CN102630680A - Bactericide composition with synergy and preparation method thereof - Google Patents
Bactericide composition with synergy and preparation method thereof Download PDFInfo
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- CN102630680A CN102630680A CN2012101016012A CN201210101601A CN102630680A CN 102630680 A CN102630680 A CN 102630680A CN 2012101016012 A CN2012101016012 A CN 2012101016012A CN 201210101601 A CN201210101601 A CN 201210101601A CN 102630680 A CN102630680 A CN 102630680A
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- thifluzamide
- tebuconazole
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- synergistic effect
- microbicide compositions
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Abstract
The invention discloses a bactericide composition with synergy and a preparation method thereof. The preparation method comprises the following steps of: adding thifluzamide, tebuconazole and additives into an enamel stirring kettle for uniform mixing, then performing airflow crushing or grinding, and then preparing into the bactericide composition containing the thifluzamide and the tebuconazole, which is of wettable powder or suspension concentrate. The thifluzamide and the tebuconazole are compounded, thus the bactericide composition has the characteristics of low toxicity, low residue, broad bactericidal spectrum, good lasting effect and low cost, and further becomes a relatively ideal high-efficiency and low-toxicity pesticide variety for controlling rice sheath blight.
Description
Technical field
The present invention relates to the pesticide processing technical field, particularly a kind of microbicide compositions and preparation method thereof with synergistic effect.
Showing has stronger preventing disease theraping effect to agricultural disease, can be widely used in preventing and treating the paddy rice multiple diseases.This microbicide compositions with synergistic effect is different from existing other bactericidal compositions or the agent of agricultural chemicals list, adopts the reasonable combination of thifluzamide and these two kinds of agricultural chemicals of Tebuconazole, can delay the generation of disease drug resistance; Use simple; Safety, control efficiency is good, and residual quantity is low environmentally safe; Promote crops safety and high-quality production, agricultural production and income is played an important role.
Background technology
The rice banded sclerotial blight disease is the main disease that hazard rice is produced, and realizes that the rice disease non-environmental pollution control is the developing direction and the objective of the struggle in agricultural plant protection field.In recent years; Though country prohibites the agricultural chemicals that on paddy rice, uses high poison and high residue; But for want of efficient disease control medicament in actual agricultural production process and use the phenomenon of persistent pesticide also comparatively general; Therefore, the novel agrochemical of efficient, the low toxicity of research and development, low-residual is a pesticide research exploitation inevitable development trend.
Thifluzamide (thifluzamide) is a kind of novel thiazole acid amide fungicides, has strong interior conductivity and the long lasting effect of inhaling.Main effect is the acidohydrogenase that suppresses in the disease fungus tricarbonic acid cycle, causes thalline dead.Thifluzamide is the succinate dehydrogenase inhibitor, because fluorine-containing, its its competitiveness in biochemical pathway is very strong, in case combine just to be difficult for recovering with substrate or enzyme.Thifluzamide all has activity to pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas, especially the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping off etc. is had special efficacy.Thifluzamide does not have activity to the phycomycetes class, and is to the disease that is caused by leaf portion pathogen, bad like the cercospora brown spot of peanut, black spot effect.Single simultaneously thifluzamide list agent with high-load is higher in present use cost.
Tebuconazole (Tebuconazole) is a kind of efficient, wide spectrum, interior absorption triazole bactericidal agent; It is the sterol demethylation inhibitor; Have protection, treat, root out three big functions, fungicidal spectrum is wide, the lasting period is long, is to be used for the seed treatment of important economic crops or the efficient germicide of foliage spray; Can prevent and treat multiple rust, powdery mildew, net blotch, root rot, the head blight of cereal crop effectively, smut and kind pass zonate spot etc.And also have resistant to lodging, characteristics such as production-increasing function is obvious.The agent of Tebuconazole list is used to prevent and treat that time limit of the main disease control of crop is longer, and the pesticide resistance of crop pest has had significant enhancing, and control efficiency descends.
Summary of the invention
The objective of the invention is to be directed against the multiple deficiency efficient at present, that wide spectrum disease control pesticidal preparations very lacks and existing agricultural chemicals list agent exists, providing a kind of is a kind of microbicide compositions with synergistic effect of product forms with wetting powder or suspending agent.
Containing active ingredient thifluzamide, Tebuconazole and auxiliary agent, filler, is benchmark with the gross weight of composition, and thifluzamide content is 15～40%, and Tebuconazole content is 3～30%, and auxiliary agent content is 2～25%, and filer content is 5～80%.
The present invention adopts the use that is mixed of thifluzamide and two kinds of low toxicity highly effective pesticides of Tebuconazole, and it had both kept the thifluzamide advantage good to the control efficiency of rice banded sclerotial blight disease, and the advantage of the sterilization wide spectrum after thifluzamide and the composite use of Tebuconazole; Can overcome thifluzamide again the phycomycetes class there is not activity, the Tebuconazole control efficiency existing shortcoming that descends year by year; Reach the purpose of compound synergic, realize the target of the nuisanceless integrated control of corps diseases, reduce other biological toxicity; The minimizing chemical substance is residual crops; Enlarge fungicidal spectrum, reduce cost, can adapt to crops such as paddy rice are produced the requirement that higher effective and lower toxic pesticide is used.Thifluzamide of the present invention and Tebuconazole novel built agricultural chemicals, low toxicity, low-residual, fungicidal spectrum are wide, and control efficiency is good, and the control cost is low, is the comparatively desirable low toxicity highly effective pesticide kind of control rice banded sclerotial blight disease.
When product forms of the present invention was wetting powder, described auxiliary agent auxiliary agent was by dispersant 1～20%, and wetting agent 1～5% is formed, and dispersant adopts lignosulfonates, NNO, draws back a kind of or any two or three mixture of powder.Wherein, lignosulfonates are selected calcium lignosulfonate or sodium lignin sulfonate for use; Wetting agent adopts sodium alkyl benzene sulfonate or alkyl benzene calcium sulfonate.That filler adopts is silica-based, a kind of or mixture in the precipitated calcium carbonate, white carbon, silica-based employing potter's clay, kaolin and diatomite etc.
When product forms of the present invention is suspending agent; Described auxiliary agent is by dispersion moisture agent 1～15%, antifreeze 0.3～3%, thickener 0.4～5%; Antifoaming agent 0.3～2% is formed; Dispersion moisture agent adopts polyoxyethylene triphenylethylene phosphenylic acid salt, or alkylnaphthalene sulfonate, or a kind of or mixture in the APES; Antifreeze adopts antifreeze to adopt alcohols, selects propane diols or glycerine or ethylene glycol for use; Thickener adopts xanthans or aluminium-magnesium silicate; Antifoaming agent adopts silicone defoaming agent.Filler adopts water.
The present invention also proposes a kind of its preparation process with microbicide compositions of synergistic effect: after earlier thifluzamide, Tebuconazole and auxiliary agent, filler fully being mixed in the enamel stirred tank; After airslide disintegrating mill pulverizing or sand mill grinding, mix again and make finished product.
The inventive method has produces many advantages such as simple, efficient, that the preparation cost is low, and environment compatibility is good.This microbicide compositions is different from existing other microbicide compositions, can suspension of pesticide resistance generation, reach the purpose of agricultural production and income and food safety production.
Embodiment
Embodiment 1 is for confirming that the different proportioning consumptions with Tebuconazole of thifluzamide are to the Rhizoctonia solani Kuhn fungistatic effect; Carried out the Toxicity Determination of the different proportionings of thifluzamide to Rhizoctonia solani Kuhn with Tebuconazole; Be made into respective concentration according to percentage by weight in the table, as follows with the result of the test report at present:
Table 1 thifluzamide and the agent of Tebuconazole list and mixture thereof are to Rhizoctonia solani Kuhn toxicity test result
Mensuration result shows that thifluzamide and Tebuconazole are mixed with 10: 1～1: 1 proportioning, can suppress the growth of Rhizoctonia solani Kuhn mycelia more by force, and the synergy that 5: 1 ratios are mixed is the most obvious.
Embodiment 2 preparations 30% thifluzamide tebuconazole suspension concentrates:
Thifluzamide 25%
Tebuconazole 5%
NPE (NP-9) (dispersion moisture agent) 8%
Propane diols (antifreeze) 1%
Xanthans (thickener) 1%
Silicone defoaming agent (SAG612) 2%
Water (filler) 58%
Take by weighing material by above-mentioned part by weight, after mixing, obtain product, prevent and treat rice-stem borer and banded sclerotial blight field control effectiveness test through the sand mill sand milling.
Table 2 30% thifluzamide tebuconazole suspension concentrates is prevented and treated 10 days preventive effects (%) behind the rice sheath blight disease medicine
(Hefei ,Anhui)
More than measuring the result shows; 30% thifluzamide tebuconazole suspension concentrates to the rice sheath blight disease preventive effect more than 80%; Compare with single agent such as 240 grams per liter thifluzamide suspending agents, 25% Tebuconazole wetting powders simultaneously; Have obvious synergistic effect, and have the remarkable advantage of non-environmental pollution control, be beneficial to agricultural extension and use.
Embodiment 3 preparations 30% thifluzamide Tebuconazole wetting powder:
Thifluzamide 25%
Tebuconazole 5%
NNO (dispersant) 3%
Sodium lignin sulfonate (dispersant) 7%
Sodium alkyl benzene sulfonate (dispersant) 1%
White carbon (filler) 59%
Take by weighing material by above-mentioned part by weight, under agitation add each material successively, after the airslide disintegrating mill pulverizing mixes again; Obtain product; Prevent and treat the rice sheath blight disease field control effectiveness test, drug effect is better, to the rice sheath blight disease preventive effect 80%; Compare with single agent such as 240 grams per liter thifluzamide suspending agents, 25% Tebuconazole wetting powders simultaneously, have obvious synergistic effect.
Table 3 30% thifluzamide Tebuconazole wetting powder is prevented and treated 10 days preventive effects (%) behind the rice sheath blight disease medicine
(Jiangdu, Jiangsu)
Claims (5)
1. the microbicide compositions that has synergistic effect; It is characterized in that containing active ingredient thifluzamide, Tebuconazole and auxiliary agent, filler; Gross weight with composition is a benchmark, and thifluzamide content is 15～40%, and Tebuconazole content is 3～30%; Auxiliary agent content is 2～25%, and filer content is 5～80%.
2. according to the said microbicide compositions with synergistic effect of claim 1, the formulation that it is characterized in that described composition is suspending agent or wetting powder.
3. according to the said microbicide compositions of claim 2, it is characterized in that the auxiliary agent of wetting powder is made up of 1～20% dispersant and 1～5% wetting agent of the gross weight that accounts for composition respectively with synergistic effect.
4. according to the said microbicide compositions of claim 2, it is characterized in that the auxiliary agent of suspending agent is made up of the gross weight that accounts for composition respectively 1～15% dispersion moisture agent, 0.3～3% antifreeze, 0.4～5% thickener and 0.3～2% antifoaming agent with synergistic effect.
5. the preparation method who has the microbicide compositions of synergistic effect according to claim 1; After it is characterized in that earlier thifluzamide, Tebuconazole and auxiliary agent, filler fully being mixed in the enamel stirred tank; After airslide disintegrating mill pulverizing or sand mill grinding, mix again and make finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101016012A CN102630680A (en) | 2012-04-10 | 2012-04-10 | Bactericide composition with synergy and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012101016012A CN102630680A (en) | 2012-04-10 | 2012-04-10 | Bactericide composition with synergy and preparation method thereof |
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| CN102630680A true CN102630680A (en) | 2012-08-15 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103329892A (en) * | 2013-07-12 | 2013-10-02 | 安徽美兰农业发展股份有限公司 | Suspending agent of thifluzamide and tebuconazole composite pesticide and preparation method of suspending agent |
| CN105340881A (en) * | 2015-11-15 | 2016-02-24 | 江苏东宝农化股份有限公司 | Sterilization suspending agent with synergistic interaction and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884754B1 (en) * | 2001-09-28 | 2005-04-26 | Syngenta Crop Protection, Inc. | Aqueous compositions for seed treatment |
| CN101790987A (en) * | 2010-03-02 | 2010-08-04 | 杭州宇龙化工有限公司 | Disinfection composite containing thifluzamide and hexaconazole |
| CN101828559A (en) * | 2010-06-02 | 2010-09-15 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
-
2012
- 2012-04-10 CN CN2012101016012A patent/CN102630680A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884754B1 (en) * | 2001-09-28 | 2005-04-26 | Syngenta Crop Protection, Inc. | Aqueous compositions for seed treatment |
| CN101790987A (en) * | 2010-03-02 | 2010-08-04 | 杭州宇龙化工有限公司 | Disinfection composite containing thifluzamide and hexaconazole |
| CN101828559A (en) * | 2010-06-02 | 2010-09-15 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing composite containing thifluzamide |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103329892A (en) * | 2013-07-12 | 2013-10-02 | 安徽美兰农业发展股份有限公司 | Suspending agent of thifluzamide and tebuconazole composite pesticide and preparation method of suspending agent |
| CN105340881A (en) * | 2015-11-15 | 2016-02-24 | 江苏东宝农化股份有限公司 | Sterilization suspending agent with synergistic interaction and preparation method thereof |
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Application publication date: 20120815 |