CN105106395A - Preparation for treating nyctalopia and preparing method - Google Patents
Preparation for treating nyctalopia and preparing method Download PDFInfo
- Publication number
- CN105106395A CN105106395A CN201510588261.4A CN201510588261A CN105106395A CN 105106395 A CN105106395 A CN 105106395A CN 201510588261 A CN201510588261 A CN 201510588261A CN 105106395 A CN105106395 A CN 105106395A
- Authority
- CN
- China
- Prior art keywords
- herba
- parts
- preparation
- subsequent use
- minute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses a preparation for treating nyctalopia. The preparation is prepared from, by weight, 9-14 parts of rhodiola rosea, 6-10 parts of koelreuteria paniculata flowers, 8-15 parts of nostoc sphaeroides, 11-16 parts of rungia pectinata, 7-15 parts of cacumen biotae, 7-13 parts of litsea rotundifolia, 10-16 parts of clove twigs, 8-12 parts of quispualis indica leaves, 7-14 parts of elsholtzia blanda benth, 9-15 parts of officinal magnolis flowers, 11-16 parts of potentilla discolor, 6-14 parts of broomjutre sida herbs, 9-13 parts of japan clover herbs and 8-14 parts of quercus fabri hance. The preparation has the advantages that compatibility of the selected medicinal medicines is suitable, and the preparation conforms to traditional Chinese medicine and modern medicine research theories and has the effects of nourishing blood, tonifying liver, clearing heat and improving eyesight, and it is found through clinical curative effcet observation that the preparation has the advantages of taking effect fast, being convenient to take, easy to absorb, safe, reliable and high in cure rate.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of preparation for the treatment of nyctalopia and preparation method thereof.
Background technology
Nyctalopia declines to low light level sensitivity, the serious symptom performance that dark adaptation time extends.How because of caused by vitamin A deficiency, also there is congenital nyctalope.Cardinal symptom is that photopic vision is almost normal, light gradually dark then blurring of vision during dusk.Because some birds such as Passeris montani saturati are congenital nyctalopia, therefore have another name called " nyctalopia ", " night blindness ", " nyctalopia eye ".
Nyctalopia can be divided into following three kinds according to its pathogenic factor: (1) temporary nyctalopia: owing to being deficient in vitamin A or affect the absorption of vitamin A because of some digestive system disease in diet, cause rod of the retina do not synthesize the raw material of rhodopsin and cause nyctalopia.This nyctalopia is temporary, as long as eat Hepar Sus domestica, Radix Dauci Sativae, cod-liver oil etc. more, gets final product the deficiency of vitimin supplement A, will soon fully recover.(2) acquired nyctalopia: often because rod of the retina malnutrition or the pathological changes of itself cause.Be common in diffuse choroiditis, the widely atrophy of choroid ischemia etc., this nyctalopia is improved gradually along with the recovery from illness of effective treatment, disease.(3) congenital night blindness: be inborn genetic oculopathy, as retinitis pigmentosa, staff cell dysplasia, loses the function of synthesis rhodopsin, so there is nyctalopia.Chinese medicine is thought: nyctalopia is that therefore mostly nyctalopia patient is older people because taste, Liver and kidney are weak, Most patients also showed dizzy weak, fear of cold is afraid of cold, inappetence.Chinese traditional treatment nyctalopia, mainly based on the Chinese medicine of the liver and the kidney tonifying.
Application publication number CN104825865A(application number 201510203570.5) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of nyctalopia, be made up of the raw material of following parts by weight: Flos Eriocauli 12-15, Faeces Vespertilionis 5-10, Fructus Lycii 10-15, Semen Cassiae 12-18, Rhizoma Atractylodis Macrocephalae 5-8, bar halberd 6-9, Cortex Magnoliae Officinalis 5-8, Fructus Kochiae 10-15, Fructus Atriplicis Sibiricae 8-10, Radix Saposhnikoviae 4-6, Hepar Caprae seu ovis 50, Herba Alii fistulosi 15-20, Rhizoma Arundinis Donacis 8-15, Cortex Eucommiae 6-10, Flos Celosiae 15-20, Herba Cirsii Linearis 15-20, Folium Ilicis 3-5, Herba Polygalae Japonicae 10-15, Fructus Broussonetiae 6-12.Application publication number CN103784811A(application number 201410016811.0) Chinese invention patent document disclose a kind of Chinese herbal medicine formula for the treatment of nyctalopia and preparation method thereof, be made up of following parts by weight proportioning: Rhizoma Atractylodis 15-20g, Hepar Caprae seu ovis 5-15g, Hepar Sus domestica 10-20g, male cowardly 5-15g, Fel Cyprinus carpio 10-20g, Flos Buddlejae 15-25g, Concha Haliotidis 15-25g, Faeces Vespertilionis 15-25g, Flos Luffae 3-8g, Folium Pini 15-25g, Herba Lobeliae Chinensis 15-25g, Herba Kummerowiae Striatae 10-15g, Flos Chrysanthemi 5-15g, Cacumen Securinegae Suffruticosae 15-25g, Fructus Lycii 5-15g, Semen Coicis 5-15g.Application publication number CN104815089A(application number 201510255342.2) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of nyctalopia, be made up of the raw material of following weight portion: Pulvis Fumi Carbonisatus 20-40 part, Flos Eriocauli 20-40 part, Faeces Vespertilionis 20-40 part, Ramulus Uncariae macrophyllae 20-40 part, Semen Juglandis 20-40 part, water 400-500 part.
Chinese medicine patient when treating nyctalopia of existing treatment nyctalopia can not get the most effectively treating after Long-term taking medicine, and the five internal organs can not get correct conditioning, and therapeutic effect is not comprehensive, easily recurs, brings great misery to patient.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that a kind of easy to prepare, compatibility is simple, the preparation of the treatment nyctalopia of determined curative effect and preparation method.This Chinese medicine preparation effect rapidly and have no side effect.
Technical scheme of the present invention is:
The preparation for the treatment of nyctalopia, is prepared from by following bulk drugs, is weight portion: Radix Rhodiolae 9-14; Flos koelreuteriae paniculatae 6-10; Nostoc 8-15; Herba rungiae pectinatae 11-16; Cacumen Platycladi 7-15; Corii Cuon alpini Camphor tree 7-13; Caulis Caryophylli 10-16; Folium Quisqualis 8-12; Herba Elsholtziae Blandae 7-14; Flos Magnoliae Officinalis 9-15; Herba Potentillae Discoloris 11-16; Herba Sidae Rhombifoliae 6-14; Herba Kummerowiae Striatae 9-13; Involucrum Querci fabri 8-14.
In preferred scheme, Radix Rhodiolae 10-13; Flos koelreuteriae paniculatae 7-9; Nostoc 10-13; Herba rungiae pectinatae 12.5-14.5; Cacumen Platycladi 9-13; Corii Cuon alpini Camphor tree 9-11; Caulis Caryophylli 12-14; Folium Quisqualis 9-11; Herba Elsholtziae Blandae 9-12; Flos Magnoliae Officinalis 11-13; Herba Potentillae Discoloris 12.5-14.5; Herba Sidae Rhombifoliae 8-12; Herba Kummerowiae Striatae 10-12; Involucrum Querci fabri 10-12.
Be more preferably, Radix Rhodiolae 11.5; Flos koelreuteriae paniculatae 8; Nostoc 11.5; Herba rungiae pectinatae 13.5; Cacumen Platycladi 11; Corii Cuon alpini Camphor tree 10; Caulis Caryophylli 13; Folium Quisqualis 10; Herba Elsholtziae Blandae 10.5; Flos Magnoliae Officinalis 12; Herba Potentillae Discoloris 13.5; Herba Sidae Rhombifoliae 10; Herba Kummerowiae Striatae 11; Involucrum Querci fabri 11.
The preparation for the treatment of nyctalopia, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use;
(3) Caulis Caryophylli, Corii Cuon alpini Camphor tree and Involucrum Querci fabri are together ground into fine powder, be placed in Chinese medicament extracting device, add the ethanol (preferably adding the ethanol that mass concentration is 60%-70%) that mass concentration is 50%-80%, heating and refluxing extraction 30-60 minute (preferred heating and refluxing extraction 40-50 minute), collect alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, spraying dry, get dry extract powder, for subsequent use;
(4) by Radix Rhodiolae, Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add the refined honey after the dilution of 0.2-0.5 times amount (preferably adding the refined honey after the dilution of 0.3-0.4 times amount), mix thoroughly, vexed 10-16 minute (preferred vexed 12-14 minute), supreme gas is steamed for degree to steamer, take out dry, smash into fine powder to pieces, for subsequent use;
(5) the raw material medicated powder mixing after being processed step (1)-(4), sieves, with water pill, makes the pill of Semen Firmianae size, to obtain final product.
The preparation method of the pill of above-mentioned treatment nyctalopia, preferred scheme is, in step (3) amount of ethanol be the 4.5-8.5 of raw material dose doubly (amount of preferred ethanol be the 5.5-7.5 of raw material dose doubly, the ethanol be more preferably be 6.5 times of raw material dose).
The preparation method of the pill of above-mentioned treatment nyctalopia, preferred scheme is, excessively 65-105 mesh sieve (preferred 75-95 mesh sieve excessively, mistake 85 mesh sieve be more preferably).
The preparation method of described tablet is:
(1) get Caulis Caryophylli and Involucrum Querci fabri mixing, the Chinese liquor adding 0.3-0.6 times amount is mixed thoroughly (Chinese liquor preferably adding 0.4-0.5 times amount is mixed thoroughly), stewing 4-8 minute (preferably stewing 5-7 minute), put in parch container, slow fire adds to propagandize hotly uses up to wine, and taking-up is dried, be ground into fine powder, for subsequent use;
(2) mixing of Flos koelreuteriae paniculatae magnolia obovata flower, adds the Mel after the dilution of 0.15-0.35 times amount (preferably adding the Mel after the dilution of 0.2-0.3 times amount), mixes thoroughly, and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(3) by Radix Rhodiolae, Nostoc, Herba rungiae pectinatae, Herba Elsholtziae Blandae and Herba Kummerowiae Striatae mixing, be placed in marmite, add the cold water (preferably adding the cold water of 6-7 times amount) of 5-8 times amount, soak under room temperature 1-2 hour (under preferred room temperature, soaking 1.2-1.8 hour), then intense fire heated and boiled, turn slow fire boiling twice, first time decocts 22-46 minute (preferably first time decocts 26-42 minute), second time decocts 10-20 minute (preferably second time decocts 13-17 minute), merge twice decocting liquid, filter, filtrate reduced in volume is to 1/4 of original volume, for subsequent use;
(4) by Cacumen Platycladi, Corii Cuon alpini Camphor tree, Folium Quisqualis, Herba Potentillae Discoloris and Herba Sidae Rhombifoliae are together ground into fine powder, be placed in percolator, with second alcohol and water for solvent, wherein the amount of solvent is the 5.5-9.5 of raw material medicated powder amount doubly (amount of preferred solvent is 6.5-8.5 times of raw material medicated powder amount), percolation is carried out according to percolation, when the amount of percolate is the 20-24 times of raw material medicated powder amount (preferably when the amount of percolate is the 21-23 times of raw material medicated powder amount), stop percolation, filter, reclaim ethanol, medicinal liquid mixes with step (3) gained medicinal liquid, being evaporated to 80 DEG C of relative densities is the thick paste of 1.28-1.30, vacuum drying gets dry extract powder, cool, porphyrize, for subsequent use,
(5) by step (1), the mixing of (2) and (4) gained medicated powder, add the magnesium stearate (preferably adding the magnesium stearate of 0.3-0.4 times of mixed powder amount) of 0.25-0.45 times of mixed powder amount, mix thoroughly, tabletted, to obtain final product.
The preparation method of the tablet of above-mentioned treatment nyctalopia, preferred scheme is, in step (4), the volume ratio of second alcohol and water is the volume ratio of the preferred second alcohol and water of 1:1.5-3.5(is 1:2-3, and the volume ratio of the second alcohol and water be more preferably is 1:2.5).
The preparation method of described capsule is:
(1) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use; Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) Radix Rhodiolae, Corii Cuon alpini Camphor tree, Caulis Caryophylli and Involucrum Querci fabri mixing is got, together be ground into fine powder, be placed in sealing in cotton bag, be placed in hermetic container, take the concentration of 3.5-6.5 times amount as the ethanol of 55% be solvent (be preferably the ethanol of 55% with the concentration of 4.5-5.5 times amount be solvent), room temperature lower seal lixiviate 2-6 days (preferred room temperature lower seal lixiviate 3-5 days), in leaching process, shake every day 3-5 time (preferred every day shakes 4 times), collect lixiviating solution, filter, reclaim ethanol, distilling under reduced pressure becomes clear paste, for subsequent use;
(3) by Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add in the rice made popular, slow fire adds to be propagandized hotly to rice to be buff, to sieve and remove rice, dry, smash into fine powder to pieces, for subsequent use;
(4) by step (1) and (3) process after raw material medicated powder mixing, join in step (2) gained clear paste, add simultaneously mass fraction be 4.5% corn starch and mass fraction be the sodium lauryl sulphate of 5.5%, mix homogeneously, granulates, granulate, drying, incapsulates shell, to obtain final product.
The preparation method of described decoction is:
(1) Nostoc and Involucrum Querci fabri are placed on tile respectively, and slow fire dries, porphyrize powder, mixing, for subsequent use;
(2) get Caulis Caryophylli, Flos koelreuteriae paniculatae, Cacumen Platycladi, Folium Quisqualis magnolia obovata flower be placed in hermetic container, add yellow wine and the Mel (preferably adding yellow wine and the Mel of 0.3-0.4 times amount) of 0.25-0.45 times amount, wherein the mass ratio of yellow wine and Mel is 3:2, stir, add a cover stewing 6-10 minute (preferably adding a cover stewing 7-9 minute), slow fire heating fried dry is degree, takes out, smash to pieces as fine powder, for subsequent use;
(3) be placed in medicine pot by the crude drug except step (1) and (2), add clear water and do not have powder 3-4cm, big fire is heated to boil, and turn little fire and decoct 30-50 minute (preferably turn little fire and decoct 35-45 minute), filter, filtrate is for subsequent use;
(4) join in above-mentioned filtrate by the crude drug after step (1) and (2) process, slow fire boiling 15-25 minute (preferred slow fire boiling 18-22 minute), filters, and filtrate reduced in volume is to 1/2 of original volume, and sterilizing encapsulates, and to obtain final product.
Scientific formula of the present invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,selected by the present invention, medical material compatibility is suitable, meets Chinese medicine and modern medicine research theory, has the tonifying liver that nourishes blood, effect of clearing away heat to improve acuity of vision;
2,this prescription, through clinical observation on the therapeutic effect, has instant effect, and taking convenience easily absorbs, the feature that safe and reliable, cure rate is high;
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Rhodiolae: base is former: be the herb of the full lobe Radix Rhodiolae of crassulaceae plants.Nature and flavor: cold in nature, sweet-puckery flavor.Gui Jing: lung meridian.Function cures mainly: promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough.Control hemoptysis, spitting of blood, pneumonia is coughed, women leucorrhea.Traumatic injury is controlled in external, burn.
Flos koelreuteriae paniculatae: base is former: be the flower of sapindaceous plant Luan Shu.Chemical analysis: leaf is containing quercitrin-2 〃-epicatechol gallate.Nature and flavor: bitter; Cold.Gui Jing: Liver Channel.Function cures mainly: liver heat removing and eyesight improving.Main conjunctival congestion and swelling pain; Many tear.
Nostoc: base is former: be the frond of nostocaceae plant Nostoc.Chemical analysis: containing Myoglobin, beta-carotene, echinenone, canthaxanthin, phospholipid, sterol and glycoside, balsam alcohols, protein, ferrum, calcium and vitamin etc.Nature and flavor: sweet; Light; Cool; Cold.Gui Jing: Liver Channel.Function cures mainly: clearing away heat to improve acuity of vision; Convergence QI invigorating.Argument is crimson swollen; Nyctalopia; Burn and scald; Chronic dysentery; Proctoptosis.
Herba rungiae pectinatae: base is former: be the herb of acanthaceous plant Herba rungiae pectinatae.Nature and flavor: mildly bitter flavor; Pungent; Cool in nature.Gui Jing: lung; Liver; Spleen channel.Function cures mainly: removing food stagnancy is stagnant; Removing fire from the liver; Clearing away damp-heat.Main food stagnation of child; Conjunctival congestion and swelling pain; Damp-heat dysentery; Hepatitis; Scrofula carbuncle; Venom.
Cacumen Platycladi: base is former: be twig and the leaf of Cupressaceae plant Cacumen Platycladi.Chemical analysis: leaf is containing volatile oil 0.6 ~ 1%, in containing thujene, absinthol, fenchone, pinene, caryophyllene etc.; Aromadendrin, Quercetin, myricetin, hinokiflavone, amentoflavone etc. are had in flavonoid.The rough general flavone content of new fresh Cacumen Platycladi is 1.72％。Also containing tannin, resin, vitamin C etc.Nature and flavor: pained, cold.Gui Jing: enter the heart, liver, large intestine channel.Function cures mainly: removing heat from blood, hemostasis, wind-damp dispelling, loose toxic swelling.Control haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia, bacillary dysentery, hypertension, cough, erysipelas, mumps, scald.Corii Cuon alpini Camphor tree:
Caulis Caryophylli: base is former: be the branch of plant clove of myrtaceae.Nature and flavor: acrid in the mouth; Property is put down.Gui Jing: return spleen; Stomach warp.Function cures mainly: cold expelling of regulating the flow of vital energy; Warming middle-JIAO to stop diarrhea.Main distension and fullness in the abdomen; Feel sick; Have loose bowels empty sliding; Indigestion.
Folium Quisqualis: base is former: medical material Ji Yuan: the leaf of Combretum Racemosum plant Fructus Quisqualis.Chemical analysis: be separated to N-methylnicotinic acid inner salt and trigonelline in leaf, L-Pro, L-days section's amide and Quisqualic Acid potassium, globulariacitrin.Globulariacitrin is got and stricture of vagina India element-3-O-β-D-Glucose glycoside of crowing in spending.Nature and flavor: acrid in the mouth; Property is put down.Gui Jing: return spleen; Stomach warp.Function cures mainly: regulating qi-flowing for strengthening spleen; Parasite killing detoxifies.Main distension and fullness in the abdomen; Infantile malnutrition; Malnutrition due to parasitic infestation; Furuncle ulcer.
Herba Elsholtziae Blandae: base is former: be the herb of labiate Elsholtzia blanda.Nature and flavor: bitter in the mouth; Pungent; Property is put down.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances.Main cold, fever; Sensible heat dysentery; Jaundice; Dysuria; Foot a word used for translation is rotten itches; Burn.
Flos Magnoliae Officinalis: base is former: be the alabastrum of Magnoliacea plant Cortex Magnoliae Officinalis or Mount Lushan Cortex Magnoliae Officinalis.Chemical analysis: alabastrum is containing magnolol, honokiol and Camphora.Pharmacological action: the tincture hydrotrope of anesthetized rabbit, the quiet note of cat or intramuscular injection Flos Magnoliae Officinalis all has hypotensive activity. and make increased heart rate.Nature and flavor: pungent; Micro-hardship; Warm in nature.Gui Jing: spleen; Stomach; Lung meridian.Function cures mainly: promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Dissipating depression of QI removing dampness.Main stagnation of liver-QI and stomach-QI; Breast gastral cavity feeling of distension and oppression; Inappetence; Poor appetite; The cards such as cold cough.
Herba Potentillae Discoloris: base is former: be the whole herb with root of Flos Rosae Multiflorae kind of plant Herba Potentillae Discoloris.Chemical analysis: root containing hydrolysable tannin and condensed tannin, and contains flavonoid.Herb contains Fumaric acid, gallic acid, protocatechuic acid, Quercetin, naringenin, nimbecetin, isophthalic acid.Pharmacological action: 1. before herb, agent flat board burrows method, has inhibitory action to shigella and shigella flexneri.2. the effect of the external nonreactive ameba of this product.3. in Herba Potentillae Discoloris, raise composition fumaric acid, gallic acid acid, protocatechuic acid, Quercetin, naringenin, kaempferol, isophthalic acid, to Fu Shi and shigella, there is bacteriostasis, especially the strongest with gallic acid and Quercetin activity, minimum inhibitory concentration is respectively 59ppm/mL and 37ppm/mL.Nature and flavor: sweet; Bitter; Flat.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main lung-heat cough with asthma; Dysentery; Malaria; Hemoptysis; Have blood in stool; Metrorrhagia; Carbuncle sore tumefacting virus; Skin ulcer tinea tuberculosis.
Herba Sidae Rhombifoliae: base is former: for Malvaceae plant carries on the back the herb of Radix sidae acutae in vain.Pharmacological action: the water-ol extracting solution of herb can shrink isolated guinea pig small intestinal, and can by medicine institute of Hangzhoupro histamine antagonism; Impact be there is no on the motion of rabbit duodenum.Its leaf, containing a large amount of phlegmatic temperament, can be used as expectorant, lubricant person.This plant is not containing amaroid, alkaloid, volatile oil, Saponin and triterpenes; Also someone reports wherein containing ephedrine person.Congener Sidahumilis has antiinflammatory action to rat formaldehyde arthritis.Nature and flavor: sweet in the mouth; Pungent; Cool.Gui Jing: the heart; Liver; Lung; Large intestine; Small intestine meridian.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.The high heat of main flu; Laryngopharynx swelling and pain; Damp-heat dysentery; Jaundice; Leukorrhagia; Stranguria; Rheumatism flaccidity is weak; Dizzy; Labor volume is weak; Hemorrhoidal bleeding; Carbuncle furuncle.
Herba Kummerowiae Striatae: base is former: be the herb of leguminous plant Herba Kummerowiae Striatae and perpendicular hair chicken.Pharmacological action: Herba Kummerowiae Striatae water logging agent in vitro to four kinds of dysentery bacteriums (Fu Shi, Song Shi, will Hayes, Shu Shi) and large intestine stalk bacterium without antibacterial action, only alcohol immersion shows faint effect to bacterium flexneri.K.stipvlacea infusion all has certain antibacterial action to Fu Shi, Shu Shi, dysentery bacterium in vitro.Nature and flavor: sweet; Pungent; Micro-hardship; Property is put down.Gui Jing: liver; Spleen; Lung; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Invigorating spleen to remove dampness; Promoting blood circulation and hemostasis.Main cold, fever; Heat-damp in summer is vomited and diarrhoea; Jaundice; Carbuncle furuncle; Dysentery; Infantile malnutrition; Stranguria with blood; Spitting of blood; Epistaxis; Traumatic injury; Leucorrhea with red and white discharge.
Involucrum Querci fabri: base is former: be the involucre with insect gall on Fagaceae white oak fruit.Chemical analysis: the acorn-cup of white oak, bark all containing tannin, seed starch-containing 30%.Nature and flavor: bitter; Puckery; Property is put down.Function cures mainly: removing food stagnancy of regulating the flow of vital energy; Improving eyesight is detoxified.Main infantile malnutrition; Hernia; Have loose bowels; Dysentery; Acute catarrhal conjunctivitis swelling pain; Furuncle.
embodiment 1the preparation for the treatment of nyctalopia, is prepared from by following bulk drugs, is weight portion (every part of 10g): Radix Rhodiolae 9 parts; Flos koelreuteriae paniculatae 6 parts; Nostoc 8 parts; Herba rungiae pectinatae 11 parts; Cacumen Platycladi 7 parts; Corii Cuon alpini Camphor tree 7 parts; Caulis Caryophylli 10 parts; Folium Quisqualis 8 parts; Herba Elsholtziae Blandae 7 parts; Flos Magnoliae Officinalis 9 parts; Herba Potentillae Discoloris 11 parts; Herba Sidae Rhombifoliae 6 parts; Herba Kummerowiae Striatae 9 parts; Involucrum Querci fabri 8 parts.
The preparation method of the pill for the treatment of nyctalopia is:
(1) Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use;
(3) Caulis Caryophylli, Corii Cuon alpini Camphor tree and Involucrum Querci fabri are together ground into fine powder, be placed in Chinese medicament extracting device, the mass concentration adding 4.5 times of raw material doses is the ethanol of 50%, heating and refluxing extraction 30 minutes, collects alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, spraying dry, get dry extract powder, for subsequent use;
(4) by Radix Rhodiolae, Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add the refined honey after the dilution of 0.2 times amount, mix thoroughly, vexed 10 minutes, to steamer, steam supreme gas for degree, take out dry, smash into fine powder to pieces, for subsequent use;
(5) the raw material medicated powder mixing after being processed step (1)-(4), crosses 65 mesh sieves, with water pill, makes the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 10-12 ball, and warm water takes, 5 days courses for the treatment of.
Model case: old XX, female, 7 years old, people from Binzhou.Occur that always do not see thing in the evening without obvious inducement before patient half wheat harvesting period, after checking to local hospital, be diagnosed as nyctalopia.Take vitamin A to treat, but curative effect is unsatisfactory always.Come my institute on April 9th, 2012 and check treatment.Check: patient's normal visual acuity on daytime, thing then can not be seen by the dark weak place of light, is diagnosed as nyctalopia.
Take the pill of the present embodiment gained treatment nyctalopia, instructions of taking: every day three times, each 10-12 ball, warm water takes, 5 days courses for the treatment of.After treating a course for the treatment of, patient's vision improves, and continues two courses for the treatment of of medication, and vision restoration is normal, and all cards are removed, and patient fully recovers, and after drug withdrawal, within three months, pays a return visit, without recurring.
embodiment 2the preparation for the treatment of nyctalopia, is prepared from by following bulk drugs, is weight portion (every part of 10g): Radix Rhodiolae 14 parts; Flos koelreuteriae paniculatae 10 parts; Nostoc 15 parts; Herba rungiae pectinatae 16 parts; Cacumen Platycladi 15 parts; Corii Cuon alpini Camphor tree 13 parts; Caulis Caryophylli 16 parts; Folium Quisqualis 12 parts; Herba Elsholtziae Blandae 14 parts; Flos Magnoliae Officinalis 15 parts; Herba Potentillae Discoloris 16 parts; Herba Sidae Rhombifoliae 14 parts; Herba Kummerowiae Striatae 13 parts; Involucrum Querci fabri 14 parts.
The preparation method of the tablet for the treatment of nyctalopia is:
(1) get Caulis Caryophylli and Involucrum Querci fabri mixing, the Chinese liquor adding 0.45 times amount is mixed thoroughly, stewing 6 minutes, puts in parch container, and slow fire adds to propagandize hotly uses up to wine, and taking-up is dried, and is ground into fine powder, for subsequent use;
(2) mixing of Flos koelreuteriae paniculatae magnolia obovata flower, adds the Mel after the dilution of 0.25 times amount, mixes thoroughly, and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(3) by Radix Rhodiolae, Nostoc, Herba rungiae pectinatae, Herba Elsholtziae Blandae and Herba Kummerowiae Striatae mixing, be placed in marmite, add the cold water of 6.5 times amount, soak 1.5 hours under room temperature, then intense fire heated and boiled, turn slow fire boiling twice, first time decocts 34 minutes, and second time decocts 15 minutes, merge twice decocting liquid, filter, filtrate reduced in volume is to 1/4 of original volume, for subsequent use;
(4) Cacumen Platycladi, Corii Cuon alpini Camphor tree, Folium Quisqualis, Herba Potentillae Discoloris and Herba Sidae Rhombifoliae are together ground into fine powder, be placed in percolator, with second alcohol and water for solvent (volume ratio of second alcohol and water is for 1:2.5), wherein the amount of solvent is 7.5 times of raw material medicated powder amount, percolation is carried out according to percolation, when the amount of percolate is 22 times of raw material medicated powder amount, stop percolation, filter, reclaim ethanol, medicinal liquid mixes with step (3) gained medicinal liquid, being evaporated to 80 DEG C of relative densities is the thick paste of 1.28-1.30, and vacuum drying gets dry extract powder, cools, porphyrize, for subsequent use;
(5) by step (1), the mixing of (2) and (4) gained medicated powder, add the magnesium stearate of 0.35 times of mixed powder amount, mix thoroughly, tabletted, to obtain final product.
The instructions of taking of gained tablet of the present invention is: every day three times, each 4-6 sheet, and warm water takes, 5 days courses for the treatment of.
embodiment 3the preparation for the treatment of nyctalopia, is prepared from by following bulk drugs, is weight portion (every part of 10g): Radix Rhodiolae 10 parts; Flos koelreuteriae paniculatae 7 parts; Nostoc 10 parts; Herba rungiae pectinatae 12.5 parts; Cacumen Platycladi 9 parts; Corii Cuon alpini Camphor tree 9 parts; Caulis Caryophylli 12 parts; Folium Quisqualis 9 parts; Herba Elsholtziae Blandae 9 parts; Flos Magnoliae Officinalis 11 parts; Herba Potentillae Discoloris 12.5 parts; Herba Sidae Rhombifoliae 8 parts; Herba Kummerowiae Striatae 10 parts; Involucrum Querci fabri 10 parts.
The preparation method of the capsule for the treatment of nyctalopia is:
(1) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use; Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) get Radix Rhodiolae, Corii Cuon alpini Camphor tree, Caulis Caryophylli and Involucrum Querci fabri mixing, be together ground into fine powder, be placed in sealing in cotton bag, be placed in hermetic container, take the concentration of 5 times amount as the ethanol of 55% be solvent, room temperature lower seal lixiviate 4 days, in leaching process, shake 4 every day, collect lixiviating solution, filter, reclaim ethanol, distilling under reduced pressure becomes clear paste, for subsequent use;
(3) by Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add in the rice made popular, slow fire adds to be propagandized hotly to rice to be buff, to sieve and remove rice, dry, smash into fine powder to pieces, for subsequent use;
(4) by step (1) and (3) process after raw material medicated powder mixing, join in step (2) gained clear paste, add simultaneously mass fraction be 4.5% corn starch and mass fraction be the sodium lauryl sulphate of 5.5%, mix homogeneously, granulates, granulate, drying, incapsulates shell, to obtain final product.
The instructions of taking of gained capsule of the present invention is: every day three times, each 4-5 grain, and warm water takes, 5 days courses for the treatment of.
embodiment 4the preparation for the treatment of nyctalopia, is prepared from by following bulk drugs, is weight portion (every part of 10g): Radix Rhodiolae 13 parts; Flos koelreuteriae paniculatae 9 parts; Nostoc 13 parts; Herba rungiae pectinatae 14.5 parts; Cacumen Platycladi 13 parts; Corii Cuon alpini Camphor tree 11 parts; Caulis Caryophylli 14 parts; Folium Quisqualis 11 parts; Herba Elsholtziae Blandae 12 parts; Flos Magnoliae Officinalis 13 parts; Herba Potentillae Discoloris 14.5 parts; Herba Sidae Rhombifoliae 12 parts; Herba Kummerowiae Striatae 12 parts; Involucrum Querci fabri 12 parts.
The preparation method of the decoction for the treatment of nyctalopia is:
(1) Nostoc and Involucrum Querci fabri are placed on tile respectively, and slow fire dries, porphyrize powder, mixing, for subsequent use;
(2) get Caulis Caryophylli, Flos koelreuteriae paniculatae, Cacumen Platycladi, Folium Quisqualis magnolia obovata flower be placed in hermetic container, add yellow wine and the Mel of 0.35 times amount, wherein the mass ratio of yellow wine and Mel is 3:2, stir, add a cover stewing 8 minutes, slow fire heating fried dry is degree, take out, smash to pieces as fine powder, for subsequent use;
(3) be placed in medicine pot by the crude drug except step (1) and (2), add clear water and do not have powder 3-4cm, big fire is heated to boil, and turn little fire and decoct 40 minutes, filter, filtrate is for subsequent use;
(4) join in above-mentioned filtrate by the crude drug after step (1) and (2) process, slow fire boiling 20 minutes, filters, and filtrate reduced in volume is to 1/2 of original volume, and sterilizing encapsulates, and to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 100-150mL, warmly takes, 5 days courses for the treatment of.
Model case: Soviet Union XX, man, 13 years old, people from Linyi.Patient a little more than a month ago Zener occurs that eyes are dry and astringent without obvious inducement, itches, and night does not see object, is diagnosed as nyctalopia at certain examination in hospital.Give vitamin AD treatment, treat one month, vision is not improved, and introduces by friend, comes my institute check medical on July 22nd, 2013.Check: patient face light yellow complexion, hair is pained, and tired, body constitution is become thin, and distinguishes that color is normal time bright and clear depending on thing, floating superficial venule of the index finger light and, tongue is stagnant light tender, and tongue is slightly sliding.Be diagnosed as nyctalopia.
Take the decoction of the present embodiment gained treatment nyctalopia, instructions of taking: twice daily, each 100-150mL, warmly takes, 5 days courses for the treatment of.After treating a course for the treatment of, patient's vision is clearly better, and spirit can; Two courses for the treatment of of continual cure, patients' visual recovery is normal, and other symptom is also obviously improved.Within after drug withdrawal three months, pay a return visit, nothing repeatedly.
embodiment 5the preparation for the treatment of nyctalopia, is prepared from by following bulk drugs, is weight portion (every part of 10g): Radix Rhodiolae 11.5 parts; Flos koelreuteriae paniculatae 8 parts; Nostoc 11.5 parts; Herba rungiae pectinatae 13.5 parts; Cacumen Platycladi 11 parts; Corii Cuon alpini Camphor tree 10 parts; Caulis Caryophylli 13 parts; Folium Quisqualis 10 parts; Herba Elsholtziae Blandae 10.5 parts; Flos Magnoliae Officinalis 12 parts; Herba Potentillae Discoloris 13.5 parts; Herba Sidae Rhombifoliae 10 parts; Herba Kummerowiae Striatae 11 parts; Involucrum Querci fabri 11 parts.
The preparation method of the pill for the treatment of nyctalopia is:
(1) Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use;
(3) Caulis Caryophylli, Corii Cuon alpini Camphor tree and Involucrum Querci fabri are together ground into fine powder, be placed in Chinese medicament extracting device, the mass concentration adding 6.5 times of raw material doses is the ethanol of 65%, heating and refluxing extraction 45 minutes, collects alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, spraying dry, get dry extract powder, for subsequent use;
(4) by Radix Rhodiolae, Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add the refined honey after the dilution of 0.35 times amount, mix thoroughly, vexed 13 minutes, to steamer, steam supreme gas for degree, take out dry, smash into fine powder to pieces, for subsequent use;
(5) the raw material medicated powder mixing after being processed step (1)-(4), crosses 85 mesh sieves, with water pill, makes the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 10-12 ball, and warm water takes, 5 days courses for the treatment of.
test example 1the clinical practice of the preparation (embodiment 5) of gained treatment nyctalopia of the present invention:
1, data and method
1.1 physical data
In May, 2010, in JIUYUE ,-2013, screened 300 routine nyctalopia patients in 4 hospitals, wherein male patient 175 example, female patient 125 example, the age 8-60 year.
1.2 diagnostic criterias:
Major part patient normal visual acuity on daytime, thing then can not be seen by night or the dark weak place of light, or within about five minutes, does not still see object at dark place, is considered as nyctalopia.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and two groups of patients, in sex, the state of an illness, age etc., through statistical procedures no significant difference (P > 0.05), have comparability.Experimental group takes gained medicine of the present invention, instructions of taking: every day three times, each 10-12 ball, and warm water takes, 5 days courses for the treatment of.Observe three courses for the treatment of of treatment altogether.Matched group uses other drug (as medicines such as SHIHUYEGUANG WAN, vitamin AD and Hepar Caprae seu ovis balls).
1.4 efficacy assessment standard
Cure: subjective symptoms disappears completely, and vision restoration is normal;
Take a turn for the better: subjective symptoms alleviates but do not disappear;
Invalid: symptom and sign are not improved.
1.5 therapeutic outcome
Two groups of patient treatment outcome's contrasts, as shown in table 1.
Table 1: two groups of patient treatment outcome's contrasts
Therapeutic effect: experimental group cures 148 examples (74%), 49 examples that take a turn for the better (24.5%), invalid 3 examples (1.5%), total effective rate is 98.5%, and experimental group successful is better than matched group.
The present invention select Radix Rhodiolae, Flos koelreuteriae paniculatae, Nostoc, Herba rungiae pectinatae, Cacumen Platycladi, Corii Cuon alpini Camphor tree and Caulis Caryophylli etc. totally 14 taste primary raw material medicines be prepared from.Fang Zhong, Flos koelreuteriae paniculatae has effect of liver heat removing and eyesight improving; Nostoc clearing away heat to improve acuity of vision, convergence QI invigorating; Herba rungiae pectinatae removing food stagnancy is stagnant, removing fire from the liver, clearing away damp-heat; The pain relieving of Corii Cuon alpini Camphor tree promoting flow of QI and blood; Flos Magnoliae Officinalis promoting the circulation of QI to alleviate the stagnation in middle-JIAO, dissipating depression of QI removing dampness; Involucrum Querci fabri is regulated the flow of vital energy removing food stagnancy, and improving eyesight is detoxified.All medicines share, ingenious prescription, and medicine is coordinated mutually, have good therapeutic effect for nyctalopia symptom, and treat three courses for the treatment of, experimental group total effective rate can reach 98.5%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the preparation of nyctalopia, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Rhodiolae 9-14; Flos koelreuteriae paniculatae 6-10; Nostoc 8-15; Herba rungiae pectinatae 11-16; Cacumen Platycladi 7-15; Corii Cuon alpini Camphor tree 7-13; Caulis Caryophylli 10-16; Folium Quisqualis 8-12; Herba Elsholtziae Blandae 7-14; Flos Magnoliae Officinalis 9-15; Herba Potentillae Discoloris 11-16; Herba Sidae Rhombifoliae 6-14; Herba Kummerowiae Striatae 9-13; Involucrum Querci fabri 8-14.
2. the preparation for the treatment of nyctalopia as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Rhodiolae 10-13; Flos koelreuteriae paniculatae 7-9; Nostoc 10-13; Herba rungiae pectinatae 12.5-14.5; Cacumen Platycladi 9-13; Corii Cuon alpini Camphor tree 9-11; Caulis Caryophylli 12-14; Folium Quisqualis 9-11; Herba Elsholtziae Blandae 9-12; Flos Magnoliae Officinalis 11-13; Herba Potentillae Discoloris 12.5-14.5; Herba Sidae Rhombifoliae 8-12; Herba Kummerowiae Striatae 10-12; Involucrum Querci fabri 10-12.
3. the preparation for the treatment of nyctalopia as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Rhodiolae 11.5; Flos koelreuteriae paniculatae 8; Nostoc 11.5; Herba rungiae pectinatae 13.5; Cacumen Platycladi 11; Corii Cuon alpini Camphor tree 10; Caulis Caryophylli 13; Folium Quisqualis 10; Herba Elsholtziae Blandae 10.5; Flos Magnoliae Officinalis 12; Herba Potentillae Discoloris 13.5; Herba Sidae Rhombifoliae 10; Herba Kummerowiae Striatae 11; Involucrum Querci fabri 11.
4. the preparation of the treatment nyctalopia as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use;
(3) Caulis Caryophylli, Corii Cuon alpini Camphor tree and Involucrum Querci fabri are together ground into fine powder, be placed in Chinese medicament extracting device, add the ethanol (preferably adding the ethanol that mass concentration is 60%-70%) that mass concentration is 50%-80%, heating and refluxing extraction 30-60 minute (preferred heating and refluxing extraction 40-50 minute), collect alcohol extract, filter, filtrate recycling ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.20-1.23, spraying dry, get dry extract powder, for subsequent use;
(4) by Radix Rhodiolae, Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add the refined honey after the dilution of 0.2-0.5 times amount (preferably adding the refined honey after the dilution of 0.3-0.4 times amount), mix thoroughly, vexed 10-16 minute (preferred vexed 12-14 minute), supreme gas is steamed for degree to steamer, take out dry, smash into fine powder to pieces, for subsequent use;
(5) the raw material medicated powder mixing after being processed step (1)-(4), sieves, with water pill, makes the pill of Semen Firmianae size, to obtain final product.
5. the preparation method of the pill for the treatment of nyctalopia according to claim 4, it is characterized in that, in step (3) amount of ethanol be the 4.5-8.5 of raw material dose doubly (amount of preferred ethanol be the 5.5-7.5 of raw material dose doubly, the ethanol be more preferably be 6.5 times of raw material dose).
6. the preparation method of the pill for the treatment of nyctalopia according to claim 4, is characterized in that, the middle 65-105 mesh sieve excessively of step (5) (preferred 75-95 mesh sieve excessively, mistake 85 mesh sieve be more preferably).
7. the preparation of the treatment nyctalopia as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) get Caulis Caryophylli and Involucrum Querci fabri mixing, the Chinese liquor adding 0.3-0.6 times amount is mixed thoroughly (Chinese liquor preferably adding 0.4-0.5 times amount is mixed thoroughly), stewing 4-8 minute (preferably stewing 5-7 minute), put in parch container, slow fire adds to propagandize hotly uses up to wine, and taking-up is dried, be ground into fine powder, for subsequent use;
(2) mixing of Flos koelreuteriae paniculatae magnolia obovata flower, adds the Mel after the dilution of 0.15-0.35 times amount (preferably adding the Mel after the dilution of 0.2-0.3 times amount), mixes thoroughly, and it is degree that slow fire is fried extremely tack-free, takes out dry, smashs into fine powder to pieces, for subsequent use;
(3) by Radix Rhodiolae, Nostoc, Herba rungiae pectinatae, Herba Elsholtziae Blandae and Herba Kummerowiae Striatae mixing, be placed in marmite, add the cold water (preferably adding the cold water of 6-7 times amount) of 5-8 times amount, soak under room temperature 1-2 hour (under preferred room temperature, soaking 1.2-1.8 hour), then intense fire heated and boiled, turn slow fire boiling twice, first time decocts 22-46 minute (preferably first time decocts 26-42 minute), second time decocts 10-20 minute (preferably second time decocts 13-17 minute), merge twice decocting liquid, filter, filtrate reduced in volume is to 1/4 of original volume, for subsequent use;
(4) by Cacumen Platycladi, Corii Cuon alpini Camphor tree, Folium Quisqualis, Herba Potentillae Discoloris and Herba Sidae Rhombifoliae are together ground into fine powder, be placed in percolator, with second alcohol and water for solvent, wherein the amount of solvent is the 5.5-9.5 of raw material medicated powder amount doubly (amount of preferred solvent is 6.5-8.5 times of raw material medicated powder amount), percolation is carried out according to percolation, when the amount of percolate is the 20-24 times of raw material medicated powder amount (preferably when the amount of percolate is the 21-23 times of raw material medicated powder amount), stop percolation, filter, reclaim ethanol, medicinal liquid mixes with step (3) gained medicinal liquid, being evaporated to 80 DEG C of relative densities is the thick paste of 1.28-1.30, vacuum drying gets dry extract powder, cool, porphyrize, for subsequent use,
(5) by step (1), the mixing of (2) and (4) gained medicated powder, add the magnesium stearate (preferably adding the magnesium stearate of 0.3-0.4 times of mixed powder amount) of 0.25-0.45 times of mixed powder amount, mix thoroughly, tabletted, to obtain final product.
8. the preparation method of the tablet for the treatment of nyctalopia according to claim 7, it is characterized in that, in step (4), the volume ratio of second alcohol and water is the volume ratio of the preferred second alcohol and water of 1:1.5-3.5(is 1:2-3, and the volume ratio of the second alcohol and water be more preferably is 1:2.5).
9. the preparation of the treatment nyctalopia as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) get Flos Magnoliae Officinalis, Flos koelreuteriae paniculatae, Cacumen Platycladi and Folium Quisqualis mixing, be placed in and fry in container, slow fire adds to be propagandized hotly to buff slightly focal spot, and taking-up cools, porphyrize powder, for subsequent use; Nostoc is placed on tile, and slow fire dries, porphyrize powder, for subsequent use;
(2) Radix Rhodiolae, Corii Cuon alpini Camphor tree, Caulis Caryophylli and Involucrum Querci fabri mixing is got, together be ground into fine powder, be placed in sealing in cotton bag, be placed in hermetic container, take the concentration of 3.5-6.5 times amount as the ethanol of 55% be solvent (be preferably the ethanol of 55% with the concentration of 4.5-5.5 times amount be solvent), room temperature lower seal lixiviate 2-6 days (preferred room temperature lower seal lixiviate 3-5 days), in leaching process, shake every day 3-5 time (preferred every day shakes 4 times), collect lixiviating solution, filter, reclaim ethanol, distilling under reduced pressure becomes clear paste, for subsequent use;
(3) by Herba rungiae pectinatae, Herba Elsholtziae Blandae, Herba Potentillae Discoloris, Herba Sidae Rhombifoliae and Herba Kummerowiae Striatae mixing, add in the rice made popular, slow fire adds to be propagandized hotly to rice to be buff, to sieve and remove rice, dry, smash into fine powder to pieces, for subsequent use;
(4) by step (1) and (3) process after raw material medicated powder mixing, join in step (2) gained clear paste, add simultaneously mass fraction be 4.5% corn starch and mass fraction be the sodium lauryl sulphate of 5.5%, mix homogeneously, granulates, granulate, drying, incapsulates shell, to obtain final product.
10. the preparation of the treatment nyctalopia as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Nostoc and Involucrum Querci fabri are placed on tile respectively, and slow fire dries, porphyrize powder, mixing, for subsequent use;
(2) get Caulis Caryophylli, Flos koelreuteriae paniculatae, Cacumen Platycladi, Folium Quisqualis magnolia obovata flower be placed in hermetic container, add yellow wine and the Mel (preferably adding yellow wine and the Mel of 0.3-0.4 times amount) of 0.25-0.45 times amount, wherein the mass ratio of yellow wine and Mel is 3:2, stir, add a cover stewing 6-10 minute (preferably adding a cover stewing 7-9 minute), slow fire heating fried dry is degree, takes out, smash to pieces as fine powder, for subsequent use;
(3) be placed in medicine pot by the crude drug except step (1) and (2), add clear water and do not have powder 3-4cm, big fire is heated to boil, and turn little fire and decoct 30-50 minute (preferably turn little fire and decoct 35-45 minute), filter, filtrate is for subsequent use;
(4) join in above-mentioned filtrate by the crude drug after step (1) and (2) process, slow fire boiling 15-25 minute (preferred slow fire boiling 18-22 minute), filters, and filtrate reduced in volume is to 1/2 of original volume, and sterilizing encapsulates, and to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510588261.4A CN105106395A (en) | 2015-09-16 | 2015-09-16 | Preparation for treating nyctalopia and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510588261.4A CN105106395A (en) | 2015-09-16 | 2015-09-16 | Preparation for treating nyctalopia and preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105106395A true CN105106395A (en) | 2015-12-02 |
Family
ID=54654672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510588261.4A Pending CN105106395A (en) | 2015-09-16 | 2015-09-16 | Preparation for treating nyctalopia and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105106395A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793848A (en) * | 2012-09-07 | 2012-11-28 | 黄平县润发药业农民专业合作社 | Traditional Chinese medicine powder for treating night blindness |
-
2015
- 2015-09-16 CN CN201510588261.4A patent/CN105106395A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102793848A (en) * | 2012-09-07 | 2012-11-28 | 黄平县润发药业农民专业合作社 | Traditional Chinese medicine powder for treating night blindness |
Non-Patent Citations (2)
| Title |
|---|
| 叶任高等: "《中医临证指南》", 31 December 2002, 人民卫生出版社 * |
| 梁凤鸣等: ""雀目" 古医籍论述", 《中国中医眼科杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107952040A (en) | For nursing one's health the Chinese herbal ointment formula and its processing method of obstruction of the circulation of vital energy constitution | |
| CN103263531B (en) | Chinese medicine composition for treating prosopalgia and preparation method thereof | |
| CN103041256B (en) | Chinese herb preparation for curing recurrent respiratory tract infection of children | |
| CN103041257B (en) | Chinese materia medica preparation for curing high fever and respiratory tract infection of children | |
| CN103041255B (en) | Chinese materia medica preparation for curing swollen sore throat and respiratory tract infection of children | |
| CN106994141B (en) | Traditional Chinese medicine composition for treating constipation and preparation method thereof | |
| CN105535682A (en) | External-application traditional Chinese medicine for treating traumatic synovitis of knee joint and preparation method | |
| CN105079451A (en) | Blood-glucose-reducing blueberry tea and preparation method thereof | |
| CN100374136C (en) | Hairy antler capsules | |
| CN104523929A (en) | Traditional Chinese medicinal composition for treating cold as well as preparation method and application of traditional Chinese medicinal composition | |
| CN104258224A (en) | Schisandra chinensis oral solution for treating lung-and-kidney yin-deficiency type chronic bronchitis and preparation method thereof | |
| CN104353043A (en) | Traditional Chinese medicine composition for treating dawn diarrhea and preparation method thereof | |
| CN104206597B (en) | A kind of schisandra health care tea alleviating YIN-deficiency of the lung and kidney symptom and preparation method thereof | |
| CN105106395A (en) | Preparation for treating nyctalopia and preparing method | |
| CN103041258B (en) | Chinese materia medica preparation for curing respiratory tract infection with poor appetite of children | |
| CN107362301A (en) | Fragrant Siberian cocklebur appetizing particle | |
| CN109381631A (en) | Compound consolidates muscles and bones and supports nephrons pulvis | |
| CN105596590A (en) | Traditional Chinese medicine preparation for treating herpes labialis and preparation method thereof | |
| CN104815267A (en) | Traditional Chinese medicine preparation capable of promoting digestion and relieving stasis to treat infantile indigestion with food retention | |
| CN105582379A (en) | Traditional Chinese medicine composition for treating liver-stomach disharmony and preparation method of traditional Chinese medicine composition | |
| CN104707031A (en) | Traditional Chinese medicine composition for treating senile osteoporosis and preparation method thereof | |
| CN103041259B (en) | Chinese materia medica preparation for curing excessive phlegm, cough and respiratory tract infection of children | |
| CN114533835A (en) | Medicine with effects of aroma and dispelling wind and promoting diuresis and preparation method thereof | |
| CN105106711A (en) | Chinese herbal preparation for preventing and treating nyctalopia and preparation method thereof | |
| CN110522867A (en) | A kind of Chinese herbal medicine for preventing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Chengdu City, Sichuan province Chenghua District 610000 Double Road No. 8 Oriental Pearl Garden 3 2-102 Applicant after: Liu Shangan Address before: 250000 Shandong, Ji'nan Flyover District, Qi Qi Road, No. 20 Applicant before: Liu Shangan |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151202 |