CN105106675A - Preparation method of thick paste for wounds after healing - Google Patents
Preparation method of thick paste for wounds after healing Download PDFInfo
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- CN105106675A CN105106675A CN201510656348.0A CN201510656348A CN105106675A CN 105106675 A CN105106675 A CN 105106675A CN 201510656348 A CN201510656348 A CN 201510656348A CN 105106675 A CN105106675 A CN 105106675A
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Abstract
The invention discloses a preparation method of thick paste for wounds after healing and aims to solve the treatment problem of discomfort in wounds after suture. The method is characterized by comprising steps as follows: mixing roots of sandhill tylophora, buckeye seeds, loose knots, gastrodia elata BI., lychee seeds, ivy glorybind rhizomes, paris roots, petrels, erythrina bark, mustard seed plaster powder (wrap-boiled), magnetite and kudzuvine roots, decocting the mixture with water, taking a filtrate after 30 min, continuously decocting dregs with water for 20 min, then taking a filtrate , mixing two filtrates, and condensing the filtrate into thick paste. Clinical experiments prove that the thick paste has the characteristics of good curative effect and higher safety when being used for treating discomfort in the wounds after suture and is worthy of clinical application and promotion.
Description
Technical field
The present invention is application for a patent for invention " a kind of nursing powder for wound after wound healing and preparation method thereof " (application number: divisional application 2013107536316).Relate to the field of Chinese medicines, be specifically related to a kind of nursing powder for wound after wound healing and preparation method thereof.
Background technology
The feature of wound of lancinating is wound neat in edge, and after wound is sewed up, most wound can obtain primary healing.But a multicenter clinical investigation shows, when primary healing, local is without red, swollen, hot, bitterly and ooze out, there is the patient of 32.63% after suture, when one month, have obvious wound sense of discomfort, show as numbness, pain, paraesthesia and local skin to harden, Proportion of patients when three months after suture with wound sense of discomfort is still 24.67%.
This its reason complexity of unresolved wound sense of discomfort is various, when one side is lancinated and is hindered, and cortex, connective tissue layer, muscle layer, tegumentary nerve has damage in various degree; On the other hand in local soft tissue repair process, due to patient body quality factor, cause interstitial fibers connective tissue (extracellular matrix) hyperplasia degree higher than normal parenchyma cytothesis process, due to this kind of fibrous connective tissue only remedy be local form instead of local parenchyma 26S Proteasome Structure and Function, cause local discomfort and skin hardening.
Still lack the therapeutic scheme for sense of discomfort after wound healing after this kind of suture at present, clinician is many causes local stagnation of QI-blood to explain according to partial cut incised wound, and recommend patient's external safflower oil blood circulation promoting and blood stasis dispelling, but exist, so this kind of therapeutic scheme is substantially invalid because this pathogenesis system there is no stagnation of QI-blood.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little thick paste preparation method for wound after healing of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of thick paste preparation method for wound after healing, it is characterized in that: by Radix Tylophorae arenicolae 10 ~ 30 parts, Semen Aesculi 6 ~ 12 parts, Lignum Pini Nodi 3 ~ 10 parts, go back 6 ~ 12 parts, bobbin, Semen Litchi 3 ~ 10 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6 ~ 12 parts, Rhizoma Paridis 6 ~ 12 parts, Potiria pectinifera (Mukller et Tro Sehel) 6 ~ 12 parts, Cortex erythrinae 6 ~ 12 parts, 1 ~ 5 part, emplastra sinapis powder, Magnetitum 3 ~ 10 parts, Radix Puerariae 10 ~ 25 parts of mixing and water addings decoctions, wherein said emplastra sinapis powder is for decocting a drug wrapped; Get filtrate after 30 minutes, medicinal residues add water and continue decoction and get filtrate after 20 minutes, and twice filtrate merges, and is condensed into thick paste.
Wherein said: Radix Tylophorae arenicolae, for the spirit of asclepiadaceae plant bamboo disappears the root of Cynanchuminamoenum (Maxim.) Loes. or aerial parts.Nature and flavor are bitter; Micro-pungent; Property is put down.Return lung meridian.Merit can the kidney invigorating, spleen invigorating, removing toxic substances.
Semen Aesculi is Hippocastanaceae plant Aesculus chinensis Bunge AesculuschinensisBge., Radix Aesculi AesculuschinensisBge.var.chekiangensis(HuetFang) dry mature seed of Fang or Aesculus AesculuswilsoniiRehd..Nature and flavor are sweet, temperature.Return liver, stomach warp.Merit can regulating the flow of QI to ease the stomach, and stomach and alleviating pain.
Lignum Pini Nodi, for Pinus tabulaeformis tabulaeformisCarr, secondly be Pinus densiflora (short leaf Pinus densiflora) PinusdensifloraSieb.etZucc., Folium seu Strobilus Pini sibiricae Pinussibirica(Loud.) Mayr., Pinus koraiensis (Korean pine) PinuskoraiensisSieb.etZucc., Pinus armandi Franch-P. Komavovii Lavl. (Lignum Pini Nodi, five must pine) PinusarmandiiFranch. and Pinus massoniana Lamb, pinus yunnanensis faranch, Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen etc. Lignum Pini Nodi, or be pinaster sick after the knob that grows.Bitter in the mouth; Warm in nature.Return liver; Kidney channel.Merit can dispeiling pathogenic wind and removing dampness; Channels sootheing and network vessel quickening; Promoting blood circulation and stopping pain.
Also bobbin, the fruit of orchid Rhizoma Gastrodiae GastrodiaelataBl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head is had a headache; Weak breath consumption of essence; Early whitening of beard and hair.
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi LitchichinensisSonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.Merit can promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) is herb or the root of dicotyledon scammonia section plant DAWANHUA CalystegiahederaceaWall..Property sweet and slightly bitter taste; Flat.Return liver; Kidney channel.Merit can spleen invigorating; Dampness removing; Regulating menstruation.
Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis ParispolyphyllaSm..Hardship, is slightly cold.Enter Liver Channel.Merit can heat-clearing and toxic substances removing, detumescence, spasmolytic.
Potiria pectinifera (Mukller et Tro Sehel) is Echinodermata Asterinidae n-butanol part of Asterina pectinifera MilleretTroschel, is used as medicine with all (removing internal organs).Nature and flavor are salty, temperature, nontoxic.Merit can YIN nourishing, tonifying YANG, wind-damp dispelling.
Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis ErythrinaindicaLam..Nature and flavor are bitter, flat.Return liver, kidney channel.Merit can wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Emplastra sinapis powder is crucifer Caulis et Folium Sinapis albee SinapisalbaL. or mustard Brassicajuncea(L.) dry mature seed of Czern.etCoss., remove fatty oil after dry grinds and obtain.Nature and flavor are pungent, temperature.Return lung meridian.Merit can warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.
Magnetitum is oxide-based mineral spinelle race magnetic iron ore, main containing ferroso-ferric oxide (Fe3O4).Nature and flavor are salty, cold.Return liver, the heart, kidney channel.Merit can suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.
Radix Puerariae, Radix Puerariae is the root of leguminous plant Pachyrhizua angulatus.Sweet, pungent, flat.Enter spleen, stomach warp.Merit can be induced sweat, rash, and relaxing muscles and tendons promotes the production of body fluid, antidiarrheal.
Composition principle: lancinate and hinder wound and do not feel like oneself and refer to when wound primary healing, local is without red, swollen, hot, bitterly and ooze out, and patient has obvious wound sense of discomfort, shows as numbness, pain, paraesthesia and local skin and hardens.This kind of its reason complexity of sense of discomfort is various, on the one hand cortex, connective tissue layer, muscle layer after wound, and tegumentary nerve has damage in various degree; On the other hand in local soft tissue repair process, due to patient body quality factor, cause interstitial fibers connective tissue (extracellular matrix) hyperplasia degree higher than normal parenchyma cytothesis process, due to this kind of fibrous connective tissue only remedy be local form instead of local parenchyma 26S Proteasome Structure and Function, cause local discomfort and skin hardening.Still lack the therapeutic scheme for sense of discomfort after this kind of wound healing at present, clinician is many causes local stagnation of QI-blood to explain according to local wound, and recommend patient's external safflower oil blood circulation promoting and blood stasis dispelling, but exist, so this kind of therapeutic scheme is substantially invalid because this pathogenesis system there is no stagnation of QI-blood.
Compared with prior art, the present invention has following characteristics:
1, we adopt Radix Tylophorae arenicolae and Semen Aesculi to coordinate for monarch drug: lung and skin phase the exterior and the interior, described Radix Tylophorae arenicolae enters lung meridian, can by adjusting being entangled with of lung network skin, Radix Tylophorae arenicolae decocting liquid can improve the albumen caused by inflammation cyst caused anti-mouse carboxymethyl cellulose and ooze out and leukocyte migration, promotes parenchyma hypertrophy; And Semen Aesculi Total saponin 5mg/kg is applied topically to, in rat Ovum Gallus domesticus album connective tissue stimulation model, can suppress fibrous connective tissue hypertrophy.
2, inventor's clinical empirical summary draws, after suture, wound does not feel like oneself relevant with local channels apoplexy cold-damp after wound, so we adopt Lignum Pini Nodi, Cortex erythrinae, Semen Litchi wind-damp dispelling, and the meridian dredging; The reason choosing this three herbal medicine in numerous related drugs is, these three kinds of Drugs are gentle, and non-dispelling the damp pathogen with drugs of bitter in taste and cold in nature, does not have the anxiety of impairment of YIN.And the Ginkgolide Component columbin contained in Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) tuber, there is mate-assist to suppress fibrous connective tissue hypertrophy.
3, after suture, wound discomfort is also relevant with the dry impairment of YIN of local blood, and stirring of wind due to deficiency of YIN and numbness, fiber crops are itched, so we adopt go back bobbin tonify deficiency subduing the wind syndrome, Potiria pectinifera (Mukller et Tro Sehel) YIN nourishing and YANG strengthening wind-damp dispelling, the two is the product of reinforcement and elimination in combination, without growing greasy anxiety.
4, Semen Sinapis eliminating phlegm eliminating stagnation, after suture, wound discomfort belongs to the wound of primary healing, this kind of wound acute stage mistake, cold-phlegm residual in meridians is all more obstinate, coordinates Semen Litchi to help tonneau so add Semen Sinapis.Semen Sinapis is containing potassium myronate, potassium myronate meets the effect generation volatile oil of water through myrosase, and main component is allyl isosulfocyanate, has stimulation, be applied to skin, there is warm sensation and make it rubescent, even causing blister, pustule, so adopt emplastra sinapis powder in prescription of the present invention, i.e. gained after mustard flour removing fatty oil, this kind of de-fatty oil method is conventional in the industry, and emplastra sinapis powder can directly be buied from market, sufficient raw.But because the present invention needs in local action more than 3 hours, so coordinate Radix Puerariae, Radix Puerariae contains much starch, can alleviate the skin irritation of Semen Sinapis.
5, the reason choosing Rhizoma Paridis in the medicine of numerous heat-clearing and toxic substances removing is, the non-bitter cold of this medicine but be slightly cold, and has the merit of spasmolytic, has effect of tonneau venation.Its our full presciption medicine partial heat, adds cold and cool medicine simply in many hot medicines, also has the merit of using corrigent.
6, Magnetitum is originally the product in important city, but rat local topical, local neutrophil phagocytosis reaction can be made to increase.
7, avoid use to take offence promoting the circulation of blood medicine, reducing local fiber hypertrophy initiating stimulates.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Radix Tylophorae arenicolae 20 parts, Semen Aesculi 10 parts, Lignum Pini Nodi 6 parts, go back 10 parts, bobbin, Semen Litchi 6 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 10 parts, Rhizoma Paridis 10 parts, Potiria pectinifera (Mukller et Tro Sehel) 10 parts, Cortex erythrinae 10 parts, 2 parts, emplastra sinapis powder, Magnetitum 6 parts, Radix Puerariae 20 parts.
The preparation method of embodiment 1 is: by Radix Tylophorae arenicolae, Semen Aesculi, Lignum Pini Nodi, go back bobbin, Semen Litchi, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Rhizoma Paridis, Potiria pectinifera (Mukller et Tro Sehel), Cortex erythrinae, emplastra sinapis powder (decocting a drug wrapped), Magnetitum, the decoction of Radix Puerariae mixing and water adding, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, be condensed into thick paste, appropriate soak is in healing on wound.
Embodiment 2, crude drug weight proportion: Radix Tylophorae arenicolae 10 parts, Semen Aesculi 6 parts, Lignum Pini Nodi 3 parts, go back 6 parts, bobbin, Semen Litchi 3 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6 parts, Rhizoma Paridis 6 parts, Potiria pectinifera (Mukller et Tro Sehel) 6 parts, Cortex erythrinae 6 parts, 1 part, emplastra sinapis powder, Magnetitum 3 parts, Radix Puerariae 10 parts.
Embodiment 3, crude drug weight proportion: Radix Tylophorae arenicolae 20 parts, Semen Aesculi 10 parts, Lignum Pini Nodi 6 parts, go back 10 parts, bobbin, Semen Litchi 6 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 10 parts, Rhizoma Paridis 10 parts, Potiria pectinifera (Mukller et Tro Sehel) 10 parts, Cortex erythrinae 10 parts, 2 parts, emplastra sinapis powder, Magnetitum 6 parts, Radix Puerariae 20 parts.
Embodiment 4, crude drug weight proportion: Radix Tylophorae arenicolae 30 parts, Semen Aesculi 12 parts, Lignum Pini Nodi 10 parts, go back 12 parts, bobbin, Semen Litchi 10 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 12 parts, Rhizoma Paridis 12 parts, Potiria pectinifera (Mukller et Tro Sehel) 12 parts, Cortex erythrinae 12 parts, 5 parts, emplastra sinapis powder, Magnetitum 10 parts, Radix Puerariae 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Semen Aesculi, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Lignum Pini Nodi, Semen Litchi coarse powder are extracted volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) emplastra sinapis powder, Magnetitum, Radix Puerariae are pulverized 150 mesh sieves respectively, and become fine powder for subsequent use;
(3) Radix Tylophorae arenicolae, go back bobbin, Rhizoma Paridis, Cortex erythrinae, Potiria pectinifera (Mukller et Tro Sehel) mixing add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, leave standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation, spraying dry, draw just material;
(4) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, add gained fine powder mixing in step 2, cross 60 mesh sieves, sterilizing, subpackage form.
During use, dress the wound place after healing with warm water.
The efficient combination of said medicine, coordinates mutually, effectively reach treatment lancinate hinder suture after the object that does not feel like oneself of wound, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: to lancinate and to hinder uncomfortable 89 examples of the original mouth of debridement and suturing postoperative primary healing patient main suit year June in January, 2011 ~ 2013, the discomfort of main suit comprises local pain, fiber crops, itches, referred pain, formication, companion or do not accompany wound surrounding tissue to harden.Wherein trunk wound 36 example, extremity wound 52 example.Be divided into matched group 30 example, thick paste group 29 example and dress group 30 example.Compare in sex, age, the distribution of incision wound before three groups of patient treatments, no significant difference (P>0.05), has comparability.
1.1.2 inclusive criteria is: 1. lancinate wound between 1 ~ 10cm, without other complication; 2. the postoperative wound primary healing of debridement and suturing; 3. in postoperative three months of debridement and suturing; Deep seated infections without red and swollen heat pain, and is got rid of in wound local; 4. non-diabetic and mental sickness medical history.
1.2 method.
1.2.1 Therapeutic Method: matched group safflower oil local is embrocated, 2 times/d.Thick paste group with the appropriate soak in gained thick paste local in the embodiment of the present invention 1 in healing on wound, 2 times/d.Dressing group dresses in healing on wound with the appropriate warm water in gained medicated powder local in the embodiment of the present invention 2,2 times/d.3 groups of treatments were all 1 course for the treatment of with 14 days, added up curative effect after the course for the treatment of.
1.2.2 criterion of therapeutical effect: recovery from illness: clinical symptoms, sign disappear; Effective: clinical symptoms, sign turn for the better by and large, and no longer affect life; Effective: clinical symptoms, sign alleviate, but still can affect sleep or life; Invalid: clinical symptoms, sign are unchanged.
1.2.3 statistical analysis: SPSS13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
2.1 3 groups of Comprehensive Clinical comparitive study: thick paste group organizes cure rate and matched group difference extremely obviously (thick paste group χ with dressing
2=9.81, P<0.05; Dress group χ
2=9.31, P<0.05), thick paste group organizes total effective rate apparently higher than matched group (thick paste group χ with dressing
2=4.54, P<0.05; Dress group χ
2=6.67, P<0.05), see the following form.
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 30 | 2(6.67%) | 8(26.67%) | 10(33.33%) | 10(33.33%) | 67.67% |
| Thick paste group | 29 | 12(41.38%) | 9(31.03%) | 6(20.69%) | 3(10.34%) | 93.10% |
| Dress group | 30 | 12(40.00%) | 10(33.33%) | 6(20.00%) | 2(6.67%) | 93.33% |
2.2 3 groups of adverse reactions of patients incidence rates: three groups all do not occur obvious adverse reaction.
3. conclusion.
This result of study shows, use thick paste group of the present invention and dress group cure rate and total effective rate apparently higher than matched group, illustrates prepared by the inventive method wound care thing that heals healed after treatment suture wound do not feel like oneself in have untoward reaction comparatively gently, the higher advantage of safety.
Claims (1)
1. the thick paste preparation method for wound after healing, it is characterized in that: by Radix Tylophorae arenicolae 10 ~ 30 parts, Semen Aesculi 6 ~ 12 parts, Lignum Pini Nodi 3 ~ 10 parts, go back 6 ~ 12 parts, bobbin, Semen Litchi 3 ~ 10 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6 ~ 12 parts, Rhizoma Paridis 6 ~ 12 parts, Potiria pectinifera (Mukller et Tro Sehel) 6 ~ 12 parts, Cortex erythrinae 6 ~ 12 parts, 1 ~ 5 part, emplastra sinapis powder, Magnetitum 3 ~ 10 parts, Radix Puerariae 10 ~ 25 parts of mixing and water addings decoctions, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is condensed into thick paste.
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| CN201310753631.6A CN103735874B (en) | 2013-12-31 | 2013-12-31 | A kind of nursing powder for wound after wound healing and preparation method thereof |
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| CN201310753631.6A Division CN103735874B (en) | 2013-12-31 | 2013-12-31 | A kind of nursing powder for wound after wound healing and preparation method thereof |
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| CN201510656348.0A Pending CN105106675A (en) | 2013-12-31 | 2013-12-31 | Preparation method of thick paste for wounds after healing |
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| CN105213637A (en) * | 2015-10-16 | 2016-01-06 | 辛秋莲 | A kind of for epidemic victim's wound disinfection nursing powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306111A (en) * | 2008-06-27 | 2008-11-19 | 天津生机集团股份有限公司 | Medicaments for treating animal trauma |
| CN102580142A (en) * | 2012-03-09 | 2012-07-18 | 王键 | Chinese medicinal liniment for postoperative healing of orthopaedic surgery and preparation method |
| CN102755414A (en) * | 2012-07-20 | 2012-10-31 | 河南科技大学 | Traditional Chinese medicine ointment for trauma wound and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100374141C (en) * | 2006-01-06 | 2008-03-12 | 王庆华 | Wound-treating powder |
| CN101204529A (en) * | 2007-12-18 | 2008-06-25 | 秦庆吉 | Medicine for wound-curing and scar-dispeling |
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2013
- 2013-12-31 CN CN201310753631.6A patent/CN103735874B/en not_active Expired - Fee Related
- 2013-12-31 CN CN201510656348.0A patent/CN105106675A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101306111A (en) * | 2008-06-27 | 2008-11-19 | 天津生机集团股份有限公司 | Medicaments for treating animal trauma |
| CN102580142A (en) * | 2012-03-09 | 2012-07-18 | 王键 | Chinese medicinal liniment for postoperative healing of orthopaedic surgery and preparation method |
| CN102755414A (en) * | 2012-07-20 | 2012-10-31 | 河南科技大学 | Traditional Chinese medicine ointment for trauma wound and preparation method thereof |
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| CN103735874A (en) | 2014-04-23 |
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