CN105125536A - Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites - Google Patents
Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites Download PDFInfo
- Publication number
- CN105125536A CN105125536A CN201510454916.9A CN201510454916A CN105125536A CN 105125536 A CN105125536 A CN 105125536A CN 201510454916 A CN201510454916 A CN 201510454916A CN 105125536 A CN105125536 A CN 105125536A
- Authority
- CN
- China
- Prior art keywords
- virus
- fungus
- antibacterial
- compositions
- dermopathic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention belongs to the technical field of pharmaceutical preparation formulae and particularly relates to a composition for treating dermatoses caused by bacteria, fungi, viruses or parasites. The composition, which is tincture, spray, cream or ointment for external use, is capable of killing various bacteria, fungi, parasites and protozoa and inhibiting various viruses, and can be used for treating various dermatoses such as dermatitis, epifolliculitis, acne, acne rosacea, non-gonococcal urethritis, condyloma acuminate, syphilis, flat wart, onychomycosis, tinea of feet and hands, tinea cruris, gonorrhea, scabies, crab lice, trichomonas parasites, chlamydial infection, herpes progenitalis, herpes zoster, measles, roseola infantum, hand-foot-mouth disease and rubella caused by the bacteria, the fungi, the viruses or the parasites. The composition which is a preparation for external use takes gossypol and double alkyl quaternary ammonium salts as main active components for sterilization, deinsectization and virus resistance and supplementally takes ascorbic acid esters of non-steroidal anti-inflammatory drugs such as ibuprofen as main active components for diminishing inflammation, easing pain and restoring and enhancing normal function of the skin, thereby being quite safe and effective.
Description
Technical field
The invention belongs to the formula technique field of pharmaceutical preparation, belong to the dermopathic compositions that treatment antibacterial, fungus, virus or parasite cause specifically.
Background technology
The skin being positioned at body surface is the maximum organ of human body, is also one of most important organ.Skin is made up of epidermis, corium, subcutaneous tissue from outside to inside.Although our skin has powerful opposing environmental stimuli, the ability of self-regeneration, the health of the mankind in the dermatosis serious threat still having many antibacterials (as folliculitis, erysipelas and leprosy), fungus (tinea manus and pedis, tinea cruris and tinea unguium etc.), virus (as hand-foot-mouth disease, verruca plana, herpes etc.) or the infection of parasite (as scabies) to cause.
These dermatosiss have a strong impact on attractive in appearance a bit, and some disease sites is responsive, and has infectiousness, has a strong impact on quality of life, even can cause long-term harmful effect, need exploitation treatment badly significantly, use safety, medical medicine applied widely.
Gossypol is Malvaceae plant cotton, tree cotton or Gossypium hirsutum L. mature seed, a kind of polyatomic phenol material of extracting in root bark, there is good antioxidant activity, and be a kind of male-contraception material, be used as effective male contraceptive pill for many years.There are some researches show, gossypol can parasiticide, antiviral.Dialkyl quaternary ammonium salt has the bactericidal effect of wide spectrum, can kill various pathogenic bacteria and fungus.The acid ascorbyl ester of the NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen has good antiinflammatory and analgesic activity, and has splendid effect showing active and skin protection, recovery and the normal function of enhancing skin.But have not yet to see using the acid ascorbyl ester of the NSAID (non-steroidal anti-inflammatory drug) such as gossypol, dialkyl quaternary ammonium salt and ibuprofen as effective active composition, any report of the external preparation such as dermopathic solution, paste, cream, lotion, ointment, tincture and Emulsion that allotment development treatment antibacterial, fungus, virus or parasite cause.
Summary of the invention
The object of this invention is to provide one and can treat antibacterial, fungus, the dermopathic compositions that virus or parasite cause, think and suffer from various dermatitis, folliculitis, acne, acne rosacea, nongonococcal urethritis, condyloma acuminatum, prunus mume (sieb.) sieb.et zucc. poison, verruca plana, tinea unguium, tinea manus and pedis, tinea cruris, gonorrhea, scabies, pubic louse, infusorian, Chlamydia infects, genital herpes, herpes zoster, measles, roseola infantum, hand-foot-mouth disease disease, rubellas etc. are multiple by antibacterial, fungus, the extensive patients of the dermatosis that virus or parasitic infection cause provides treatment agent, them are made to get well early.The invention provides one and both can kill various antibacterial, fungus, parasite and protozoon, again can antiinflammatory, analgesia, the various virus of suppression external preparation, can be made into external-use tincture, hydrojet, lotion, cream, ointment or ointment.Compared with existing external use medicine for treating dermatosis agent; this external preparation with gossypol and dialkyl quaternary ammonium salt be sterilization, deinsectization, antiviral principle active component; the acid ascorbyl ester being aided with the NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen is the principle active component of antiinflammatory, analgesia, recovery and the normal function of enhancing skin; by spreading upon on the skin of disease sites; drug effect is played in the dermis through epidermis, retention; safety is also more effective more; skin surface is killed immediately with the pathogen entering skin, thus obtains good curative effect.
Object of the present invention can be achieved through the following technical solutions:
Prepare a kind of compositions.Said composition is made up of following ingredients:
1) aryl second (propanoic acid) acid ascorbyl ester, content is 1000mg/kg to 300g/kg;
2) gossypol, content is 0 to 300g/kg;
3) dialkyl quaternary ammonium salt, content is 300 to 3000mg/kg;
4) acceptable substrate.
The feature of aryl (second) propanoic acid acid ascorbyl ester wherein for meeting the compound of formula (I), its enantiomer, racemic mixture and diastereomer, and the addition salts of itself and pharmaceutically acceptable acid or alkali:
Wherein R representative:
Gossypol is wherein selected from gossypol or its enantiomer, racemic mixture, or the addition salts of itself and acetic acid.Dialkyl quaternary ammonium salt wherein can be two decyl dimethyl ammonium bromide, also can be didodecyldimethylammbromide bromide, two dodecyldimethylamine base ammonium bromide, DHAB, DDA or the combination of one or more wherein.The ethanol water of can be concentration be 10 ~ 75% (v/v) of substrate wherein, can be jointly be dissolved or dispersed in by wetting agent and surfactant the emulsion or cream that are formed in water, also can be surfactant dissolves or be dispersed in the ointment formed in oil.Oil wherein can be Oleum Gossypii semen, also can be soybean oil, Petiolus Trachycarpi oil, olive oil or the combination of one or more wherein.Wetting agent wherein can be glycerol, and also can be propylene glycol, butanediol or the combination of one or more wherein, content be 1%wt. to 50%wt..Surfactant wherein can be TWEEN Series, and also can be Span series, lecithin, monoglyceride, sucrose ester or the combination of one or more wherein, content be 0.01%wt. to 10%wt..
The form of this compositions can be tincture, also can be solution, paste, cream, lotion, ointment, Emulsion, hydrojet or ointment.This compositions can be reached the dermopathic object for the treatment of antibacterial, fungus, virus or parasite and causing with mode disease sites be applied on skin such as spraying, put on the skin, be coated with, smear.
Beneficial effect:
Late Cambrian of the present invention is with gossypol, aryl second (propanoic acid) acid ascorbyl ester and dialkyl quaternary ammonium salt are that this compositions of main active possesses good treatment antibacterial, fungus, the dermopathic ability that virus or parasite cause, various dermatitis can be used for the treatment of as a kind of external preparation, folliculitis, acne, acne rosacea, nongonococcal urethritis, condyloma acuminatum, prunus mume (sieb.) sieb.et zucc. poison, verruca plana, tinea unguium, tinea manus and pedis, tinea cruris, gonorrhea, scabies, pubic louse, infusorian, Chlamydia infects, genital herpes, herpes zoster, measles, roseola infantum, hand-foot-mouth disease disease, rubellas etc. are multiple by antibacterial, fungus, the dermatosis that virus or parasitic infection cause.
Detailed description of the invention
Example below will illustrate operational approach of the present invention, but can not as limitation of the invention.
Embodiment 1
5g sorbester p17 and 15g Tween 80 are dissolved in 780g water, then add 200g glycerol, be deployed into 1kg substrate.
In this substrate 800g, add gossypol acetate 97g and ascorbic acid ibuprofen ester 100g, limit edged stirs, and makes them be dispersed in uniformly in substrate.Then continue to stir, add two decyl dimethyl ammonium bromide 3g while stirring, continue after interpolation to stir 30min, namely obtain unguentum.
Unguentum substrate is according to unguentum: the dilution proportion of substrate=10:0,1:1,1:9, is deployed into the preparation of different pharmaceutical content concn for examination.
Embodiment 2
5g Ovum Gallus domesticus Flavus lecithin and 15g monoglyceride are dissolved in 980g Oleum Gossypii semen, are deployed into 1kg oleaginous base.
In this oleaginous base 600g, add DHAB 3g, gossypol acetate 97g and ascorbic acid ketoprofen ester 300g, limit edged stirs, and makes them be dispersed in uniformly in oleaginous base, continues to stir 30min, namely obtain ointment after interpolation.
Ointment oleaginous base is according to ointment: the dilution proportion of oleaginous base=10:0,1:1,1:9, is deployed into the preparation of different pharmaceutical content concn for examination.
Embodiment 3
Didodecyldimethylammbromide bromide 3g, gossypol 300g and ascorbic acid Flurbiprofen axetil 47g is added in 75% ethanol water 650g, limit edged stirs, make them be dispersed in 75% ethanol water uniformly, continue after interpolation to stir 30min, namely obtain tincture.
Tincture with 75% ethanol water according to tincture: the dilution proportion of 75% ethanol water=10:0,1:1,1:9, the preparation being deployed into different pharmaceutical content concn is for examination.
Embodiment 4
Test staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa and Candida albicans are carried out separation and Culture respectively, gets single colonies typical inoculation ordinary nutrient agar medium slant, at 37 DEG C, cultivate 24hrs.Wash lawn on lower inclined plane with the normal saline containing tryptone 10g/L, fully concussion mixing is mixed with the bacteria suspension of desired concn.Get 0.01ml bacteria suspension respectively to drip and contaminate on aseptic Xinhua filter paper (1cm × 1cm), put the dry 30min of 37 DEG C of incubators, make bacterial carrier for subsequent use.
By the consumption of 1 bacterium sheet 5ml, the preparation of the variant medicament contg concentration prepared by embodiment 1-3 is dispensed in sterilized petri dishes, put equilibrium temperature 10min in 20 DEG C of water baths, bacterium sheet is dropped in preparation, acts on to the stipulated time, take out bacterium sheet, put into the test tube that 5ml nertralizer is housed.Neutralization 10min, through fully shaking eluting, getting eluent 0.5ml and being inoculated in sterilized petri dishes, pours into the mixing of plain agar culture medium.Put 37 DEG C of incubators and cultivate 48hrs, carry out count plate, and calculate killing rate.Test at least repeats 3 times.
Result shows, the preparation effect 20min diluted with preparation effect 5min or 1:9 of 1:1 dilution, all reaches 100% to the killing rate of the staphylococcus aureus on the carrier scraps of paper, escherichia coli, Pseudomonas aeruginosa and Candida albicans
Embodiment 5
Every milliliter 20 ~ 300,000 HEPs inoculate 96 porocyte culture plates, every hole 0.1ml, 37 DEG C, 5%CO
2cultivate 24hrs.Discard culture fluid afterwards, add appropriate herpes simplex virus type 2, after absorption 1h, discard virus liquid, what add the variant medicament contg concentration prepared by embodiment 1-3 supplies test preparation, often kind of 2 holes, 37 DEG C, 5%CO
2cultivate.Observation of cell pathological changes after 48hrs, complete pathological changes is 4; 75% pathological changes is 3; 50% pathological changes is 2; 25% pathological changes is 1; Anosisly become 0.If cell controls, virus control and positive control, positive control is acycloguanosine.
Experimental result shows, preparation series of the present invention, no matter tincture, and unguentum, or ointment, all have good antiviral activity.
Embodiment 6
Take from mice (C57BL/6, female, 22-24g, every only gather 50 tails) human-like acaricide larva pH maintained 7.5 by the HEPES of 20mM and be added with penicillin (100UI/mL), streptomycin (100mg/mL) and 10% calf serum (FBS, Gibco) RPMI1640 solvent washing.After washing, human-like acaricide is transferred on 24-well culture plate, the human-like acaricide of every hole 8-15 tail.Add 2mL in every hole and wash solvent.Then by human-like acaricide at 37 DEG C, containing in the humid air of 5%CO2, cultivate 30 to 60min.Then the preparation that embodiment 1-3 obtains is added.75% alcoholic solution of the human-like acaricide same volume of blank group, substrate or oleaginous base process, the positive controls human-like acaricide health skin scabies of 100 μMs rather processes.The vigor of human-like acaricide, the change of figure and the survival of human-like acaricide are observed with inverted microscope (Leica, Germany) when 24,48 and 72hrs respectively and are monitored.The death of human-like acaricide is defined as Continuous Observation 2min there are no mobility, is adding the change of morphology and figure.Experimental result lists in table 1.
The various preparation of table 1 is to the lethal effect of the human-like acaricide of In vitro culture
75% alcohol solvent, substrate and oleaginous base are the negative control not adding any medicine; Health skin scabies is rather as positive control.
Experimental result shows, preparation series of the present invention, no matter tincture, unguentum, or ointment, all has that extraordinary to kill human-like acaricide active.
Embodiment 7
According to the method for embodiment 1, substrate is prepared by the formula described in table 2, then in substrate, add dialkyl quaternary ammonium salt, gossypol, aryl (second) propanoic acid acid ascorbyl ester by the formula described in table 3, obtain a series of liniment, Emulsion or cream ointment and supply test preparation accordingly.
The formula of table 2 substrate
The formula of table 3 liniment, Emulsion or cream ointment
According to the method for embodiment 4 ~ 6, investigate the sterilization of preparation, antiviral and deinsectization effect, all obtain the result identical with the preparation prepared by embodiment 1.Experimental result shows, they also have dermopathic effect that good treatment antibacterial, fungus, virus or parasite cause.
Embodiment 8
According to the method for embodiment 2, oleaginous base is prepared by the formula described in table 4, then in oleaginous base, add dialkyl quaternary ammonium salt, gossypol, aryl (second) propanoic acid acid ascorbyl ester by the formula described in table 5, obtain a series of ointment and supply test preparation accordingly.
The formula of table 4 oleaginous base
The formula of table 5 ointment
According to the method for embodiment 4 ~ 6, investigate the sterilization of preparation, antiviral and deinsectization effect, all obtain the result identical with the preparation prepared by embodiment 2.Experimental result shows, they also have dermopathic effect that good treatment antibacterial, fungus, virus or parasite cause.
Embodiment 9
According to the method for embodiment 3, in alcoholic solution, add dialkyl quaternary ammonium salt, gossypol, aryl (second) propanoic acid acid ascorbyl ester by the formula described in table 6, obtain a series of tincture agent and supply test preparation accordingly.
The formula of table 6 tincture
According to the method for embodiment 4 ~ 6, investigate the sterilization of preparation, antiviral and deinsectization effect, all obtain the result identical with the preparation prepared by embodiment 3.Experimental result shows, they also have dermopathic effect that good treatment antibacterial, fungus, virus or parasite cause.
Claims (10)
1. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause.Said composition is made up of following ingredients:
1) aryl second (propanoic acid) acid ascorbyl ester, content is 1000mg/kg to 300g/kg;
2) gossypol, content is 0 to 300g/kg;
3) dialkyl quaternary ammonium salt, content is 300 to 3000mg/kg;
4) acceptable substrate.
2. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 1, it is characterized in that described aryl (second) propanoic acid acid ascorbyl ester, it is characterized by the compound meeting formula (I), its enantiomer, racemic mixture and diastereomer, and the addition salts of itself and pharmaceutically acceptable acid or alkali:
Wherein R representative:
3. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 1, it is characterized in that described gossypol is selected from gossypol or its enantiomer, racemic mixture, or the addition salts of itself and acetic acid.
4. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 1, it is characterized in that described dialkyl quaternary ammonium salt can be two decyl dimethyl ammonium bromide, also can be didodecyldimethylammbromide bromide, two dodecyldimethylamine base ammonium bromide, DHAB, DDA or the combination of one or more wherein.
5. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 1, it is characterized in that described substrate can be concentration be the ethanol water of 10 ~ 75% (v/v), can be jointly be dissolved or dispersed in by wetting agent and surfactant the emulsion or cream that are formed in water, also can be surfactant dissolves or be dispersed in the ointment formed in oil.
6. treating the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 5, it is characterized in that described oil can be Oleum Gossypii semen, also can be soybean oil, Petiolus Trachycarpi oil, olive oil or the combination of one or more wherein.
7. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 5, it is characterized in that described wetting agent can be glycerol, also can be propylene glycol, butanediol or the combination of one or more wherein, content be 1%wt. to 50%wt..
8. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 5, it is characterized in that described surfactant can be TWEEN Series, also can be Span series, lecithin, monoglyceride, sucrose ester or the combination of one or more wherein, content be 0.01%wt. to 10%wt..
9. treat the dermopathic compositions that antibacterial, fungus, virus or parasite cause as claimed in claim 1, it is characterized in that the form of described compositions can be tincture, also can be solution, paste, cream, lotion, ointment, Emulsion, hydrojet or ointment.
10. the dermopathic compositions that the treatment antibacterial as described in claim 1 or 9, fungus, virus or parasite cause, is characterized in that the dermopathic object that described treatment antibacterial, fungus, virus or parasite cause is reached by the disease sites described compositions be applied on skin in modes such as spraying, put on the skin, be coated with, smear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510454916.9A CN105125536B (en) | 2015-07-29 | 2015-07-29 | Treat bacterium, fungi, virus or dermopathic composition caused by parasite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510454916.9A CN105125536B (en) | 2015-07-29 | 2015-07-29 | Treat bacterium, fungi, virus or dermopathic composition caused by parasite |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105125536A true CN105125536A (en) | 2015-12-09 |
| CN105125536B CN105125536B (en) | 2018-05-04 |
Family
ID=54711360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510454916.9A Active CN105125536B (en) | 2015-07-29 | 2015-07-29 | Treat bacterium, fungi, virus or dermopathic composition caused by parasite |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105125536B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116763849A (en) * | 2020-05-24 | 2023-09-19 | 许颢瀚 | Formula for inhibiting skin diseases |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044455A (en) * | 1989-01-25 | 1990-08-08 | 乌兹别克苏维埃共和国科学院生物有机化学研究所 | The purification process of 2,2 ,-two (1,6,7-trihydroxy--3-methyl-5-sec.-propyl-8-naphthaldehyde) |
| CN101454269A (en) * | 2006-03-30 | 2009-06-10 | 密执安州立大学董事会 | Production of gossypol co-crystals |
| CN101550119A (en) * | 2009-05-11 | 2009-10-07 | 江南大学 | Aryl (ethanoic) propanoic acid ascorbyl ester, preparation method thereof and medicament containing same |
| CN101642449A (en) * | 2009-09-08 | 2010-02-10 | 梁宗贵 | Skin mucous membrane disinfectants and preparation method thereof |
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
-
2015
- 2015-07-29 CN CN201510454916.9A patent/CN105125536B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1044455A (en) * | 1989-01-25 | 1990-08-08 | 乌兹别克苏维埃共和国科学院生物有机化学研究所 | The purification process of 2,2 ,-two (1,6,7-trihydroxy--3-methyl-5-sec.-propyl-8-naphthaldehyde) |
| CN101454269A (en) * | 2006-03-30 | 2009-06-10 | 密执安州立大学董事会 | Production of gossypol co-crystals |
| CN101550119A (en) * | 2009-05-11 | 2009-10-07 | 江南大学 | Aryl (ethanoic) propanoic acid ascorbyl ester, preparation method thereof and medicament containing same |
| CN101642449A (en) * | 2009-09-08 | 2010-02-10 | 梁宗贵 | Skin mucous membrane disinfectants and preparation method thereof |
| CN103316261A (en) * | 2013-06-27 | 2013-09-25 | 广西信业生物技术有限公司 | Medical antibacterial liquid and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116763849A (en) * | 2020-05-24 | 2023-09-19 | 许颢瀚 | Formula for inhibiting skin diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105125536B (en) | 2018-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102387793B (en) | Antiseptic compositions comprising silver ions and menthol and uses thereof | |
| ES2360803T3 (en) | COMPOSITIONS AND ANTIMICROBIAL THERAPEUTIC METHODS. | |
| CN105165844B (en) | A kind of nematicidal composition of fluorine-containing thiophene worm sulfone | |
| CA2933594C (en) | Acid-solubilized copper-ammonium complexes and copper-zinc-ammonium complexes, compositions, preparations, methods, and uses | |
| CN101214355A (en) | Compound eugenol nano emulsion composition and preparation thereof | |
| US20220211751A1 (en) | High molecular iodine concentration compositions, pharmaceutical formulations, preparation and uses | |
| JP2007534765A (en) | Method for treating plant diseases by microorganisms | |
| CN105125536A (en) | Composition for treating dermatoses caused by bacteria, fungi, viruses or parasites | |
| CN106267329A (en) | A kind of plants essential oil gel dressing and its preparation method and application | |
| CN106565536A (en) | Isolongifolenone oxime ether derivative, and preparation method and application thereof | |
| CN104886165A (en) | Compound air disinfectant and preparation method thereof | |
| CN109122687A (en) | Glycollate complex fungicide and its application | |
| CN108208034A (en) | A kind of desinsection and the biological insecticides of fertilizer efficiency one and preparation method thereof | |
| CN1187073C (en) | Medicine composition for treating and its prepn. method | |
| CN114651825A (en) | Macadimia nut stem canker inhibitor based on molecular disease resistance approach | |
| CN102846489B (en) | Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof | |
| CN103109869A (en) | All-natural special disinfectant for aquaculture | |
| CN102349920B (en) | Sulfanilamide medicament composition for wound surface | |
| CN106109588A (en) | A kind of spray treating tinea pedis and preparation method thereof | |
| CN104922110A (en) | Composition capable of contracepting offspring and preventing infection of venereal disease and acquired immune deficiency syndrome | |
| CN106508920A (en) | Bactericidal composition comprising C4H7Cl2O4P and difenoconazole | |
| CN105434431A (en) | Multifunctional externally applied antibacterial preparation, and preparing method and application thereof | |
| KR100487103B1 (en) | Pharmaceutical Preparation for Treatment of Dermatoses Containing Silver Compound as Effective Ingredient | |
| CN105994303B (en) | A kind of bactericidal composition containing fluoxastrobin and chitosan | |
| Negash et al. | Common Antiseptics: Mechanism Of Action And Its Uses In Animal |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180409 Address after: Jinxi road Binhu District 214122 Jiangsu city of Wuxi province No. 100 Applicant after: Wuxi Hongrui Bio-Pharma-Tech Co.,Ltd. Address before: 210009 1106, room 1, 17 Huashan Road, Gaochun Economic Development Zone, Nanjing, Jiangsu Applicant before: Nanjing Tianhong Intellectual Property Agency Co.,Ltd. Effective date of registration: 20180409 Address after: 210009 1106, room 1, 17 Huashan Road, Gaochun Economic Development Zone, Nanjing, Jiangsu Applicant after: Nanjing Tianhong Intellectual Property Agency Co.,Ltd. Address before: No. 1800 road 214122 Jiangsu Lihu Binhu District City of Wuxi Province Applicant before: Jiangnan University |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |