CN1051308C - 噁唑烷－2－酮衍生物和含有这些物质的药物 - Google Patents

噁唑烷－2－酮衍生物和含有这些物质的药物 Download PDF

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Publication number
CN1051308C
CN1051308C CN94112939A CN94112939A CN1051308C CN 1051308 C CN1051308 C CN 1051308C CN 94112939 A CN94112939 A CN 94112939A CN 94112939 A CN94112939 A CN 94112939A CN 1051308 C CN1051308 C CN 1051308C
Authority
CN
China
Prior art keywords
phenyl
methoxymethyl
oxazolidin
cyclohexyl
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN94112939A
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English (en)
Chinese (zh)
Other versions
CN1109054A (zh
Inventor
J·博古亚
H·布鲁德
R·雅各布-劳特恩
S·略沃
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1109054A publication Critical patent/CN1109054A/zh
Application granted granted Critical
Publication of CN1051308C publication Critical patent/CN1051308C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN94112939A 1993-12-13 1994-12-09 噁唑烷－2－酮衍生物和含有这些物质的药物 Expired - Fee Related CN1051308C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH3701/93 1993-12-13
CH370193 1993-12-13
CH292794 1994-09-27
CH2927/94 1994-09-27

Publications (2)

Publication Number Publication Date
CN1109054A CN1109054A (zh) 1995-09-27
CN1051308C true CN1051308C (zh) 2000-04-12

Family

ID=25691748

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94112939A Expired - Fee Related CN1051308C (zh) 1993-12-13 1994-12-09 噁唑烷－2－酮衍生物和含有这些物质的药物

Country Status (21)

Country Link
US (1) US5574055A (enExample)
EP (1) EP0657440B1 (enExample)
JP (1) JP2602635B2 (enExample)
KR (1) KR100362295B1 (enExample)
CN (1) CN1051308C (enExample)
AT (1) ATE191480T1 (enExample)
AU (1) AU684319B2 (enExample)
CA (1) CA2135861A1 (enExample)
CZ (1) CZ291030B6 (enExample)
DE (1) DE59409270D1 (enExample)
DK (1) DK0657440T3 (enExample)
ES (1) ES2145087T3 (enExample)
GR (1) GR3033815T3 (enExample)
HU (1) HU221809B1 (enExample)
IL (1) IL111890A (enExample)
NO (1) NO305204B1 (enExample)
NZ (1) NZ270083A (enExample)
PT (1) PT657440E (enExample)
RU (1) RU2133743C1 (enExample)
TW (1) TW286317B (enExample)
UA (1) UA44691C2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4332384A1 (de) * 1993-09-23 1995-03-30 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten III
FR2751651B1 (fr) * 1996-07-25 1998-09-04 Synthelabo Derives de 3-(benzo[b]thien-3-yl)oxazolidin-2-one, leur procede de preparation et leur application en therapeutique
US5969146A (en) * 1995-10-11 1999-10-19 Synthelabo Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof
FR2739856B1 (fr) * 1995-10-11 1997-11-14 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
FR2751653B1 (fr) * 1996-07-25 1998-09-04 Synthelabo Derives de 3-benzofuranyloxazolidin-2-one, leur procede de preparation et leur application en therapeutique
DE19601264A1 (de) * 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601265A1 (de) * 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
HRP970049A2 (en) 1996-02-06 1998-04-30 Bayer Ag New heteroaryl oxazolidinones
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
JP3865450B2 (ja) * 1997-02-14 2007-01-10 田辺製薬株式会社 パーキンソニズム治療剤
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
CN1311787A (zh) 1998-06-05 2001-09-05 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物
GB9912417D0 (en) * 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
RU2213959C2 (ru) * 2001-01-15 2003-10-10 Войсковая часть 61469 МО РФ Способ количественного определения о-алкиловых эфиров метилфосфоновой кислоты в водных матрицах методом реакционной газовой хроматографии с атомно-эмиссионным детектированием
MXPA03006958A (es) * 2001-02-05 2003-11-18 Upjohn Co Composicion para administracion rectal de farmaco antibacterial de oxazolidinona.
EP1448536A1 (en) 2001-11-29 2004-08-25 Merck & Co., Inc. Cyclopropyl-containing oxazolidinone antibiotics and derivatives thereof
ATE471937T1 (de) * 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
WO2005028467A1 (en) * 2003-09-15 2005-03-31 Anadys Pharmaceuticals, Inc. Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
WO2007102082A1 (en) * 2006-03-09 2007-09-13 Glenmark Pharmaceuticals Limited High oxazolidinone content solid dosage forms
EP2181993A1 (en) * 2006-03-31 2010-05-05 Research Foundation Itsuu Laboratory Antimicrobial oxazolidinone derivatives
JO2972B1 (en) * 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687918C (en) * 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
AU2008258487B2 (en) * 2007-06-08 2012-11-15 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
EP2152271B1 (en) * 2007-06-08 2015-10-21 Janssen Pharmaceutica, N.V. Piperidine/piperazine derivatives
CN101883768A (zh) 2007-10-02 2010-11-10 财团法人乙卯研究所 具有7元杂环的噁唑烷酮衍生物
JP5579170B2 (ja) * 2008-06-05 2014-08-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｄｇａｔ阻害剤とｐｐａｒ作動薬を含有する薬剤組み合わせ物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381037A2 (fr) * 1977-02-22 1978-09-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2, leur procede de preparation et leur application therapeutique
US4250318A (en) * 1977-08-26 1981-02-10 Delalande S.A. Novel 5-hydroxymethyl oxazolidinones, the method of preparing them and their application in therapeutics
US4517197A (en) * 1980-06-04 1985-05-14 Delalande S.A. -N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and pharmaceutical compositions containing same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1180089A (en) * 1967-10-20 1970-02-04 Delalande Sa Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation
FR2356422A1 (fr) * 1976-03-01 1978-01-27 Delalande Sa Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US5254577A (en) * 1988-07-29 1993-10-19 The Du Pont Merck Pharmaceutical Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
FR2653017B1 (fr) * 1989-10-17 1995-05-05 Delalande Sa Derives d'aryl-3 oxazolidinone-2, leur procede de preparation et leur application en therapeutique.
US5182296A (en) * 1989-10-26 1993-01-26 Tanabe Seiyaky Co., Ltd. Naphthyloxazolidone derivatives
FR2675504B1 (fr) * 1991-04-16 1995-01-27 Delalande Sa Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique.
ATE194981T1 (de) * 1992-04-30 2000-08-15 Taiho Pharmaceutical Co Ltd Oxazolidinderivat und sein pharmazeutisch verträgliches salz

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381037A2 (fr) * 1977-02-22 1978-09-15 Delalande Sa Nouvelles hydroxymethyl-5 oxazolidinones-2, leur procede de preparation et leur application therapeutique
US4250318A (en) * 1977-08-26 1981-02-10 Delalande S.A. Novel 5-hydroxymethyl oxazolidinones, the method of preparing them and their application in therapeutics
US4517197A (en) * 1980-06-04 1985-05-14 Delalande S.A. -N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and pharmaceutical compositions containing same

Also Published As

Publication number Publication date
CZ291030B6 (cs) 2002-12-11
RU2133743C1 (ru) 1999-07-27
HUT72315A (en) 1996-04-29
AU8023394A (en) 1995-06-22
NO944802L (no) 1995-06-14
KR100362295B1 (ko) 2003-03-03
EP0657440B1 (de) 2000-04-05
IL111890A (en) 1998-12-06
RU94043806A (ru) 1996-10-27
HU221809B1 (hu) 2003-01-28
CN1109054A (zh) 1995-09-27
NO305204B1 (no) 1999-04-19
NO944802D0 (no) 1994-12-12
ATE191480T1 (de) 2000-04-15
UA44691C2 (uk) 2002-03-15
PT657440E (pt) 2000-09-29
ES2145087T3 (es) 2000-07-01
EP0657440A1 (de) 1995-06-14
CA2135861A1 (en) 1995-06-14
JPH07196634A (ja) 1995-08-01
NZ270083A (en) 1996-02-27
US5574055A (en) 1996-11-12
AU684319B2 (en) 1997-12-11
KR950017993A (ko) 1995-07-22
HU9403494D0 (en) 1995-02-28
JP2602635B2 (ja) 1997-04-23
GR3033815T3 (en) 2000-10-31
IL111890A0 (en) 1995-03-15
DE59409270D1 (de) 2000-05-11
DK0657440T3 (da) 2000-09-04
CZ312694A3 (en) 1995-08-16
TW286317B (enExample) 1996-09-21

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