mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid, the preventing and treating of Shenmu-Yanan railway have obvious increasing
Effect is acted on, and co-toxicity coefficient is all higher than 120.
Application Example three
For examination evil mite：European red mite
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Effective cause of acequinocyl and azacyclotin active compound and the two different ratio mixture is determined by pilot study
Dead concentration range.
The acequinocyl of table 11 compounds the toxicity test analysis of results table to European red mite with azacyclotin
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient (CTC) |
| Acequinocyl | — | 1.52 | — |
| Azacyclotin | — | 2.98 | — |
| Go out Man Kun ︰ azacyclotins | 80:1 | 0.86 | 177.82 |
| Go out Man Kun ︰ azacyclotins | 50:1 | 0.81 | 189.47 |
| Go out Man Kun ︰ azacyclotins | 30:1 | 0.80 | 193.05 |
| Go out Man Kun ︰ azacyclotins | 15:1 | 0.74 | 211.89 |
| Go out Man Kun ︰ azacyclotins | 10:1 | 0.71 | 224.07 |
| Go out Man Kun ︰ azacyclotins | 5:1 | 0.70 | 236.45 |
| Go out Man Kun ︰ azacyclotins | 1:2 | 0.84 | 268.74 |
| Go out Man Kun ︰ azacyclotins | 1:8 | 1.09 | 247.06 |
| Go out Man Kun ︰ azacyclotins | 1:15 | 1.20 | 234.30 |
| Go out Man Kun ︰ azacyclotins | 1:30 | 1.35 | 214.13 |
| Go out Man Kun ︰ azacyclotins | 1:40 | 1.50 | 194.14 |
| Go out Man Kun ︰ azacyclotins | 1:50 | 1.61 | 181.69 |
| Go out Man Kun ︰ azacyclotins | 1:80 | 1.68 | 175.32 |
As shown in Table 11, acequinocyl is matched in 1 80~80 ︰ 1 of ︰ with azacyclotin to European red mite, and co-toxicity coefficient is big
In 120, illustrate that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~80, when the proportioning of acequinocyl and azacyclotin exists
During 1 30~15 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and co-toxicity coefficient is all higher than 210.Wherein when acequinocyl and azacyclotin weight
Than for 1:Co-toxicity coefficient is maximum when 2, and synergistic effect is the most obvious.Find that acequinocyl is with azacyclotin proportioning through applicant's experiment
15：1、10：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：12、1：14、
1：15、1：20、1：25、1：When 30 to the red spider in various crop, yellow spider, rust mite, Panonychus citri, goitre mite, tetranychus viennensis,
Yellow tea mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid, the preventing and treating of Shenmu-Yanan railway have obvious synergistic effect, and co-toxicity coefficient is equal
More than 120.
Application Example four
For examination evil mite：Cotton red spider
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Effective cause of acequinocyl and fenbutatin oxide active compound and the two different ratio mixture is determined by pilot study
Dead concentration range.
The acequinocyl of table 12 compounds the toxicity test analysis of results table to cotton red spider with fenbutatin oxide
As shown in Table 12, acequinocyl is matched in 1 80~80 ︰ 1 of ︰ with fenbutatin oxide to cotton red spider, and co-toxicity coefficient is big
In 120, illustrate that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~80, when the proportioning of acequinocyl and fenbutatin oxide exists
During 1 30~15 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and co-toxicity coefficient is all higher than 215.Wherein when acequinocyl and fenbutatin oxide weight
Than for 1:Co-toxicity coefficient is maximum when 2, and synergistic effect is the most obvious.Find that acequinocyl is with fenbutatin oxide proportioning through applicant's experiment
15：1、10：1、9：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：
9、1：10、1：15、1：20、1：25、1：When 30, to the red spider in various crop, yellow spider, rust mite, Panonychus citri, goitre mite,
Tetranychus viennensis, yellow tea mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid, the preventing and treating of Shenmu-Yanan railway have obvious synergistic effect,
Co-toxicity coefficient is all higher than 120.
Application Example five
For examination evil mite：Apple Tetranychus urticae
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Effective cause of acequinocyl and the former medicine of flufenzine and the two different ratio mixture is determined by pilot study
Dead concentration range.
The acequinocyl of table 13 compounds the toxicity test analysis of results table to apple Tetranychus urticae with flufenzine
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient (CTC) |
| Acequinocyl | — | 1.61 | — |
| Flufenzine | — | 0.52 | — |
| Go out Man Kun ︰ flufenzines | 80:1 | 0.89 | 176.54 |
| Go out Man Kun ︰ flufenzines | 50:1 | 0.82 | 188.93 |
| Go out Man Kun ︰ flufenzines | 40:1 | 0.79 | 194.32 |
| Go out Man Kun ︰ flufenzines | 30:1 | 0.68 | 222.42 |
| Go out Man Kun ︰ flufenzines | 15:1 | 0.62 | 230.82 |
| Go out Man Kun ︰ flufenzines | 8:1 | 0.54 | 243.94 |
| Go out Man Kun ︰ flufenzines | 4:1 | 0.45 | 255.56 |
| Go out Man Kun ︰ flufenzines | 1:1 | 0.33 | 243.94 |
| Go out Man Kun ︰ flufenzines | 1:5 | 0.26 | 232.21 |
| Go out Man Kun ︰ flufenzines | 1:10 | 0.25 | 228.52 |
| Go out Man Kun ︰ flufenzines | 1:20 | 0.27 | 205.28 |
| Go out Man Kun ︰ flufenzines | 1:40 | 0.28 | 194.83 |
| Go out Man Kun ︰ flufenzines | 1:50 | 0.30 | 181.26 |
| Go out Man Kun ︰ flufenzines | 1:80 | 0.31 | 174.55 |
As shown in Table 13, acequinocyl is matched in 1 80~80 ︰ 1 of ︰ with flufenzine to apple Tetranychus urticae, and co-toxicity coefficient is equal
More than 120, illustrate that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~80, when acequinocyl and the proportioning of flufenzine
In 1 10~30 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and co-toxicity coefficient is all higher than 220, wherein when acequinocyl and flufenzine weight
Amount is than being 4:Co-toxicity coefficient is maximum when 1, and synergistic effect is the most obvious.Find that acequinocyl is with flufenzine proportioning through applicant's experiment
10：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：12、1：14、1：15、
1：20、1：25、1：It is yellow to the red spider in various crop, yellow spider, rust mite, Panonychus citri, goitre mite, tetranychus viennensis, tea when 30
Mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid, the preventing and treating of Shenmu-Yanan railway have obvious synergistic effect, and co-toxicity coefficient is all higher than
120。
Application Example six
For examination evil mite：Apple tree red spider
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Effective cause of acequinocyl and fenisobromolate active compound and the two different ratio mixture is determined by pilot study
Dead concentration range.
The acequinocyl of table 14 compounds the toxicity test analysis of results table to apple tree red spider with fenisobromolate
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient (CTC) |
| Acequinocyl | — | 1.49 | — |
| Fenisobromolate | — | 4.15 | — |
| Go out Man Kun ︰ fenisobromolates | 80:1 | 0.88 | 170.67 |
| Go out Man Kun ︰ fenisobromolates | 50:1 | 0.86 | 175.46 |
| Go out Man Kun ︰ fenisobromolates | 40:1 | 0.80 | 189.21 |
| Go out Man Kun ︰ fenisobromolates | 20:1 | 0.78 | 197.04 |
| Go out Man Kun ︰ fenisobromolates | 10:1 | 0.72 | 219.75 |
| Go out Man Kun ︰ fenisobromolates | 5:1 | 0.74 | 225.44 |
| Go out Man Kun ︰ fenisobromolates | 1:1 | 0.89 | 246.38 |
| Go out Man Kun ︰ fenisobromolates | 1:3 | 1.10 | 260.87 |
| Go out Man Kun ︰ fenisobromolates | 1:8 | 1.39 | 249.16 |
| Go out Man Kun ︰ fenisobromolates | 1:15 | 1.64 | 227.67 |
| Go out Man Kun ︰ fenisobromolates | 1:30 | 1.81 | 216.82 |
| Go out Man Kun ︰ fenisobromolates | 1:40 | 2.04 | 194.96 |
| Go out Man Kun ︰ fenisobromolates | 1:50 | 2.13 | 188.26 |
| Go out Man Kun ︰ fenisobromolates | 1:80 | 2.28 | 178.11 |
As shown in Table 14, acequinocyl is matched in 1 80~80 ︰ 1 of ︰ with fenisobromolate to apple tree red spider, and co-toxicity coefficient is equal
More than 120, illustrate that both show synergistic effect at the mixture in the range of the ︰ 1 of 1 ︰ 80~80, when the proportioning of acequinocyl and fenisobromolate
In 1 30~10 ︰ 1 of ︰, synergistic effect becomes apparent protruding, and co-toxicity coefficient is all higher than 215, wherein when acequinocyl and fenisobromolate weight
Amount is than being 1:Co-toxicity coefficient is maximum when 3, and synergistic effect is the most obvious.Find that acequinocyl is with fenisobromolate proportioning through applicant's experiment
10：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：12、1：14、1：15、
1：20、1：25、1：It is yellow to the red spider in various crop, yellow spider, rust mite, Panonychus citri, goitre mite, tetranychus viennensis, tea when 30
Mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid, the preventing and treating of Shenmu-Yanan railway have obvious synergistic effect, and co-toxicity coefficient is all higher than
120。
Effect experiment part：Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided, and comparison medicament 15% is gone out mite
Quinone suspending agent (autogamy), 20% clofentezine suspension agent (purchased in market), 25% azacyclotin wettable powder (purchased in market), 25% fenbutatin oxide hang
Floating agent (purchased in market), 10% flufenzine suspending agent (autogamy), 500 g/l of fenisobromolate missible oil (purchased in market).
The acequinocyl of Application Example seven and active component B and its compounding preventing and treating mandarin tree red spider test of pesticide effectiveness, this experiment
Investigation mandarin tree red spider damage index of spider mites before Shaanxi Province Hanzhong suburban area, medicine is arranged in, early period of origination dispenser is done harm in mite, after dispenser
Investigate damage index of spider mites and calculate preventive effect within 3 days, 15 days, 30 days.Result of the test is as follows：
The acequinocyl of table 15 and active component B and its compounding preventing and treating mandarin tree red spider test of pesticide effectiveness
As can be seen from Table 15, acequinocyl after active component B compoundings with can effectively prevent and treat mandarin tree red spider, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is long.Target crop is had no adverse effects in experiment scope of medication.
The acequinocyl of Application Example eight and active component B and its compounding preventing and treating apple tree tetranychus viennensis test of pesticide effectiveness, this examination
Test and be arranged in investigation apple tree tetranychus viennensis damage index of spider mites before Shaanxi Province Weinan City Dengcheng County, medicine, early period of origination dispenser is done harm in mite,
5 days after dispenser, investigate damage index of spider mites and calculate preventive effect within 20 days, 45 days.Result of the test is as follows：
The acequinocyl of table 16 and active component B and its compounding preventing and treating apple tree tetranychus viennensis test of pesticide effectiveness
As can be seen from Table 16, acequinocyl and energy effectively preventing and treating apple-tree tetranychus viennensis after active component B compoundings, preventing and treating effect
Fruit is superior to the preventive effect of single dose, and preventive effect phase is long.Target crop is had no adverse effects in experiment scope of medication.
The acequinocyl of Application Example nine and active component B and its compounding preventing and treating tomato goitre mite test of pesticide effectiveness, this test arrangement
Tomato goitre mite damage index of spider mites is investigated before Xian District, Shanxi Province suburban area, medicine, early period of origination dispenser is done harm in mite, 3 days after dispenser, 10
My god, 30 days investigation damage index of spider mites and calculate preventive effect.Result of the test is as follows：
The acequinocyl of table 17 and active component B and its compounding preventing and treating tomato goitre mite test of pesticide effectiveness
As can be seen from Table 17, acequinocyl and active component B and its compounding preventing and treating tomato goitre mite, prevention effect are superior to list
The preventive effect of agent, and preventive effect phase is long.Target crop is had no adverse effects in experiment scope of medication.
The acequinocyl of Application Example ten and active component B and its compounding preventing and treating mandarin tree Panonychus citri test of pesticide effectiveness, this experiment
Investigation mandarin tree Panonychus citri damage index of spider mites before Shaanxi Province Hanzhong suburban area, medicine is arranged in, early period of origination dispenser is done harm in mite, after dispenser
Investigate damage index of spider mites and calculate preventive effect within 3 days, 15 days, 30 days.Result of the test is as follows：
The acequinocyl of table 18 and active component B and its compounding preventing and treating mandarin tree Panonychus citri test of pesticide effectiveness
As can be seen from Table 18, acequinocyl after active component B compoundings with can effectively prevent and treat mandarin tree Panonychus citri, prevention effect
The preventive effect of single dose is superior to, and preventive effect phase is long.Target crop is had no adverse effects in experiment scope of medication.
The acequinocyl of Application Example 11 and active component B and its compounding preventing and treating cotton red spider test of pesticide effectiveness, this experiment
Investigation cotton red spider damage index of spider mites before Shaanxi Province Weinan City Dali County, medicine is arranged in, early period of origination dispenser is done harm in mite, after dispenser
Investigate damage index of spider mites and calculate preventive effect within 3 days, 15 days, 30 days.Result of the test is as follows：
The acequinocyl of table 19 and active component B and its compounding preventing and treating cotton red spider test of pesticide effectiveness
As can be seen from Table 19, acequinocyl after active component B compoundings with can effectively prevent and treat cotton red spider, and prevention effect is equal
Better than the preventive effect of single dose, and preventive effect phase is long.Target crop is had no adverse effects in experiment scope of medication.
The acequinocyl of Application Example 12 and active component B and its compounding preventing and treating yellow tea mite test of pesticide effectiveness, this test arrangement
Before Sichuan Province Yaan suburban area, medicine investigate yellow tea mite damage index of spider mites, mite do harm to early period of origination dispenser, 3 days after dispenser, 10 days,
20 days investigation damage index of spider mites simultaneously calculate preventive effect.Result of the test is as follows：
The acequinocyl of table 20 and active component B and its compounding preventing and treating yellow tea mite test of pesticide effectiveness
As can be seen from Table 20, acequinocyl after active component B compoundings with can effectively prevent and treat yellow tea mite, and prevention effect is superior to
The preventive effect of single dose, and preventive effect phase is long.Target crop is had no adverse effects in experiment scope of medication.
The experiment by different places throughout the country is drawn afterwards, acequinocyl and clofentezine, azacyclotin, fenbutatin oxide, fluorine mite
It is yellow to the red spider in various crop, yellow spider, rust mite, Panonychus citri, goitre mite, tetranychus viennensis, tea after piperazine, fenisobromolate compounding
The preventive effect of the common evil mites such as mite, Tetranychus cinnabarinus, Tetranychus urticae, beginning tetranychid, Shenmu-Yanan railway is anti-better than single dose more than 95%
Effect, synergistic effect is obvious.
Claims (8)
1. a kind of miticide composition containing acequinocyl, effective active composition is active components A and active component B, it is characterised in that：
Active components A is the ︰ 1 of 1 ︰ 80 ~ 80 with active component B weight ratio, and described active components A is selected from acequinocyl, and active component B is selected from
One of azacyclotin, fenbutatin oxide, fenisobromolate are planted.
2. the miticide composition according to claim 1 containing acequinocyl, it is characterised in that：Active components A and active component B
Weight ratio be the ︰ 1 of 1 ︰ 50 ~ 50.
3. the miticide composition according to claim 2 containing acequinocyl, it is characterised in that：
The weight ratio of acequinocyl and azacyclotin is the ︰ 1 of 1 ︰ 30 ~ 15；
The weight ratio of acequinocyl and fenbutatin oxide is the ︰ 1 of 1 ︰ 30 ~ 15；
The weight ratio of acequinocyl and fenisobromolate is the ︰ 1 of 1 ︰ 30 ~ 10.
4. the miticide composition according to any one of claim 1 to 3 containing acequinocyl, it is characterised in that：Composition system
Into wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspension
Agent.
5. the miticide composition according to claim 4 containing acequinocyl is used for the purposes for preventing and treating evil mite on crops.
6. purposes according to claim 5, it is characterised in that described evil mite includes：Red spider, yellow spider, goitre mite, tea
Yellow mite.
7. purposes according to claim 5, it is characterised in that described evil mite includes：Tetranychus viennensis, Tetranychus cinnabarinus, two
Variegated leaf mite, beginning tetranychid, Shenmu-Yanan railway.
8. purposes according to claim 5, it is characterised in that described evil mite includes：Rust mite, Panonychus citri.
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| CN1635834A (en) * | 2000-03-21 | 2005-07-06 | 拜尔公司 | Combinations of active ingredients with insecticidal and acaricidal properties |
| CN101884331A (en) * | 2010-07-08 | 2010-11-17 | 东莞市瑞德丰生物科技有限公司 | Synergistic mite killing composition |
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| JP5091470B2 (en) * | 2006-12-05 | 2012-12-05 | クミアイ化学工業株式会社 | Agricultural and horticultural compositions |
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| CN1635834A (en) * | 2000-03-21 | 2005-07-06 | 拜尔公司 | Combinations of active ingredients with insecticidal and acaricidal properties |
| CN101884331A (en) * | 2010-07-08 | 2010-11-17 | 东莞市瑞德丰生物科技有限公司 | Synergistic mite killing composition |
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