A kind of lopseed composition for treating Osteoarthritis
Technical field
The application belongs to field of Chinese medicinal composition more particularly to a kind of lopseed composition for treating Osteoarthritis.
Background technology
Osteoarthritis is a kind of progressive retrogression pathological changes, and cardinal symptom is arthralgia, swelling, stiff, lopsided and work(
Energy obstacle etc..The clinical method of Current therapeutic Osteoarthritis mainly has closing needle therapeutic, ammonia sugar therapy, expectant treatment, operation
Treatment and Chinese medicine treatment.Chinese medicine thinks that osteoarthritis belongs to " bi Zheng " scope with pain for main performance, and there is discussion in ancient Chinese medicine doctor generation
And have accumulated a large amount of experience, it is believed that the origin cause of formation of bi Zheng is caused by wind-cold damp pathogen invasion, such as《Plain Questions numbness opinions》It points out:" wind, it is cold,
Wet three gas is miscellaneous extremely, combined into numbness.”《The all numbness source streams of miscellaneous diseases source stream rhinoceros candle》Cloud:" numbness person closes.Three gas are miscellaneous extremely, hide from view channels and collaterals,
Vim and vigour are not all right, cannot dispel at any time scattered, therefore are numbness long.”.Interpretation of the cause, onset and process of an illness key invades channels and collaterals for exopathogen and causes " to hinder through vessle-Bi symptom-complex, qi and blood is not
It is logical ", qi and blood stagnation is locally into arthroncus, dysfunction, and general rule is not shown in arthralgia to passages through which vital energy circulates.Therefore " warp is caught in treatment
Vessle-Bi symptom-complex resistance, qi and blood are obstructed " this interpretation of the cause, onset and process of an illness treated.Clinically many patients are reluctant oral traditional Chinese medicine, so finding a kind of simplicity
It is effective to obtain external treatment of traditional Chinese medicine, there is realistic meaning to treating this kind of patient.
We coordinate infrared therapy Osteoarthritis under clinical practice and instruction of Chinese Medicine theory using compound lopseed
Obtaining good therapeutic effect, (military calm and peaceful, Kang Xiuli lopseeds are applied with cooperation infrared therapy 30 [J] China Chinese medicine of Osteoarthritis
Medicine science and technology, 2017,24 (6):802-803.), but in clinical treatment finding the lopseed preparation, there is also certain defects, main
It is:The lopseed preparation needs to coordinate infrared ray that could obtain preferable therapeutic effect, and effect is treated if without using infrared ray
Fruit substantially reduces, although infrared ray is widely used in clinic, infrared ray (IR) radiation is not to be regarded as complete to human skin
Completely without evil, research shows that infrared ray can destroy dermal extracellular matrix structural proteins, cause premature skin ageing;Infrared ray spoke
Penetrate it is similar to ultraviolet radiation, can result in and accelerate skin actinicity damage generation, such as early ageing and carcinogenesis, infrared ray
(IR) irradiation human skin fibroblasts may inhibit type i collagen, upset type III collagen, lead to I by inducing c-Jun expression
Collagen Type VI and type III collagen are out of proportion, cause the generation of skin photoage.
Moreover, due to needing infrared radiation, the equipment, patient per are not required to when treating for general family
Hospital could complete to treat, time and effort consuming.
Therefore, the presence based on problem above, we, which are badly in need of preparing one kind, not needing infrared ray and can reach preferable treatment
The lopseed preparation of effect, use at home for patient.Moreover, we are also badly in need of preparing a kind of improved lopseed system
Agent, to reduce its anaphylactoid side effect to skin.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of lopseed compositions for treating Osteoarthritis.
A kind of lopseed composition for treating Osteoarthritis, including medicinal powder and concoction, the medicinal powder is by asarum, Chinese pine
Section, licorice composition;The concoction group is made of fresh lopseed, fresh Siberian cocklebur grass, ginger, white wine and light-coloured vinegar.
The lopseed composition of above-mentioned treatment Osteoarthritis, it is characterised in that asarum, Pine Nodular Branch, licorice weight match
Than being 30: 60: 60.
The lopseed composition of above-mentioned treatment Osteoarthritis, it is characterised in that fresh lopseed, fresh Siberian cocklebur grass, life
The weight proportion of ginger, white wine and light-coloured vinegar is 500: 100: 500: 20: 20.
The lopseed composition of above-mentioned treatment Osteoarthritis, it is characterised in that the preparation method of medicinal powder is:Take asarum 30
Part, 60 parts of Pine Nodular Branch, 60 parts of licorice, pulverize respectively, are sufficiently mixed uniformly.
The lopseed composition of the treatment Osteoarthritis, it is characterised in that the preparation method of concoction is:With fresh
500 grams, fresh Siberian cocklebur grass 100g of bone grass, ginger 500 grams (peelings) are pounded tiny blocky (using juice as standard), are added respectively
Each 20g of white wine, light-coloured vinegar, is fitted into cotton bag and tightens to obtain the final product.
In use, medicinal powder is first spread on articular surface, then concoction is covered in medicinal powder surface, about 7-8 centimetres altogether of thickness is controlled
During treatment, the juice in concoction can be infiltrated from cotton bag and medicinal powder mixing after treatment is played to osteoarthritis jointly
Effect.
Rheumatism treatment key is to release patient pain, and lopseed is civil to be mainly used for traumatic injury, rheumatic Bi syndrome, is had good
Good analgesic effect.In China, most area is distributed, and north and south various regions have cultivation, resource very abundant, picking to be easy, face
Bed is widely used in arthralgia pain due to rheumatism, muscles and bones contracture, cold-dampness limb gas etc..Nature and flavor:It is sweet, pungent, warm, have dispelling wind and eliminating dampness, relaxing tendons and activating collaterals,
The benefits of promoting blood circulation and stopping pain, especially suitable arthralgia, such as《Compendium of Materia Medica》Lopseed " control muscles and bones all rheumatalgia pain contractures ", separately
Outside, this product it is pungent enter Liver Channel, have relaxing tendons and activating collaterals the benefits of, for caused by diseases caused by external factors ailment said due to cold or exposure limbs passages through which vital energy circulates contraction cannot relax turn freely, can
With expelling wind and clearing away cold, relaxing tendons and activating collaterals, such as《The sweet peaceful green Chinese herbal medicine choosing in Shan》Lopseed " controls muscles and bones contraction ", can be saturating using Local out dressing
Enter channels and collaterals, blood vessels, and has the characteristics that wind-dispelling, promoting blood circulation, analgesic.It is suitable containing gingerol and a variety of volatile oil, lopseed in ginger
To joint, another ginger, white wine, light-coloured vinegar can ward off the cold promoting blood circulation, dredging the channel ginger fiber pervasion, and four share into paste then expelling wind and clearing away cold
The benefits of damp dispelling and pain relieving, is notable, and more readily promotes skin absorption, and ginger, white wine, light-coloured vinegar can ward off the cold promoting blood circulation, dredging the channel, close
With at notable the benefits of pasting then functions dispelling wind and clearing away cold, removing dampness analgesic.
Asarum is gained the name because its root is thin, acrid flavour is bitter, has strong fragrance, arrogant taste strong, can be apt to relieving exterior syndrome and dispelling cold wind-expelling pain-stopping
It dispels the chill of internal organs, channels and collaterals, is always considered as the key medicine of stupid numbness,《Sheng Nong's herbal classic》Meaning:" hundred section contractions, arthralgia pain due to rheumatism, extremely
Flesh ".Xu Ling tires " asarum is warm-natured, and can expel cold air, evacuation up and down ailment said due to cold or exposure, can not enter without micro-, nowhere less than." Chinese pine
It saves, bitter temperature is nontoxic, is good at dispelling wind and removing obstruction in the meridians, dredges sharp joint, be considered as rheumatism good medicine, for the joint caused pain of a variety of causes, swells
Swollen discomfort etc. is effective, and Zhu Liangchun has found its length for having qi-restoratives to consolidate, and to thin damage severe and lingering illness as all, there is the work(of recovery greatly, and Bones and joints
It is sick big how long empty sick long, therefore can simultaneous treatment of principal and subordinate symptoms.Asarum can enhance the power of skin permeation of drugs, guide drugs to illness station with Pine Nodular Branch with using,
Pine Nodular Branch matter heavily fortified point gas strength can help the power of the strong help of asarum, with Radix Glycyrrhizae with using, the pungent strong caused skin of asarum flavour of a drug can be prevented uncomfortable.
Fresh Siberian cocklebur grass:Siberian cocklebur grass acrid flavour has the function of wind-damp dispelling degrading the channel stopping numbness pain, cures mainly wind-cold-dampness arthralgia, poison enters
Marrow, waist and knee wind toxin, evil dead blood of meat etc.,《Book on Chinese herbal medicine covers bamboo fish trap》It says:" chasing after wind to appoint in marrow ",《Sheng Nong's herbal classic》:" main cold pain, wind
Wet, general arthralgia " exists《Compendium of Materia Medica》《Prescriptions for Succouring the Sick》《The new compilation of materia medica》《Elementary Medicine》《The precious member of longevity generation》Deng treatment rheumatism all on the books
Siberian cocklebur was once classified as the product of medicine-food two-purpose by the discussion of rheumatism, the Tang Dynasty, and few side effects civil that Siberian cocklebur grass external application for curing is applied alone to close more
The experience of pain is saved, therefore adds Siberian cocklebur grass in improvement side, is mashed with fresh lopseed, Siberian cocklebur grass and is inhaled conducive to drug ingedient
It receives, ginger, white wine, light-coloured vinegar can ward off the cold promoting blood circulation, dredging the channel, and it is notable the benefits of then functions dispelling wind and clearing away cold, removing dampness relieves pain to share into paste, more
Readily facilitate skin absorption, make local qi and blood circulation, wind-cold damp pathogen that must dispel, play altogether warming and activating meridian, the promoting flow of qi and blood circulation, swelling and pain relieving it
Effect, therefore the symptoms such as arthralgia, swelling can be alleviated.
It has used asarum and Siberian cocklebur grass to reinforce Medicated Permeation effect, therefore has not reused infrared ray.
Lopseed, Siberian cocklebur grass, ginger, asarum etc. have certain stimulation, the reduction master of pessimal stimulation to skin and mucosa
If because of the use at licorice medicine end.Radix Glycyrrhizae is since sugariness is apparent, so hundred poison can be solved and coordinating the drug actions of a prescription, Sui You states it is old it
Claim,《Collected statements on the herbal foundation》:" and middle QI invigorating, the medicine of qi-restoratives removing toxic substances.”《Book on Chinese herbal medicine is just》It says:" sweet, the property that must be neutralized of taste has tune to mend
Work(, therefore the solution that obtains of poison its poison, rigid medicine the sum of obtains its property ...." and medicine-feeding be combined together, can mitigate drug it is strong,
Toxicity prevents it excessively high strong and hinders just, has the particular utility eliminated or mitigate adverse reaction, alleviates the stimulation to skin
Effect, makes adverse reaction reduce, and in addition and the hot medicine of prescription kind is more, though acrid energy dispersing superficial exopathogens, are difficult to ensure drug effect
Persistently, compatibility Radix Glycyrrhizae, can keeping with sweet medicine, it is anxious to delay pungent medicine, can not only help the work(of its analgesic, but also can prevent that it is stimulated too, and
The clearing heat and detoxicating curative effect of licorice opposes each other and yet also complement each other with the hot effect of above-mentioned drug, mutually swashs and coordinate, and increases curative effect.Modern times grind
Study carefully proof, the principle active component of Radix Glycyrrhizae is triterpene saponin, flavonoids, alkaloid and polysaccharide compound.It has confirmed sweet
Straw colour ketone has the effects that apparent anti-oxidant, anti-inflammatory and antiallergic action, antiulcer, analgesia, antibacterial, antitumor, and use is sweet
Adverse reaction reduction after grass meal, it is likely to because glycyrrhiza total flavonoid has a preferable itching-relieving action, mechanism and antihistamine and
Inhibit mast cell degranulation related.
Articular skin surface is spread on using medicinal powder, finds that skin surface applies when using moxibustion treatment rheumatism derived from my section
Curative effect higher when medicinal powder combination concoction is used together, therefore extract experience from.Medicinal powder and being used cooperatively for liquid are clinically better than
The liquid for directly preparing lopseed, Siberian cocklebur grass, asarum, oil section pine and Radix Glycyrrhizae and white wine, light-coloured vinegar.
Compared with prior art, the present invention having the beneficial effect that:
Cure rate is improved significantly.It is increased to 48.4% by 33.3%, hence it is evident that alleviate pain, improve the life matter of patient
Amount.
Adverse reaction is decreased obviously.There are 5 skin pessimal stimulation symptoms in control group, and treatment group only has 2 patients, bad
Significant reaction reduces, and alleviates stimulation of the external therapy to skin, patient is made to be more prone to receive, and improves patient compliance.
Using medicinal powder in such a way that pack external application is combined, two kinds of external treatment of traditional Chinese medicine are combined, it is easier to be improved curative effect, be subtracted
Light side effect.The reason of improvement is derived from clinical practice experience, this curative effect improves is the reasonable disposition of prescription, the same medicine bag of medicinal powder
In various drugs be combined together, on the one hand can reduce pessimal stimulation of the drug to skin, treatment on the other hand can be remarkably reinforced
Effect, substantially increases patient compliance, alleviates patient suffering.
Does not avoid infrared ray by infrared therapy apparatus again and be possible to the harmful effect caused by human body, significantly facilitate
Patient, because operation is simple, patient can be in after configuring drug Self-operating treatment.
The advantage and characteristic of tcm clinical practice is that simplicity is honest and clean and tests that this method is easy to operate at all, and safety avoids drug oral
Various side effects, adverse reaction is few and is not required to handle, and economical and practical, patient is acceptant, and compliance is high, clinical effectiveness compared with
It is good, it is worth clinical expansion.
Specific implementation mode
In order to which the present invention is furture elucidated, a series of embodiments are given below, these embodiments be entirely it is illustrative, it
Only be used for the present invention specifically describe, be not construed as limitation of the present invention.
Embodiment 1
30 parts of asarum, 60 parts of Pine Nodular Branch, 60 parts of licorice are taken, is pulverized respectively, uniform medicinal powder is sufficiently mixed.
With 500 parts of fresh lopseed, 100 parts of fresh Siberian cocklebur grass, ginger 500 parts (peelings), be pounded respectively it is tiny it is blocky (with
Juice is standard), white wine, each 20 parts of light-coloured vinegar is added, is fitted into cotton bag and tightens up to concoction.
In use, medicinal powder is first spread on articular surface, then concoction is covered in medicinal powder surface, about 7-8 centimetres of thickness, treatment
In the process, the juice in concoction can be infiltrated from cotton bag and medicinal powder is mixed with and plays therapeutic effect to joint jointly.
Embodiment 2
50 parts of asarum, 100 parts of Pine Nodular Branch, 100 parts of licorice are taken, is pulverized respectively, uniform medicinal powder is sufficiently mixed.
With 1000 parts of fresh lopseed, 400 parts of fresh Siberian cocklebur grass, ginger 1000 parts (peelings) is pounded tiny bulk respectively
(using juice as standard) is added white wine, each 80 parts of light-coloured vinegar, is fitted into cotton bag and tightens up to concoction.
In use, medicinal powder is first spread on articular surface, then concoction is covered in medicinal powder surface, about 7-8 centimetres of thickness, treatment
In the process, the juice in concoction can be infiltrated from cotton bag and medicinal powder is mixed with and plays therapeutic effect to joint jointly.
Comparative example 1
General information
All case histories are selected from our hospital outpatient service arthralgia person.
Treatment group:In May, -2018 in June, 2017 is given according to patient's the principle of voluntariness and treats, this group totally 31 patients, man 12
Example, female 19 is minimum 38 years old of age, 75 years old maximum, the course of disease most short January, longest 23 years.Unilateral side morbidity 20, bilateral joint hair
Disease 11.
Control group 1:In July, 2016 in September, -2016 patient as a control group, given also according to patient's the principle of voluntariness
Treatment, totally 30 patients, man 12, female 18, the age is 40 years old minimum, 75 years old maximum, the course of disease most short January, longest 20 years.It is unilateral
Morbidity 20, bilateral joint are fallen ill 10.
Control group 2:The patient in May, -2017 in October, 2016 as a control group, gives also according to patient's the principle of voluntariness
Treatment, totally 28 patients, man 11, female 17, the age is 33 years old minimum, 74 years old maximum, the course of disease most short January, longest 22 years.It is unilateral
Morbidity 17, bilateral joint are fallen ill 11.
Diagnostic criteria Western medicine diagnostic criteria:Reference《Chinese osteoarthritis diagnosis and treatment guide》(version in 2007).Syndrome in TCM is waited to see the doctor
Disconnected standard reference《New Chinese medicine guideline of clinical investigations》The diagnosis basis of (revised edition in 2002) " heumatism ", disease classification.
Discharge standard does not meet Osteoarthritis diagnostic criteria person;It is serious to be associated with cardiovascular and cerebrovascular, liver, kidney and hemopoietic system
Disease and insane;Gestation or women breast-feeding their children, allergic constitution person;It is associated with bone tumour, bone tuberculosis or blood vesssls and nerves injuries
Person and nonspecific inflammation;Patient cannot adhere to treating, and can not judge the not congruent judgement person that affects the treatment of curative effect or data.
Adverse reaction observation index:Skin irritatin phenomenon and allergic reaction are leading indicator.Skin whether there is or not itch, shouting pain,
The adverse reactions such as burn feeling, erythema, erythema, bubble.
Treatment group
Drug is prepared and usage:30 grams of choice of drug asarum, 60 grams of Pine Nodular Branch, 60 grams of licorice, are ground into medicinal powder, according to joint
Size selects medicinal powder appropriate, spreads on joint.Each joint 500 grams of fresh lopseed, fresh Siberian cocklebur grass 100g, ginger 500
Gram (peeling) is pounded tiny blocky (using juice as standard), white wine, each 20g of light-coloured vinegar is added, is fitted into cotton bag and tightens respectively,
It spreads on the medicinal powder of joint, about 7-8 centimetres altogether of thickness.
It is primary to turn within every 5 minutes medicine bag, treats 40 minutes altogether.
Control group 1
Drug is prepared and usage:Each joint is pounded tiny bulk respectively with 500 grams of fresh lopseed, ginger 500 grams (peelings)
(using juice as standard) is added white wine, each 20g of light-coloured vinegar, is fitted into cotton bag and tightens, spread on joint, about 7-8 centimetres of thickness.
After Infrared radiation patient is applied with, using infrared radiation medicinal bag, turn within every 2 minutes that medicine bag is primary, and concurrent irradiation 40 divides
Clock.
Control group 2
Drug is prepared and usage:30 grams of choice of drug asarum, 60 grams of Pine Nodular Branch, 60 grams of licorice obtain medicinal extract after alcohol extracting concentrates,
Each joint is pounded tiny blocky (using juice as standard), is added respectively with 500 grams of fresh lopseed, ginger 500 grams (peelings)
The medicinal extract of above-mentioned asarum, Pine Nodular Branch and licorice is added white wine, each 20g of light-coloured vinegar, is fitted into cotton bag and tightens, spread on joint,
About 7-8 centimetres of thickness.
It is primary to turn within every 5 minutes medicine bag, treats 40 minutes altogether.
Therapeutic effect
Efficacy assessment standard
Reference<People's Republic of China's traditional Chinese medicine industry standard Chinese medical disease Standardization of diagnosis and curative effect>Heumatism card is drafted.Clinic is controlled
More:Arthralgia, swelling disappear, and movable function restores normal, and laboratory examination is normal;It improves:Arthralgia, swelling mitigate,
Joint movement function improves;It is not cured:Arthralgia and swelling it is unchanged or aggravate.
Efficacy evaluation
Treatment group:It totally 31, cures 15 (48.4%), improves 15 (48.4.0%), invalid 1 (3.2%), total effective rate
96.8%.
Control group 1:It totally 30, cures 10 (33.3%), improves 18 (60%), it is invalid 2 (6.7%), it is total effective
Rate 93.3%.
Control group 2:It totally 28, cures 14 (50%), improves 13 (46.4%), it is invalid 1 (3.5%), it is total effective
Rate 96.4%.
Adverse reaction:
Treatment group 1:There are 2 patients skin irritation sense, burn feeling occur, no erythema, erythema, bubble, symptom disappears in 24 hours.
Control group 1:There are 5 patients skin irritation sense, burn feeling, no erythema, erythema occur, wherein 2 patients have itch
Sense, is not required to handle, and symptom disappears in 24 hours, and bubble occur in 2 patients, untreated, disappear after 5 days.
Control group 2:There are 4 patients skin irritation sense, burn feeling, no erythema, erythema occur, wherein 2 patients have scratchiness,
It is not required to handle, symptom disappears in 24 hours, and bubble occur in 2 patients, untreated, disappear after 5 days.
Statistical analysis
For statistical analysis using SPSS13.0 statistical packages, measurement data indicates, measurement data is examined with t, enumeration data
Use x2It examines, with P<0.05 is statistically significant.
Patient's ordinary circumstance comparison result is shown in Table 1
Patient's ordinary circumstance comparison result is shown in Table 1
1 three groups of genders of table, age, the course of disease, single bilateral morbidity (n=30.)
Compared with the control group.* P > 0.05.Treatment group and control group data are passed through in gender, age, the course of disease, affected limbs etc.
There was no significant difference for statistical analysis (P > 0.05), is comparable.Two groups of Clinical efficacy comparisons the results are shown in Table 2.
2 two groups of table Clinical efficacy comparison N/ (P/%)
Compared with the control group.*P<0.05.Treatment group and control group data are significant through statistical analysis in terms of clinical efficacy
Difference.
Treatment group compares with control group 1, and cure rate significantly improves earlier above, and another treatment group's improvement rate decline is due to cure rate
Caused by raising, invalid case history is reduced earlier above, and adverse reaction is substantially reduced, and total effective rate improves.Treatment group and 2 phase of control group
Than although total effective rate no difference of science of statistics, the adverse reaction for the treatment of group significantly reduces, and illustrates the combination of medicinal powder and concoction
It is better than exclusive use concoction.