CN105142620B - 用于受控释放抗生物膜剂的纳米颗粒 - Google Patents

用于受控释放抗生物膜剂的纳米颗粒 Download PDF

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Publication number
CN105142620B
CN105142620B CN201480023441.1A CN201480023441A CN105142620B CN 105142620 B CN105142620 B CN 105142620B CN 201480023441 A CN201480023441 A CN 201480023441A CN 105142620 B CN105142620 B CN 105142620B
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npc
therapeutic agent
composition
npcs
biofilm
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CN105142620A (zh
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丘·库
丹尼尔·贝努瓦
马利斯·I·克莱因
伍德 梅甘·L·法尔塞塔
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University of Rochester
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University of Rochester
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201480023441.1A 2013-02-25 2014-02-25 用于受控释放抗生物膜剂的纳米颗粒 Expired - Fee Related CN105142620B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361768929P 2013-02-25 2013-02-25
US61/768,929 2013-02-25
PCT/US2014/018211 WO2014130994A1 (en) 2013-02-25 2014-02-25 Nanoparticles for controlled release of anti-biofilm agents

Publications (2)

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CN105142620A CN105142620A (zh) 2015-12-09
CN105142620B true CN105142620B (zh) 2018-09-28

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US (1) US9566247B2 (enExample)
EP (1) EP2958557B1 (enExample)
JP (1) JP6309980B2 (enExample)
CN (1) CN105142620B (enExample)
AU (1) AU2014218569B2 (enExample)
CA (1) CA2902157A1 (enExample)
WO (1) WO2014130994A1 (enExample)

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EP3265062B1 (en) * 2015-03-04 2019-05-22 Dow Global Technologies LLC Copolymers as excipients for effective solubilization of poorly water-soluble substances from solid mixtures
JP7465494B2 (ja) * 2015-10-21 2024-04-11 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン ナノ粒子での微小空洞及び虫歯の処置及び検出
WO2017176796A1 (en) 2016-04-04 2017-10-12 University Of Virginia Patent Foundation Compositions and methods for preventing and treating disease
WO2018026764A1 (en) * 2016-08-01 2018-02-08 University Of Rochester Nanoparticles for controlled release of anti-biofilm agents and methods of use
CN106370636B (zh) * 2016-08-31 2019-02-26 中国科学院新疆生态与地理研究所 一种检测生物膜表面吸附纳米颗粒的方法
JP2020509087A (ja) * 2017-02-23 2020-03-26 アリラ ヘルス ボストン エルエルシーＡｌｉｒａ Ｈｅａｌｔｈ Ｂｏｓｔｏｎ Ｌｌｃ バイオフィルムを破壊する環境に優しい抗菌製剤、その開発、およびその使用
MX2019010359A (es) * 2017-03-03 2019-10-22 Procter & Gamble Metodos para cuantificar un ion en una biopelicula dental.
AU2018255269B2 (en) * 2017-04-17 2023-03-09 The University Of Chicago Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease
MX394131B (es) 2017-05-16 2025-03-04 Johnson & Johnson Consumer Inc Partículas revestidas y sus usos.
DE102017130893A1 (de) * 2017-12-21 2019-06-27 Paul Hartmann Ag pH regulierende Wundauflage
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US12484770B2 (en) 2018-09-06 2025-12-02 Greenmark Biomedical Inc. Dental imaging and/or curing system
CN109091453A (zh) * 2018-09-18 2018-12-28 成都爱睿康美医疗科技有限责任公司 葡萄糖响应性的可注射纳米凝胶及其制备方法和应用
WO2020084471A1 (en) * 2018-10-22 2020-04-30 Takeda Pharmaceutical Company Limited Nanoparticle encapsulation to target g protein-coupled receptors in endosomes
CN109827814A (zh) * 2019-03-11 2019-05-31 南京大学 一种新型大气颗粒物琼脂采样膜制备及免溶剂提取细胞暴露方法
WO2020198468A1 (en) * 2019-03-26 2020-10-01 Temple University-Of The Commonwealth System Of Higher Education Smart composite with antibiofilm, mineralizing, and antiinfection therapeutic effects
US12195755B2 (en) 2019-05-20 2025-01-14 Brown University Placental lipid bilayer for cell-free molecular interaction studies
DE102019122569A1 (de) 2019-08-22 2021-02-25 Mühlbauer Technology Gmbh Flavonoidderivat
US20210179884A1 (en) 2019-12-17 2021-06-17 Columbia Insurance Company Redox chased suspension bead additives for paints and stains
CN116887866A (zh) 2020-12-03 2023-10-13 巴特尔纪念研究院 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法
JP2024516108A (ja) 2021-04-07 2024-04-12 バテル・メモリアル・インスティテュート 非ウイルス性担体を同定および使用するための迅速な設計、構築、試験、および学習技術
US20250235394A1 (en) * 2021-11-19 2025-07-24 The Regents Of The University Of Michigan Biofilm-targeting nanoparticles to increase the anticaries effect of fluoride
EP4543992A1 (en) 2022-07-11 2025-04-30 Benjamin Moore & Co. Stain blocking architectural compositions with cationic resin and nonionic resin blends
CN115671264B (zh) * 2023-01-04 2023-03-07 云南伦扬科技有限公司 一种用于靶向光催化变形链球菌生物膜的级联纳米酶
WO2024226999A1 (en) * 2023-04-28 2024-10-31 Brown University Methods of making and using nanoparticles for treatment of microbial biofilms
CN116570734B (zh) * 2023-07-13 2023-10-13 四川大学华西医院 一种具有靶向功能的核壳壳结构药物胶束及其制备方法
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CN118955827B (zh) * 2024-07-31 2025-09-12 安徽农业大学 一种纳米载体及其制备方法和应用

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AU2014218569A1 (en) 2015-10-15
EP2958557A4 (en) 2016-11-30
AU2014218569B2 (en) 2018-10-04
JP2016509067A (ja) 2016-03-24
US9566247B2 (en) 2017-02-14
JP6309980B2 (ja) 2018-04-11
US20150374634A1 (en) 2015-12-31
EP2958557A1 (en) 2015-12-30
EP2958557B1 (en) 2019-11-27
CA2902157A1 (en) 2014-08-28
CN105142620A (zh) 2015-12-09
WO2014130994A1 (en) 2014-08-28

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