CN105147952A - Traditional Chinese and western medicine compound injection for great occipital neuralgia and preparation method thereof - Google Patents
Traditional Chinese and western medicine compound injection for great occipital neuralgia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses traditional Chinese and western medicine compound injection for great occipital neuralgia and a preparation method thereof. The injection is prepared from the following medicinal raw materials: toona leaves, Indian nightshade roots, loquat cores, iris confusa, neocinnamomum lecomtei liou, ustilago nuda, urtica macrorrhiza, alpine cladonia, delonix regia, calastrus flagellaris rupr, heterohairy monkshood root, root of scopolia sinensis hemsl, womwoodleaf ampelocissus root, hedyotis tenelliflora, clerodendron inerme, ternate-leaved rabdosia, pratt mountainash root-bark, haloragis micrantha, Japanese snake gourd root, osmanthus fragrans, dolomiaea berardioidea, wilson citrus seed, glomeris, atropine, vitamin C, thiamine, zinc gluconate and magnesium sulfate. The injection has the effects of activating blood circulation, dredging collaterals, dispelling wind and cold, diminishing swelling, removing stasis, soothing liver, regulating qi, diminishing inflammation and relieving pain, can be used for relieving local muscle spasm, improving local microcirculation of nerve involvement and nourishing nerves, and is advantageous to focus regeneration and repair. Furthermore, drugs can directly reach a focus with good absorption, by means of local injection, so that the injection has quick response, is convenient to treat, acupuncture, massage and other complicated processes can be reduced, and the blank of the prior art can be filled up.
Description
Technical field
The present invention relates to medical art, specifically relate to a kind of Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve and preparation method thereof.
Background technology
Neuralgia of greater occipital nerve refers to (rear pillow part) paroxysmal or rest pain in greater occipital nerve distribution, also can paroxysmal aggravation on lasting pain basis.Often because wind and cold, flu cause, also can be frequently true because of the cause of disease had caused by the cervical spondylosis such as cervical trauma, Hypertrophic cervical spondylosis.Clinical manifestation be one or both sides rear pillow part or hold concurrently containing napex acupuncture sample, lancinate sample or burn sample pain, during pain, patient dare not rotary head, and incidence is in straight configuration sometimes.There are tenderness, greater occipital nerve areal area (C2-3) i.e. ear top line in visible large neural exit of having a medical check-up with down to the hyperpathia of hairline place or go down.
In recent years, the understanding of clinician to neuralgia of greater occipital nerve improves gradually, the Therapeutic Method of bibliographical information comprises the multiple treatment meanss such as acupuncture and moxibustion treatment, drug injection therapy, Western medicine therapy, physiotherapy, combination of Chinese and Western medicine composite treatment and surgical operation therapy, great majority treatment is based on Western medicine in conjunction with the therapy such as acusector, small needle knife, and the simple report using medicine to adjust the inherent physiological function of human body but never has.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve and preparation method thereof, good therapeutic effect can be reached by using merely medicine, Therapeutic Method is simple and easy to do, and cure rate is high, fills up the blank of prior art.
As claimed in claim 1, technical scheme of the present invention is, a kind of Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 80 ~ 150g, Radix Solani indici 50 ~ 100g, Radix Eriobotryae 40 ~ 90g, Rhizoma Tupistrae Wattii 45 ~ 90g, Mu Dali king 20 ~ 60g, Ustilago nuda (Jens.) Rostr. 20 ~ 50g, the blue or green fiber crops 30 ~ 60g that lives, Cladonia alpestris (L.) Rabenh. 50 ~ 120g, Ramulus et Folium Delonicis regiae 40 ~ 100g, sting luxuriant fruits of Celastrus orbiculatus Thunb 100 ~ 200g, Radix Aconiti Heterotrichi 0.5 ~ 1.0g, it fluffy daughter root 5 ~ 15g, Radix Ampelocissi artemisiaefoilae 30 ~ 160g, stone maple medicine 50 ~ 100g, Clerodendron inerme (L.) Gaertn. 8 ~ 20g, Herba Rabdosiae Ternifoliae 30 ~ 70g, Sorbus unguicilata Koehne 40 ~ 120g, Herba Haloragidis Micranthae 25 ~ 50g, Radix Trichosanthis Cucumeroidis 30 ~ 80g, Liquor Flos osmanthi Distillata 20 ~ 30g, thick leaf Radix Vladimiriae 30 ~ 50g, wilson citrus seed 30 ~ 150g, Prospiroboli joannsi 2 ~ 8g, atropine 1 ~ 4g, vitamin C 5 ~ 20g, thiamine 3 ~ 10g, zinc gluconate 12 ~ 20g, magnesium sulfate 6 ~ 15g.
Further, the described Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 115g, Radix Solani indici 75g, Radix Eriobotryae 65g, Rhizoma Tupistrae Wattii 67.5g, Mu Dali king 40g, Ustilago nuda (Jens.) Rostr. 35g, the blue or green numb 45g that lives, Cladonia alpestris (L.) Rabenh. 85g, Ramulus et Folium Delonicis regiae 70g, sting luxuriant fruits of Celastrus orbiculatus Thunb 150g, Radix Aconiti Heterotrichi 0.75g, it fluffy daughter root 10g, Radix Ampelocissi artemisiaefoilae 95g, stone maple medicine 75g, Clerodendron inerme (L.) Gaertn. 14g, Herba Rabdosiae Ternifoliae 50g, Sorbus unguicilata Koehne 80g, Herba Haloragidis Micranthae 37.5g, Radix Trichosanthis Cucumeroidis 55g, Liquor Flos osmanthi Distillata 25g, thick leaf Radix Vladimiriae 40g, wilson citrus seed 90g, Prospiroboli joannsi 5g, atropine 2.5g, vitamin C 12.5g, thiamine 6.5g, zinc gluconate 16g, magnesium sulfate 10.5g.
For a preparation method for the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, concrete steps are as follows:
(1) Folium toonae sinensis 80 ~ 150g is got, Radix Solani indici 50 ~ 100g, Radix Eriobotryae 40 ~ 90g, Mu Dali king 20 ~ 60g, Ustilago nuda (Jens.) Rostr. 20 ~ 50g, the blue or green fiber crops 30 ~ 60g that lives, Cladonia alpestris (L.) Rabenh. 50 ~ 120g, Ramulus et Folium Delonicis regiae 40 ~ 100g, sting luxuriant fruits of Celastrus orbiculatus Thunb 100 ~ 200g, Radix Ampelocissi artemisiaefoilae 30 ~ 160g, stone maple medicine 50 ~ 100g, Clerodendron inerme (L.) Gaertn. 8 ~ 20g, Herba Rabdosiae Ternifoliae 30 ~ 70g, Sorbus unguicilata Koehne 40 ~ 120g, Herba Haloragidis Micranthae 25 ~ 50g, Radix Trichosanthis Cucumeroidis 30 ~ 80g, thick leaf Radix Vladimiriae 30 ~ 50g, wilson citrus seed 30 ~ 150g, be processed into coarse powder, add the water of 3 ~ 5 times of medical material weight, soak 2 ~ 3 hours, the wet medical material obtained loads in extraction pot together with its soak, decoct extraction twice, the weight that first time adds water is 4 ~ 6 times of former weighing medical material weight, decoct 1.5 ~ 2.5 hours, the weight that second time adds water is 3 ~ 5 times of former weighing medical material weight, decocts 0.5 ~ 1.0 hour, merges extracted twice liquid, filter, when to be concentrated into crude drug part by weight be 1: 1, be cooled to 40 ~ 50 DEG C by filtrate, add 80 ~ 90% ethanol, make ethanol content reach 65 ~ 75%, stir, leave standstill 48h, get supernatant, sucking filtration, obtain filtrate, reclaim ethanol to solution without alcohol taste, being evaporated to water content is 80 ~ 90%, for extracting solution I, stand-by,
(2) Rhizoma Tupistrae Wattii 45 ~ 90g, the fluffy daughter root 5 ~ 15g in sky is got, pulverize, cross 20 ~ 50 mesh sieves, the concentration adding 3 ~ 5 times of volumes is the ethanol of 75%, at 85 DEG C, water-bath is extracted 2 ~ 3 hours, obtain extracting solution, add the water of 2.5 ~ 3 times of volumes in gained extracting solution, hold over night, filter to get filtrate, being evaporated to water content is 80 ~ 90%, is extracting solution II, stand-by;
(3) get Radix Aconiti Heterotrichi 0.5 ~ 1.0g, Prospiroboli joannsi 2 ~ 8g, pulverize, add the water of 3 ~ 5 times of medical material weight, soak 2 ~ 3 hours, the wet medical material obtained loads in container together with its soak, carries out hyperpressure extraction respectively, pressure 300 ~ 350MPa, dwell time 12 ~ 15min, merge two kinds of extracting solution, then add ethanol, stir and leave standstill 4 ~ 10 hours, filter, obtain filtrate, being evaporated to water content is 80 ~ 90%, is extracting solution III, stand-by;
(4) extracting solution I, the extracting solution II prepared by above-mentioned steps (1) to (3), extracting solution III are merged, add natural clarifying agent, stir, temperature remains on 55 ~ 65 DEG C, leaves standstill after 5 ~ 10 hours, high speed centrifugation, get supernatant, 0.35 ~ 0.65 μm of microporous filter membrane filters filter, obtains a liquid, stand-by;
(5) get Liquor Flos osmanthi Distillata 20 ~ 30g, be dissolved in 30 ~ 60ml water for injection, after fully dissolving, obtain b liquid, for subsequent use;
(6) get atropine 1 ~ 4g, vitamin C 5 ~ 20g, thiamine 3 ~ 10g, zinc gluconate 12 ~ 20g, magnesium sulfate 6 ~ 15g, be dissolved in 30 ~ 80ml water for injection, after fully dissolving, obtain c liquid, for subsequent use;
(7) in dispensing canister by a liquid, b liquid, c liquid mix homogeneously, use sodium hydroxide solution adjust pH, be adjusted to 6.8 ± 0.3, add to the full amount of water for injection, cold preservation 48 hours, with filling and sealing machine by above-mentioned liquid medicine filling in ampoule bottle, sterilizing.
Further, the natural clarifying agent in described step (4) is ZTC1+1II, clarification, good impurity removing effect, improves the purity of medicine.
Further, in described step (6), concentration of sodium hydroxide solution is 25 ~ 30%.
Further, in described step (7), fill condition is: air purity rank is 100 grades, and room temperature is 15 ~ 25 DEG C, strict with standard execution, improves drug safety.
Further, described step (7) sterilizing adopt time 121 DEG C, 0.15 ~ 0.20Mpa leads to steam sterilization, sterilizing is 30 minutes, and steam sterilization both can killing microorganisms, can reduce again the destruction of nutritional labeling to greatest extent, improve the utilization rate of raw material.
Wherein, Folium toonae sinensis: [nature and flavor] are bitter is flat.[function cures mainly] antiinflammatory, removing toxic substances, parasite killing, pathogenic wind expelling toxic removing.
Radix Solani indici: [function cures mainly] dissipating blood stasis for subsidence of swelling, anti-inflammatory analgetic.
Radix Eriobotryae: [nature and flavor] are bitter; Flat; Nontoxic [function cures mainly] preventing phlegm from forming and stopping coughing, depressed liver-energy dispersing and QI regulating." control hernia, consumer edema, sharp joint, controls scrofula.
Rhizoma Tupistrae Wattii [nature and flavor] is pungent; Bitter; Cold; [function cures mainly] heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding; Reducing swelling and alleviating pain.Main cold anemopyretic; Cough pharyngalgia; Tonsillitis; Lymphadenitis; Injury and bone fracture; Stomachache is spitted blood; Traumatic hemorrhage.
Mu Dali king: [nature and flavor] are pungent, temperature.Slightly poisonous.[function cures mainly] wind-damp dispelling, relaxing muscles and tendons network, promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.Cure mainly rheumatic ostalgia, traumatic injury, lumbar muscle strain, neuralgia.
Ustilago nuda (Jens.) Rostr.: [nature and flavor] are pungent; Cold [return through] heart channel [function cures mainly] expelling pathogenic factors from muscles for clearing heat; Relieving restlessness is quenched the thirst.
The blue or green fiber crops that live: [nature and flavor] are bitter, pungent, temperature.[function cures mainly] checking hyperfunction of the liver for relieving convulsion; Wind-damp dispelling, spasmolytic, removing toxic substances.For rheumatic arthritis, hypertension, infantile convulsion, puerperal convulsion, urticaria, venom.
Cladonia alpestris (L.) Rabenh.: [nature and flavor] are light is flat.[function cures mainly] suppressing the hyperactive liver and subsiding YANG, regulating menstruation, hemostasis.
Ramulus et Folium Delonicis regiae: [nature and flavor] are sweet; Light; Cold [function cures mainly] suppressing the hyperactive liver and subsiding YANG.
Sting luxuriant fruits of Celastrus orbiculatus Thunb: [nature and flavor] are bitter; Pungent; Flat [function cures mainly] mind tranquilizing and the heart calming; Activating collaterals to relieve pain; Removing toxic substances and promoting subsidence of swelling.Main palpitation and insomnia; Bones and muscles pain; Waist lower limb is numb; Toothache; Sore swollen toxin.
Radix Aconiti Heterotrichi: [nature and flavor] are pungent, bitter, temperature.Large poison.[function cures mainly] expelling wind and cold, activating collaterals to relieve pain.For rheumatic arthritis, lumbar muscle strain, soft tissue contusion, articular sprain, intercostal neuralgia.
It fluffy daughter root: [nature and flavor] are pungent, bitter, temperature.Very toxic.[function cures mainly] expelling wind and cold, relaxing muscles and tendons and activating QI and blood in the collateral, pain relieving.For traumatic injury, arthralgia, paralysis, tetanus.
Radix Ampelocissi artemisiaefoilae: [nature and flavor] pungent, puckery, micro-fiber crops, are slightly cold.[function cures mainly] connects muscles and bones, hemostasis and anti-inflammation, pain relieving.Cure mainly fracture, weapons are hindered, burn, carbuncle.
Stone maple medicine: [nature and flavor] micro-hardship; Flat; Cold [function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.
Clerodendron inerme (L.) Gaertn.: [nature and flavor] are bitter, cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, dissipating blood stasis is active.For rheumatic arthritis, lumbago and skelalgia, sciatica, stomachache, cold, fever, malaria, hepatitis, hepatosplenomegaly; Skin eczema is controlled in external, treating swelling and pain by traumatic injury, traumatic hemorrhage.
Herba Rabdosiae Ternifoliae: [nature and flavor] pungent micro-hardship, temperature.[function cures mainly] " Guangxi Chinese herbal medicine ": dispersing wind-cold, removing toxic substances and promoting subsidence of swelling, pain relieving.
Sorbus unguicilata Koehne: [nature and flavor] are pungent; Temperature; Nontoxic [function cures mainly] dispels the wind, cold expelling.
Herba Haloragidis Micranthae: [nature and flavor] are bitter, cool.[function cures mainly] heat clearing away, relieving constipation, invigorates blood circulation, removing toxic substances, repercussive blood.
Radix Trichosanthis Cucumeroidis: [nature and flavor] are bitter, cold.[function cures mainly] is purged heat and is led to knot; Dissipating blood stasis for subsidence of swelling, promoting blood circulation.
Liquor Flos osmanthi Distillata: [nature and flavor] " detailed outline is picked up any lost article from the road ": " mildly bitter flavor." [function cures mainly] depressed liver-energy dispersing and QI regulating; Being amusing, it is dirty to ward off; Improving eyesight; Wet one's whistle.Main depression of liver-QI; The breast side of body does not relax; Swelling of the gum; Toothache; Dry pharynx; Dry mouth; Halitosis.
Thick leaf Radix Vladimiriae: [function cures mainly] depressed liver-energy dispersing and QI regulating, benefiting stomach and stopping pain.
Wilson citrus seed: [function cures mainly] is soothing the liver, pain relieving.Prospiroboli joannsi: [nature and flavor] are salty, temperature.[function cures mainly] dispelling wind and removing obstruction in the collateral, relaxing muscles and tendons to promote blood circulation, detumescence dissipating blood stasis.Main air pain of dampness syndrome; The contracture of muscle arteries and veins; Traumatic injury; Fracture swells and ache.
Atropine: have and stimulate or suppress central nervous system's effect, have spasmolysis.
Vitamin C: participate in liver metabolism directly, promotes that hepatic glycogen is formed. increases vitamin C concentration in body, hepatocyte resistance can be protected and promote liver cell regeneration.
Magnesium sulfate: can suppress central nervous system, lax skeletal muscle, has calmness, spasmolytic and lowers the effects such as intracranial pressure.
Operation instruction: this injection is injected patient's greater occipital nerve ditch, per injection amount is 1500 units, injection every day once, 10th is a course for the treatment of.
The invention has the beneficial effects as follows: the Chinese medicine and western medicine compound injection that the present invention is used for the treatment of neuralgia of greater occipital nerve has effect of promoting blood circulation to remove obstruction in the collateral, expelling wind and cold, detumescence dissipating blood stasis, depressed liver-energy dispersing and QI regulating, anti-inflammatory analgetic, local muscle spasm can also be alleviated, improve neural involvement local microcirculation, trophic nerve, is beneficial to focus Regeneration and Repair.The Chinese medicine and western medicine compound injection that the present invention is used for the treatment of neuralgia of greater occipital nerve is prepared into injection, effective ingredient content is high, local injection can make medicine go directly focus, trap is good, instant effect, treatment is convenient, eliminates the complex process such as acupuncture, massage, has filled up the blank of simple this disease of medicine preparation for treating in prior art.
Detailed description of the invention
Embodiment 1:
A kind of Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 80g, Radix Solani indici 50g, Radix Eriobotryae 40g, Rhizoma Tupistrae Wattii 45g, Mu Dali king 20g, Ustilago nuda (Jens.) Rostr. 20g, the blue or green numb 30g that lives, Cladonia alpestris (L.) Rabenh. 50g, Ramulus et Folium Delonicis regiae 40g, sting luxuriant fruits of Celastrus orbiculatus Thunb 100g, Radix Aconiti Heterotrichi 0.5g, it fluffy daughter root 5g, Radix Ampelocissi artemisiaefoilae 30g, stone maple medicine 50g, Clerodendron inerme (L.) Gaertn. 8g, Herba Rabdosiae Ternifoliae 30g, Sorbus unguicilata Koehne 40g, Herba Haloragidis Micranthae 25g, Radix Trichosanthis Cucumeroidis 30g, Liquor Flos osmanthi Distillata 20g, thick leaf Radix Vladimiriae 30g, wilson citrus seed 30g, Prospiroboli joannsi 2g, atropine 1g, vitamin C 5g, thiamine 3g, zinc gluconate 12g, magnesium sulfate 6g.
This is used for the preparation method of the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, and concrete steps are as follows:
(1) Folium toonae sinensis 80g is got, Radix Solani indici 50g, Radix Eriobotryae 40g, Rhizoma Tupistrae Wattii 45g, Mu Dali king 20g, Ustilago nuda (Jens.) Rostr. 20g, the blue or green numb 30g that lives, Cladonia alpestris (L.) Rabenh. 50g, Ramulus et Folium Delonicis regiae 40g, sting luxuriant fruits of Celastrus orbiculatus Thunb 100g, Radix Aconiti Heterotrichi 0.5g, it fluffy daughter root 5g, Radix Ampelocissi artemisiaefoilae 30g, stone maple medicine 50g, Clerodendron inerme (L.) Gaertn. 8g, Herba Rabdosiae Ternifoliae 30g, Sorbus unguicilata Koehne 40g, Herba Haloragidis Micranthae 25g, Radix Trichosanthis Cucumeroidis 30g, Liquor Flos osmanthi Distillata 20g, thick leaf Radix Vladimiriae 30g, wilson citrus seed 30g, be processed into coarse powder, add the water of 3 times of medical material weight, soak 2 hours, the wet medical material obtained loads in extraction pot together with its soak, decoct extraction twice, the weight that first time adds water is 4 times of former weighing medical material weight, decoct 1.5 hours, the weight that second time adds water is 3 times of former weighing medical material weight, decocts 0.5 hour, merges extracted twice liquid, filter, when to be concentrated into crude drug part by weight be 1: 1, be cooled to 40 DEG C by filtrate, add 80% ethanol, make ethanol content reach 65%, stir, leave standstill 48h, get supernatant, sucking filtration, obtain filtrate, reclaim ethanol to solution without alcohol taste, being evaporated to water content is 80%, for extracting solution I, stand-by,
(2) Rhizoma Tupistrae Wattii 45g, the fluffy daughter root 5g in sky is got, pulverize, cross 20 mesh sieves, the concentration adding 3 times of volumes is the ethanol of 75%, at 85 DEG C, water-bath extracts 2 hours, obtain extracting solution, add the water of 2.5 times of volumes in gained extracting solution, hold over night, filter to get filtrate, being evaporated to water content is 80%, is extracting solution II, stand-by;
(3) get Radix Aconiti Heterotrichi 0.5g, Prospiroboli joannsi 2g, pulverize, add the water of 3 times of medical material weight, soak 2 hours, the wet medical material obtained loads in container together with its soak, carries out hyperpressure extraction respectively, pressure 300MPa, dwell time 12min, merge two kinds of extracting solution, then add ethanol, stir and leave standstill 4 hours, filter, obtain filtrate, being evaporated to water content is 80%, is extracting solution III, stand-by;
(4) extracting solution I, the extracting solution II prepared by above-mentioned steps (1) to (3), extracting solution III are merged, add natural clarifying agent ZTC1+1II, its clarification, good impurity removing effect, improve the purity of medicine, stir, temperature remains on 55 DEG C, leaves standstill after 5 hours, high speed centrifugation, get supernatant, 0.35 μm of microporous filter membrane filters filter, obtains a liquid, stand-by;
(5) get Liquor Flos osmanthi Distillata 20g, be dissolved in 30ml water for injection, after fully dissolving, obtain b liquid, for subsequent use;
(6) get atropine 1g, vitamin C 5g, thiamine 3g, zinc gluconate 12g, magnesium sulfate 6g, be dissolved in 30ml water for injection, after fully dissolving, obtain c liquid, for subsequent use;
(7) in dispensing canister by a liquid, b liquid, c liquid mix homogeneously, be the sodium hydroxide solution adjust pH of 25% by concentration, be adjusted to 6.5, add to the full amount of water for injection, cold preservation 48 hours, with filling and sealing machine by above-mentioned liquid medicine filling in ampoule bottle, sterilizing; Described fill condition is: air purity rank is 100 grades, and room temperature is 15 DEG C, strict with standard execution, improves drug safety; What described sterilizing adopted is 121 DEG C, 0.15Mpa leads to steam sterilization, and sterilizing is 30 minutes, and steam sterilization both can killing microorganisms, can reduce again the destruction of nutritional labeling to greatest extent, improve the utilization rate of raw material.
Embodiment 2:
A kind of Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 115g, Radix Solani indici 75g, Radix Eriobotryae 65g, Rhizoma Tupistrae Wattii 67.5g, Mu Dali king 40g, Ustilago nuda (Jens.) Rostr. 35g, the blue or green numb 45g that lives, Cladonia alpestris (L.) Rabenh. 85g, Ramulus et Folium Delonicis regiae 70g, sting luxuriant fruits of Celastrus orbiculatus Thunb 150g, Radix Aconiti Heterotrichi 0.75g, it fluffy daughter root 10g, Radix Ampelocissi artemisiaefoilae 95g, stone maple medicine 75g, Clerodendron inerme (L.) Gaertn. 14g, Herba Rabdosiae Ternifoliae 50g, Sorbus unguicilata Koehne 80g, Herba Haloragidis Micranthae 37.5g, Radix Trichosanthis Cucumeroidis 55g, Liquor Flos osmanthi Distillata 25g, thick leaf Radix Vladimiriae 40g, wilson citrus seed 90g, Prospiroboli joannsi 5g, atropine 2.5g, vitamin C 12.5g, thiamine 6.5g, zinc gluconate 16g, magnesium sulfate 10.5g.
This is used for the preparation method of the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, and concrete steps are as follows:
(1) Folium toonae sinensis 115g is got, Radix Solani indici 75g, Radix Eriobotryae 65g, Rhizoma Tupistrae Wattii 67.5g, Mu Dali king 40g, Ustilago nuda (Jens.) Rostr. 35g, the blue or green numb 45g that lives, Cladonia alpestris (L.) Rabenh. 85g, Ramulus et Folium Delonicis regiae 70g, sting luxuriant fruits of Celastrus orbiculatus Thunb 150g, Radix Aconiti Heterotrichi 0.75g, it fluffy daughter root 10g, Radix Ampelocissi artemisiaefoilae 95g, stone maple medicine 75g, Clerodendron inerme (L.) Gaertn. 14g, Herba Rabdosiae Ternifoliae 50g, Sorbus unguicilata Koehne 80g, Herba Haloragidis Micranthae 37.5g, Radix Trichosanthis Cucumeroidis 55g, Liquor Flos osmanthi Distillata 25g, thick leaf Radix Vladimiriae 40g, wilson citrus seed 90g, Prospiroboli joannsi 5g, be processed into coarse powder, add the water of 4 times of medical material weight, soak 2.5 hours, the wet medical material obtained loads in extraction pot together with its soak, decoct extraction twice, the weight that first time adds water is 5 times of former weighing medical material weight, decoct 2 hours, the weight that second time adds water is 4 times of former weighing medical material weight, decocts 0.75 hour, merges extracted twice liquid, filter, when to be concentrated into crude drug part by weight be 1: 1, be cooled to 45 DEG C by filtrate, add 85% ethanol, make ethanol content reach 70%, stir, leave standstill 48h, get supernatant, sucking filtration, obtain filtrate, reclaim ethanol to solution without alcohol taste, being evaporated to water content is 85%, for extracting solution I, stand-by,
(2) Rhizoma Tupistrae Wattii 67.5g, the fluffy daughter root 10g in sky is got, pulverize, cross 35 mesh sieves, the concentration adding 4 times of volumes is the ethanol of 75%, at 85 DEG C, water-bath extracts 2.5 hours, obtain extracting solution, add the water of 2.75 times of volumes in gained extracting solution, hold over night, filter to get filtrate, being evaporated to water content is 85%, is extracting solution II, stand-by;
(3) get Radix Aconiti Heterotrichi 0.75g, Prospiroboli joannsi 5g, pulverize, add the water of 4 times of medical material weight, soak 2.5 hours, the wet medical material obtained loads in container together with its soak, carries out hyperpressure extraction respectively, pressure 325MPa, dwell time 13.5min, merge two kinds of extracting solution, then add ethanol, stir and leave standstill 7 hours, filter, obtain filtrate, being evaporated to water content is 85%, is extracting solution III, stand-by;
(4) extracting solution I, the extracting solution II prepared by above-mentioned steps (1) to (3), extracting solution III are merged, add natural clarifying agent ZTC1+1II, its clarification, good impurity removing effect, improve the purity of medicine, stir, temperature remains on 60 DEG C, leaves standstill after 7.5 hours, high speed centrifugation, get supernatant, 0.5 μm of microporous filter membrane filters filter, obtains a liquid, stand-by;
(5) get Liquor Flos osmanthi Distillata 25g, be dissolved in 45ml water for injection, after fully dissolving, obtain b liquid, for subsequent use;
(6) get atropine 2.5g, vitamin C 12.5g, thiamine 6.5g, zinc gluconate 16g, magnesium sulfate 10.5g, be dissolved in 55ml water for injection, after fully dissolving, obtain c liquid, for subsequent use;
(7) in dispensing canister by a liquid, b liquid, c liquid mix homogeneously, be the sodium hydroxide solution adjust pH of 27.5% by concentration, be adjusted to 6.8, add to the full amount of water for injection, cold preservation 48 hours, with filling and sealing machine by above-mentioned liquid medicine filling in ampoule bottle, sterilizing; Described fill condition is: air purity rank is 100 grades, and room temperature is 20 DEG C, strict with standard execution, improves drug safety; What described sterilizing adopted is 121 DEG C, 0.175Mpa leads to steam sterilization, and sterilizing is 30 minutes, and steam sterilization both can killing microorganisms, can reduce again the destruction of nutritional labeling to greatest extent, improve the utilization rate of raw material.
Embodiment 3:
A kind of Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 150g, Radix Solani indici 100g, Radix Eriobotryae 90g, Rhizoma Tupistrae Wattii 90g, Mu Dali king 60g, Ustilago nuda (Jens.) Rostr. 50g, the blue or green numb 60g that lives, Cladonia alpestris (L.) Rabenh. 120g, Ramulus et Folium Delonicis regiae 100g, sting luxuriant fruits of Celastrus orbiculatus Thunb 200g, Radix Aconiti Heterotrichi 1.0g, it fluffy daughter root 15g, Radix Ampelocissi artemisiaefoilae 160g, stone maple medicine 100g, Clerodendron inerme (L.) Gaertn. 20g, Herba Rabdosiae Ternifoliae 70g, Sorbus unguicilata Koehne 120g, Herba Haloragidis Micranthae 50g, Radix Trichosanthis Cucumeroidis 80g, Liquor Flos osmanthi Distillata 30g, thick leaf Radix Vladimiriae 50g, wilson citrus seed 150g, Prospiroboli joannsi 8g, atropine 4g, Catergen 0g, thiamine 10g, zinc gluconate 20g, magnesium sulfate 15g.
This is used for the preparation method of the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, and concrete steps are as follows:
(1) Folium toonae sinensis 150g is got, Radix Solani indici 100g, Radix Eriobotryae 90g, Mu Dali king 60g, Ustilago nuda (Jens.) Rostr. 50g, the blue or green numb 60g that lives, Cladonia alpestris (L.) Rabenh. 120g, Ramulus et Folium Delonicis regiae 100g, sting luxuriant fruits of Celastrus orbiculatus Thunb 200g, Radix Ampelocissi artemisiaefoilae 160g, stone maple medicine 100g, Clerodendron inerme (L.) Gaertn. 20g, Herba Rabdosiae Ternifoliae 70g, Sorbus unguicilata Koehne 120g, Herba Haloragidis Micranthae 50g, Radix Trichosanthis Cucumeroidis 80g, thick leaf Radix Vladimiriae 50g, wilson citrus seed 150g, be processed into coarse powder, add the water of 5 times of medical material weight, soak 3 hours, the wet medical material obtained loads in extraction pot together with its soak, decoct extraction twice, the weight that first time adds water is 6 times of former weighing medical material weight, decoct 2.5 hours, the weight that second time adds water is 5 times of former weighing medical material weight, decocts 1.0 hours, merges extracted twice liquid, filter, when to be concentrated into crude drug part by weight be 1: 1, be cooled to 50 DEG C by filtrate, add 90% ethanol, make ethanol content reach 75%, stir, leave standstill 48h, get supernatant, sucking filtration, obtain filtrate, reclaim ethanol to solution without alcohol taste, being evaporated to water content is 90%, for extracting solution I, stand-by,
(2) Rhizoma Tupistrae Wattii 90g, the fluffy daughter root 15g in sky is got, pulverize, cross 50 mesh sieves, the concentration adding 5 times of volumes is the ethanol of 75%, at 85 DEG C, water-bath extracts 3 hours, obtain extracting solution, add the water of 3 times of volumes in gained extracting solution, hold over night, filter to get filtrate, being evaporated to water content is 90%, is extracting solution II, stand-by;
(3) get Radix Aconiti Heterotrichi 1.0g, Prospiroboli joannsi 8g, pulverize, add the water of 5 times of medical material weight, soak 3 hours, the wet medical material obtained loads in container together with its soak, carries out hyperpressure extraction respectively, pressure 350MPa, dwell time 15min, merge two kinds of extracting solution, then add ethanol, stir and leave standstill 10 hours, filter, obtain filtrate, being evaporated to water content is 90%, is extracting solution III, stand-by;
(4) extracting solution I, the extracting solution II prepared by above-mentioned steps (1) to (3), extracting solution III are merged, add natural clarifying agent ZTC1+1II, its clarification, good impurity removing effect, improve the purity of medicine, stir, temperature remains on 65C, leaves standstill after 10 hours, high speed centrifugation, get supernatant, 0.65 μm of microporous filter membrane filters filter, obtains a liquid, stand-by;
(5) get Liquor Flos osmanthi Distillata 30g, be dissolved in 60ml water for injection, after fully dissolving, obtain b liquid, for subsequent use;
(6) get atropine 4g, Catergen 0g, thiamine 10g, zinc gluconate 20g, magnesium sulfate 15g, be dissolved in 80ml water for injection, after fully dissolving, obtain c liquid, for subsequent use;
(7) in dispensing canister by a liquid, b liquid, c liquid mix homogeneously, be the sodium hydroxide solution adjust pH of 25 ~ 30% by concentration, be adjusted to 7.1, add to the full amount of water for injection, cold preservation 48 hours, with filling and sealing machine by above-mentioned liquid medicine filling in ampoule bottle, sterilizing; Described fill condition is: air purity rank is 100 grades, and room temperature is 25 DEG C, strict with standard execution, improves drug safety; What described sterilizing adopted is 121 DEG C, 0.20Mpa leads to steam sterilization, and sterilizing is 30 minutes, and steam sterilization both can killing microorganisms, can reduce again the destruction of nutritional labeling to greatest extent, improve the utilization rate of raw material.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. the Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve, it is characterized in that, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 80 ~ 150g, Radix Solani indici 50 ~ 100g, Radix Eriobotryae 40 ~ 90g, Rhizoma Tupistrae Wattii 45 ~ 90g, Mu Dali king 20 ~ 60g, Ustilago nuda (Jens.) Rostr. 20 ~ 50g, the blue or green fiber crops 30 ~ 60g that lives, Cladonia alpestris (L.) Rabenh. 50 ~ 120g, Ramulus et Folium Delonicis regiae 40 ~ 100g, sting luxuriant fruits of Celastrus orbiculatus Thunb 100 ~ 200g, Radix Aconiti Heterotrichi 0.5 ~ 1.0g, it fluffy daughter root 5 ~ 15g, Radix Ampelocissi artemisiaefoilae 30 ~ 160g, stone maple medicine 50 ~ 100g, Clerodendron inerme (L.) Gaertn. 8 ~ 20g, Herba Rabdosiae Ternifoliae 30 ~ 70g, Sorbus unguicilata Koehne 40 ~ 120g, Herba Haloragidis Micranthae 25 ~ 50g, Radix Trichosanthis Cucumeroidis 30 ~ 80g, Liquor Flos osmanthi Distillata 20 ~ 30g, thick leaf Radix Vladimiriae 30 ~ 50g, wilson citrus seed 30 ~ 150g, Prospiroboli joannsi 2 ~ 8g, atropine 1 ~ 4g, vitamin C 5 ~ 20g, thiamine 3 ~ 10g, zinc gluconate 12 ~ 20g, magnesium sulfate 6 ~ 15g.
2. the Chinese medicine and western medicine compound injection for neuralgia of greater occipital nerve as claimed in claim 1, it is characterized in that, mainly consisting of of every 1000mL injection Raw medicine: Folium toonae sinensis 115g, Radix Solani indici 75g, Radix Eriobotryae 65g, Rhizoma Tupistrae Wattii 67.5g, Mu Dali king 40g, Ustilago nuda (Jens.) Rostr. 35g, the blue or green numb 45g that lives, Cladonia alpestris (L.) Rabenh. 85g, Ramulus et Folium Delonicis regiae 70g, sting luxuriant fruits of Celastrus orbiculatus Thunb 150g, Radix Aconiti Heterotrichi 0.75g, it fluffy daughter root 10g, Radix Ampelocissi artemisiaefoilae 95g, stone maple medicine 75g, Clerodendron inerme (L.) Gaertn. 14g, Herba Rabdosiae Ternifoliae 50g, Sorbus unguicilata Koehne 80g, Herba Haloragidis Micranthae 37.5g, Radix Trichosanthis Cucumeroidis 55g, Liquor Flos osmanthi Distillata 25g, thick leaf Radix Vladimiriae 40g, wilson citrus seed 90g, Prospiroboli joannsi 5g, atropine 2.5g, vitamin C 12.5g, thiamine 6.5g, zinc gluconate 16g, magnesium sulfate 10.5g.
3., as claimed in claim 1 or 2 for a preparation method for the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, it is characterized in that, concrete steps are as follows:
(1) Folium toonae sinensis 80 ~ 150g is got, Radix Solani indici 50 ~ 100g, Radix Eriobotryae 40 ~ 90g, Mu Dali king 20 ~ 60g, Ustilago nuda (Jens.) Rostr. 20 ~ 50g, the blue or green fiber crops 30 ~ 60g that lives, Cladonia alpestris (L.) Rabenh. 50 ~ 120g, Ramulus et Folium Delonicis regiae 40 ~ 100g, sting luxuriant fruits of Celastrus orbiculatus Thunb 100 ~ 200g, Radix Ampelocissi artemisiaefoilae 30 ~ 160g, stone maple medicine 50 ~ 100g, Clerodendron inerme (L.) Gaertn. 8 ~ 20g, Herba Rabdosiae Ternifoliae 30 ~ 70g, Sorbus unguicilata Koehne 40 ~ 120g, Herba Haloragidis Micranthae 25 ~ 50g, Radix Trichosanthis Cucumeroidis 30 ~ 80g, thick leaf Radix Vladimiriae 30 ~ 50g, wilson citrus seed 30 ~ 150g, be processed into coarse powder, add the water of 3 ~ 5 times of medical material weight, soak 2 ~ 3 hours, the wet medical material obtained loads in extraction pot together with its soak, decoct extraction twice, the weight that first time adds water is 4 ~ 6 times of former weighing medical material weight, decoct 1.5 ~ 2.5 hours, the weight that second time adds water is 3 ~ 5 times of former weighing medical material weight, decocts 0.5 ~ 1.0 hour, merges extracted twice liquid, filter, when to be concentrated into crude drug part by weight be 1: 1, be cooled to 40 ~ 50 DEG C by filtrate, add ethanol, make ethanol content reach 65 ~ 75%, stir, leave standstill 48h, get supernatant, sucking filtration, obtain filtrate, reclaim ethanol to solution without alcohol taste, being evaporated to water content is 80 ~ 90%, for extracting solution I, stand-by,
(2) Rhizoma Tupistrae Wattii 45 ~ 90g, the fluffy daughter root 5 ~ 15g in sky is got, pulverize, cross 20 ~ 50 mesh sieves, the concentration adding 3 ~ 5 times of volumes is the ethanol of 75%, at 85 DEG C, water-bath is extracted 2 ~ 3 hours, obtain extracting solution, add the water of 2.5 ~ 3 times of volumes in gained extracting solution, hold over night, filter to get filtrate, being evaporated to water content is 80 ~ 90%, is extracting solution II, stand-by;
(3) Radix Aconiti Heterotrichi 0.5 ~ 1.0g, Prospiroboli joannsi 2 ~ 8g is got, pulverize, load in container, carry out hyperpressure extraction respectively, merge two kinds of extracting solution, then add ethanol, stir and leave standstill 4 ~ 10 hours, filter, obtain filtrate, being evaporated to water content is 80 ~ 90%, is extracting solution III, stand-by;
(4) extracting solution I, the extracting solution II prepared by above-mentioned steps (1) to (3), extracting solution III are merged, add natural clarifying agent, stir, temperature remains on 55 ~ 65 DEG C, leaves standstill after 5 ~ 10 hours, high speed centrifugation, get supernatant, 0.35 ~ 0.65 μm of microporous filter membrane filters filter, obtains a liquid, stand-by;
(5) get Liquor Flos osmanthi Distillata 20 ~ 30g, be dissolved in 30 ~ 60ml water for injection, after fully dissolving, obtain b liquid, for subsequent use;
(6) get atropine 1 ~ 4g, vitamin C 5 ~ 20g, thiamine 3 ~ 10g, zinc gluconate 12 ~ 20g, magnesium sulfate 6 ~ 15g, be dissolved in 30 ~ 80ml water for injection, after fully dissolving, obtain c liquid, for subsequent use;
(7) in dispensing canister by a liquid, b liquid, c liquid mix homogeneously, use sodium hydroxide solution adjust pH, be adjusted to 6.8 ± 0.3, add to the full amount of water for injection, cold preservation 48 hours, with filling and sealing machine by above-mentioned liquid medicine filling in ampoule bottle, sterilizing.
4., as claimed in claim 3 for a preparation method for the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, it is characterized in that, the natural clarifying agent in step (4) is ZTC1+1II.
5. as claimed in claim 3 for a preparation method for the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, it is characterized in that, in step (6), concentration of sodium hydroxide solution is 25 ~ 30%.
6. as claimed in claim 3 for a preparation method for the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, it is characterized in that, in step (7), fill condition is: air purity rank is 100 grades, and room temperature is 15 ~ 25 DEG C.
7., as claimed in claim 3 for a preparation method for the Chinese medicine and western medicine compound injection of neuralgia of greater occipital nerve, it is characterized in that, step (7) sterilizing adopt time 121 DEG C, 0.15 ~ 0.20Mpa leads to steam sterilization, sterilizing is 30 minutes.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010241796A (en) * | 2009-03-17 | 2010-10-28 | Daiichi Sankyo Co Ltd | PHARMACEUTICAL COMPOSITION CONTAINING BICYCLIC gamma-AMINO ACID DERIVATIVE |
| CN103330833A (en) * | 2013-06-24 | 2013-10-02 | 顾燕君 | Traditional Chinese medicine for treating great occipital neuralgia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010241796A (en) * | 2009-03-17 | 2010-10-28 | Daiichi Sankyo Co Ltd | PHARMACEUTICAL COMPOSITION CONTAINING BICYCLIC gamma-AMINO ACID DERIVATIVE |
| CN103330833A (en) * | 2013-06-24 | 2013-10-02 | 顾燕君 | Traditional Chinese medicine for treating great occipital neuralgia |
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| 《内科学》编委会: "《内科学》", 30 June 2010, 中医古籍出版社 * |
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