CN105165836A - Sterilization composition containing prothioconazole and cyflufenamid - Google Patents
Sterilization composition containing prothioconazole and cyflufenamid Download PDFInfo
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- CN105165836A CN105165836A CN201510423475.6A CN201510423475A CN105165836A CN 105165836 A CN105165836 A CN 105165836A CN 201510423475 A CN201510423475 A CN 201510423475A CN 105165836 A CN105165836 A CN 105165836A
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- cyflufenamid
- prothioconazoles
- bactericidal composition
- composition containing
- powdery mildew
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Abstract
The invention discloses a sterilization composition containing prothioconazole and cyflufenamid. The composition comprises a common assistant, prothioconazole and cyflufenamid, a weight part ratio of prothioconazole to cyflufenamid is 20:1-1:20, and the total weight percentage of prothioconazole and cyflufenamid in the sterilization composition is 1-90%. The sterilization composition is suitable for controlling powdery mildew of crops, has an obviously better control effect than single doses, reduces the use dosage of pesticides and reduces the cost.
Description
Technical field
The present invention relates to pesticide sterilizing composite, be with prothioconazoles and cyflufenamid for active ingredient, be applicable to prevent and treat crop powdery mildew.
Background technology
Prothioconazoles; english common name Prothioconazole; for triazolinthione series bactericidal agent; it is the demethylation effect on the precursor-lanosterol of sterol in Antifungi or the liquor-saturated l4 position of 24-methylene dihydro Mi hair; i.e. demethylation inhibitors (DMIs); not only there is good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.Prothioconazoles is mainly used in control cereal crop as numerous diseases such as wheat, barley, rape, peanut, paddy rice and legume crops.Almost there is good control efficiency, as the powdery mildew, banded sclerotial blight, fusarium wilt, leaf spot, rust, stalk break, net blotch, moire disease etc. of Wheat and barley to all wheat class diseases; The soil-borne disease of oily Lay and peanut can also be prevented and treated, as stalk break, and main foliage disease, as gray mold, black spot, brown spot, balck shank, stalk break and rust etc.
Cyflufenamid, english common name cyflufenamid is the acid amide fungicides for preventing and treating various crop powdery mildew, suppresses the formation of the haustorium on Powdery Mildew mycelia and growth, the growth of secondary hyphae and conidial formation.
Cyflufenamid is systemic fungicide, has excellent protection, therapeutic activity, holding effect is active and resistance of rainwater washing against is active; With the numerous bactericide used at present without cross resistance, there are excellent effect and characteristic to the powdery mildew of various vegetables and wheat class.
Found by test, prothioconazoles and cyflufenamid Fusicladium used in combination (Fusicladium), ring Fusicladium (Sphlocaea) and Erysiphaceae (Erysiphales) pathogen tool pathogen have synergistic function especially in 20:1 ~ 1:20 proportion, to have obvious synergistic effect to Erysiphaceae (Erysiphales) pathogen.
Can excipient be the formulation agriculturally commonly used by certain technological means prothioconazoles and cyflufenamid composition.
Summary of the invention
The technical problem that the present invention need solve be to provide a kind of efficient, low toxicity, quick-acting are good and the lasting period is long, are conducive to the bactericidal composition containing prothioconazoles and cyflufenamid that crop powdery mildew does harm to the comprehensive regulation.
For solving the problem, the technical solution adopted in the present invention is: a kind of bactericidal composition containing prothioconazoles and cyflufenamid, comprise usual auxiliaries, prothioconazoles and cyflufenamid, the ratio of weight and number of prothioconazoles and cyflufenamid is 20:1-1:20, and prothioconazoles and the percentage by weight of cyflufenamid weight summation in bactericidal composition are 1-90%.
Further: the above-mentioned bactericidal composition containing prothioconazoles and cyflufenamid can be mixed with suspending agent, dispersible oil-suspending agent according to well known to a person skilled in the art method, water dispersible granules, wetting powder.
The described bactericidal composition containing prothioconazoles and cyflufenamid also contains the usual auxiliaries of preparation needed for pesticidal preparations, usual auxiliaries is the mixing of one or more in solvent, emulsifier, wetting agent, stabilizing agent, dispersant, thickener, pH adjusting agent, defoamer, antifreezing agent, filler etc., be known substance, various auxiliary agents conventional in pesticidal preparations, can change to some extent according to different situations, be not particularly limited.
The described bactericidal composition containing prothioconazoles and cyflufenamid, for preventing and treating crop powdery mildew, the especially crop powdery mildew such as wheat, apple, cucumber, grape, strawberry, ornamental flower.
, early stage or the use of disease initial stage of origination should be there is in disease when applying in bactericidal composition provided by the invention.
Bactericidal composition provided by the invention, usually adopts the method for spraying to use, also can adopt other operation techniques agriculturally applied as required.
Bactericidal composition provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention, shows obvious synergistic effect in certain ratio range, and the control efficiency of composition is significantly improved than single dose, reduces the using dosage of agricultural chemicals, decreases the impact of agricultural chemicals on environment, reduces drug cost.
2, the active ingredient mechanism of action of bactericidal composition provided by the invention is different, and the application of composition can delay or overcome the generation of disease drug resistance, extends the service life of medicament, is conducive to the comprehensive regulation of disease.
Embodiment
In order to understand essence of the present invention better, be described further by following examples, but the present invention is not limited to these embodiments.
According to the abundant method of Sun Yun, the synergy of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), namely CTC≤80 are joint action of antagonism, and 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.Actual measurement toxicity index (ATI)=(EC of standard agent
50the EC of/reagent agent
50) × 100; In the toxicity index × mixture of theoretical toxicity index TTI=A medicament the percentage composition+B medicament of A medicament toxicity index × mixture in the percentage composition of B medicament; Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
Embodiment one: prothioconazoles cyflufenamid is to the Toxicity Determination of dlumeria graminis cereal specialized form (Blumeriagraminisf.sp.tritici).
Subjects picks up from wheat powdery mildew pathogen dlumeria graminis cereal specialized form (Blumeriagraminisf.sp.tritici) in field, method reference " People's Republic of China (PRC) agricultural industry criteria NY/T1156.4-2006 ", pot experiment method.
Table 1, prothioconazoles cyflufenamid are to the Toxicity Determination result of dlumeria graminis cereal specialized form (Blumeriagraminisf.sp.tritici)
As shown in Table 1, prothioconazoles and cyflufenamid mixture are between 20:1 ~ 1:20, and have obvious synergistic effect to dlumeria graminis cereal specialized form (Blumeriagraminisf.sp.tritici), co-toxicity coefficient is all more than 155.
Embodiment two: prothioconazoles cyflufenamid is to the Toxicity Determination of monofilament shell (Sphaerothecafuliginea).
Subjects is pick up from powdery mildew of cucumber pathogen monofilament shell (Sphaerothecafuliginea) in field, pot experiment method.
Table 2, prothioconazoles cyflufenamid are to the Toxicity Determination result of monofilament shell (Sphaerothecafuliginea)
As shown in Table 2, prothioconazoles and cyflufenamid mixture are between 20:1 ~ 1:20, and have obvious synergistic effect to Tartar internal thread powdery mildew (Leveillulataurica), co-toxicity coefficient is all more than 150.
Embodiment three: prothioconazoles cyflufenamid hooks the Toxicity Determination of silk shell bacterium (Uncinulanecator) to grape.
Subjects is pick up from grape powdery mildew pathogen Tartar internal thread powdery mildew (Leveillulataurica) in field, pot experiment method.
Table 3, prothioconazoles cyflufenamid hook the Toxicity Determination result of silk shell bacterium (Uncinulanecator) to grape
As shown in Table 3, prothioconazoles and cyflufenamid mixture are between 20:1 ~ 1:20, and hook silk shell bacterium (Uncinulanecator) to grape and have obvious synergistic effect, co-toxicity coefficient is all more than 150.
Below in conjunction with preparation method's embodiment to further instruction of the present invention.
Embodiment four: (prothioconazoles cyflufenamid suspending agent)
Pulverized in advance in proportion by above-mentioned formula, then add in sand mill and grind, after high shear mixing, allotment obtains the prothioconazoles cyflufenamid suspending agent of corresponding percentage by weight.
Embodiment five: 40% prothioconazoles cyflufenamid suspending agent
Prothioconazoles 305 grams, cyflufenamid 103 grams, 35 grams, lignosulfonates sodium, 31 grams, fatty acid ester sodium sulphate, to methoxyl group fatty acyl anilinesulfonic acid 5.1 grams, fatty alcohol-polyoxyethylene ether 5.1 grams, glycerine 5.2 grams, xanthans 1.1 grams, deionized water complements to 1000 grams, above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, after high shear mixing, allocate prothioconazoles cyflufenamid suspending agent processed, after testing, prothioconazoles content 30.3%, cyflufenamid content 10.2%, total effective content 40.5%.
Embodiment six: for preventing and treating wheat powdery mildew
The spraying of 200ga.i./ha thin up pressed by 40.7% prothioconazoles cyflufenamid suspending agent, after medicine, the preventive effect of 7 days, 14 days is 88.2%, 82.1%, 50% prothioconazoles water dispersible granules presses 200ga.i./ha, 10% cyflufenamid suspending agent by the spraying of 200ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 80.2%, 71.4% and 82.3%, 70.1%.Prothioconazoles and the composite rear synergistic effect of cyflufenamid obvious, single dose is better than to the preventive effect successful of wheat powdery mildew, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of a kind of wheat powdery mildew.
Embodiment seven: for preventing and treating powdery mildew of cucumber
The spraying of 180ga.i./ha thin up pressed by 40.7% prothioconazoles cyflufenamid suspending agent, after medicine, the preventive effect of 7 days, 14 days is 91.2%, 84.3%, 50% prothioconazoles water dispersible granules presses 180ga.i./ha, 10% cyflufenamid suspending agent by the spraying of 180ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 81.1%, 70.2% and 81.6%, 71.4%.Prothioconazoles and the composite rear synergistic effect of cyflufenamid obvious, single dose is better than to the preventive effect successful of powdery mildew of cucumber, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of a kind of powdery mildew of cucumber.
Embodiment eight: (prothioconazoles cyflufenamid oil-suspending agent)
Above-mentioned material (except organobentonite) is joined in reactor mixer together, stir 2 hours, open pan feeding valve at the bottom of still, material is injected stage sand grinding machine to grind, fineness of materials 98% after grinding is by discharging after 1-5um, material puts into high-shear emulsifying still again together with the organobentonite dissolved in advance, namely can be made into the prothioconazoles cyflufenamid oil-suspending agent of the good corresponding percentage by weight of flowing to property after emulsification.
Embodiment nine: 30% prothioconazoles cyflufenamid oil-suspending agent
Prothioconazoles 155 grams, cyflufenamid 154 grams, 45 grams, lignosulfonates sodium, fatty alcohol-polyoxyethylene ether 52 grams, methyl oleate 249 grams, organobentonite 83 grams, dodecyl sodium sulfonate calcium salt 60 grams, turpentine oil complements to 1000 grams, is pulverized in advance in proportion by above-mentioned formula, add in sand mill again and grind, the obtained prothioconazoles cyflufenamid oil-suspending agent of allotment after high shear mixing, after testing, prothioconazoles effective content 15.2%, cyflufenamid effective content 15.1%, total effective content 30.3%.
Embodiment ten: for preventing and treating grape powdery mildew
30.3% prothioconazoles cyflufenamid oil-suspending agent presses the spraying of 500mg/kg thin up, after medicine, the preventive effect of 7 days, 14 days is 90.1%, 82.4%, 50% prothioconazoles water dispersible granules presses 500mg./kg, 10% cyflufenamid suspending agent by the spraying of 500mg/kg thin up, and after medicine, 7 days, 14 days preventive effects are respectively 80.1%, 71.5% and 81.2%, 69.3%.Prothioconazoles and the composite rear synergistic effect of cyflufenamid obvious, single dose is better than to the preventive effect successful of grape powdery mildew, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of a kind of grape powdery mildew.
Embodiment 11: for preventing and treating apple mildew
30.3% prothioconazoles cyflufenamid oil-suspending agent presses the spraying of 180ga.i./ha thin up, after medicine, the preventive effect of 7 days, 14 days is 91.2%, 83.5%, 50% prothioconazoles water dispersible granules presses 180ga.i./ha, 10% cyflufenamid suspending agent by the spraying of 180ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 82.2%, 73.1% and 81.4%, 69.9%.Prothioconazoles and the composite rear synergistic effect of cyflufenamid obvious, single dose is better than to the preventive effect successful of apple mildew, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of a kind of apple mildew.
Embodiment 12: (prothioconazoles cyflufenamid water dispersible granules)
Above-mentioned material is added in cone-type mixer together and mixes; pulverize by airslide disintegrating mill; material after pulverizing mixes through cone-type mixer again; mixed fineness of materials 98% is by 600 mesh standard sieves; add in kneader and be kneaded into plasticity material; finally this material is put into Squeezinggranulator extruder grain, after drying, screening, after granulation, namely obtain the prothioconazoles cyflufenamid water dispersible granules of corresponding percentage by weight.
Embodiment 13: 60% prothioconazoles cyflufenamid water dispersible granules
Prothioconazoles 456 grams, cyflufenamid 155 grams, sodium lignin sulfonate 42 grams, 60 grams, polycarboxylic acids sodium, glucose 52 grams, 39 grams, the withered powder of tea, kaolin complements to 1000.By above-mentioned formula in proportion dry pulverization process, granulation, drying, screening make and obtain prothioconazoles cyflufenamid water dispersible granules, after testing, prothioconazoles effective content 45.1%, cyflufenamid effective content 15.2%, total effective content 60.3%.
Embodiment 14: for preventing and treating powdery mildew of strawberry
60.3% prothioconazoles cyflufenamid water dispersible granules presses the spraying of 150ga.i./ha thin up, after medicine, the preventive effect of 7 days, 14 days is 90.2%, 83.4%, 50% prothioconazoles water dispersible granules presses 150ga.i./ha, 10% cyflufenamid suspending agent by the spraying of 150ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 81.2%, 71.3% and 82.2%, 71.3%.Prothioconazoles and the composite rear synergistic effect of cyflufenamid obvious, single dose is better than to the preventive effect successful of powdery mildew of strawberry, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of a kind of powdery mildew of strawberry.
Embodiment 15: (prothioconazoles cyflufenamid wetting powder)
Above-mentioned material is added in cone-type mixer together and mixes, pulverize by airslide disintegrating mill, material after pulverizing is again through cone-type mixer mixing, and mixed fineness of materials 98%, by 600 mesh standard sieves, obtains the prothioconazoles cyflufenamid wetting powder of corresponding percentage by weight.
Embodiment 16: 50% prothioconazoles cyflufenamid wetting powder
Prothioconazoles 357 grams, cyflufenamid 152 grams, lignosulfonates calcium 54 grams, lauryl sodium sulfate 41 grams, sodium butylnaphthalenesulfonate 52 grams, white carbon 51 grams, kaolin complements to 1000 grams.Mix entering in blender after above-mentioned formula in proportion coarse crushing, namely prothioconazoles cyflufenamid wetting powder is obtained again after air-flow crushing, after testing, prothioconazoles effective content 35.1%, cyflufenamid effective content 15.3%, total effective content 50.4%.
Embodiment 17: for preventing and treating Rose Powdery Mildew
The spraying of 150ga.i./ha thin up pressed by 50.4% prothioconazoles cyflufenamid wetting powder, after medicine, the preventive effect of 7 days, 14 days is 90.8%, 82.6%, 50% prothioconazoles water dispersible granules presses 150ga.i./ha, 10% cyflufenamid suspending agent by the spraying of 150ga.i./ha thin up, and after medicine, 7 days, 14 days preventive effects are respectively 80.5%, 70.0% and 81.3%, 68.2%.Prothioconazoles and the composite rear synergistic effect of cyflufenamid obvious, single dose is better than to the preventive effect successful of Rose Powdery Mildew, obviously reduce when in compound drug, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of a kind of Rose Powdery Mildew.
Claims (5)
1. one kind contains the bactericidal composition of prothioconazoles and cyflufenamid, comprise usual auxiliaries, prothioconazoles and cyflufenamid, it is characterized in that: the ratio of weight and number of prothioconazoles and cyflufenamid is 20:1-1:20, prothioconazoles and the percentage by weight of cyflufenamid weight summation in bactericidal composition are 1-90%.
2. a kind of bactericidal composition containing prothioconazoles and cyflufenamid according to claim 1, is characterized in that: described bactericidal composition also contains usual auxiliaries, to make the application forms being applicable to agriculturally using.
3. a kind of bactericidal composition containing prothioconazoles and cyflufenamid according to claim 2, is characterized in that: described application forms is suspending agent, the one dispersibled in oil-suspending agent, water dispersible granules, wetting powder.
4. a kind of bactericidal composition containing prothioconazoles and cyflufenamid according to any one of a claim 1-3 is applied on control crop powdery mildew.
5. a kind of bactericidal composition containing prothioconazoles and cyflufenamid according to claim 4, is characterized in that: described crops are wheat, apple, cucumber, grape, strawberry, ornamental flower.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| US20100298139A1 (en) * | 2007-06-06 | 2010-11-25 | Bayer Cropscience Ag | Fungicide active ingredient combinations |
| CN102308808A (en) * | 2011-10-10 | 2012-01-11 | 海利尔药业集团股份有限公司 | Antibacterial composition containing cyflufenamid and triazole bactericides |
| CN103814904A (en) * | 2014-02-28 | 2014-05-28 | 海利尔药业集团股份有限公司 | Bactericidal composition containing prothioconazole and cyflufenamid |
-
2015
- 2015-07-19 CN CN201510423475.6A patent/CN105165836A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1642423A (en) * | 2002-03-21 | 2005-07-20 | 巴斯福股份公司 | Fungicidal mixtures |
| US20100298139A1 (en) * | 2007-06-06 | 2010-11-25 | Bayer Cropscience Ag | Fungicide active ingredient combinations |
| CN102308808A (en) * | 2011-10-10 | 2012-01-11 | 海利尔药业集团股份有限公司 | Antibacterial composition containing cyflufenamid and triazole bactericides |
| CN103814904A (en) * | 2014-02-28 | 2014-05-28 | 海利尔药业集团股份有限公司 | Bactericidal composition containing prothioconazole and cyflufenamid |
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