CN105120892B - 包含艰难梭菌cdtb和/或cdta蛋白的元件的免疫原性组合物 - Google Patents

包含艰难梭菌cdtb和/或cdta蛋白的元件的免疫原性组合物 Download PDF

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Publication number
CN105120892B
CN105120892B CN201380073503.5A CN201380073503A CN105120892B CN 105120892 B CN105120892 B CN 105120892B CN 201380073503 A CN201380073503 A CN 201380073503A CN 105120892 B CN105120892 B CN 105120892B
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cdtb
protein
cdta
seq
sequence
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CN105120892A (zh
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C.卡斯塔多
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380073503.5A 2012-12-23 2013-12-20 包含艰难梭菌cdtb和/或cdta蛋白的元件的免疫原性组合物 Active CN105120892B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1223342.5 2012-12-23
GBGB1223342.5A GB201223342D0 (en) 2012-12-23 2012-12-23 Immunogenic composition
PCT/EP2013/077762 WO2014096393A1 (en) 2012-12-23 2013-12-20 Immunogenic composition comprising elements of c. difficile cdtb and/or cdta proteins

Publications (2)

Publication Number Publication Date
CN105120892A CN105120892A (zh) 2015-12-02
CN105120892B true CN105120892B (zh) 2020-07-31

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CN201380073503.5A Active CN105120892B (zh) 2012-12-23 2013-12-20 包含艰难梭菌cdtb和/或cdta蛋白的元件的免疫原性组合物

Country Status (12)

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US (2) US9669083B2 (enExample)
EP (1) EP2934579B1 (enExample)
JP (1) JP6515036B2 (enExample)
CN (1) CN105120892B (enExample)
AR (1) AR094275A1 (enExample)
AU (1) AU2013366450A1 (enExample)
BR (1) BR112015014727B8 (enExample)
CA (1) CA2894951C (enExample)
ES (1) ES2748054T3 (enExample)
GB (1) GB201223342D0 (enExample)
SG (1) SG11201504701UA (enExample)
WO (1) WO2014096393A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6121421B2 (ja) 2010-09-03 2017-04-26 バルネバ オーストリア ジーエムビーエイチ Ｃ．ディフィシルの毒素ａおよび毒素ｂタンパク質の単離ポリペプチドならびにその使用
AU2012245904B2 (en) 2011-04-22 2016-04-21 Wyeth Llc Compositions relating to a mutant Clostridium difficile toxin and methods thereof
CN103974718A (zh) * 2011-12-08 2014-08-06 诺华股份有限公司 基于艰难梭菌毒素的疫苗
BR122016023101B1 (pt) * 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
ES2749701T3 (es) * 2014-06-25 2020-03-23 Glaxosmithkline Biologicals Sa Composición inmunógena de Clostridium difficile
IL269258B2 (en) * 2017-03-15 2023-09-01 Novavax Inc Methods and compositions for inducing immune responses against Clostridium difficile
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
CN112703006A (zh) 2018-06-19 2021-04-23 葛兰素史密丝克莱恩生物有限公司 免疫原性组合物
CN111793130B (zh) * 2019-03-20 2021-09-14 华中农业大学 一株副猪嗜血杆菌CdtB杂交瘤细胞及单克隆抗体应用
EP4003256B1 (en) 2019-07-30 2025-12-10 The Government of The United States, as Represented by The Secretary of The Army Layered composite for scar treatment and prevention
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
WO2025029561A2 (en) * 2023-07-28 2025-02-06 University Of South Florida Vaccine containing rbd2 of cdtb component from binary toxin cdt of clostridioides difficile

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039816A (zh) * 2012-01-27 2014-09-10 默沙东公司 包含重组毒素的针对艰难梭菌的疫苗

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010213708B2 (en) * 2009-02-11 2015-12-10 Cedars-Sinai Medical Center Antibody to cytolethal distending toxin of Campylobacter jejuni
WO2011060431A2 (en) 2009-11-16 2011-05-19 University Of Maryland Baltimore Multivalent live vector vaccine against clostridium difficile-associated disease
JP6121421B2 (ja) * 2010-09-03 2017-04-26 バルネバ オーストリア ジーエムビーエイチ Ｃ．ディフィシルの毒素ａおよび毒素ｂタンパク質の単離ポリペプチドならびにその使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039816A (zh) * 2012-01-27 2014-09-10 默沙东公司 包含重组毒素的针对艰难梭菌的疫苗

Also Published As

Publication number Publication date
US20150313985A1 (en) 2015-11-05
AU2013366450A1 (en) 2015-07-23
JP6515036B2 (ja) 2019-05-15
US9669083B2 (en) 2017-06-06
CA2894951C (en) 2023-05-09
CA2894951A1 (en) 2014-06-26
US20180043005A1 (en) 2018-02-15
EP2934579A1 (en) 2015-10-28
BR112015014727A2 (pt) 2017-10-10
ES2748054T3 (es) 2020-03-12
WO2014096393A1 (en) 2014-06-26
BR112015014727B1 (pt) 2022-08-02
BR112015014727B8 (pt) 2022-09-20
GB201223342D0 (en) 2013-02-06
EP2934579B1 (en) 2019-08-07
CN105120892A (zh) 2015-12-02
JP2016504993A (ja) 2016-02-18
SG11201504701UA (en) 2015-07-30
AR094275A1 (es) 2015-07-22

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