CN101129974A - Traditional Chinese medicine composition for treating hepatopathy and method of preparing the same - Google Patents
Traditional Chinese medicine composition for treating hepatopathy and method of preparing the same Download PDFInfo
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- CN101129974A CN101129974A CNA2007100126334A CN200710012633A CN101129974A CN 101129974 A CN101129974 A CN 101129974A CN A2007100126334 A CNA2007100126334 A CN A2007100126334A CN 200710012633 A CN200710012633 A CN 200710012633A CN 101129974 A CN101129974 A CN 101129974A
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Abstract
The invention relates to a Chinese medicinal composition for treating hepatic diseases and process for preparation, which consists of charging 6-8 times of water into Sedum sarmentosum 35-65 parts, curcuma root 15-45 parts, radix isatidis 10-30 parts, bupleurum root 10-30 parts, grilling 2 hours, extracting the filtrate, charging 4-6 times of water again, grilling 1 hour, extracting the filtrate, mixing the filtrates and filtering, charging 4-6 times of water into schisandra fruit, grilling 2 hours, extracting the filtrate, charging 3-4 times of water again, grilling 1 hour, extracting the filtrate, mixing the two filtrates and filtering, extracting seeds of schisandra fruit dross, decompressing and drying, disintegrating into fines with 60 mesh sieves, merging the two soups, concentrating the filtrate into thick grease with specific gravity of 1. 10-1. 20, charging schisandra fruit powder and krestin fines 1-4 parts, finally mixing uniformly.
Description
Technical field
The invention belongs to medicine and preparation, particularly relate to a kind of Chinese medicine composition and preparation method for the treatment of hepatopathy.
Background technology
Hepatopathy is a kind of commonly encountered diseases, frequently-occurring disease, has a strong impact on the healthy of the mankind.In China, particularly at vast rural area sickness rate than higher, be that China classifies one of ten principal diseases that are detrimental to health greatly as, this sick medicine of existing treatment is many, in the Western medicine curative effect reasonable be interferon and other medicines partner treatment, but its use cost height, the unable medical expense of bearing of general patient, and Western medicine has inevitable toxic and side effects, and untoward reaction brings huge misery to the patient.Occur many medicines in the Chinese medicine in recent years, can effectively treat hepatitis, but the formation more complicated of these medicines, because the crude drug quantity of selecting for use is many, the Chinese medicine medical material place of production is different, and standard is indeterminate, quality is uncontrollable, uncertain therapeutic efficacy is cut, and effect slowly.
Summary of the invention
The present invention is intended to overcome the deficiencies in the prior art, and a kind of Chinese medicine composition and preparation method of treatment hepatopathy of clearing away heat-damp and promoting diuresis is provided.
A kind of Chinese medicine composition for the treatment of hepatopathy of the present invention, its raw material medicaments in part by weight meter of making active ingredient consist of the mixture of 3～10 parts of 1～4 part of krestin, 35～65 parts of Herba Sedis, 10～30 parts of Radix Bupleuri, 15～45 parts of Radix Curcumaes, 10～30 parts of Radix Isatidis and Fructus Schisandrae Chinensis.Be mixed and made into tablet, capsule, granule, pill, oral liquid, injection or other conventional formulation by pharmaceutical carrier commonly used in above-mentioned each medicinal raw material and the pharmacy and additive or adjuvant.
The Chinese medicine Herba Sedi that the present invention selects for use has eliminating damp-heat, the antidotal effect.Be used for jaundice due to damp-heat, dysuria, carbuncle skin infection; Diseases such as acute, chronic hepatitis; Radix Curcumae has regulating qi to disperse stagnation, heart fire-clearing upset-relieving, the effect of promoting the function of the gallbladder to alleviate jaundice.Be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, diseases such as jaundice dark coloured urine; Radix Bupleuri has reconciling superficies and interior, and is soothing the liver, the effect of yang invigorating.Be used for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, diseases such as menoxenia; It is astringent or styptic treatment for spontaneous sweating that Fructus Schisandrae Chinensis has convergence, supplementing QI for promoting the production of body fluid, the effect of kidney calming.Be used for incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, diseases such as palpitation and insomnia; Radix Isatidis has heat-clearing and toxic substances removing, the effect of removing heat from blood sore-throat relieving.Be used for maculae caused by violent heat pathogen, crimson tongue is purple dark, major part pestilence, erysipelas, diseases such as carbuncle.
The method of quality control of raw medicinal material of the present invention is as follows:
(1) Fructus Schisandrae Chinensis is differentiated in the side: get compositions 3g, add chloroform 30ml, supersound process 30 minutes filters, and medicinal residues are standby; Filtrate is concentrated into 1ml, as need testing solution.Other gets deoxyschizandrin, schisandrin B reference substance, adds methanol and makes the solution that every 1ml contains 1mg respectively, in contrast product solution.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test, draw need testing solution 5 μ l, reference substance solution 2 μ l, put in same silica gel G F respectively
254On the lamellae, be developing solvent, launch, take out, dry, put under the ultra-violet lamp (254nm) and inspect with petroleum ether (30～60 ℃)-Ethyl formate-formic acid (15: 5: 1) upper solution.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
(2) Radix Bupleuri is differentiated in the side: get compositions 3g, add chloroform 30ml, supersound process 30 minutes filters, the slag of getting it filled is flung to chloroform, adds methanol 30ml, reflux 30 minutes, filter, filtrate evaporate to dryness, residue add water 20ml makes dissolving, is transferred in the separatory funnel, with water saturated n-butanol extraction 2 times, each 15ml merges n-butyl alcohol liquid, with ammonia solution washing 2 times, each 20ml divides and gets upper solution, evaporate to dryness, residue add methanol 1ml makes dissolving, as need testing solution.Other gets Radix Bupleuri control medicinal material 2g, shines medical material solution in pairs with legal system.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005), draw each 5 μ l～10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, (15: 40: 22: 10) lower floor's solution of placing below 10 ℃ was developing solvent, launched, and took out with chloroform-ethyl acetate-methanol-water, dry, spray to be containing 10% ethanol solution of sulfuric acid of 1% paradime thylaminobenzaldehyde, and 60 ℃ to be heated to the speckle colour developing clear, puts respectively under daylight and the uviol lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, daylight shows down the speckle of a same color; Under the ultra-violet lamp (365nm), show an identical yellow fluorescence speckle.
(3) Herba Sedi is differentiated in the side: get compositions 3g, porphyrize adds 85% ethanol 20ml, supersound process 30 minutes filters the filtrate water bath method, residue adds water 10ml makes dissolving, uses water saturation n-butanol extraction 2 times, each 10ml, merge n-butyl alcohol liquid, wash each 5ml, n-butyl alcohol liquid water bath method with water 2 times, residue adds methanol 1ml makes dissolving, as need testing solution.Other gets Herba Sedi control medicinal material 2g, adds water 50ml, and heating and refluxing extraction 30 minutes filters, and filtrate is concentrated into 10ml, makes control medicinal material solution with the sample method.According to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia version in 2005) test, draw each 5 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, with chloroform-methanol (99: 1) is developing solvent, launches, and takes out, dry, put under the ultra-violet lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the yellow-green fluorescence speckle of same color.
Assay: measure according to high performance liquid chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 D).Chromatographic condition and system suitability test octadecylsilane chemically bonded silica are filler; Methanol-water (13: 7) is a mobile phase; The detection wavelength is 250nm.Number of theoretical plate calculates by the schisandrin peak should be not less than 3000.
The preparation of reference substance solution: it is an amount of that precision takes by weighing the schisandrin reference substance, adds methanol and make the solution that every 1ml contains 60 μ g, promptly.
The preparation of need testing solution: get the content under the content uniformity item, grind well, get 1g, the accurate title, decide, and puts in the tool plug conical flask, the accurate methanol 25ml that adds, claim to decide weight, supersound process (power 250W, frequency 20KHz) 30 minutes, take out, put coldly, claim to decide weight again, add methanol and supply the weight that subtracts mistake, shake up, filter, get subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 10 μ l of need testing solution of drawing, inject chromatograph of liquid, measure, promptly.
Every of this product contains Fructus Schisandrae Chinensis in schisandrin (C24H3207), must not be less than 0.20mg.
The preparation method of this medicine is:
Get above-mentioned parts by weight of Chinese traditional medicine material, 6～8 times the decocting that Herba Sedi, Radix Curcumae, Radix Isatidis, Radix Bupleuri is added its total amount boiled 2 hours, got its filtrate, added 4～6 times of decoctings again and boiled and got its filtrate in 1 hour, and the filtrate of obtaining for twice is merged, and filtered, and is standby; Fructus Schisandrae Chinensis decocts with water secondary, adds for the first time water and decocts for 4～6 times and got its filtrate in 2 hours, adds water for the second time and decocts for 3～4 times and got its filtrate in 1 hour, and the filtrate of obtaining for twice is merged, and filters, and is standby; The slag of getting it filled is removed remaining peel, sarcocarp, plants skin, gets kernel, and drying under reduced pressure is ground into fine powder with 60 mesh sieve sheets, sieves, and is standby; Merge above-mentioned two kinds of medicinal liquids, concentrating under reduced pressure becomes thick paste, and relative density 1.10～1.20 adds the magnolia vine fruit kernel powder, the krestin fine powder, and mixing, 80 ℃ of drying under reduced pressure incapsulate, and make 1000, promptly.
Function cures mainly: clearing away heat-damp and promoting diuresis, soothing liver-QI for relieving depression.Be used for acute and chronic hepatitis, alcoholic liver, fatty liver etc.
Usage and dosage: oral, one time 6～8,2 times on the one.
A kind of Chinese medicine composition compatibility for the treatment of hepatopathy of the present invention is reasonable, cost is low, has the effect of clearing away heat-damp and promoting diuresis, the liver protecting and ALT lowering.This Chinese medicine composition medical material is stable, and standard is clear and definite, and is quality controllable, and green natural has no side effect and untoward reaction, and is safe and reliable.
The specific embodiment
Embodiment 1
A kind of Chinese medicine composition for the treatment of hepatopathy of the present invention, its raw material medicaments in part by weight meter of making active ingredient consist of 3～10 parts of 1～4 part of krestin, 35～65 parts of Herba Sedis, 10～30 parts of Radix Bupleuri, 15～45 parts of Radix Curcumaes, 10～30 parts of Radix Isatidis and Fructus Schisandrae Chinensis;
Be preparation as follows:
A, 6～8 times the decocting that Herba Sedi, Radix Curcumae, Radix Isatidis, Radix Bupleuri are added its total amount boiled 2 hours, got its filtrate, added 4～6 times of decoctings again and boiled and got its filtrate in 1 hour, and the filtrate of obtaining for twice is merged, and filtered;
B, Fructus Schisandrae Chinensis is decocted with water secondary, add water for the first time and decoct for 4～6 times and got its filtrate in 2 hours, add water for the second time and decoct for 3～4 times and got its filtrate in 1 hour, the filtrate of obtaining for twice is merged, filter;
C, with the remaining Fructus Schisandrae Chinensis medicinal residues of b step, remove remaining peel, sarcocarp, kind skin, get kernel, 80 ℃ of drying under reduced pressure are ground into fine powder with 60 mesh sieve sheets;
D, get filtrate that a, b step make and mix concentrating under reduced pressure and become thick paste, relative density is 1.10～1.20, adds the Fructus Schisandrae Chinensis kernel powder that krestin fine powder and c step make, mixing, 80 ℃ of drying under reduced pressure are ground into middle coarse powder, add proper amount of sugar or Mel, make pill.
Embodiment 2
Preparation method with krestin 1 gram, Herba Sedi 45 grams, Radix Bupleuri 15 grams, Radix Curcumae 25 grams, Radix Isatidis 15 grams and Fructus Schisandrae Chinensis 5 grams are pressed embodiment 1 is ground into middle coarse powder, adds appropriate amount of starch, makes granule, is pressed into 1000, sugar coating or film-coat.
Embodiment 3
Get Herba Sedi 55 gram, Radix Curcumae 35 grams, Radix Isatidis 25 grams, Radix Bupleuri 25 grams and add water, decoct secondary, add water 980 grams for the first time, decocted 2 hours, add water 700 grams for the second time, decocted 1 hour, collecting decoction, filtration, standby; Fructus Schisandrae Chinensis 7 grams decoct with water secondary, add water 35 grams for the first time, decoct 2 hours, add water 28 grams for the second time, decoct 1 hour, and collecting decoction filters, and is standby; Merge above-mentioned two kinds of medicinal liquids, concentrating under reduced pressure becomes thick paste, relative density 1.10～1.20, and drying under reduced pressure is pulverized and is fine powder.With above-mentioned fine powder, krestin fine powder 2 gram mixings, adopt proper method to sterilize; Add suitable quantity of water and sugar, make liquid oral liquid.
Embodiment 4
Get Herba Sedi 50 gram, Radix Curcumae 30 grams, Radix Isatidis 20 grams, Radix Bupleuri 20 grams, water 840 grams, decocted 2 hours, take out filtrate after, add water 720 grams again and decocted 1 hour, get its filtrate, and last time obtained filtrate mixing, filtration, standby; Fructus Schisandrae Chinensis 6 gram add water 30 grams decoct took out filtrate in 2 hours after, add water 24 grams again and decocted 1 hour, get its filtrate, and last time obtained filtrate mixes, filtration, standby; Get the Fructus Schisandrae Chinensis medicinal residues, remove remaining peel, sarcocarp, plant skin, get kernel, 80 ℃ of drying under reduced pressure are ground into fine powder with 60 mesh sieve sheets, sieve, and are standby; Merge above-mentioned two kinds of medicinal liquids, concentrating under reduced pressure becomes thick paste, and relative density 1.10～1.20 adds the magnolia vine fruit kernel powder, krestin fine powder 1.52 grams, mixing, 80 ℃ of drying under reduced pressure, be ground into middle coarse powder, incapsulate, make 1000 Peroral solid dosage form capsules (comprising soft capsule).
The zoopery of medicine of the present invention
1, acute toxicity test
Give continuous 7 days of mice with this Chinese medicinal composition capsules of being equivalent to 350 times of clinical medicine doses, the mice activity freely, diet is normal, hair is glossy, no loose stool etc., does not see any toxic reaction.
2, long term toxicity test:
This Chinese medicinal composition capsules is to the influence of rat important organ (X ± SD)
| Group | The heart | Liver | Spleen | Lung | Kidney |
| Matched group high dose group low dose group | 0.45±0.05 0.45±0.05 0.44±0.06 | 5.58±0.71 5.78±0.68 5.92±0.59 | 0.38±0.13 0.36±0.09 0.32±0.14 | 1.29±0.63 1.36±0.45 1.47±0.46 | 1.34±0.11 1.17±0.09 1.21±0.15 |
The back influence to the rat important organ of 2 weeks of drug withdrawal (X ± SD)
| Group | The heart | Liver | Spleen | Lung | Kidney |
| Matched group high dose group low dose group | 0.47±0.07 0.48±0.07 0.45±0.06 | 5.18±0.69 5.86±0.64 5.04±0.70 | 0.43±0.15 0.39±0.09 0.44±0.13 | 1.31±0.29 1.28±0.42 1.50±0.59 | 1.17±0.18 1.24±0.16 1.19±0.15 |
Rat was pressed 19.134g/kg and 9.567g/kg successive administration 90 days, body weight, erythrocyte, hemoglobin, leukocyte, albumin, blood urea nitrogen flesh liver to rat all do not have obvious influence, the important organ heart, liver, spleen, lung, kidney system nothing obviously change, and mirror is observed internal organs does not down have the pathology variation.Illustrate that the clinical long-term oral medication of this Chinese medicinal composition capsules does not have obvious toxic-side effects, clinical can taking for a long time.
3, to the protective effect of liver:
This Chinese medicinal composition capsules is hindered the protective effect of membranous type to mouse experiment liver deduction
This Chinese medicine composition is to the protective effect of carbon tetrachloride hepatic injury (X ± SD)
| Group | Size of animal | Dosage (g/kg) | SGP(u/ml) (X±SD) | The P value |
| High dose group low dose group positive controls blank group carbon tetrachloride group | 10 10 10 10 10 | 2 18 158 | 568±46 723±59 542±57 438±63 920±30 | ＜0.01 ＜0.01 ＜0.01 ＜0.01 |
Herba Sedi in the side has obvious protective effect to the subacute hepatic injury of the rat due to the CCL4, and energy is transaminase lowering obviously, and clinical effectiveness shows; single Herba Sedi therapeutic activity hepatitis 1054 examples; obvious effective rate 74.4% has clearing away heat-damp and promoting diuresis, Detoxication, is used for diseases such as jaundice due to damp-heat.And has a liver protecting function.
Experimental result proves that this Chinese medicinal composition capsules has protective effect to carbon tetrachloride induced mice acute liver damage, and poh the Mus acute liver damage that can significantly resist due to the carbon tetrachloride is compared no significance difference with positive controls.
The clinical observation of this Chinese medicine composition:
Clinical general curative effect
| Group | Cure | Take a turn for the better | Do not heal | Total effective rate | X 2p |
| Treatment group matched group 2 matched groups 1 | 172 56 55 | 113 33 32 | 15 11 13 | 95％ 89％ 87％ | X 2＝3.42 P＞0.05 P＞0.05 |
By clinical 300 example observations, 100 routine matched groups 1 (Liver-Restoring Tablet) and 100 routine matched group 2 (GANJIAXIN PIAN) result verification, this Chinese medicinal composition capsules all is better than matched group, krestin has the human body cell of promotion immunologic function in the side, Herba Sedi, Fructus Schisandrae Chinensis have clear improvement liver function, transaminase lowering effect, the Radix Curcumae blood circulation promoting and blood stasis dispelling, the Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, the Radix Isatidis heat-clearing and toxic substances removing.All medicines share and can suppress fibroplasia and promote fiber absorbs, promote impaired hepatocyte to recover, and feel sick, abdominal distention, hepatalgia disappears, and diet increases, weak alleviating, and liver function recovery is normal.Instant effect, stable curative effect are not found any untoward reaction.
Claims (4)
1. Chinese medicine composition for the treatment of hepatopathy, the raw material medicaments in part by weight meter that it is characterized in that making active ingredient consists of the mixture of 3～10 parts of 1～4 part of krestin, 35～65 parts of Herba Sedis, 10～30 parts of Radix Bupleuri, 15～45 parts of Radix Curcumaes, 10～30 parts of Radix Isatidis and Fructus Schisandrae Chinensis, and described component can be Chinese crude drug or the Chinese medicine extract that is equivalent to above-mentioned Chinese crude drug crude drug amount.
2. a kind of Chinese medicine composition for the treatment of hepatopathy as claimed in claim 1 is characterized in that 5～7 parts of 1～2 part of krestin, 45～55 parts of Herba Sedis, 15～25 parts of Radix Bupleuri, 25～35 parts of Radix Curcumaes, 15～25 parts of Radix Isatidis and Fructus Schisandrae Chinensis.
3. a kind of Chinese medicine composition for the treatment of hepatopathy as claimed in claim 1 or 2 is characterized in that 6 parts of 1.52 parts of krestins, 50 parts of Herba Sedis, 20 parts of Radix Bupleuri, 30 parts of Radix Curcumaes, 20 parts of Radix Isatidis and Fructus Schisandrae Chinensis.
4. preparation method for the treatment of the Chinese medicine composition of hepatopathy is characterized in that the prescription of claim 1 or 2 compatibilities is carried out the preparation of following steps:
A, the decocting that Herba Sedi, Radix Curcumae, Radix Isatidis, Radix Bupleuri are added 6～8 times of its total amounts boiled 2 hours, got its filtrate, added 4～6 times of decoctings again and boiled and got its filtrate in 1 hour, and the filtrate of obtaining for twice is mixed, and filtered;
B, Fructus Schisandrae Chinensis is decocted with water secondary, add water for the first time and decoct for 4～6 times and got its filtrate in 2 hours, add water for the second time and decoct for 3～4 times and got its filtrate in 1 hour, the filtrate of obtaining for twice is mixed, filter;
C, with the remaining Fructus Schisandrae Chinensis medicinal residues of b step, remove remaining peel, sarcocarp, kind skin, get kernel, 80 ℃ of drying under reduced pressure are ground into fine powder with 60 mesh sieve sheets;
D, get filtrate that a, b step make and mix concentrating under reduced pressure and become thick paste, relative density is 1.10～1.20, adds the Fructus Schisandrae Chinensis kernel powder that krestin fine powder and c step make, mixing, and 80 ℃ of drying under reduced pressure are ground into middle coarse powder, promptly make patent medicine.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919979B (en) * | 2009-06-11 | 2012-08-15 | 北京亚东生物制药有限公司 | Detection method of traditional Chinese medicine composition for soothing liver-qi stagnation and tonifying spleen and removing dampness |
| CN102698195A (en) * | 2012-06-07 | 2012-10-03 | 黄芸 | Radix-curcumae traditional Chinese medicinal oral liquid for treating chronic hepatitis and preparation method |
| CN103655941A (en) * | 2013-12-16 | 2014-03-26 | 郑仕君 | Chinese herbal medicine formula for treating hepatitis B and preparation method of Chinese herbal medicine formula |
| US10729713B2 (en) * | 2016-04-21 | 2020-08-04 | Guangdong Provincial Hospital Of Chinese Medicine | Pharmaceutical composition for treating hepatitis, liver fibrosis, and liver cancer |
| CN113057948A (en) * | 2020-01-02 | 2021-07-02 | 上海信谊万象药业股份有限公司 | Preparation process of soft capsule preparation |
-
2007
- 2007-08-30 CN CNB2007100126334A patent/CN100571761C/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101919979B (en) * | 2009-06-11 | 2012-08-15 | 北京亚东生物制药有限公司 | Detection method of traditional Chinese medicine composition for soothing liver-qi stagnation and tonifying spleen and removing dampness |
| CN102698195A (en) * | 2012-06-07 | 2012-10-03 | 黄芸 | Radix-curcumae traditional Chinese medicinal oral liquid for treating chronic hepatitis and preparation method |
| CN103655941A (en) * | 2013-12-16 | 2014-03-26 | 郑仕君 | Chinese herbal medicine formula for treating hepatitis B and preparation method of Chinese herbal medicine formula |
| CN103655941B (en) * | 2013-12-16 | 2016-03-30 | 郑仕君 | A kind of Chinese herbal medicine for the treatment of hepatitis B and preparation method thereof |
| US10729713B2 (en) * | 2016-04-21 | 2020-08-04 | Guangdong Provincial Hospital Of Chinese Medicine | Pharmaceutical composition for treating hepatitis, liver fibrosis, and liver cancer |
| CN113057948A (en) * | 2020-01-02 | 2021-07-02 | 上海信谊万象药业股份有限公司 | Preparation process of soft capsule preparation |
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| Publication number | Publication date |
|---|---|
| CN100571761C (en) | 2009-12-23 |
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Owner name: HEILONGJIANG TIANYI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ZHAO YANYI Effective date: 20100928 |
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Effective date of registration: 20100928 Address after: 163316 Jianshe Road high tech Zone, Heilongjiang, No. 245, Patentee after: Heilongjiang Tianyi Pharmaceutical Co., Ltd. Address before: 163316 No. 245, Daqing Development Zone, Heilongjiang, Jianshe Road Patentee before: Zhao Yanyi |