CN105079489A - Traditional Chinese medicine composition capable of promoting wound healing and preparation method of composition - Google Patents
Traditional Chinese medicine composition capable of promoting wound healing and preparation method of composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine capable of promoting wound healing, particularly to traditional Chinese medicine composition capable of promoting wound healing and a preparation method of a preparation of the composition, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition capable of promoting wound healing is prepared from medicinal materials as follows: common andrographis herbs, gentian roots, common bletilla tubers, myrrh, safflower, Chinese angelica, sappan wood, cloves and sesame oil. Various traditional Chinese medicinal materials of the traditional Chinese medicine composition can have the synergistic effect, activate blood circulation, promote menstruation, stop bleeding, relieve pain, realize the anti-bacterial effect, eliminate inflammations, eliminate blood stasis and subdue swelling, and can have effects of activating cells, repairing damaged cells, promoting tissue repair and regeneration and promoting quick wound healing without scars when being used together.
Description
Technical field
The present invention relates to a kind of Chinese medicine promoting wound healing, be specifically related to a kind ofly promote the Chinese medicine composition of wound healing and the preparation method of preparation thereof, belong to the field of Chinese medicines.
Technical background
The early changes of wound be wound local have tissue necrosis in various degree and rupture of blood vessel hemorrhage, can occur inflammatory reaction in a few hours, show as hyperemia, serosity oozes out, local is red and swollen.Then the blood in wound and the Fibrinogen in transudate solidify formation grumeleuse very soon, and some grumeleuse dry tack frees form crust, and grumeleuse and crust play a part to protect wound.After wound contraction, the flood skin of edge of wound and subcutaneous tissue move to center, and wound contraction thus wound surface reduce.Then be bottom wound and edge grows granulation tissue, fill and lead up wound.Though cicatrix edge of wound can be made to combine more securely also for attractive in appearance after wound healing brings very large problem.Such as, after incision of abdominal wall healing, if cicatrization is weak, tensile strength is lower, and scar tissue itself lacks flexibility in addition, therefore the effect of Intra-abdominal pressure can make the outwards bulging gradually of healing mouth sometimes, forms abdominal hernia.
According to degree of injury and with or without infection, wound healing can be divided into following three types:
Primary healing (healingbyfirstintention) sees that tissue defect is few, edge of wound is neat, without infecting, through bonding or the involutory tight wound of wound surface after sewing up, such as operative incision.Only have a small amount of blood clot in this wound, inflammatory reaction is slight, and promoting epidermization just can by wound covering in 24 ~ 48 hours.Granulation tissue just can grow from edge of wound at the 3rd day and to be filled up by wound very soon, and within 5 ~ 6 days, collagen fiber form (now can take out stitches), within about 2 ~ 3 weeks, heal completely, leave a linear scar.The time of primary healing is short, forms cicatrix few.
Secondary healing (healingbysecondintention) sees that tissue defect is comparatively large, edge of wound is not whole, trembles out, cannot be neatly involutory, or with the wound infected.Healing and the primary healing of this wound have following different: 1. because slough is many, or owing to infecting, continue to cause local organization degeneration, necrosis, inflammatory reaction is obvious.Only have by the time to infect and controlled, after slough is eliminated, regeneration could start.2. wound is large, and wound contraction is obvious, bottom wound and the edge granulation tissue that grows volume wound is filled and led up.The time of 3. healing is longer, and the cicatrix of formation is larger.
Form the hard crust of pitchy after the blood of subcrustal healing (healingunderscab) wound surface, transudate and downright bad material drying, under crust, carry out above-mentioned agglutination.After epithelium regeneration completes, namely crust comes off.Subcrustal healing required time is usually comparatively long without crust person, because first crust must dissolve by promoting epidermization now, and then could forward growth.Crust is unfavorable for bacterial growth due to drying, therefore has certain protective effect to wound.If but exudate is more under crust, especially during existing bacteriological infection, the obstacle that crust has become exudate drain to discharge on the contrary, makes infection increase the weight of, and is unfavorable for healing.
Summary of the invention
The technical problem to be solved in the present invention is that exploitation one can prevent and treat wound infection, and collagen fiber are formed soon, promote wound healing, form the few Chinese medicine composition of cicatrix more afterwards.
The present invention is achieved through the following technical solutions: a kind of Chinese medicine composition promoting wound healing, is prepared from by following medical material: Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli and Oleum sesami.
Further preferably, present invention also offers the weight portion of each taste Chinese crude drug in the Chinese medicine composition component of above-mentioned promotion wound healing:
Herba Andrographis 3-9, Radix Gentianae 1-4, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9, Myrrha 1-7, Flos Carthami 1-5, Radix Angelicae Sinensis 1-6, Lignum Sappan 1-6, Flos Caryophylli 1-6 and Oleum sesami 20-80.
As preferably, in Chinese medicine composition of the present invention, the weight of ingredients is:
Herba Andrographis 6, Radix Gentianae 3, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Myrrha 3, Flos Carthami 3, Radix Angelicae Sinensis 3, Lignum Sappan 3, Flos Caryophylli 3 and Oleum sesami 30.
In Chinese medicine composition of the present invention,
Herba Andrographis: nature and flavor is bitter, cold.Gui Jing, GUIXIN, lung, large intestine, urinary bladder channel.Function cures mainly, heat-clearing and toxic substances removing, removing heat from blood, detumescence.For cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.
Radix Gentianae: nature and flavor, bitter, cold.Gui Jing, returns liver, gallbladder meridian.Function cures mainly, heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor, bitter, sweet, puckery, be slightly cold.Gui Jing, returns lung, liver, stomach warp.Function cures mainly, astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Myrrha: nature and flavor is bitter; Flat.Gui Jing, liver; Spleen; The heart; Kidney channel.Function cures mainly, promoting blood circulation and stopping pain; Detumescence and promoting granulation.Main breast abdomen stasis of blood pain; Dysmenorrhea; Amenorrhea; Lump in the abdomen; Traumatic injury; Carbuncle skin infection; Intestinal carbuncle; Conjunctival congestion and swelling pain
Flos Carthami: nature and flavor, pungent, temperature.Gui Jing, GUIXIN, Liver Channel.Function cures mainly, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Angelicae Sinensis: nature and flavor, sweet, acrid, warm.Gui Jing, returns liver, the heart, spleen channel.Function cures mainly, and enriches blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Lignum Sappan: nature and flavor is sweet, salty, flat.Gui Jing, GUIXIN, liver, spleen channel.Function cures mainly, promoting the circulation of blood blood stasis dispelling, reducing swelling and alleviating pain.For amenorrhea dysmenorrhea, postpartum stagnation, breast ventral spine pain, wound swells and ache.
Flos Caryophylli: nature and flavor, pungent, temperature.Gui Jing, returns spleen, stomach, lung, kidney channel.Function cures mainly, warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Oleum sesami: nature and flavor, sweet, cool.Gui Jing, " must book on Chinese herbal medicine be joined ": " entering meridian of Hand-YANG MING ".Function cures mainly, moistening dryness for relaxing bowels, removing toxic substances, granulation promoting.Control dryness of the intestine constipation, ascarid, abdominal pain due to retention of food, skin ulcer swells, ulcer, scabies, chapped skin.
Another object of the present invention is to provide a kind of preparation method of Chinese medicine composition of above-mentioned promotion wound healing, and its step comprises the following steps:
(1), Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli and Oleum sesami is taken by Chinese prescription of the present invention;
(2), by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, add Oleum sesami after mixing, stir, be heated to 90-100 degree Celsius, be incubated after 30-60 minute and filter, obtain filtrate;
(3), namely step (2) gained filtrate subpackage is obtained oil preparation.
Compared with prior art, Herba Andrographis, Radix Gentianae heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Flos Carthami, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha astringing to arrest bleeding, detumescence and promoting granulation.Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Oleum sesami: removing toxic substances and promoting granulation, coordinating the actions of various ingredients in a prescription.Above-mentioned medical material can be worked in coordination with mutually, both can promoting blood circulation to restore menstrual flow, hemostasis and pain-relieving, again can anti-inflammation, dissipating blood stasis for subsidence of swelling.Serve activating cell, repair damaged cell, promote reparation and the regeneration of tissue; Promote wound healing, do not produce cicatrix effect again.
Chinese medicine composition of the present invention there is following advance:
1, there is hemostasis and pain-relieving, the activity of active cell, improve the immunocompetence at wound surface place, play prevention infection, anti-infective effect.
2, the metabolism of cell can be accelerated, promote cell division propagation, accelerated cell growth.
3, short treating period, effective percentage are high, have no side effect.
4, preparation process is simple, and preparation stabilization is easy to apply.
Detailed description of the invention
Embodiment 1
1), Herba Andrographis 6kg, Radix Gentianae 3kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 6kg, Myrrha 3kg, Flos Carthami 3kg, Radix Angelicae Sinensis 3kg, Lignum Sappan 3kg, Flos Caryophylli 3kg and Oleum sesami 30kg is taken by Chinese prescription of the present invention;
(2), by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, add Oleum sesami after mixing, stir, be heated to 90 degrees Celsius, be incubated after 45 minutes and filter, obtain filtrate;
(3), namely step (2) gained filtrate subpackage is obtained oil preparation.
Embodiment 2
(1), Herba Andrographis 9kg, Radix Gentianae 4kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 3kg, Myrrha 3kg, Flos Carthami 3kg, Radix Angelicae Sinensis 3kg, Lignum Sappan 3kg, Flos Caryophylli 5kg and Oleum sesami 40kg is taken by Chinese prescription of the present invention;
(2), by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, add Oleum sesami after mixing, stir, be heated to 95 degrees Celsius, be incubated after 30 minutes and filter, obtain filtrate;
(3), namely step (2) gained filtrate subpackage is obtained oil preparation.
Embodiment 3
(1), Herba Andrographis 4kg, Radix Gentianae 1kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 2kg, Myrrha 6kg, Flos Carthami 4kg, Radix Angelicae Sinensis 4kg, Lignum Sappan 4kg, Flos Caryophylli 4kg and Oleum sesami 50kg is taken by Chinese prescription of the present invention;
(2), by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, add Oleum sesami after mixing, stir, be heated to 95 degrees Celsius, be incubated after 45 minutes and filter, obtain filtrate;
(3), namely step (2) gained filtrate subpackage is obtained oil preparation.
Embodiment 4
(1), Herba Andrographis 3kg, Radix Gentianae 4kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 9kg, Myrrha 7kg, Flos Carthami 5kg, Radix Angelicae Sinensis 4kg, Lignum Sappan 6kg, Flos Caryophylli 5kg and Oleum sesami 50kg is taken by Chinese prescription of the present invention;
(2), by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, add Oleum sesami after mixing, stir, be heated to 98 degrees Celsius, be incubated after 60 minutes and filter, obtain filtrate;
(3), namely step (2) gained filtrate subpackage is obtained oil preparation.
Embodiment 5
(1), Herba Andrographis 4kg, Radix Gentianae 2kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 4kg, Myrrha 2kg, Flos Carthami 2kg, Radix Angelicae Sinensis 2kg, Lignum Sappan 2kg, Flos Caryophylli 2kg and Oleum sesami 30kg is taken by Chinese prescription of the present invention;
(2), by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, add Oleum sesami after mixing, stir, be heated to 90 degrees Celsius, be incubated after 60 minutes and filter, obtain filtrate;
(3), namely step (2) gained filtrate subpackage is obtained oil preparation.
Oil preparation of the present invention is tested the impact of rat model wound healing
1. laboratory animal and Experimental agents:
Laboratory animal: cleaning grade Wistar rat 100, male and female half and half, body weight quality 210 ± 30g;
Experimental agents: oil preparation prepared by embodiment 1.
2. modeling method:
With 1% ketalar (3mL/kg) intraperitoneal injection of anesthesia.Rat back cut-off footpath is the circular incision 1 of 1cm, cut off skin holostrome, subcutaneous superficial fascia until muscle layer, after hemostasis on wound surface with liquid manure 1mL (normal person's fresh excreta 5g, add normal saline 5mL, mixing, centrifugal, get supernatant), fix with oily yarn, dressing, adhesive tape, dismantle after 48h, wound has purulent secretion, has excrement stink person for modeling success.
3. experiment grouping:
Successful 80 rats of random selecting model, are divided into matched group, test group at random, often organize 40.
4. experimental technique:
Two groups of rats adopt normal saline to clean a wound, and adopt iodophor disinfection, wrapping dressing.Matched group presses penicillin sodium 140,000 units/kg intraperitoneal injection.Test group is except pressing penicillin sodium 140,000 units/kg intraperitoneal injection, and the oil preparation simultaneously embodiment 1 prepared is coated with and touches wound, and every day respectively changes dressings once sooner or later.
After modeling the 4th, 8,12,16d, 4 batches (often criticize and often organize 8 rats) are divided to put to death rat, 0.5cm × 0.5cm granulation tissue is cut at edge of wound, put in carnoy fluid and fix 45min, paraffin embedding, section, row conventional H E dyes, and adopts light microscopic and MPIAS-500 color pathological picture and text analytical system to observe.
The computing formula of wound surface CI: wound surface CI=(1-treatment after wound surface area/original wound surface area) × 100%, result with
represent, between statistical procedures method employing group, t inspection, the results are shown in Table 1.
Fibroblast number: each specimen observes 5 visuals field, fibroblast number in counting granulation tissue, and average (fibroblast number/each visual field).Result with
represent, t inspection between statistical procedures method employing group, result is see table 2.
5. experimental result
Form face CI for 5.1 liang to compare, see table 1.
Table 1 liang is formed face CI and is compared (%)
Compare with matched group,
*p < 0.01.
5.2 liang of comparisons forming fibroblast number in the granulation tissue of face, see table 2.
Table 2 liang form fibroblast number in the granulation tissue of face comparison (
n=8)
Compare with matched group,
*p < 0.05,
#p < 0.01.
Visible oil preparation of the present invention can the activity of active cell, accelerates the metabolism of cell, promotes cell division propagation, accelerated cell growth, thus promote wound healing.
Clinical data:
1) physical data
Operative incision patient 100 example is collected in this clinical trial altogether, is divided into matched group and test group, makes two groups in age, sex, the course of disease etc., possess comparability on statistical significance.
2) test method
Matched group: conventional treatment.
Experimental group: the oil preparation that after conventional treatment prepared by the obliterating embodiment of the present invention 1, changes dressings twice every day, continuously treatment 7 days.
3) evaluation criterion
Cure: wound heals completely, no longer needs medication;
Effective: wound substantially heals or forms a scab;
Effective: wound obviously reduces, the performance such as inflammation alleviates;
Invalid: wound does not improve significantly even more serious.
5) result of the test
Table 3 result of the test statistical analysis table
| Group | Number of cases | Cure (rate) | Effective | Effectively | Invalid | Total effective rate |
| Test group | 50 | 47(94.0％) | 3 | 0 | 0 | 100.0％ |
| Matched group | 50 | 32(64.0％) | 6 | 4 | 8 | 84.0％ |
Oil preparation prepared by visible Chinese medicine composition of the present invention has and promotes wound healing fast, the advantage that cure rate is high.
Non-stimulated when oil preparation of the present invention is changed dressings in addition, without sense of discomfort, without any side effects, can not destroy normal organizational structure, patient is easy to accept, and compliance is good.
Find that experimental group cures patient's almost preventing from scar additionally by observation, cicatrix is slight, does not almost affect the appearance.And matched group cures patient, generally leave serious cicatrix.
Claims (6)
1. promote a Chinese medicine composition for wound healing, it is characterized in that, be prepared from by following medical material: Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli and Oleum sesami.
2. a kind of Chinese medicine composition promoting wound healing as claimed in claim 1, is characterized in that, can be prepared from by the preferred medical material by following weight portion further:
Herba Andrographis 3-9, Radix Gentianae 1-4, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9, Myrrha 1-7, Flos Carthami 1-5, Radix Angelicae Sinensis 1-6, Lignum Sappan 1-6, Flos Caryophylli 1-6 and Oleum sesami 20-80.
3. a kind of Chinese medicine composition promoting wound healing as claimed in claim 2, is characterized in that, can be prepared from by the medical material of following weight portion by override:
Herba Andrographis 6, Radix Gentianae 3, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Myrrha 3, Flos Carthami 3, Radix Angelicae Sinensis 3, Lignum Sappan 3, Flos Caryophylli 3 and Oleum sesami 30.
4. the Chinese medicine composition of the promotion wound healing as described in claim 1-3, is characterized in that, described Chinese medicine composition is external preparation.
5. the Chinese medicine composition promoting wound healing as claimed in claim 4, it is characterized in that, described external preparation is oil preparation.
6. the Chinese medicine composition promoting wound healing as claimed in claim 4, it is characterized in that, described oil preparation comprises following steps:
(1) Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli and Oleum sesami is taken by Chinese prescription of the present invention;
(2) by Herba Andrographis, Radix Gentianae, Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Flos Carthami, Radix Angelicae Sinensis, Lignum Sappan, Flos Caryophylli, pulverize and sieve respectively, after mixing, add Oleum sesami, stir, be heated to 90-100 degree Celsius, be incubated after 30-60 minute and filter, obtain filtrate;
(3) namely step (2) gained filtrate subpackage is obtained oil preparation.
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Cited By (1)
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| CN116808141A (en) * | 2023-06-21 | 2023-09-29 | 浙江医鼎医用敷料有限公司 | Wound care ointment and preparation method thereof |
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| JPS54151113A (en) * | 1978-05-13 | 1979-11-28 | Lion Dentifrice Co Ltd | Partitioned substance having wound treating action |
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