CN105102637B - 提取胰腺癌诊断生物标志物的方法、用于该方法的计算装置、胰腺癌诊断生物标志物以及包含该生物标志物的胰腺癌诊断装置 - Google Patents
提取胰腺癌诊断生物标志物的方法、用于该方法的计算装置、胰腺癌诊断生物标志物以及包含该生物标志物的胰腺癌诊断装置 Download PDFInfo
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- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
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Abstract
Description
成熟_id | miRNA_id | 序列 |
hsa-let-7g-3p | hsa-let-7g | CUGUACAGGCCACUGCCUUGC |
hsa-miR-7-2-3p | hsa-mir-7-2 | CAACAAAUCCCAGUCUACCUAA |
hsa-miR-23a-5p | hsa-mir-23a | GGGGUUCCUGGGGAUGGGAUUU |
hsa-miR-27a-5p | hsa-mir-27a | AGGGCUUAGCUGCUUGUGAGCA |
hsa-miR-92a-1-5p | hsa-mir-92a-1 | AGGUUGGGAUCGGUUGCAAUGCU |
hsa-miR-92a-2-5p | hsa-mir-92a-2 | GGGUGGGGAUUUGUUGCAUUAC |
hsa-miR-122-5p | hsa-mir-122 | UGGAGUGUGACAAUGGUGUUUG |
hsa-miR-154-3p | hsa-mir-154 | AAUCAUACACGGUUGACCUAUU |
hsa-miR-183-5p | hsa-mir-183 | UAUGGCACUGGUAGAAUUCACU |
hsa-miR-204-5p | hsa-mir-204 | UUCCCUUUGUCAUCCUAUGCCU |
hsa-miR-208b-3p | hsa-mir-208b | AUAAGACGAACAAAAGGUUUGU |
hsa-miR-425-5p | hsa-mir-425 | AAUGACACGAUCACUCCCGUUGA |
hsa-miR-510-5p | hsa-mir-510 | UACUCAGGAGAGUGGCAAUCAC |
hsa-miR-520a-5p | hsa-mir-520a | CUCCAGAGGGAAGUACUUUCU |
hsa-miR-552-3p | hsa-mir-552 | AACAGGUGACUGGUUAGACAA |
hsa-miR-553 | hsa-mir-553 | AAAACGGUGAGAUUUUGUUUU |
hsa-miR-557 | hsa-mir-557 | GUUUGCACGGGUGGGCCUUGUCU |
hsa-miR-608 | hsa-mir-608 | AGGGGUGGUGUUGGGACAGCUCCGU |
hsa-miR-611 | hsa-mir-611 | GCGAGGACCCCUCGGGGUCUGAC |
hsa-miR-612 | hsa-mir-612 | GCUGGGCAGGGCUUCUGAGCUCCUU |
hsa-miR-671-5p | hsa-mir-671 | AGGAAGCCCUGGAGGGGCUGGAG |
hsa-miR-1200 | hsa-mir-1200 | CUCCUGAGCCAUUCUGAGCCUC |
hsa-miR-1275 | hsa-mir-1275 | GUGGGGGAGAGGCUGUC |
hsa-miR-1276 | hsa-mir-1276 | UAAAGAGCCCUGUGGAGACA |
hsa-miR-1287-5p | hsa-mir-1287 | UGCUGGAUCAGUGGUUCGAGUC |
Claims (9)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2013-0042329 | 2013-04-17 | ||
KR1020130042329A KR102058996B1 (ko) | 2013-04-17 | 2013-04-17 | 췌장암 진단용 바이오마커, 이를 위한 컴퓨팅 장치 및 이의 제어 방법 |
KR1020130122634A KR102138517B1 (ko) | 2013-10-15 | 2013-10-15 | 췌장암 진단용 바이오마커의 추출 방법, 이를 위한 컴퓨팅 장치, 췌장암 진단용 바이오마커 및 이를 포함하는 췌장암 진단 장치 |
KR10-2013-0122634 | 2013-10-15 | ||
PCT/KR2014/003300 WO2014171730A1 (en) | 2013-04-17 | 2014-04-16 | Method for extracting biomarker for diagnosing pancreatic cancer, computing device therefor, biomarker for diagnosing pancreatic cancer and device for diagnosing pancreatic cancer including the same |
Publications (2)
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CN105102637A CN105102637A (zh) | 2015-11-25 |
CN105102637B true CN105102637B (zh) | 2018-05-22 |
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US (1) | US20160055297A1 (zh) |
CN (1) | CN105102637B (zh) |
WO (1) | WO2014171730A1 (zh) |
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EP3091457B1 (en) * | 2015-05-02 | 2018-10-24 | F. Hoffmann-La Roche AG | Point-of-care testing system |
GB201608192D0 (en) * | 2016-05-10 | 2016-06-22 | Immunovia Ab | Method, array and use thereof |
TWI607332B (zh) * | 2016-12-21 | 2017-12-01 | 國立臺灣師範大學 | Correlation between persistent organic pollutants and microRNAs station |
CN107513490B (zh) * | 2017-09-29 | 2021-03-16 | 重庆京因生物科技有限责任公司 | 一种基于poct模式的全自动医用荧光pcr分析系统 |
CN108103198B (zh) * | 2018-02-13 | 2019-10-01 | 朱伟 | 一种与胰腺癌辅助诊断相关的血浆miRNA标志物及其应用 |
WO2020025228A1 (en) * | 2018-07-31 | 2020-02-06 | Otto-Von-Guericke-Universität Magdeburg | EUKARYOTIC TRANSLATION INITIATION FACTORS (EIFs) AS NOVEL BIOMARKERS IN PANCREATIC CANCER |
CN109971862A (zh) * | 2019-02-14 | 2019-07-05 | 辽宁省肿瘤医院 | C9orf139和MIR600HG作为胰腺癌预后标志物及其确立方法 |
EP4008793A4 (en) * | 2019-08-02 | 2023-04-12 | Kabushiki Kaisha Toshiba | ANALYTICAL METHOD AND KIT |
AU2022306397A1 (en) * | 2021-07-09 | 2024-01-25 | Dana-Farber Cancer Institute, Inc. | Circulating microrna signatures for pancreatic cancer |
CN114107296A (zh) * | 2021-11-23 | 2022-03-01 | 中国辐射防护研究院 | miR-1287-5p及其作为辐射损伤早期诊断的分子标志物的用途 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613748A (zh) * | 2009-06-09 | 2009-12-30 | 中国人民解放军第二军医大学 | 一种检测胰腺癌血清标志物的方法 |
WO2011075873A1 (zh) * | 2009-12-24 | 2011-06-30 | 北京命码生科科技有限公司 | 胰腺癌标记物及其检测方法、试剂盒和生物芯片 |
CN102435665A (zh) * | 2011-09-23 | 2012-05-02 | 浙江省新华医院 | 胰腺癌早期诊断的血清肿瘤标志物、检测方法和诊断模型 |
WO2012155918A2 (en) * | 2011-05-17 | 2012-11-22 | Herlev Hospital | Microrna biomarkers for prognosis of patients with pancreatic cancer |
CN102876676A (zh) * | 2012-09-24 | 2013-01-16 | 南京医科大学 | 一种与胰腺癌相关的血清/血浆miRNA标志物及其应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101343616B1 (ko) * | 2010-10-08 | 2013-12-20 | 연세대학교 산학협력단 | 췌장암 치료용 약제학적 조성물 및 췌장암 치료제 스크리닝 방법 |
-
2014
- 2014-04-16 US US14/784,550 patent/US20160055297A1/en not_active Abandoned
- 2014-04-16 WO PCT/KR2014/003300 patent/WO2014171730A1/en active Application Filing
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101613748A (zh) * | 2009-06-09 | 2009-12-30 | 中国人民解放军第二军医大学 | 一种检测胰腺癌血清标志物的方法 |
WO2011075873A1 (zh) * | 2009-12-24 | 2011-06-30 | 北京命码生科科技有限公司 | 胰腺癌标记物及其检测方法、试剂盒和生物芯片 |
WO2012155918A2 (en) * | 2011-05-17 | 2012-11-22 | Herlev Hospital | Microrna biomarkers for prognosis of patients with pancreatic cancer |
CN102435665A (zh) * | 2011-09-23 | 2012-05-02 | 浙江省新华医院 | 胰腺癌早期诊断的血清肿瘤标志物、检测方法和诊断模型 |
CN102876676A (zh) * | 2012-09-24 | 2013-01-16 | 南京医科大学 | 一种与胰腺癌相关的血清/血浆miRNA标志物及其应用 |
Non-Patent Citations (2)
Title |
---|
"Ranking of microRNA target prediction scores by Pareto front analysis;Sudhakar Sahoo等;《Computational Biology and Chemistry》;20101231;第34卷;第285页右栏第3段至第286页左栏第1段 * |
miRGator v2.0 : an integrated system for functional investigation of microRNAs;Sooyoung Cho等;《Nucleic Acids Research》;20101109;第39卷;D158–D162 * |
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