CN105148112A - Traditional Chinese medicine composition for whitening and removing freckles - Google Patents
Traditional Chinese medicine composition for whitening and removing freckles Download PDFInfo
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- CN105148112A CN105148112A CN201510619186.3A CN201510619186A CN105148112A CN 105148112 A CN105148112 A CN 105148112A CN 201510619186 A CN201510619186 A CN 201510619186A CN 105148112 A CN105148112 A CN 105148112A
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Abstract
The invention relates to a traditional Chinese medicine composition for whitening and removing freckles. The composition is prepared into one of tea bags, granules, water pills and capsules from the following raw materials by adding auxiliary materials according to a conventional method. The raw materials comprise, by weight, 5-20 parts of ginseng, 5-20 parts of angelica sinensis, 5-15 parts of radix angelicae, 5-15 parts of poria cocos, 5-30 parts of coix seeds, 10-30 parts of peach kernels, 5-15 parts of flos carthami, 5-20 parts of folium mori, 51-30 parts of polygonatum kingianum and 5-30 parts of fructus lycii. The traditional Chinese medicine composition has the advantages of relieving dark skin, chloasma and other symptoms.
Description
Technical field
The present invention relates to Chinese medicine health care product and Chinese medicine field of pharmaceutical technology, particularly relate to the Chinese medicine composition for whitening and speckle dispelling.
Background technology
TCM Culture is in history culture succession process over the past thousands of years, constantly by inheritance and innovation, at present, adopt Chinese medicine health preserving and health-care effect to receive much concern, and play an important role at the daily life of modern and the various aspects such as disease treatment, prevention and health care.Along with the transformation of modern people's live and work mode, rhythm of life is constantly accelerated, in addition due to air pollution, radiation, stay up late, drink, the sub-health status that factor causes such as the irregular and operating pressure of diet is large, have a strong impact on people's daily life quality and duty, the skin chloasma that especially above factor causes, speckle, the symptom such as dark and gloomy.
Chloasma is the disease that a kind of common facial yellowish-brown pigementation is formed, and with normal skin distinct, has a strong impact on attractive in appearance, belongs to the excessive dermatosis of the melanin deposition day after tomorrow.Cause the factor of chloasma a lot, from the angle of the traditional Chinese medical science, think that chloasma betides insufficiency of vital energy and blood or internal injury caused by excess of seven emotions, improper diet and overtiredness, causes qi and blood disorder more, and essence and blood can not be gone up flourish in face.Select Chinese medicine health care product synthesis treatment, have safety, effectively, the features such as side effect is little, enjoy the favor of consumer, Development volue is comparatively large, wide market.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition for whitening and speckle dispelling improving the symptoms such as skin is dark and gloomy, chloasma.
For solving the problem, Chinese medicine composition for whitening and speckle dispelling of the present invention, is characterized in that: said composition is added adjuvant according to a conventional method by the raw material of following weight parts and made one in teabag, granule, watered pill or capsule: Radix Ginseng 5 ~ 20, Radix Angelicae Sinensis 5 ~ 20, the Radix Angelicae Dahuricae 5 ~ 15, Poria 5 ~ 15, Semen Coicis 5 ~ 30, Semen Persicae 10 ~ 30, Flos Carthami 5 ~ 15, Folium Mori 5 ~ 20, Rhizoma Polygonati 51 ~ 30, Fructus Lycii 5 ~ 30.
Radix Angelicae Sinensis in side of the present invention, Radix Ginseng have QI invigorating, nourish blood effect be monarch drug, Semen Persicae, Flos Carthami promoting blood circulation to restore menstrual flow, as ministerial drug, Rhizoma Polygonati, Fructus Lycii invigorating the liver and kidney, benefit essence is as making medicine, the Radix Angelicae Dahuricae, Semen Coicis, Folium Mori, Poria has invigorating spleen to remove dampness, and the merit of dispeling the wind, as adjuvant drug.All medicines share, and have QI invigorating, nourish blood, invigorate blood circulation, benefit essence, effect that invigorating spleen to remove dampness dispels the wind.
Function cures mainly: improve the current people especially symptom such as dark and gloomy, the chloasma of the skin that causes such as the large or environment undesirable element of fast, the pressure of women's daily life rhythm.
Usage and dosage: teabag every bag 5 ± 0.5g, each 1 bag, every day 2 times.Boiled water is taken after mixing it with water.
Granule every 0.4g, each serving with 3, every day 3 times.
The effective content being equivalent to the crude drug of more than 5g each serving consumption of watered pill, capsule.
The present invention compared with prior art has the following advantages:
1, each raw material choose integration of edible and medicinal herbs of the present invention Chinese medicine or be food and medicine Chinese medicine, containing abundant flavone, saponin, polysaccharide, trace element and other plurality kinds of health care compositions.All medicines, according to the mutual compatibility of Chinese medical theory, make the property of medicine strengthen, have QI invigorating, nourish blood, invigorate blood circulation, benefit essence, effect that invigorating spleen to remove dampness dispels the wind; And select pure natural raw material, safe and reliable.
2, acute toxicity test:
2.1 materials and methods
2.1.1 laboratory animal and medicine
Adopt the present composition to make whitening and speckle dispelling granule, (every gram is equivalent to raw medicinal herbs 1g), prepare with distilled water before use.Laboratory animal is Kunming mouse, body weight 20g ± 1g, male and female half and half, arranges 1 dosage group and blank group.Medicine and animal Jun You Gansu university of TCM provide.
2.2 experimental technique
Observe and disposablely give the mice whitening and speckle dispelling toxic reaction that granule produces and death condition, measure its acute toxicity.Through many experiments, because its toxicity is lower, one time gastric infusion cannot measure its LD
50.
Therefore select maximum dosage-feeding method according to " Chinese medicine, natural drug acute toxicity test technological guidance principle ", give by Cmax and the maximum gavage capacity (40mL/kg) of single point 2 gavages.Recording this product, can to join maximum gavage concentration be 0.5g/mL, by 40mL/kg/ inferior to 2 administrations in 24 hours, then mouse stomach administration acute toxicity test dose design is 40g/kg, for 30.7 times of quantity (calculate by body surface area, its small mouse dose,equivalent is: 10g/ people × 0.0026 ÷ 20g=1.3g/KgBW)
The preparation of 2.3 need testing solutions
Precise this product 25.0g, puts in 50ml volumetric flask, adds appropriate distilled water shake well, make to dissolve completely, and then adding distil water is settled to 50mL.The test sample concentration prepared is 0.5g/mL, fully stirs test sample before gavage.
2.4 grouping and administrations
Different sexes animal is divided into 2 groups at random, is respectively matched group and administration group, often organize each 5 of male and female.Mouse stomach administration, gavage amount is 0.8mL/10g.Divide 2 administrations, each gavage interval 12h, matched group gives isopyknic distilled water.Administration fasting in evening in first 1 day.
2.5 Indexs measure
Gastric infusion started record, totally 7 days the same day, and the behavioral activity of male and female mice in record 7d, fur, breathing, defecation, appetite and food ration, body weight, nose, eye, oral cavity are with or without abnormal secretion thing etc. and death condition.Dead animal becomes celestial at once, observes the change of mice main organs (heart, liver, spleen, lung, kidney etc.), and carries out pathologic finding.Put to death whole survival mice after 7d, dissect and postmortem internal organs.
2.6 result
Mice is movable normal after test medicine 3 gavages, has no overt toxicity reaction; In 7d, mice activity freely, and behavior, the mental status are normal, hair color light, and drinking-water of ingesting is all right, atremia, writhing and stick up tail; , there is not other untoward reaction and death condition in nose, eye, oral cavity secretions without exception.Put to death after 7d, do not find that internal organs are abnormal through dissection and postmortem.Mouse Weight change is in table 1.
Mouse Weight change (g, x ± s) of table 1 acute toxicity testing
Experimental result display present composition toxicity is extremely low, does not measure LD
50, therefore carry out maximum tolerated dose experiment.The granule mice maximum tolerance determination result that the present composition is made shows, the mice maximum tolerated dose on the 1st of this medicine is 40g/kg (amounting to crude drug in whole total amount), being about clinical Coming-of-Age Day (calculates by body surface area with dosage, its small mouse dose,equivalent is: 10g/ people × 0.0026 ÷ 20g=1.3g/KgBW) 30.7 times, have no toxic reaction, therefore think that this compositions is safe, nontoxic within the scope of therapeutic dose.
3, clinical experiment I:
(1) clinical data: random selecting working women population, the range of age is between 25 ~ 45 years old, and health without other diseases, and suffers from skin chloasma disease person.
(2) test method:
The treatment of the present composition is not adopted to be blank group, record blank group crowd's chloasma symptom variation and persistent period, Continuous Observation 14 days.Experimental group is suffer from chloasma disease crowd to take the obtained compositions of the embodiment of the present invention, boiled water is taken after being infused in hot water or decoction, every day 2 ~ 3 bags, each 1 bag, other medicine for removing speckle be taken or be taked to duration of test must not, and record medicine group crowd organizes chloasma symptom variation and persistent period with blank.
(3) curative effect determinate standard:
Effective: compared with blank group, chloasma all disappears or disappearance rate reach more than 70% or color and luster obviously weaken.
Effective: compared with blank group, chloasma not all disappear or disappearance mistake rate reach more than 30% or color and luster weaken.
Invalid: compared with blank group, chloasma disappears and has no change or color and luster weakens and is not improved.
(4) experimental result
Observe after each group of experimenter take the present composition, compare the improvement situation of chloasma with blank assay group.The results are shown in Table 2.
Table 2
As shown in Table 2, size and the mottle color and luster of women's chloasma is obviously improved after taking the present composition as seen.
4, clinical experiment II:
1. clinical data: choose white collar and treat more crowd with courtesy, the range of age is between 30 ~ 45 years old, and performance has chloasma and dim complexion, and lusterless complexion symptom is tested crowd.
2. test method:
The treatment of the present composition is not adopted to be blank group, record blank group crowd's chloasma and complexion symptom variation and persistent period, Continuous Observation 14 days.Experimental group is suffer from chloasma disease and dim complexion crowd to take the obtained compositions of the embodiment of the present invention, boiled water is taken after being infused in hot water or decoction, every day 2 ~ 3 bags, each 1 bag, other medicine for removing speckle be taken or be taked to duration of test must not, and record medicine group crowd organizes chloasma symptom variation and persistent period with blank.
3. curative effect determinate standard:
Effective: compared with blank group, chloasma disappearance rate reach more than 70% or complexion recover normal.
Effective: compared with blank group, chloasma does not all disappear or disappearance mistake rate reaches more than 30% or complexion improvement.
Invalid: compared with blank group, chloasma disappear have no change or complexion unchanged.
4. experimental result
Observe after each group of experimenter take the present composition, compare the improvement situation of chloasma and complexion with blank assay group.The results are shown in Table 3.
Table 3
As shown in Table 3, size and the mottle color and luster of women's chloasma is obviously improved after taking the present composition as seen.
Detailed description of the invention
embodiment 1for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made teabag: Radix Ginseng 20kg, Radix Angelicae Sinensis 20kg, Radix Angelicae Dahuricae 5kg, Poria 5kg, Semen Coicis 5kg, Semen Persicae 10kg, Flos Carthami 10kg, Folium Mori 5kg, Rhizoma Polygonati 10kg, Fructus Lycii 10kg.
Its preparation method is as follows: first selected by all medicines, removing impurity and non-medicinal effects; Then weigh each component by formula, and distinguish coarse crushing, drying; Secondly pulverize after all coarse crushings and the mixing of dried component, and cross 100 ~ 150 mesh sieves, obtain powder, this powder adds correctives mixing according to a conventional method after sterilizing, adopt aseptic filter paper bag subpackage, finally become the teabag of every bag of 5 ± 0.5g with medicinal composite film packaging.
embodiment 2for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made granule: Radix Ginseng 15kg, Radix Angelicae Sinensis 15kg, Radix Angelicae Dahuricae 5kg, Poria 5kg, Semen Coicis 5kg, Semen Persicae 10kg, Flos Carthami 10kg, Folium Mori 5kg, Rhizoma Polygonati 15kg, Fructus Lycii 15kg.
Its preparation method is as follows: first selected by all medicines, removing impurity and non-medicinal effects; Then weigh each component by formula, after soaking respectively solid-liquid ratio be 1:6 ~ 10, temperature is 80 ~ 100 DEG C, extraction time is 1 ~ 3 time, each extraction time be the condition of 0.5 ~ 2h under carry out water extraction according to a conventional method, obtain each component extracting solution; Filter after described each component extracting solution mixing, obtain filtrate, after this filtrate is concentrated under temperature is the condition of 80 ~ 100 DEG C, obtain concentrate; Described concentrate is crushed to 80 ~ 150 orders after being dried to constant weight through 60 ~ 85 DEG C, obtains powder; Described powder adds mannitol, aspartame and dextrin, starch through granulation, granulate, drying after sterilizing according to a conventional method, finally becomes the granule of every bag of 5 ± 0.5g with medicinal composite film packaging.
embodiment 3for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made watered pill: Radix Ginseng 5kg, Radix Angelicae Sinensis 5kg, Radix Angelicae Dahuricae 15kg, Poria 15kg, Semen Coicis 15kg, Semen Persicae 15kg, Flos Carthami 15kg, Folium Mori 5kg, Rhizoma Polygonati 5kg, Fructus Lycii 5kg.
Its preparation method is as follows: first selected by all medicines, removing impurity and non-medicinal effects; Then weigh each component by formula, after soaking respectively solid-liquid ratio be 1:6 ~ 10, temperature is 80 ~ 100 DEG C, extraction time is 1 ~ 3 time time, each extraction time be the condition of 0.5 ~ 2h under carry out water extraction according to a conventional method, obtain each component extracting solution; Filter after described each component extracting solution mixing, obtain filtrate, this filtrate obtains concentrate after concentrating under reduced pressure under temperature is the condition of 85 DEG C; Described concentrate is crushed to 80 ~ 150 orders after being dried to constant weight through 60 ~ 85 DEG C, obtains powder; Described powder adds magnesium stearate, starch through general ball after sterilizing according to a conventional method, makes the watered pill of every ball 0.3 ± 0.1g.
embodiment 4for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made capsule: Radix Ginseng 10kg, Radix Angelicae Sinensis 15kg, Radix Angelicae Dahuricae 10kg, Poria 10kg, Semen Coicis 10kg, Semen Persicae 10kg, Flos Carthami 10kg, Folium Mori 10kg, Rhizoma Polygonati 10kg, Fructus Lycii 10kg.
Its preparation method is as follows: first selected by all medicines, removing impurity and non-medicinal effects; Then each component is weighed by formula; Then mixed by all components, add water by 8 times of its weight decocts at 90 ~ 120 DEG C of temperature, decocts number of times 2 times, each 1.5h, and gained decocting liquid filters, merging filtrate; When described filtrate is concentrated into 50 DEG C according to a conventional method, relative density is the thick paste of 1.25 ~ 1.30; Finally, described thick paste is dried to constant weight, after pulverizing 80 ~ 120 mesh sieves, makes granule according to a conventional method, by every 1000 encapsulated and get final product.
embodiment 5for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made one in teabag, granule, watered pill or capsule: Radix Ginseng 5kg, Radix Angelicae Sinensis 10kg, Radix Angelicae Dahuricae 5kg, Poria 10kg, Semen Coicis 30kg, Semen Persicae 10kg, Flos Carthami 5kg, Folium Mori 5kg, Rhizoma Polygonati 10kg, Fructus Lycii 10kg.
embodiment 6for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made one in teabag, granule, watered pill or capsule: Radix Ginseng 5kg, Radix Angelicae Sinensis 10kg, Radix Angelicae Dahuricae 5kg, Poria 10kg, Semen Coicis 10kg, Semen Persicae 30kg, Flos Carthami 15kg, Folium Mori 5kg, Rhizoma Polygonati 5kg, Fructus Lycii 5kg.
embodiment 7for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made one in teabag, granule, watered pill or capsule: Radix Ginseng 5kg, Radix Angelicae Sinensis 10kg, Radix Angelicae Dahuricae 5kg, Poria 10kg, Semen Coicis 10kg, Semen Persicae 10kg, Flos Carthami 5kg, Folium Mori 20kg, Rhizoma Polygonati 12.5kg, Fructus Lycii 12.5kg.
embodiment 8for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made one in teabag, granule, watered pill or capsule: Radix Ginseng 5kg, Radix Angelicae Sinensis 10kg, Radix Angelicae Dahuricae 5kg, Poria 15kg, Semen Coicis 10kg, Semen Persicae 10kg, Flos Carthami 5kg, Folium Mori 5kg, Rhizoma Polygonati 30kg, Fructus Lycii 5kg.
embodiment 9for the Chinese medicine composition of whitening and speckle dispelling, said composition is added adjuvant according to a conventional method by the raw material of following weight parts and is made one in teabag, granule, tablet or capsule: Radix Ginseng 5kg, Radix Angelicae Sinensis 10kg, Radix Angelicae Dahuricae 5kg, Poria 10kg, Semen Coicis 15kg, Semen Persicae 10kg, Flos Carthami 5kg, Folium Mori 5kg, Rhizoma Polygonati 5kg, Fructus Lycii 30kg.
Claims (1)
1. for the Chinese medicine composition of whitening and speckle dispelling, it is characterized in that: said composition is added adjuvant according to a conventional method by the raw material of following weight parts and made one in teabag, granule, watered pill or capsule: Radix Ginseng 5 ~ 20, Radix Angelicae Sinensis 5 ~ 20, the Radix Angelicae Dahuricae 5 ~ 15, Poria 5 ~ 15, Semen Coicis 5 ~ 30, Semen Persicae 10 ~ 30, Flos Carthami 5 ~ 15, Folium Mori 5 ~ 20, Rhizoma Polygonati 51 ~ 30, Fructus Lycii 5 ~ 30.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106858591A (en) * | 2017-03-03 | 2017-06-20 | 威海百合生物技术股份有限公司 | One kind is dispelled macula lutea wrinkle health food and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135914A (en) * | 1996-03-20 | 1996-11-20 | 张凤春 | Oral liquid for health-care and skin protection |
| CN103211748A (en) * | 2013-04-24 | 2013-07-24 | 朱珠 | Natural whitening pearl barley flour as well as preparation method and application thereof |
-
2015
- 2015-09-25 CN CN201510619186.3A patent/CN105148112A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135914A (en) * | 1996-03-20 | 1996-11-20 | 张凤春 | Oral liquid for health-care and skin protection |
| CN103211748A (en) * | 2013-04-24 | 2013-07-24 | 朱珠 | Natural whitening pearl barley flour as well as preparation method and application thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中医世家: "老中医自制纯中药护肤品", 《HTTPBBS.GXSKY.COMFORUM-VIEWTHREAD.PHPMOD=VIEWTHREAD&TID=10852857&EXTRA=PAGE%3D1&PAGE=1》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106858591A (en) * | 2017-03-03 | 2017-06-20 | 威海百合生物技术股份有限公司 | One kind is dispelled macula lutea wrinkle health food and preparation method thereof |
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