CN105123990B - 一种制备稳定型芝麻酚微乳液的方法 - Google Patents

一种制备稳定型芝麻酚微乳液的方法 Download PDF

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CN105123990B
CN105123990B CN201510641790.6A CN201510641790A CN105123990B CN 105123990 B CN105123990 B CN 105123990B CN 201510641790 A CN201510641790 A CN 201510641790A CN 105123990 B CN105123990 B CN 105123990B
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sesamol
microemulsion
ethyl alcohol
absolute ethyl
ultrasound
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CN105123990A (zh
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侯利霞
汪学德
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Henan University of Technology
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract

本发明提供了一种制备稳定型芝麻酚微乳液的方法，以乙酸异戊酯为油相，加入乳化剂十二烷基三甲基氯化铵和Span 80，超声混匀；将制备的含芝麻酚的无水乙醇溶液、KCl溶液分别按顺序加入上述溶液中混匀，即得到澄清透明、含一定浓度芝麻酚的微乳液。该产品液滴半径为1‑100 nm，稳定性好，室温下长期间储存无分层现象。

Description

一种制备稳定型芝麻酚微乳液的方法
技术领域
本发明涉及食品、轻工技术领域，具体说是涉及一种制备稳定型芝麻酚微乳液的方法。
背景技术
微乳液是有两种互不相溶的连续介质如水、油通过加入表面活性剂双亲分子从而形成的均相液体体系，适合方便地应用于食品、化妆品及药品等。微乳液一般分为三种类型：油包水型、水包油型和双连续型微乳液，如图1所示。
发明内容
本发明的目的是提供一种制备稳定型芝麻酚微乳液的方法，利用微乳液体系中胶束的加溶作用、以及表面活性剂十二烷基三甲基氯化铵与主成分芝麻酚之间的静电引力作用，即得到澄清透明、含一定浓度芝麻酚的微乳液。该产品稳定性好，室温下长期间储存无分层现象。
一种制备稳定型芝麻酚微乳液的方法，其特征在于，
a、在超声、50℃条件下以乙酸异戊酯为油相，加入0.01-0.1g/mL的乳化剂十二烷基三甲基氯化铵和5 - 70 g/mL的Span 80，超声频率为20-80 KHz，震荡30 - 60 min、混匀，得到均一的溶液；
b、在无水乙醇中加入10 - 100 g/mL的芝麻酚，震荡、溶解，得到含芝麻酚的无水乙醇溶液；
c、在超声、50℃条件下，将步骤b得到含芝麻酚的无水乙醇溶液按照体积比10-50:50-90，逐滴缓慢加入到步骤a得到的溶液中，超声频率为20-80 KHz，震荡30 - 60 min、混匀；
d、将pH 7.0，浓度为0.15 mol/L的KCl 溶液按照体积比5-30 ：70-95，向步骤c得到的溶液中逐滴缓慢加入，并不断震荡50 min，即得到澄清透明、含一定浓度芝麻酚的微乳液。
附图说明
图1 微乳液微观结构示意图（a）W/O型微乳液；(b)O/W型微乳液；(c)双连续型微乳液
发明专利“一种抗氧化油包水微乳液的制备方法”（CN 103211281 B）报道了加入桃仁分离蛋白，以增加微乳液的抗氧化能力；发明专利“山茶油微乳液及其制备方法”（CN103283866 B）报道了对不同的原料选择、原料配比等进行优化，制备了山茶油微乳液。
芝麻酚，又名3,4-亚甲二氧基苯酚，是芝麻油的重要的香气成分，也是芝麻油重要的品质稳定剂。芝麻酚具有非常强的抗氧化能力，常用于食品、医药的抗氧化剂，同时它更是合成抗高血压药物、心血管药物的重要的起始原料。在中性条件下，芝麻酚带负电荷。
本专利提供的一种制备稳定型芝麻酚微乳液的方法。选用阳离子型表面活性剂十二烷基三甲基氯化铵，其在非极性溶剂体系中形成带正电荷的内核，除了通常微乳液体系中胶束的加溶作用之外，与带负电荷的芝麻酚还存在静电引力作用，从而形成稳定的微乳液体系。
具体实施方式
本发明以下将结合实例做进一步描述，但并不限制本发明。
实施例1：
a、在超声、50℃条件下以乙酸异戊酯为油相，加入0.02 g/mL的乳化剂十二烷基三甲基氯化铵和10 g/mL的Span 80，超声频率为20 KHz，震荡50 min、混匀，得到均一的溶液；
b、在无水乙醇中加入50 g/mL的芝麻酚，震荡、溶解，得到含芝麻酚的无水乙醇溶液；
c、在超声、50℃条件下，将步骤b得到含芝麻酚的无水乙醇溶液按照体积比20 :80，逐滴缓慢加入到步骤a得到的溶液中，超声频率为20KHz，震荡60 min、混匀；
d、将pH 7.0，浓度为0.15 mol/L的KCl 溶液按照体积比25 ：75，向步骤c得到的溶液中逐滴缓慢加入，并不断震荡50 min，即得到澄清透明、含一定浓度芝麻酚的微乳液。
实施例2：
a、在超声、50℃条件下以乙酸异戊酯为油相，加入0.05 g/mL的乳化剂十二烷基三甲基氯化铵和50 g/mL的Span 80，超声频率为20 KHz，震荡60 min、混匀，得到均一的溶液；
b、在无水乙醇中加入80 g/mL的芝麻酚，震荡、溶解，得到含芝麻酚的无水乙醇溶液；
c、在超声、50℃条件下，将步骤b得到含芝麻酚的无水乙醇溶液按照体积比40 :60，逐滴缓慢加入到步骤a得到的溶液中，超声频率为20KHz，震荡40 min、混匀；
d、将pH 7.0，浓度为0.15 mol/L的KCl 溶液按照体积比10 ：90，向步骤c得到的溶液中逐滴缓慢加入，并不断震荡50 min，即得到澄清透明、含一定浓度芝麻酚的微乳液。

Claims (1)

1.一种制备稳定型芝麻酚微乳液的方法，其特征在于：
a、在超声、50℃条件下以乙酸异戊酯为油相，加入0.01 - 0.1 g/mL的乳化剂十二烷基三甲基氯化铵和5 - 70 g/mL的Span 80，超声频率为20-80 KHz，震荡30 - 60 min、混匀，得到均一的溶液；
b、在无水乙醇中加入10 - 100 g/mL的芝麻酚，震荡、溶解，得到含芝麻酚的无水乙醇溶液；
c、在超声、50℃条件下，将步骤b得到含芝麻酚的无水乙醇溶液按照体积比10-50 :50-90，逐滴缓慢加入到步骤a得到的溶液中，超声频率为20-80 KHz，震荡30 - 60 min、混匀；
d、将pH 7.0，浓度为0.15 mol/L的KCl 溶液按照体积比5-30 ：70-95，向步骤c得到的溶液中逐滴缓慢加入，并不断震荡50 min，即得到澄清透明、含一定浓度芝麻酚的微乳液。
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