CN105106867A - Traditional Chinese medicine-western medicine composite external preparation for treating eczematous dermatitis and herpes and application thereof - Google Patents
Traditional Chinese medicine-western medicine composite external preparation for treating eczematous dermatitis and herpes and application thereof Download PDFInfo
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Abstract
The invention relates to traditional Chinese medicine-western medicine composite external preparation for treating eczematous dermatitis and herpes. The preparation comprises begonia fimbristipula, physalis permviana, brucea javanica, insect gall, sphagnum, uncinata spikemoss herb, schizonepeta spike, notopterygium root, rhizoma ligustici, protea cynaroides, hairyvein agrimony, Paederia cavaleriei Levl., centipeda minima, indigo naturalis, aspongopus, morinda officinalis, menthol, lychnis coronata, curcuma zedoary, oldenlandia diffusa, musk, Halenia elliptica D. Don, fructus cnidii, epimedium, fructus evodiae, venenum bufonis, prepared mylabris, lygodium japonicum, prepared pokeberry root, borneol, glyptostrobus pensilis bark, tripterygium glycosides bark, lycopodium clavatum, rhizoma paridis, gypsum rubrum, prepared cuttlefish, rhubarb, radix euphorbiae lantu, radix scrophulariae, oriental wormwood, gentiana macrophylla, rhizoma chuanxiong, bermudagrass herb, herba alyxiae sinensis, felwort, dendrobium, gleditsia sinensis sting, radix curcumae, nano activated carbon, clobetasol propionate, triphosadenine, sodium carbonate, triacontanol, soybean phospholipid, eugenol, isopropyl laurate, lanolin, metronidazole, troxerutin, oryzanol, disodium 1-[2-(2-carboxyethoxy)ethyl]-1-(2-carboxyethyl)-4,5-dihydro-2-undecyl-1H-imidazolium hydroxide, zinc sulfate, probucol, ammonium dodecyl poly oxyethylene sulfate, ascorbic acid and ethanol.
Description
Technical field
The invention belongs to surgery of Chinese medicine, be specifically related to surgery of Chinese medicine medicine for external use technical field.
Background technology
Surgery of Chinese medicine is an important clinical subject, symptom is various, current dermatitis, herpes, tinea manus and pedis, cystic hyperplasia of breast, wound, the open otch postoperative hemorrhage of operation, pain, edema, the open sore part does not heal, and nasal cavity, anal canals etc. are mucocutaneous hemorrhage, pain, edema is clinical common sympton, traditional Chinese medical science medical science or doctor trained in Western medicine medical science are for hemostasis and pain-relieving, the research of detumescence and promoting granulation is a lot, investigate according to clinical practice and interrelated data, at present for human body surgery carbuncle, cellulitis, treat, the antibiotics of skin ulcer and the disease such as traumatic injury and fracture, ubiquity cost is high, therapeutic effect is not remarkable, and have the weak points such as side effect, as oxytetracycline ointment, tetracycline ointment, erythromycin ointments etc. are limited efficiency still, effect is single, still can not meet Present clinical needs, current patient is except having requirement for drug effect, for attractive in appearance also have required by, eliminate cicatrix as far as possible.The medicine of existing treatment wound, uses inconvenience, can leave cicatrix more afterwards at skin surface, affects attractive in appearance.Had a lot of application, such as CN103622994A relates to a kind of compound recipe ice two unguentum flavum.Application for a patent for invention CN1329894A relates to a kind of medicine with eliminating inflammation and expelling toxin putrefaction removing wart.But these application compositions are single, offer limited effectiveness.Herpes and dermatitis, tinea manus and pedis are all skin stubborn diseases, and in order to overcome these diseases, applicant has done clinical research for many years and drawn the solution of the present invention.
Summary of the invention
For overcoming the defect of above-mentioned prior art, the invention provides a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes, this external preparation is made up of Chinese medicine major ingredient extract and other adjuvants; Described Chinese medicine major ingredient extract by weight component meter comprises following raw material:
Rhizoma Begoniae Fimbristipulatae 5-10 part, Calyx Seu Fructus Physalis 5-10 part, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
Other adjuvants described by weight component meter comprise following component:
Particle diameter is the active carbon nanoparticles 0.5 part of 100-300 nanometer, clobetasol propionate 0.5 part, adenosine triphosphate 0.3 part, sodium carbonate 0.3 part, triacontanol 0.3 part, soybean phospholipid 0.3 part, eugenol 0.3 part, isopropyl laurate 0.3 part, lanoline 0.2 part, metronidazole 0.2 part, troxerutin 0.2 part, oryzanol 0.2 part, lauroyl both sexes base disodium beclomethasone 0.1 part, 0.1 part, zinc sulfate, Probucol 0.1 part, lauryl polyethenoxy ether sodium sulfate 0.1 part, 0.05 part, ascorbic acid, ethanol 0.05 part.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Chinese medicine major ingredient extract extracts according to following steps,
Step one, select commercially available super micron mill, ratio is by weight taken: Rhizoma Begoniae Fimbristipulatae 5-10 part, Calyx Seu Fructus Physalis 5-10 part, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
To 180 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation, then stir stand-by;
Step 2, mixed dust formulation step one obtained, add deionized water, and volume ratio is 1: (10-30), afterwards microwave time 5-10min, microwave power 800W-1000W, and precipitation 5-10 minute, gets supernatant and be described Chinese medicine major ingredient extract.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
The Calyx Seu Fructus Physalis Herb comprising Calyx Seu Fructus Physalis fruit selected by described Calyx Seu Fructus Physalis; Described Calyx Seu Fructus Physalis Herb carries out pretreatment in advance, pretreatment afterproduct is substituted Calyx Seu Fructus Physalis and directly pulverizes afterproduct.Described Calyx Seu Fructus Physalis Herb pretreatment afterproduct directly joins in the mixed dust formulation of other components of step one; Described Calyx Seu Fructus Physalis Herb pre-treatment step is as follows: by the Calyx Seu Fructus Physalis Herb after cleaning, add after adopting first 75 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of deionized water making beating, add the α-amylase of 1.5 ~ 2%, the 20 ~ 30min that liquefies under 60 ~ 70 DEG C of conditions obtains Calyx Seu Fructus Physalis pretreatment afterproduct.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Herba Lycopodii directly adopts Herba Lycopodii extract to substitute Herba Lycopodii and directly pulverizes afterproduct.Described Herba Lycopodii extract adopts following steps to extract:
(1) with the Herba Lycopodii that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;
(2), after clean Herba Lycopodii being drained or dried, wall cell disruption powder is broken into Herba Lycopodii coarse powder;
(3) by the water-cooled leaching 12 ~ 24 hours of Herba Lycopodii coarse powder;
(4) enzymolysis
1) Herba Lycopodii adjusting PH with base value 7-8, adds cellulase 15 ~ 30U by every gram of Herba Lycopodii raw material, enzymolysis 2 hours at the temperature of 45 ~ 53 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;
2) add 3 ~ 5 weight parts waters in Herba Lycopodii filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;
3) add 3 ~ 5 weight parts waters in the filtering residue b of Herba Lycopodii, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;
4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;
(5) concentrating under reduced pressure
By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Herba Lycopodii extract.
Preferably, the Chinese and western medicine compound external preparation of described treatment dermatitis and eczema, herpes, wherein:
Described tomentose fevervine herb directly adopts tomentose fevervine herb extract to substitute tomentose fevervine herb and directly pulverizes afterproduct.Described tomentose fevervine herb extract adopts following steps to extract:
The preparation process of described tomentose fevervine herb is as follows: dry tomentose fevervine herb deionized water is cleaned and is placed in frying equipment, adopts the slow fire parch 10-15min of 100-130 DEG C, fries to micro-yellow, takes out, cool; Then use commercially available pulverizing mill by the tomentose fevervine herb micronizing that cools to 200-250 order, add deionized water, water and gained tomentose fevervine herb micropowder ratio (W/W) 120: 1, microwave time 5-7min afterwards, microwave power 800W-1000W, precipitation 5-8 minute, gets supernatant.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes conveniently pharmaceutical methods can make unguentum, spray, gel.
Described a kind of application of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes is applied to dermatitis and eczema, herpes, surgery damage, allergic dermatitis, tinea manus and pedis.
Beneficial effect
The Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema disclosed by the invention, herpes, object of the present invention, is supplementary existing for the pure Chinese medicine of dermatitis and eczema, herpes or the deficiency of pure Western medicine preparation, takes stopgap measures and do not control the defect of root, there is provided a kind of bioavailability high, quick release, effective fast, antibiotic anti-infection, antiinflammatory, anhydrate swollen, reparation is festered, detoxify, pathogenic fire purging, toxic and side effects is less, and pollution-free in producing, treatment dermatitis and eczema with low cost, the external preparation of herpes.The object of this invention is to provide and have that cost is low, cure rate is high, drug action is strong, the quick-acting removing toxic substances and promoting subsidence of swelling pain-stopping external use preparations of several functions without any side effects, the various commonly encountered diseases for the treatment of surgery, frequently-occurring disease, not only Be very effective is reliable, and be that patient saves a large amount of expenses for medicine, all Chinese medicine plant costs related to are low, are worthy to be popularized.
Detailed description of the invention
Embodiment 1
The invention provides a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes, this external preparation is by Chinese medicine major ingredient
Extract and other adjuvants composition; Described Chinese medicine major ingredient extract by weight component meter comprises following raw material:
Rhizoma Begoniae Fimbristipulatae 5 parts, Calyx Seu Fructus Physalis 5 parts, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
Other adjuvants described by weight component meter comprise following component:
Particle diameter is the active carbon nanoparticles 0.5 part of 100 nanometers, clobetasol propionate 0.5 part, adenosine triphosphate 0.3 part, sodium carbonate 0.3 part, triacontanol 0.3 part, soybean phospholipid 0.3 part, eugenol 0.3 part, isopropyl laurate 0.3 part, lanoline 0.2 part, metronidazole 0.2 part, troxerutin 0.2 part, oryzanol 0.2 part, lauroyl both sexes base disodium beclomethasone 0.1 part, 0.1 part, zinc sulfate, Probucol 0.1 part, lauryl polyethenoxy ether sodium sulfate 0.1 part, 0.05 part, ascorbic acid, ethanol 0.05 part.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Chinese medicine major ingredient extract extracts according to following steps,
Step one, select commercially available super micron mill, ratio is by weight taken: Rhizoma Begoniae Fimbristipulatae 5 parts, Calyx Seu Fructus Physalis 5 parts, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
To 180 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation, then stir stand-by;
Step 2, mixed dust formulation step one obtained, add deionized water, and volume ratio is 1: (10-30), afterwards microwave time 5-10min, microwave power 800W-1000W, and precipitation 5-10 minute, gets supernatant and be described Chinese medicine major ingredient extract.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
The Calyx Seu Fructus Physalis Herb comprising Calyx Seu Fructus Physalis fruit selected by described Calyx Seu Fructus Physalis; Described Calyx Seu Fructus Physalis Herb carries out pretreatment in advance, pretreatment afterproduct is substituted Calyx Seu Fructus Physalis and directly pulverizes afterproduct.Described Calyx Seu Fructus Physalis Herb pretreatment afterproduct directly joins in the mixed dust formulation of other components of step one; Described Calyx Seu Fructus Physalis Herb pre-treatment step is as follows: by the Calyx Seu Fructus Physalis Herb after cleaning, add after adopting first 75 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of deionized water making beating, add the α-amylase of 1.5 ~ 2%, the 20 ~ 30min that liquefies under 60 ~ 70 DEG C of conditions obtains Calyx Seu Fructus Physalis pretreatment afterproduct.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Herba Lycopodii directly adopts Herba Lycopodii extract to substitute Herba Lycopodii and directly pulverizes afterproduct.Described Herba Lycopodii extract adopts following steps to extract:
(1) with the Herba Lycopodii that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;
(2), after clean Herba Lycopodii being drained or dried, wall cell disruption powder is broken into Herba Lycopodii coarse powder;
(3) by the water-cooled leaching 12 ~ 24 hours of Herba Lycopodii coarse powder;
(4) enzymolysis
1) Herba Lycopodii adjusting PH with base value 7-8, adds cellulase 15 ~ 30U by every gram of Herba Lycopodii raw material, enzymolysis 2 hours at the temperature of 45 ~ 53 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;
2) add 3 ~ 5 weight parts waters in Herba Lycopodii filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;
3) add 3 ~ 5 weight parts waters in the filtering residue b of Herba Lycopodii, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;
4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;
(5) concentrating under reduced pressure
By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Herba Lycopodii extract.
Preferably, the Chinese and western medicine compound external preparation of described treatment dermatitis and eczema, herpes, wherein:
Described tomentose fevervine herb directly adopts tomentose fevervine herb extract to substitute tomentose fevervine herb and directly pulverizes afterproduct.Described tomentose fevervine herb extract adopts following steps to extract:
The preparation process of described tomentose fevervine herb is as follows: dry tomentose fevervine herb deionized water is cleaned and is placed in frying equipment, adopts the slow fire parch 10-15min of 100-130 DEG C, fries to micro-yellow, takes out, cool; Then use commercially available pulverizing mill by the tomentose fevervine herb micronizing that cools to 200-250 order, add deionized water, water and gained tomentose fevervine herb micropowder ratio (W/W) 120: 1, microwave time 5-7min afterwards, microwave power 800W-1000W, precipitation 5-8 minute, gets supernatant.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes conveniently pharmaceutical methods can make unguentum, spray, gel.
Described a kind of application of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes is applied to dermatitis and eczema, herpes, surgery damage, allergic dermatitis, tinea manus and pedis.
Embodiment 2
The invention provides a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes, this external preparation is made up of Chinese medicine major ingredient extract and other adjuvants; Described Chinese medicine major ingredient extract by weight component meter comprises following raw material:
Rhizoma Begoniae Fimbristipulatae 7.5 parts, Calyx Seu Fructus Physalis 7.5 parts, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
Other adjuvants described by weight component meter comprise following component:
Particle diameter is the active carbon nanoparticles 0.5 part of 200 nanometers, clobetasol propionate 0.5 part, adenosine triphosphate 0.3 part, sodium carbonate 0.3 part, triacontanol 0.3 part, soybean phospholipid 0.3 part, eugenol 0.3 part, isopropyl laurate 0.3 part, lanoline 0.2 part, metronidazole 0.2 part, troxerutin 0.2 part, oryzanol 0.2 part, lauroyl both sexes base disodium beclomethasone 0.1 part, 0.1 part, zinc sulfate, Probucol 0.1 part, lauryl polyethenoxy ether sodium sulfate 0.1 part, 0.05 part, ascorbic acid, ethanol 0.05 part.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Chinese medicine major ingredient extract extracts according to following steps,
Step one, select commercially available super micron mill, ratio is by weight taken: Rhizoma Begoniae Fimbristipulatae 7.5 parts, Calyx Seu Fructus Physalis 7.5 parts, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
To 180 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation, then stir stand-by;
Step 2, mixed dust formulation step one obtained, add deionized water, and volume ratio is 1: (10-30), afterwards microwave time 5-10min, microwave power 800W-1000W, and precipitation 5-10 minute, gets supernatant and be described Chinese medicine major ingredient extract.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
The Calyx Seu Fructus Physalis Herb comprising Calyx Seu Fructus Physalis fruit selected by described Calyx Seu Fructus Physalis; Described Calyx Seu Fructus Physalis Herb carries out pretreatment in advance, pretreatment afterproduct is substituted Calyx Seu Fructus Physalis and directly pulverizes afterproduct.Described Calyx Seu Fructus Physalis Herb pretreatment afterproduct directly joins in the mixed dust formulation of other components of step one; Described Calyx Seu Fructus Physalis Herb pre-treatment step is as follows: by the Calyx Seu Fructus Physalis Herb after cleaning, add after adopting first 75 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of deionized water making beating, add the α-amylase of 1.5 ~ 2%, the 20 ~ 30min that liquefies under 60 ~ 70 DEG C of conditions obtains Calyx Seu Fructus Physalis pretreatment afterproduct.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Herba Lycopodii directly adopts Herba Lycopodii extract to substitute Herba Lycopodii and directly pulverizes afterproduct.Described Herba Lycopodii extract adopts following steps to extract:
(1) with the Herba Lycopodii that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;
(2), after clean Herba Lycopodii being drained or dried, wall cell disruption powder is broken into Herba Lycopodii coarse powder;
(3) by the water-cooled leaching 12 ~ 24 hours of Herba Lycopodii coarse powder;
(4) enzymolysis
1) Herba Lycopodii adjusting PH with base value 7-8, adds cellulase 15 ~ 30U by every gram of Herba Lycopodii raw material, enzymolysis 2 hours at the temperature of 45 ~ 53 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;
2) add 3 ~ 5 weight parts waters in Herba Lycopodii filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;
3) add 3 ~ 5 weight parts waters in the filtering residue b of Herba Lycopodii, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;
4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;
(5) concentrating under reduced pressure
By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Herba Lycopodii extract.
Preferably, the Chinese and western medicine compound external preparation of described treatment dermatitis and eczema, herpes, wherein:
Described tomentose fevervine herb directly adopts tomentose fevervine herb extract to substitute tomentose fevervine herb and directly pulverizes afterproduct.Described tomentose fevervine herb extract adopts following steps to extract:
The preparation process of described tomentose fevervine herb is as follows: dry tomentose fevervine herb deionized water is cleaned and is placed in frying equipment, adopts the slow fire parch 10-15min of 100-130 DEG C, fries to micro-yellow, takes out, cool; Then use commercially available pulverizing mill by the tomentose fevervine herb micronizing that cools to 200-250 order, add deionized water, water and gained tomentose fevervine herb micropowder ratio (W/W) 120: 1, microwave time 5-7min afterwards, microwave power 800W-1000W, precipitation 5-8 minute, gets supernatant.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes conveniently pharmaceutical methods can make unguentum, spray, gel.
Described a kind of application of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes is applied to dermatitis and eczema, herpes, surgery damage, allergic dermatitis, tinea manus and pedis.
Embodiment 3
The invention provides a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes, this external preparation is made up of Chinese medicine major ingredient extract and other adjuvants; Described Chinese medicine major ingredient extract by weight component meter comprises following raw material:
Rhizoma Begoniae Fimbristipulatae 10 parts, Calyx Seu Fructus Physalis 10 parts, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
Other adjuvants described by weight component meter comprise following component:
Particle diameter is the active carbon nanoparticles 0.5 part of 300 nanometers, clobetasol propionate 0.5 part, adenosine triphosphate 0.3 part, sodium carbonate 0.3 part, triacontanol 0.3 part, soybean phospholipid 0.3 part, eugenol 0.3 part, isopropyl laurate 0.3 part, lanoline 0.2 part, metronidazole 0.2 part, troxerutin 0.2 part, oryzanol 0.2 part, lauroyl both sexes base disodium beclomethasone 0.1 part, 0.1 part, zinc sulfate, Probucol 0.1 part, lauryl polyethenoxy ether sodium sulfate 0.1 part, 0.05 part, ascorbic acid, ethanol 0.05 part.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Chinese medicine major ingredient extract extracts according to following steps,
Step one, select commercially available super micron mill, ratio is by weight taken: Rhizoma Begoniae Fimbristipulatae 10 parts, Calyx Seu Fructus Physalis 10 parts, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
To 180 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation, then stir stand-by;
Step 2, mixed dust formulation step one obtained, add deionized water, and volume ratio is 1: (10-30), afterwards microwave time 5-10min, microwave power 800W-1000W, and precipitation 5-10 minute, gets supernatant and be described Chinese medicine major ingredient extract.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
The Calyx Seu Fructus Physalis Herb comprising Calyx Seu Fructus Physalis fruit selected by described Calyx Seu Fructus Physalis; Described Calyx Seu Fructus Physalis Herb carries out pretreatment in advance, pretreatment afterproduct is substituted Calyx Seu Fructus Physalis and directly pulverizes afterproduct.Described Calyx Seu Fructus Physalis Herb pretreatment afterproduct directly joins in the mixed dust formulation of other components of step one; Described Calyx Seu Fructus Physalis Herb pre-treatment step is as follows: by the Calyx Seu Fructus Physalis Herb after cleaning, add after adopting first 75 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of deionized water making beating, add the α-amylase of 1.5 ~ 2%, the 20 ~ 30min that liquefies under 60 ~ 70 DEG C of conditions obtains Calyx Seu Fructus Physalis pretreatment afterproduct.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes:
Described Herba Lycopodii directly adopts Herba Lycopodii extract to substitute Herba Lycopodii and directly pulverizes afterproduct.Described Herba Lycopodii extract adopts following steps to extract:
(1) with the Herba Lycopodii that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;
(2), after clean Herba Lycopodii being drained or dried, wall cell disruption powder is broken into Herba Lycopodii coarse powder;
(3) by the water-cooled leaching 12 ~ 24 hours of Herba Lycopodii coarse powder;
(4) enzymolysis
1) Herba Lycopodii adjusting PH with base value 7-8, adds cellulase 15 ~ 30U by every gram of Herba Lycopodii raw material, enzymolysis 2 hours at the temperature of 45 ~ 53 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;
2) add 3 ~ 5 weight parts waters in Herba Lycopodii filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;
3) add 3 ~ 5 weight parts waters in the filtering residue b of Herba Lycopodii, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;
4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;
(5) concentrating under reduced pressure
By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Herba Lycopodii extract.
Preferably, the Chinese and western medicine compound external preparation of described treatment dermatitis and eczema, herpes, wherein:
Described tomentose fevervine herb directly adopts tomentose fevervine herb extract to substitute tomentose fevervine herb and directly pulverizes afterproduct.Described tomentose fevervine herb extract adopts following steps to extract:
The preparation process of described tomentose fevervine herb is as follows: dry tomentose fevervine herb deionized water is cleaned and is placed in frying equipment, adopts the slow fire parch 10-15min of 100-130 DEG C, fries to micro-yellow, takes out, cool; Then use commercially available pulverizing mill by the tomentose fevervine herb micronizing that cools to 200-250 order, add deionized water, water and gained tomentose fevervine herb micropowder ratio (W/W) 120: 1, microwave time 5-7min afterwards, microwave power 800W-1000W, precipitation 5-8 minute, gets supernatant.
Described a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes conveniently pharmaceutical methods can make unguentum, spray, gel.
Described a kind of application of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes is applied to dermatitis and eczema, herpes, surgery damage, allergic dermatitis, tinea manus and pedis.
Clinical treatment situation:
Patient one: week certain, female, 33 years old, cold sores, long-term tinea manus and pedis, through using pharmaceutical preparation of the present invention after 3 days, the transference cure such as herpes, tinea manus and pedis, continued use after 5 days, other symptoms also disappear, skin smooth, use 1 course for the treatment of that is after 1 month continuously, above symptom substantially no longer occurs, after 2 courses for the treatment of, then above-mentioned symptom can not be there is.
Patient two: Korea Spro, man, 423 years old, haircut industry practitioner, hand skin situation is bad, and the back of the hand has herpes even to fester, through using pharmaceutical preparation of the present invention after 3 days, symptom alleviates, continue use after 5 days, other symptoms also improve, after using 1 course for the treatment of continuously, above symptom no longer occurs, skin is good.
Patient three: Lee, man, 46 years old, genital herpes, long-term tinea manus and pedis, and easy face is got angry long pox, and through using invention formulation after 3 days, symptom alleviates, and continue use after 5 days, all symptoms improve, and after using 1 course for the treatment of continuously, above symptom no longer occurs.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (6)
1. treat a Chinese and western medicine compound external preparation for dermatitis and eczema, herpes, it is characterized in that: this external preparation is made up of Chinese medicine major ingredient extract and other adjuvants; Described Chinese medicine major ingredient extract by weight component meter comprises following raw material:
Rhizoma Begoniae Fimbristipulatae 5-10 part, Calyx Seu Fructus Physalis 5-10 part, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
Other adjuvants described by weight component meter comprise following component:
Particle diameter is the active carbon nanoparticles 0.5 part of 100-300 nanometer, clobetasol propionate 0.5 part, adenosine triphosphate 0.3 part, sodium carbonate 0.3 part, triacontanol 0.3 part, soybean phospholipid 0.3 part, eugenol 0.3 part, isopropyl laurate 0.3 part, lanoline 0.2 part, metronidazole 0.2 part, troxerutin 0.2 part, oryzanol 0.2 part, lauroyl both sexes base disodium beclomethasone 0.1 part, 0.1 part, zinc sulfate, Probucol 0.1 part, lauryl polyethenoxy ether sodium sulfate 0.1 part, 0.05 part, ascorbic acid, ethanol 0.05 part.
2. a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes according to claim 1-2, is characterized in that:
Described Chinese medicine major ingredient extract extracts according to following steps,
Step one, select commercially available super micron mill, ratio is by weight taken: Rhizoma Begoniae Fimbristipulatae 5-10 part, Calyx Seu Fructus Physalis 5-10 part, Fructus Bruceae 5 parts, insect gall 5 parts, bog moss 5 parts, CUIYUNCAO 5 parts, Herba Schizonepetae 5 parts, Rhizoma Et Radix Notopterygii 3 parts, Rhizoma Ligustici 3 parts, emperor spends 3 parts, Herba Agrimoniae 3 parts, tomentose fevervine herb 3 parts, Herba Centipedae 3 parts, Indigo Naturalis 3 parts, Aspongopus 3 parts, Radix Morindae Officinalis 3 parts, Mentholum 3 parts, Herba lychnidis coronatae 3 parts, Rhizoma Curcumae 3 parts, Herba Hedyotidis Diffusae 3 parts, 2 parts, Moschus, Radix haleniae ellipticae 2 parts, Fructus Cnidii 2 parts, Herba Epimedii 2 parts, Fructus Evodiae 2 parts, Venenum Bufonis 2 parts, Mylabris Phalerata (processed) 2 parts, Spora Lygodii 2 parts, Radix Phytolaccae processed 2 parts, Borneolum Syntheticum 2 parts, Cortex Glyptostrobi Pensilis 2 parts, common threewingnut bark 2 parts, Herba Lycopodii 2 parts, Rhizoma Paridis 2 parts, Mirabilitum crystallina 2 parts, moxibustion sepiellae seu sepiae 2 parts, Radix Et Rhizoma Rhei 2 parts, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 2 parts, Radix Scrophulariae 1 part, Herba Artemisiae Scopariae 1 part, Radix Gentianae Macrophyllae 1 part, Rhizoma Chuanxiong 1 part, Herba cynodontis 1 part, Herba Alyxiae Sinensis 1 part, Radix Gentianae 1 part, Herba Dendrobii 1 part, Spina Gleditsiae 1 part, Radix Curcumae 1 part,
To 180 orders after pulverizing respectively by superfine powder machine, be then mixed to get mixed dust formulation, then stir stand-by;
Step 2, mixed dust formulation step one obtained, add deionized water, and volume ratio is 1: (10-30), afterwards microwave time 5-10min, microwave power 800W-1000W, and precipitation 5-10 minute, gets supernatant and be described Chinese medicine major ingredient extract.
3. a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes according to claim 2, is characterized in that:
The Calyx Seu Fructus Physalis Herb comprising Calyx Seu Fructus Physalis fruit selected by described Calyx Seu Fructus Physalis; Described Calyx Seu Fructus Physalis Herb carries out pretreatment in advance, pretreatment afterproduct is substituted Calyx Seu Fructus Physalis and directly pulverizes afterproduct.Described Calyx Seu Fructus Physalis Herb pretreatment afterproduct directly joins in the mixed dust formulation of other components of step one; Described Calyx Seu Fructus Physalis Herb pre-treatment step is as follows: by the Calyx Seu Fructus Physalis Herb after cleaning, add after adopting first 75 DEG C of blanch 2 ~ 4min in 0.02% sodium sulfite solution to soak and carry out color retention in 1 hour, add 2 ~ 3 times of deionized water making beating, add the α-amylase of 1.5 ~ 2%, the 20 ~ 30min that liquefies under 60 ~ 70 DEG C of conditions obtains Calyx Seu Fructus Physalis pretreatment afterproduct.
4. a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes according to claim 2, is characterized in that:
Described Herba Lycopodii directly adopts Herba Lycopodii extract to substitute Herba Lycopodii and directly pulverizes afterproduct.Described Herba Lycopodii extract adopts following steps to extract:
(1) with the Herba Lycopodii that 80 DEG C ~ 100 DEG C of hot water drip washing is not pulverized;
(2), after clean Herba Lycopodii being drained or dried, wall cell disruption powder is broken into Herba Lycopodii coarse powder;
(3) by the water-cooled leaching 12 ~ 24 hours of Herba Lycopodii coarse powder;
(4) enzymolysis
1) Herba Lycopodii adjusting PH with base value 7-8, adds cellulase 15 ~ 30U by every gram of Herba Lycopodii raw material, enzymolysis 2 hours at the temperature of 45 ~ 53 DEG C, intermittent stirring, filters, abandons filtering residue a, obtains filtrate A;
2) add 3 ~ 5 weight parts waters in Herba Lycopodii filtering residue a, at the temperature of 75 ~ 85 DEG C, lixiviate 1 ~ 2 hour, filters, abandons filtering residue b, obtain liquor B;
3) add 3 ~ 5 weight parts waters in the filtering residue b of Herba Lycopodii, lixiviate 30 ~ 45 minutes at 90 ~ 100 DEG C of temperature, filters, abandons filtering residue c, obtain liquor C;
4) merge the filtrate of A, B, C tri-times, refilter, collect micro-filtrate;
(5) concentrating under reduced pressure
By micro-filtrate under the condition of steam pressure≤0.15Mpa, vacuum≤700mmhg, temperature 80 ~ 100 DEG C, adopt vacuum-concentrcted to become paste, obtain paste Herba Lycopodii extract.
5. a kind of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes according to claim 1, is characterized in that: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes conveniently pharmaceutical methods can make unguentum, spray, gel.
6. a kind of application of Chinese and western medicine compound external preparation for the treatment of dermatitis and eczema, herpes according to claim 1, is characterized in that: the Chinese and western medicine compound external preparation of this treatment dermatitis and eczema, herpes is applied to dermatitis and eczema, herpes, surgery damage, allergic dermatitis, tinea manus and pedis.
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Citations (3)
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| CN1254581A (en) * | 1998-11-20 | 2000-05-31 | 段在义 | Chinese patent medicine for treating cancers and unknown toxic swellings (subcutaneous ulcer and carbuncle) and its preparing process |
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| CN102210848A (en) * | 2011-06-03 | 2011-10-12 | 张孝昌 | Medicament for treating skin disease, and preparation method thereof |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1254581A (en) * | 1998-11-20 | 2000-05-31 | 段在义 | Chinese patent medicine for treating cancers and unknown toxic swellings (subcutaneous ulcer and carbuncle) and its preparing process |
| CN1328836A (en) * | 2001-06-22 | 2002-01-02 | 宾永明 | Ointment for curing hemorrhoids |
| CN102210848A (en) * | 2011-06-03 | 2011-10-12 | 张孝昌 | Medicament for treating skin disease, and preparation method thereof |
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| 庄国康等: "《当代中医皮肤科临床家丛书》", 31 October 2014, 中国医药科技出版社 * |
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Application publication date: 20151202 |