CN1686249A - Xingxiang tuerfeng soft capsule and its preparation technology - Google Patents
Xingxiang tuerfeng soft capsule and its preparation technology Download PDFInfo
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- CN1686249A CN1686249A CN 200510024650 CN200510024650A CN1686249A CN 1686249 A CN1686249 A CN 1686249A CN 200510024650 CN200510024650 CN 200510024650 CN 200510024650 A CN200510024650 A CN 200510024650A CN 1686249 A CN1686249 A CN 1686249A
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Abstract
A softcapsule of Xingxiangtuerfeng is prepared from the extract of Xingxiangtuerfeng, suspending aid, wetting agent and plant oil. It features higher curative effect and biologic utilization rate.
Description
Technical field
The present invention relates to a kind of Ainsliaea fragrans Champ soft capsule and preparation technology thereof, belong to the soft capsule preparation technology.
Background technology
Chronic cervicitis is modal a kind of in the gynaecopathia, is changed by acute cervicitis, accounts for the over half of married woman, has occurred rejuvenation trend now.After being more common in childbirth, miscarriage or surgical injury cervix uteri, the suppurative inflammation that staphylococcus, escherichia coli, streptococcus, bacillus pyocyaneus etc. cause, pathogen such as virus, infusorian are invaded and are caused infection.Can be divided into four kinds of cervical erosion, cervical polyp, cervical hypertrophy, cervix uteri nano-capsule.Wherein common with cervical erosion again.Suffer from chronic cervicitis and often show as leucorrhoea grow in quantity, be purulence, can have leucorrhea to be mingled with the blood streak, occur contact bleeding (back of promptly having sexual intercourse is hemorrhage) sometimes, flank pain can appear in inflammation patient more widely, even can cause infertility.Cervicitis and cervical cancer are in close relations, and relevant anti-cancer reconnaissance information shows that cervix uteri does not have rotten to the corn person has 0.39% to suffer from cervical cancer, has 2.05% to suffer from cervical cancer and suffer from the uterine erosion person.The Ainsliasa fragrans Champ preparation has heat-clearing and toxic substances removing, the effect of promoting tissue regeneration by removing blood stasis; Be used for the leukorrheal diseases of damp invasion of lower energizer, show as leukorrhagia, yellow skin is sticky, and chronic cervicitis is seen above patient.Clinical efficacy is good, is widely used.Because of it is a Chinese medicine preparation, toxic and side effects is less, and the patient can long-term prescription.
The Ainsliasa fragrans Champ preparation that has gone on the market at present has the Ainsliasa fragrans Champ sheet; But tablet because of its in vivo disintegration longer, bioavailability is low, has influenced its due curative effect to a certain extent on the contrary; So select a preferable dosage form for Ainsliasa fragrans Champ, be one and want the problem that solves and fail to realize.
Summary of the invention
Task of the present invention is the deficiency of being carried according in the above-mentioned background technology, provides a kind of disintegration time in vivo short, bioavailability and curative effect height, steady quality, taking convenience, toxic and side effects is little, and can cover the Ainsliasa fragrans Champ novel form and the preparation technology thereof of its bitterness.
The technical solution of finishing task of the present invention is such: this soft capsule comprises capsule material and capsulation solution, wherein the capsule material is made up of components such as gelatin, plasticizer, purified water, pigment, ethyl hydroxybenzoate, Polyethylene Glycol, the part by weight of gelatin, plasticizer, purified water is 1: 0.3-0.6: 0.8-1.3, the percentage composition of ethyl hydroxybenzoate is 0.05-0.1%, the percentage composition of Polyethylene Glycol is 1-3%, is equipped with the capsule material that an amount of different pigment is made various color and lusters; Capsulation solution is made up of Ainsliasa fragrans Champ dry extract, suspending agent, wetting agent and Oleum Glycines (or Oleum Camelliae), wherein the consumption of Ainsliasa fragrans Champ dry extract is 60 350 grams, 5%-50% for capsulation solution weight, the suspending agent consumption is 1-5%, the wetting agent consumption is 1-5%, and Oleum Glycines (or Oleum Camelliae) consumption is the 40-90% of capsulation solution weight.Its preparation technology is: 1, put into strap clamp cover stainless steel water bath by measuring gelatin and purified water, stirring at room treats that gelatin expansion post-heating makes its dissolving and filtration to 55-65 ℃, adds other adjuvants in the filtrate again and stir to be mixed with capsule shell fluid.2, by measuring Ainsliasa fragrans Champ extractum, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, add recipe quantity Oleum Glycines, Polyethylene Glycol-6000 or soybean phospholipid, after being controlled at 30-40 ℃ of stirring and crossing colloid mill, add Ainsliasa fragrans Champ oil, stirring and filtering is mixed with capsulation solution.3, the capsule shell fluid and the capsulation solution that prepare are made soft capsule in the soft capsule press.
The present invention is owing to adopted new dosage form, and the material of optimization formula composition, all deficiencies of Ainsliasa fragrans Champ tablet have been overcome, it shortens in vivo disintegration greatly, and bioavailability and curative effect all increase, and helps oral and long-term storage, its preparation technology is simple, with short production cycle, production cost is low, is present comparatively ideal Ainsliasa fragrans Champ novel form.
Specific embodiment
Now in conjunction with the embodiments the present invention is done a description.
Embodiment 1:
Get dried cream 60 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 1% or 2% and 1% or 2% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae), after being controlled at 30-40 ℃ of stirring and crossing colloid mill, cross 100 orders, make medicinal liquid with top sieve; Got gelatin 250 grams, glycerol 100 grams and water 300 grams by weight 1: 0.4: 1.2, or by weight getting gelatin 300 grams, glycerol 90 grams and water 300 grams at 1: 0.3: 1, or by weight getting gelatin 250, glycerol 100 and water 325 grams at 1: 0.4: 1.3, be equipped with 1% or 2% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are made 1000 of soft capsules with the soft capsule press.
Embodiment 2
Get dried cream 110 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 1% or 2% and 1% or 2% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae), after being controlled at 30-40 ℃ of stirring and crossing colloid mill, cross 100 orders, make medicinal liquid with top sieve; Got gelatin 250 grams, glycerol 100 grams and water 200 grams by weight 1: 0.4: 0.8, or by weight getting gelatin 250 grams, glycerol 125 and water 250 grams at 1: 0.5: 1, or by weight getting gelatin 250 grams, glycerol 150 grams and water 325 grams at 1: 0.6: 1.3, be equipped with 1% or 2% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Embodiment 3
Get dried cream 160 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 1% or 2% and 2% or 3% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae), after being controlled at 30-40 ℃ of stirring and crossing colloid mill, cross 100 orders, make medicinal liquid with top sieve; Got gelatin 250 grams, glycerol 100 grams and water 200 grams by weight 1: 0.4: 0.8, or by weight getting gelatin 250 grams, glycerol 125 and water 250 grams at 1: 0.5: 1, or by weight getting gelatin 250 grams, glycerol 150 grams and water 325 grams at 1: 0.6: 1.3, be equipped with 1% or 2% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Embodiment 4
Get dried cream 220 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 2% or 3% and 2% or 3% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae), after being controlled at 30-40 ℃ of stirring and crossing colloid mill, cross 100 orders, make medicinal liquid with top sieve; Got gelatin 250 grams, glycerol 100 grams and water 200 grams by weight 1: 0.4: 0.8, or by weight getting gelatin 250 grams, glycerol 125 and water 225 grams at 1: 0.5: 0.9, or by weight getting gelatin 250 grams, glycerol 150 grams and water 300 grams at 1: 0.6: 1.2, be equipped with 1% or 2% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Embodiment 5
Get dried cream 250 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 2% or 3% and 2% or 3% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae) after being controlled at 30-40 ℃ of stirring and crossing colloid mill, is equipped with Ainsliasa fragrans Champ oil 30 grams, cross 100 orders with top sieve, make medicinal liquid; Got gelatin 250 grams, glycerol 100 grams and water 200 grams by weight 1: 0.4: 0.8, or by weight getting gelatin 250 grams, glycerol 125 and water 250 grams at 1: 0.5: 1, or by weight getting gelatin 250 grams, glycerol 150 grams and water 325 grams at 1: 0.6: 1.3, be equipped with 1% or 2% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Get dried cream 300 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 3% or 4% and 3% or 4% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae), after being controlled at 30-40 ℃ of stirring and crossing colloid mill, cross 100 orders, make medicinal liquid with top sieve; Got gelatin 250 grams, glycerol 100 grams and water 200 grams by weight 1: 0.4: 0.8, or by weight getting gelatin 250 grams, glycerol 125 and water 250 grams at 1: 0.5: 1, or by weight getting gelatin 250 grams, glycerol 150 grams and water 300 grams at 1: 0.6: 1.2, be equipped with 2% or 3% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Embodiment 7
Get dried cream 330 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 3% or 4% and 3% or 4% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae) after being controlled at 30-40 ℃ of stirring and crossing colloid mill, is equipped with Ainsliasa fragrans Champ oil 40 grams, cross 100 mesh sieves, make medicinal liquid; Got gelatin 250 grams, glycerol 100 grams and water 175 grams by weight 1: 0.4: 0.7, or by weight getting gelatin 250 grams, glycerol 150 and water 275 grams at 1: 0.6: 1.1, or by weight getting gelatin 250 grams, glycerol 125 grams and water 200 grams at 1: 0.5: 0.8, be equipped with 2% or 3% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Embodiment 8
Get dried cream 350 grams of Ainsliasa fragrans Champ, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, the glycerol of adding 4% or 5% and 4% or 5% Polyethylene Glycol-6000, an amount of vegetable oil (Oleum Glycines or Oleum Camelliae) after being controlled at 30-40 ℃ of stirring and crossing colloid mill, is equipped with Ainsliasa fragrans Champ oil 45 grams, cross 100 mesh sieves, make medicinal liquid; Got gelatin 300 grams, glycerol 120 grams and water 210 grams by weight 1: 0.4: 0.7, or by weight getting gelatin 250 grams, glycerol 150 and water 250 grams at 1: 0.6: 1, or by weight getting gelatin 250 grams, glycerol 125 grams and water 200 grams at 1: 0.5: 0.8, be equipped with 2% or 3% Polyethylene Glycol-6000, ethyl hydroxybenzoate 0.05% is made the capsule material in right amount with pigment.Above-mentioned medicinal liquid and capsule material are pressed into 1000 of soft capsules with encapsulating machine.
Although described some relevant embodiment preferred of the present invention here; those skilled in the art can recognize; can carry out various changes and improvements to the present invention but do not deviate from essence of the present invention; we are intended to statement, and these changes and improvements all fall within the scope of protection of present invention.
Claims (4)
1 one kinds of Ainsliaea fragrans Champ soft capsules is characterized in that: consist of capsulation solution and capsule material, said capsulation solution is made up of Ainsliasa fragrans Champ dry extract, suspending agent, wetting agent, vegetable oil; The consumption of said Ainsliasa fragrans Champ dry extract is; Be the 5%-50% of capsulation solution weight; Vegetable oil consumption in the said capsulation solution is the 40%-90% of capsulation solution weight; Suspending agent in the said capsulation solution is a kind of or its mixture of Cera Flava, Polyethylene Glycol, soybean phospholipid, and its consumption is the 1%-5% of capsulation solution weight; Wetting agent in the said capsulation solution is a kind of of propylene glycol, glycerol or its mixture, and its consumption is the 1%-5% of capsulation solution weight.
2, Ainsliaea fragrans Champ soft capsule according to claim 1 is characterized in that: described capsule material is made up of gelatin, plasticizer, Polyethylene Glycol, purified water, pigment; Plasticizer in the said capsule material is a polyhydric alcohol, as one or more of glycerol, sorbitol.
3, Ainsliaea fragrans Champ soft capsule according to claim 2, it is characterized in that: the part by weight of said gelatin, plasticizer, purified water is 1: 0.3-0.6: 0.8-1.3, the weight percentage of ethyl hydroxybenzoate is 0.05-0.1%, the weight percentage of Polyethylene Glycol is 1-3%, can add the soft capsule that an amount of pigment is made various color and lusters.
4, the preparation technology of Ainsliaea fragrans Champ soft capsule according to claim 1, it is characterized in that: finish: (1), put into strap clamp cover stainless steel water bath by measuring gelatin and purified water by following steps, stirring at room, treat that gelatin expansion post-heating makes its dissolving and filtration to 55-65 ℃, add other adjuvants in the filtrate again and stir to be mixed with capsule shell fluid; (2), by measuring the Ainsliasa fragrans Champ dry extract, pulverized 100 orders with top sieve, put into strap clamp cover stainless steel water bath, add one or more of an amount of Oleum Glycines, wetting agent, suspending agent such as Cera Flava, Polyethylene Glycol-6000, soybean phospholipid, after being controlled at 30-40 ℃ of stirring and crossing colloid mill, stirring and filtering is mixed with capsulation solution; (3), the capsule shell fluid and the capsulation solution that prepare are made soft capsule in the soft capsule press.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510024650 CN1686249A (en) | 2005-03-22 | 2005-03-22 | Xingxiang tuerfeng soft capsule and its preparation technology |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510024650 CN1686249A (en) | 2005-03-22 | 2005-03-22 | Xingxiang tuerfeng soft capsule and its preparation technology |
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| CN1686249A true CN1686249A (en) | 2005-10-26 |
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| CN 200510024650 Pending CN1686249A (en) | 2005-03-22 | 2005-03-22 | Xingxiang tuerfeng soft capsule and its preparation technology |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485458B (en) * | 2009-02-16 | 2012-08-01 | 钱志明 | Health product containing dendrobium, ginseng and matrimony vine |
| CN105125612A (en) * | 2015-10-23 | 2015-12-09 | 云南云龙制药股份有限公司 | Preparation method and application of frangrant ainsliaea herb soft capsule |
-
2005
- 2005-03-22 CN CN 200510024650 patent/CN1686249A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485458B (en) * | 2009-02-16 | 2012-08-01 | 钱志明 | Health product containing dendrobium, ginseng and matrimony vine |
| CN105125612A (en) * | 2015-10-23 | 2015-12-09 | 云南云龙制药股份有限公司 | Preparation method and application of frangrant ainsliaea herb soft capsule |
| CN105125612B (en) * | 2015-10-23 | 2017-09-05 | 云南云龙制药股份有限公司 | A kind of preparation method and application of Ainsliaea fragrans Champ soft capsule |
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