CN105163740A - 治疗和防治肠道损伤、紧密连接部功能障碍相关疾病的方法和组合物 - Google Patents

治疗和防治肠道损伤、紧密连接部功能障碍相关疾病的方法和组合物 Download PDF

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Publication number
CN105163740A
CN105163740A CN201480009770.0A CN201480009770A CN105163740A CN 105163740 A CN105163740 A CN 105163740A CN 201480009770 A CN201480009770 A CN 201480009770A CN 105163740 A CN105163740 A CN 105163740A
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CN
China
Prior art keywords
glycerophosphate
core
enteric coating
exercise
intestinal injury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480009770.0A
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English (en)
Chinese (zh)
Inventor
A·E·克利杰曼
M·T·韦斯
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PRELIEF Inc
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PRELIEF Inc
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Publication date
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Publication of CN105163740A publication Critical patent/CN105163740A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
CN201480009770.0A 2013-02-20 2014-02-20 治疗和防治肠道损伤、紧密连接部功能障碍相关疾病的方法和组合物 Pending CN105163740A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361766976P 2013-02-20 2013-02-20
US61/766,976 2013-02-20
US201361827080P 2013-05-24 2013-05-24
US61/827,080 2013-05-24
US201361897672P 2013-10-30 2013-10-30
US61/897,672 2013-10-30
PCT/US2014/017408 WO2014130678A2 (en) 2013-02-20 2014-02-20 Methods and compositions of treating and preventing intestinal injury and diseases related to tight junction dysfunction

Publications (1)

Publication Number Publication Date
CN105163740A true CN105163740A (zh) 2015-12-16

Family

ID=50240015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480009770.0A Pending CN105163740A (zh) 2013-02-20 2014-02-20 治疗和防治肠道损伤、紧密连接部功能障碍相关疾病的方法和组合物

Country Status (9)

Country Link
US (1) US20150374725A1 (https=)
EP (1) EP2958567A2 (https=)
JP (1) JP2016509059A (https=)
KR (1) KR20150141943A (https=)
CN (1) CN105163740A (https=)
AU (1) AU2014218903A1 (https=)
HK (1) HK1219868A1 (https=)
MX (1) MX2015010765A (https=)
WO (1) WO2014130678A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR101476A1 (es) 2014-08-07 2016-12-21 Acerta Pharma Bv Métodos para tratar cánceres, enfermedades inmunes y autoinmunes, y enfermedades inflamatorias en base a la tasa de ocupación de la tirosin quinasa de bruton (btk) y a la tasa de resíntesis de la tirosin quinasa de bruton (btk)
EP3345591A1 (en) * 2017-01-06 2018-07-11 Oystershell NV Oral dosage form for enhanced solubilization of a poorly soluble active agent and method of preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1487834A (zh) * 2001-01-19 2004-04-07 �����깫˾ 减轻哺乳动物肠道和泌尿生殖道的不适症状和生理状况的方法
CN1816324A (zh) * 2003-07-04 2006-08-09 尼克麦德丹麦公司 口服用的含甲状旁腺激素(pth)的药物组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2993837A (en) * 1959-07-13 1961-07-25 Frosst & Co Charles E Enteric coated tablets
US5665415A (en) 1995-07-26 1997-09-09 Akpharma Inc. Composition and method for increasing the pH of acid foods
US7402323B2 (en) 2002-08-21 2008-07-22 Akpharma, Inc. Compositions and methods for treating skin conditions
AR045068A1 (es) * 2003-07-23 2005-10-12 Univ Missouri Formulacion de liberacion inmediata de composiciones farmaceuticas
WO2008100980A1 (en) * 2007-02-14 2008-08-21 Prelief Inc. Methods for treating or preventing inflammation using a glycerophosphate salt
US20080220084A1 (en) * 2007-03-09 2008-09-11 Pfantastic Medical Research Institute, Llc Combination therapy for alleviating pain-related conditions
EP2180895A4 (en) * 2007-08-30 2012-04-11 Prelief Inc METHODS FOR IMPROVING THE HEALING OF ORAL INJURY USING GLYCEROPHOSPHATE SALT
WO2009052489A2 (en) * 2007-10-19 2009-04-23 Alba Therapeutics Corporation Novel inhibitors of mammalian tight junction opening

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1487834A (zh) * 2001-01-19 2004-04-07 �����깫˾ 减轻哺乳动物肠道和泌尿生殖道的不适症状和生理状况的方法
CN1816324A (zh) * 2003-07-04 2006-08-09 尼克麦德丹麦公司 口服用的含甲状旁腺激素(pth)的药物组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SANDRA L. GOSS, ET AL.: "Determination of calcium salt solubility with changes in pH and PCO2, simulating varying gastrointestinal environments", 《JOURNAL OF PHARMACY AND PHARMACOLOGY》 *

Also Published As

Publication number Publication date
WO2014130678A2 (en) 2014-08-28
KR20150141943A (ko) 2015-12-21
EP2958567A2 (en) 2015-12-30
MX2015010765A (es) 2016-05-09
WO2014130678A3 (en) 2014-11-20
AU2014218903A1 (en) 2015-09-17
US20150374725A1 (en) 2015-12-31
JP2016509059A (ja) 2016-03-24
HK1219868A1 (zh) 2017-04-21

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