CN105125612A - Preparation method and application of frangrant ainsliaea herb soft capsule - Google Patents
Preparation method and application of frangrant ainsliaea herb soft capsule Download PDFInfo
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- CN105125612A CN105125612A CN201510694870.8A CN201510694870A CN105125612A CN 105125612 A CN105125612 A CN 105125612A CN 201510694870 A CN201510694870 A CN 201510694870A CN 105125612 A CN105125612 A CN 105125612A
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- soft capsule
- fragrans champ
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- microwave extracting
- ethanol
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- 239000007901 soft capsule Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title claims abstract description 25
- 241000132064 Ainsliaea Species 0.000 title abstract 5
- 239000003814 drug Substances 0.000 claims abstract description 29
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 206010021143 Hypoxia Diseases 0.000 claims abstract description 12
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 62
- 241001038618 Ainsliaea fragrans Species 0.000 claims description 27
- 238000000605 extraction Methods 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 10
- 235000012424 soybean oil Nutrition 0.000 claims description 10
- 239000003549 soybean oil Substances 0.000 claims description 10
- 230000000274 adsorptive effect Effects 0.000 claims description 9
- 230000006837 decompression Effects 0.000 claims description 9
- 239000003480 eluent Substances 0.000 claims description 9
- 238000010828 elution Methods 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 238000004064 recycling Methods 0.000 claims description 9
- 229920005989 resin Polymers 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 4
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 18
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
- 230000001225 therapeutic effect Effects 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 206010002660 Anoxia Diseases 0.000 description 4
- 241000976983 Anoxia Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 230000007953 anoxia Effects 0.000 description 4
- 239000012467 final product Substances 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- -1 phosphate amine Chemical class 0.000 description 3
- 208000032467 Aplastic anaemia Diseases 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 230000002008 hemorrhagic effect Effects 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000001395 Acute radiation syndrome Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001529246 Platymiscium Species 0.000 description 1
- 206010068142 Radiation sickness syndrome Diseases 0.000 description 1
- 206010038669 Respiratory arrest Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 210000004976 peripheral blood cell Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a preparation method of a frangrant ainsliaea herb soft capsule. The frangrant ainsliaea herb soft capsule is prepared from 3,000 g of frangrant ainsliaea herb serving as bulk drugs through microwave extraction. The content is greatly increased, and the dosage is reduced. The invention further provides an application of the frangrant ainsliaea herb soft capsule in preparing red blood cell increase drugs and anti-hypoxia drugs.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of preparation method and application of Ainsliaea fragrans Champ soft capsule.
Background technology
Ainsliaea fragrans Champ soft capsule is recorded in ministry standard, prescription is Ainsliasa fragrans Champ 3000g, get Ainsliasa fragrans Champ 3000g and add 10 times amount water extraction three times, each 2 hours, collecting decoction, filtrate is concentrated into the clear paste that relative density is 1.10-1.20 (60 DEG C), adds ethanol and makes alcohol content reach 70%, hold over night, divides and gets supernatant; Precipitate with 70% washing with alcohol secondary, washing liquid and supernatant merge.Reclaim ethanol and be concentrated into relative density 1.35 (60 DEG C), add soybean oil in right amount, ground and mixed is even, is pressed into soft capsule 1000, obtains final product.In prior art, not yet there is Ainsliaea fragrans Champ soft capsule extracting the report adopting microwave technology in preparation, and adopt the methods such as water boiling and precipitation with ethanol, technique is coarse, backward, and impurity is many, causes patient's consumption excessive, be inconvenient to take, had a strong impact on this product and applied clinically.
In prior art, former Ainsliaea fragrans Champ soft capsule, oral.A 4-6 grain, 3 times on the one 30 days is a course for the treatment of, the Ainsliaea fragrans Champ soft capsule Chinese crude drug amount of the Ainsliaea fragrans Champ soft capsule Unit Weight adopting the present invention to be prepared into increases, therefore only need 3 at every turn, within 1st, take 3 times, under the condition with more active component, greatly reduce dose.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of preparation method of Ainsliaea fragrans Champ soft capsule.
Another object of the present invention is to provide a kind of Ainsliaea fragrans Champ soft capsule to raise the application in erythrocyte medicine and anti-hypoxia medicament in preparation.
Technical scheme: the object of the invention is by following scheme realize:
A kind of preparation method of Ainsliaea fragrans Champ soft capsule, be made up as crude drug of Ainsliasa fragrans Champ 3000g, described method is made up of the following step: get Ainsliasa fragrans Champ 3000g, pulverize, add 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, add soybean oil appropriate, ground and mixed is even, be pressed into soft capsule 800, obtain.
The preparation method of described Ainsliaea fragrans Champ soft capsule, described microwave extracting power 500W, each extraction 6 minutes.
Described Ainsliaea fragrans Champ soft capsule raises the application in erythrocyte medicine in preparation, Ainsliaea fragrans Champ soft capsule is made up as crude drug of Ainsliasa fragrans Champ 3000g, preparation method is made up of the following step: get Ainsliasa fragrans Champ 3000g, pulverize, add 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, add soybean oil appropriate, ground and mixed is even, be pressed into soft capsule 800, obtain.
Described Ainsliaea fragrans Champ soft capsule raises the application in erythrocyte medicine in preparation, described microwave extracting power 500W, each extraction 6 minutes.
The application of described Ainsliaea fragrans Champ soft capsule in preparation anti-hypoxia medicament, Ainsliaea fragrans Champ soft capsule is made up as crude drug of Ainsliasa fragrans Champ 3000g, preparation method is made up of the following step: get Ainsliasa fragrans Champ 3000g, pulverize, add 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, add soybean oil appropriate, ground and mixed is even, be pressed into soft capsule 800, obtain.
The application of described Ainsliaea fragrans Champ soft capsule in preparation anti-hypoxia medicament, described microwave extracting power 500W, each extraction 6 minutes.
Ainsliasa fragrans Champ is Compositae Ainsliaea fragrans Champ. platymiscium., with all herbal medicine.Xia Qiu gathers, and cleans, using fresh herb or dry for subsequent use.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: get Ainsliasa fragrans Champ 3000g, pulverizes, adds 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400W, extracts 2 times, each 4 minutes, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, it is appropriate to add soybean oil, ground and mixed is even, is pressed into soft capsule 800, obtains final product.
Embodiment 2: get Ainsliasa fragrans Champ 3000g, pulverizes, adds 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 500W, extracts 2 times, each 6 minutes, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, it is appropriate to add soybean oil, ground and mixed is even, is pressed into soft capsule 800, obtains final product.
Embodiment 3: get Ainsliasa fragrans Champ 3000g, pulverizes, adds 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 600W, extracts 2 times, each 8 minutes, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, it is appropriate to add soybean oil, ground and mixed is even, is pressed into soft capsule 800, obtains final product.
Embodiment 4: Ainsliaea fragrans Champ soft capsule raises erythrocytic experimentation data
One, the present invention is to the therapeutical effect of post hemorrhagic mice
Impact on post hemorrhagic mice: ICR mice 40, ♀ ♂ half and half, Nanjing Medical University's Experimental Animal Center, is divided into 4 groups (n=10).Except normal saline group, other group every mice, from orbital vein blood-letting 0.5ml, is got blood survey again and all respectively organizes index after 24h, then continuous gastric infusion 1 week, after last administration 1h, gets the full whole bliid platelet analyzer of blood F-800 survey These parameters from orbital venous plexus.The present invention is prepared by above-described embodiment 2.
Table 1 the present invention is to because of caused oligocythemic therapeutical effect of losing blood
Compare with model group: * p<0.05**p<0.01
Result shows, blood-letting mice is after taking the present invention and treating 7 days, and 2 administration groups compare respectively at model group, and its erythrocyte is significantly higher than model group, close to normal saline group.
Two, the present invention causes oligocythemic therapeutical effect to cyclophosphamide
Preventive and therapeutic effect to the damage of mouse bone marrow cells hemopoietic function: ICR mice 40, ♀ ♂ dual-purpose, Nanjing Medical University's Experimental Animal Center, be divided into 4 groups (n=10), i.e. normal saline group, modeling group, 5g/kg group and 10g/kg group, oral administration, every day 1 time.0th, except normal saline group, other respectively organized mice lumbar injection cycli phosphate amine 80mg/kg respectively, then continued administration 3 days on 5th, 10.1h after last administration, gets blood from orbital venous plexus, surveys erythrocyte, gets femur bone marrow counting number of nucleated cells.The present invention is prepared by above-described embodiment 2.
Table 2 the present invention is on the erythrocytic impact of caused by cyclophosphamide
Compare with normal saline group: * p<0.05**p<0.01
Result shows, compares with normal saline group, and cycli phosphate amine can make mouse bone marrow cells damage, and causes peripheral blood cells to decline, and of the present invention group is compared with model group, all obviously can resist the red decline of cycli phosphate amine induced mice.
Three, the present invention is to oligocythemic therapeutical effect caused by benzene
Impact on Induced Aplastic Anemia Mice: Kunming mouse 48, ♀ ♂ dual-purpose, Nanjing Medical University's Experimental Animal Center, be divided into 4 groups (n=12), except normal saline group, other group mouse subcutaneous injection benzene 0.5ml/kg, continuous 12 days, the same day of modeling, simultaneously oral administration, every day 1 time, totally 18 days, 1h after last administration, orbital venous plexus gets blood, survey erythrocyte, get femur bone marrow counting number of nucleated cells.The present invention is prepared by above-described embodiment 2.
Table 3 the present invention is to oligocythemic therapeutical effect caused by benzene
Compare with model group: * p<0.05**p<0.01
Result shows, 2 administration groups compare respectively at model group, all obviously can resist the erythrocytic decline of Induced Aplastic Anemia Mice caused by benzene.
Four, the present invention is to oligocythemic therapeutical effect caused by radiation
For the therapeutical effect of research to acute radiation sickness, the impact of mouse hemopoietic recovery is irradiated in the present invention observing various dose on 6.5Gy.The present invention is prepared by above-described embodiment 2.
Table 4 the present invention is to oligocythemic therapeutical effect (the 10th day) caused by radiation
Compare with modeling group: * p<0.05**p<0.01
Result shows, give and being subject to according to after the every Japanese invention 5 of mice and 10g/kg treatment, the Restoration model of peripheral red blood cells is accelerated, with 10g dosage group effect for the best.
Conclusion: the present invention significantly can raise erythrocyte, can be used for preparing raising erythrocytic medicine.
Embodiment 4: the present invention improves the pharmacodynamic study of anoxia endurance
Laboratory animal: Kunming mouse, male, body weight 18-22g, Shanghai Slac Experimental Animal Co., Ltd. provides, production licence: SCXK (Shanghai) 2007-0005.
Experimental agents: prepare by the preparation method of above-described embodiment 2, obtain soft capsule finished product, low dosage, middle dosage and high dose are respectively 10g crude drug amount/kg, 20g crude drug amount/kg and 40g crude drug amount/kg, positive drug gold day board heart source cellulose capsule, Xiamen Goldensun Technology Co., Ltd., No. 0249th, hygienic food and health number (1999), lot number: 20110423, dosage is 1g/kg.
Instrument and reagent: 250mL ground wide mouthed bottle, operating scissors, 1mL syringe, stopwatch, vaseline, sodica calx.
Oxygen deficit tolerance is tested: select healthy mice 50, separate 10 at random as normal group, all the other 40 mices, be divided into 4 groups at random: high dose group, middle dosage group, low dose group, positive drug gold day board heart source cellulose capsule group, wherein 3 dosage groups, gold day board heart source cellulose capsule groups press above-mentioned dosage gastric infusion, normal group is to the water of 0.2ml, every morning 1 time, continuous 30d, last gave experiment tested material after 1 hour, mice was put into respectively the 250mL ground wide mouthed bottle (every bottle of mice) filling 5g sodica calx; Smear bottleneck with vaseline, cover tightly, make it air tight; The immediate record time take respiratory arrest as index, and record mice is the death time because of anoxia.
The present invention is on the impact ((X scholar D) of mice normobaric hypoxia time-to-live
* p<0.05 is compared with normal group; * compares p<0.01 with normal group
The normobaric hypoxia time-to-live of of the present invention group of mice is significantly longer than normal group, and has significant difference, and illustrate that the present invention has raising anoxia endurance, compared with positive drug, the time-to-live is long, illustrates that improving anoxia endurance effect is better than positive drug.
Claims (6)
1. the preparation method of an Ainsliaea fragrans Champ soft capsule, be made up as crude drug of Ainsliasa fragrans Champ 3000g, it is characterized in that described method is made up of the following step: get Ainsliasa fragrans Champ 3000g, pulverize, add 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, add soybean oil appropriate, ground and mixed is even, be pressed into soft capsule 800, obtain.
2. the preparation method of Ainsliaea fragrans Champ soft capsule according to claim 1, is characterized in that described microwave extracting power 500W, each extraction 6 minutes.
3. Ainsliaea fragrans Champ soft capsule raises the application in erythrocyte medicine in preparation according to claim 1, it is characterized in that Ainsliaea fragrans Champ soft capsule is made up as crude drug of Ainsliasa fragrans Champ 3000g, preparation method is made up of the following step: get Ainsliasa fragrans Champ 3000g, pulverize, add 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, add soybean oil appropriate, ground and mixed is even, be pressed into soft capsule 800, obtain.
4. Ainsliaea fragrans Champ soft capsule raises the application in erythrocyte medicine in preparation according to claim 3, it is characterized in that described microwave extracting power 500W, each extraction 6 minutes.
5. the application of Ainsliaea fragrans Champ soft capsule in preparation anti-hypoxia medicament according to claim 1, it is characterized in that Ainsliaea fragrans Champ soft capsule is made up as crude drug of Ainsliasa fragrans Champ 3000g, preparation method is made up of the following step: get Ainsliasa fragrans Champ 3000g, pulverize, add 70% ethanol of 2L, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 400-600W, extract 2 times, each 4-8 minute, combining extraction liquid, concentrated, be added on D101 macroporous adsorptive resins, 50% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated, add soybean oil appropriate, ground and mixed is even, be pressed into soft capsule 800, obtain.
6. the application of Ainsliaea fragrans Champ soft capsule in preparation anti-hypoxia medicament according to claim 5, is characterized in that described microwave extracting power 500W, each extraction 6 minutes.
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| CN201510694870.8A CN105125612B (en) | 2015-10-23 | 2015-10-23 | A kind of preparation method and application of Ainsliaea fragrans Champ soft capsule |
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| CN201510694870.8A CN105125612B (en) | 2015-10-23 | 2015-10-23 | A kind of preparation method and application of Ainsliaea fragrans Champ soft capsule |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686249A (en) * | 2005-03-22 | 2005-10-26 | 江西天海药业股份有限公司 | Xingxiang tuerfeng soft capsule and its preparation technology |
| CN101293003A (en) * | 2008-06-17 | 2008-10-29 | 江西天佑药业有限公司 | Effect section of frangrant ainsliaea herb, preparation method and application thereof |
| CN101380347A (en) * | 2008-10-14 | 2009-03-11 | 沈阳药科大学 | Ainsliaea fragrans Champ total flavone extract and extraction method and use thereof |
| CN101569643A (en) * | 2009-03-16 | 2009-11-04 | 云南云龙制药有限公司 | Ainsliaea fragrans champ soft capsule and preparation method thereof |
| CN102100720A (en) * | 2011-02-15 | 2011-06-22 | 江西本草天工科技有限责任公司 | Ainsliaea fragrans champ caffeoylquinic acid extracts and preparation and application thereof |
-
2015
- 2015-10-23 CN CN201510694870.8A patent/CN105125612B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1686249A (en) * | 2005-03-22 | 2005-10-26 | 江西天海药业股份有限公司 | Xingxiang tuerfeng soft capsule and its preparation technology |
| CN101293003A (en) * | 2008-06-17 | 2008-10-29 | 江西天佑药业有限公司 | Effect section of frangrant ainsliaea herb, preparation method and application thereof |
| CN101380347A (en) * | 2008-10-14 | 2009-03-11 | 沈阳药科大学 | Ainsliaea fragrans Champ total flavone extract and extraction method and use thereof |
| CN101569643A (en) * | 2009-03-16 | 2009-11-04 | 云南云龙制药有限公司 | Ainsliaea fragrans champ soft capsule and preparation method thereof |
| CN102100720A (en) * | 2011-02-15 | 2011-06-22 | 江西本草天工科技有限责任公司 | Ainsliaea fragrans champ caffeoylquinic acid extracts and preparation and application thereof |
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Address after: No. 5 Jinghong Road, Changhong Community, Ala Street Office, Kunming Economic Development Zone, China (Yunnan) Pilot Free Trade Zone, Kunming City, Yunnan Province, 650217 Patentee after: YUNNAN YUNLONG PHARMACEUTICAL Co.,Ltd. Address before: No.5 Jinghong Road, Kunming Economic and Technological Development Zone, Yunnan Province Patentee before: YUNNAN YUNLONG PHARMACEUTICAL Co.,Ltd. |