CN105077236A - Highland barley composite special dietary nutritional powder with auxiliary blood glucose reducing function and preparation method thereof - Google Patents

Abstract

The present invention discloses a highland barley composite special dietary nutritional powder with auxiliary blood glucose reducing function and a preparation method thereof. The nutritional powder comprises the following raw materials by weight: 30 to 45 parts of puffed highland barley flour, 1 to 5 parts of beta glucan powder, 2 to 10 parts of high-quality protein, 2 to 5 parts of nutritional lipids, 3 to 10 parts of medicine food homology plant extracts, 10 to 20 parts of functional natural ingredients, 0.1 to 0.5 part of complex vitamins and 2 to 4.5 parts of complex minerals. The preparation method comprises seven steps of material selecting, washing, crushing, puffing, crushing, primary auxiliary material blending, secondary auxiliary material blending, mixing, sterilizing and canning. According to the invention, to aim at the unreasonable diet components, imbalance nutrition and other problems of current diabetes, a plurality of high-quality protein, medicine food homology plant extracts, functional natural ingredients complex vitamins, complex minerals and other materials are matched to prepare the nutritional powder. The nutritional powder with various functional components has a better blood glucose reducing effect.

Description

Special meals nutrient powder of highland barley compound of auxiliary hyperglycemic and preparation method thereof

Technical field

The present invention relates to diet nutritional field, refer to special meals nutrient powder of a kind of highland barley compound of auxiliary hyperglycemic and preparation method thereof particularly.

Background technology

Diabetes take chronic hyperglycemia as feature, one group of metabolic disease that defect of insulin secretion and/or insulin resistance cause, and to become thin etc. as main clinical manifestation to drink many food diuresis, the traditional Chinese medical science is called " diabetes " more.The diabetic of latest survey display China has reached 1.14 hundred million, and maturity-onset diabetes Proportion of patients is 9.7%, and within more than 60 years old, crowd's incidence of disease is up to 20.4%, and the incidence of disease of overweight crowd reaches 18.5%.Modern study shows, blood sugar in diabetic patients concentration raises, and free radical produces and increases with release, thus impaired isle β cell reduce the sensitiveness of peripheral tissues to insulin, cause diabetes to occur and development.But; methods for the treatment of most widely used is clinically medicinal treatment at present; use these methods; fundamentally can not protect and repair impaired islet beta cell function; and the course for the treatment of is long; side effect is large, and the patient using insulin to carry out hypoglycemic also needs life-long therapy, all brings very large misery to patient mental and the human body.Therefore, people seek more preferably medicine and methods for the treatment of for a long time.

Research shows; diabetes B can be prevented controlled, and key how effectively to prevent to intervene early stage at onset diabetes, effectively reduces blood sugar between period of disease; protect and repair impaired islet beta cell function, to greatest extent the emergence and development of Control and prevention complication.Diabetes patient is by " rational diet therapy ", and namely adopting the mode of " generation meal ", may be one of interference method that compliance is best, curative effect is stable.Hypoglycemic special meal nutritional food huge number in the market, but the effect of lowering blood sugar of most products is verified without scientific experiment, and mouthfeel is not good.

The present invention is directed to the characteristics of incidence of diabetes and the diabetic worries for " food ", and " food " is to the importance of diabetic.Receiving on traditional Chinese medicine marrow basis in conjunction with modern medicine study Advanced Idea; by the theory of drug research and development and the method for systematic science; by extensively screening cereal materials and protection beta Cell of islet functional component, strict compatibility and function, reasonably combined nutrition and the processing verifying functional component, develop a diet nutritional powder with function of reducing blood sugar being main nutrient composition with highland barley flour, functional component, high-quality protein, unrighted acid, electrolytes and minerals.Diet nutritional powder has the effect of three aspects: (1) protect beta Cell of islet; (2) auxiliary hyperglycemic; (3) provide full nutrition.

At present, the hypoglycemic special meals nutrient powder that market is sold or antihypelipidemic product of a great variety, but most special meals nutrient powder components compatibility has no scientific experiment checking and the relevant report of system, and function of reducing blood sugar is indefinite, mislead selection and the use of diabetic or consumer.

Hypoglycemic medicine is divided into Western medicine antidiabetic drug and Chinese medicine antidiabetic drug, and Western medicine antidiabetic drug is roughly divided into again orally-taken blood sugar reducing medicine and injection hypoglycemic medicine.Wherein conventional at home at present orally-taken blood sugar reducing medicine is based on non-insulin class medicine, and this kind of medicine is divided into Drugs Promoting Insulin Secretion class, biguanides, α ~ glycosidase inhibitor class, insulin sensitizer etc.Injection hypoglycemic medicine mainly contains insulin and similar medicine etc. thereof.This kind of Western medicine antidiabetic drug long-term taking or injection side effect comparatively large, large to the burden of liver kidney, often cause nausea, vomit, the ill symptoms such as apocleisis, anorexia.

Chinese medicine antidiabetic drug common are diabetes pill, diabetes pill, clonidine capsule etc., and this kind of Chinese patent drug is according to China's traditional medicine prescription, also has the active component extracted from Chinese medicine, natural drug to make.But this kind of medicine needs to carry out medication according to different symptoms and physique, and the scope of application is less, the effect of diabetic's generation meal cannot be met.

The special meals nutrient powder of conventional hypoglycemic has special meals nutrient powder (Shandong Tianjiu Biotechnology Co., Ltd.) of Sheng Weijia hypoglycemic, the special meals in strong happy mill No. 1 hypoglycemic nutrition powder (Shanghai Tongji Biological Product Co., Ltd.), special meals grain dust (Tianjin Zhen Wutang Food Co., Ltd) of my hall precious, the special meals nutrient powder of Tang Yikang hypoglycemic (the honest treasure in Tianjin I hall food limited company), the hall of meals special meals generation meal grain dust (the honest treasure in Tianjin I hall food limited company) etc., but and have no the relevant hypoglycemic effect of scientific experiment to the function of reducing blood sugar composition in these special meals nutrient powder and verify and the relevant report of compatibility, hypoglycemic effect is indefinite.

Publication number be the Chinese invention patent of CN103736071A disclose a kind of there is auxiliary hyperglycemic effect composition and application, preparation method, said composition raw material consists of highland barley, emblic, turmeric, rhizoma zingiberis, sea-buckthorn part, bent letter, makes health food in conventional manner.This invention mainly utilizes hypoglycemic effect of beta glucan in highland barley, and selected auxiliary material are herbal raw material medicine.

Publication number is a kind of beta-glucan composition of Chinese invention patent and the application thereof of CN102907606A, and with beta glucan powder, ultra micro carrot meal, ultra micro highland barley flour, antierythrite, isomalto-oligosaccharide is main composition composition.This invention has reducing blood lipid, reduces the effect of cholesterol, and selected material is plant or the plant extracts of integration of drinking and medicinal herbs.

Publication number is a kind of hypoglycemic milk tea powder of buckwheat of Chinese invention patent and the preparation method of CN104106631A, and its raw material comprises buckwheat, pumpkin flower, schefflera arboricola, common rockvine herb, glutinous rehmannia, Radix agastaches, honeysuckle, purslane, Agricus blazei, thousand pages of bean curd, highland barley flour, Coconut Juice, konjaku, aloe pulp, Kelp Powder, gold carp soup, fennel powder, pine needle meal, nutrition interpolation powder.This invention, using buckwheat as major ingredient, using various vegetables, fruit as auxiliary material, focuses on the effect emphasized sharp water defaecation, delay senility, and often eats and just can reach effect that is hypoglycemic, hypertension and hyperlipemia.

Grant number is that the Chinese invention patent of ZL02113578.9 discloses a kind of hypoglycemic fat-reducing beans, it be with konjaku powder and soluble dietary fiber for primary raw material, add evening primrose oil, perilla oil and vitamin E, the product of the sugared beans shape adopting conventional method to make.This invention utilizes the hypoglycemic of polydextrose in konjaku and soluble dietary fiber, suppresses obesity effect.

Grant number is that the Chinese invention patent of ZL02139449.0 discloses a kind of Tianqi sugar-reducing capsule, and it is formed by the Radix Astragali, root of Chinese trichosanthes, the fruit of glossy privet, the stem of noble dendrobium, sun-dried ginseng, the root bark of Chinese wolf-berry, the coptis, Fructus Corni, eclipta, these processing of crude drugs of Chinese gall.Mainly utilize the function of reducing blood sugar of the Radix Astragali and root of Chinese trichosanthes, and with plurality of Chinese raw material, as auxiliary material.

Application number be 200810181494.2 Chinese invention patent disclose a kind of fat-eliminating antihypelipidemic health tea, it selects lotus leaf, root of Chinese trichosanthes, raw hawthorn, reed rhizome, blue or green tea, lotus, rhizoma nelumbinis and gynostemma pentaphylla as raw material, forms through Preparation process.This invention is mainly selected to disappear the plant of lipid, accelerates metabolism and the discharge of fat, utilizes selected plant to carry out fat-eliminating antihypelipidemic in the mode of tonifying yin of promoting the production of body fluid.

Application number is that the Chinese invention patent of 200910143155.X discloses a kind of avenabeta glucosan capsule for descend of blood fat and preparation method thereof, and it is the soft capsule made for raw material with avenabeta glucosan and linseed oil.This invention mainly has the effect reducing T-CHOL removing triglycerides, simultaneously auxiliary hyperglycemic.

In above-mentioned patent or product; the extract component of medicinal and edible plant and Chinese herbal medicine raw material or extract is mainly utilized to carry out being combined into hypoglycemic product; but have no the screening of scientific experiment method to its active ingredient and the checking of effect of use system; lack the scientific validation to its compatibility; more have no Patents and the product of protection and reparation islet beta cell function, diabetes and the demand meeting diabetic cannot be effected a radical cure.

Summary of the invention

The object of the invention is for the deficiencies in the prior art; receiving on traditional Chinese medicine marrow basis in conjunction with modern medicine study Advanced Idea; from protection islet beta cell function angle; there is provided special meals nutrient powder of a kind of highland barley compound of auxiliary hyperglycemic and preparation method thereof, the special meals nutrient powder of this highland barley compound has protection beta Cell of islet, improves immunity, reduces blood sugar, Control and prevention features of complications.

For achieving the above object, the special meals nutrient powder of the highland barley compound of a kind of auxiliary hyperglycemic provided by the invention, its raw material forms according to the composite mineral matter of ratio of weight and number meter by the puffing highland barley powder of 30 ~ 45 parts, the beta glucan powder of 1 ~ 5 part, the high-quality protein of 2 ~ 10 parts, the nutrition lipid of 2 ~ 5 parts, the medicinal and edible plant extract of 3 ~ 10 parts, the functional natural ingredients of 10 ~ 20 parts, the composite vitamin of 0.1 ~ 0.5 part and 2 ~ 4.5 parts; Wherein, described beta glucan powder is from the one in highland barley, yeast, oat or barley, and beta glucan mass content >=20 wherein.Medicinal and edible plant extract is counted by ratio of weight and the number of copies and is made up of the Bitter Melon P.E of the tomato extract of 0.1 ~ 3 part, the kudzu root extract of 0.1 ~ 5 part, the yam extract of 0.1 ~ 5 part and 0.1 ~ 10 part.

Further, described functional natural ingredients is made up of the CPP of the antierythrite of 0.1 ~ 2 part, the xylitol of 0.1 ~ 2 part, the β ~ carrotene of 0.1 ~ 5 part, the inulin of 0.1 ~ 15 part, the Tea Polyphenols of 0.1 ~ 5 part, the lutein ester of 0.1 ~ 5 part, the astaxanthin of 0.1 ~ 5 part and 0.1 ~ 10 part by weight.

Again further, described composite vitamin is counted by ratio of weight and the number of copies by the niacinamide of 0.1 ~ 15 part, the calcium pantothenate of 0.1 ~ 10 part, the dimension A acetate of 0.01 ~ 10 part, the thiamine hydrochloride of 0.01 ~ 2 part, the riboflavin of 0.01 ~ 2 part, the VB of 0.01 ~ 2 part ₆, the Vitamin D3 of 0.01 ~ 2 part, the L ~ ascorbic acid of 0.1 ~ 40 part and 0.1 ~ 15 part dimension E acetate composition.

Again further, described composite mineral matter is counted by ratio of weight and the number of copies and is made up of the chromium trichloride of the calcium carbonate of 0.01 ~ 20 part, the calcium monohydrogen phosphate of 1 ~ 40 part, the ferrous sulfate of 0.01 ~ 10 part, the magnesium sulfate of 0.01 ~ 20 part, the zinc lactate of 0.01 ~ 5 part and 0.01 ~ 5 part.

Again further, described high-quality protein is one or more in lactalbumin, WPC, soybean protein isolate, soybean protein, lactoferrin, skimmed soybean protein, wheat gluten and pea protein; Described nutrition lipid is one or more in micro-algae oil-bound distemper, sunflower seeds oil-bound distemper and peanut oil-bound distemper.

Again further, the raw material of the special meals nutrient powder of described highland barley compound forms according to the composite mineral matter of ratio of weight and number meter by the puffing highland barley powder of 45 parts, the beta glucan powder of 5 parts, the high-quality protein of 10 parts, the sunflower seeds oil-bound distemper of 5 parts, the medicinal and edible plant extract of 10 parts, the functional natural ingredients of 20 parts, the composite vitamin of 0.5 part and 4.5 parts according to ratio of weight and number meter; Wherein,

Described high-quality protein is counted by weight and is made up of the lactalbumin of 5 parts, the soybean protein isolate of 10 parts and the lactoferrin of 5 parts;

Described medicinal and edible plant extract is counted by weight and is made up of the tomato extract of 3 parts, the kudzu root extract of 5 parts, the yam extract of 5 parts, the Bitter Melon P.E of 10 parts;

Described functional natural ingredients is counted by weight and is made up of the antierythrite of 0.5 part, the xylitol of 0.5 part, the beta carotene of 2 parts, the inulin of 10 parts, the Tea Polyphenols of 2 parts, the lutein ester of 1 part, 1 part of astaxanthin and 10 parts of CPPs.

Described composite vitamin is counted by weight by the niacinamide of 2 parts, the calcium pantothenate of 2 parts, the dimension A acetate of 4 parts, the thiamine hydrochloride of 0.1 part, the riboflavin of 0.1 part, the VB of 0.1 part ₆, the Vitamin D3 of 0.1 part, the L-AA of 10 parts and 5 parts dimension E acetate composition.

Described composite mineral matter is counted by weight and is made up of the calcium carbonate of 5 parts, the calcium monohydrogen phosphate of 5 parts, the ferrous sulfate of 5 parts, the magnesium sulfate of 3 parts, the zinc lactate of 3 parts, the chromium trichloride of 0.1 part.

Again further, the raw material of the special meals nutrient powder of described highland barley compound according to ratio of weight and number meter by the puffing highland barley powder of 45 parts, the beta glucan powder of 5 parts, the high-quality protein of 8 parts, micro-algae oil-bound distemper of 3 parts, the medicinal and edible plant extract of 8 parts, the functional natural ingredients of 20 parts, the composite vitamin of 0.5 part, the composite mineral matter of 4.5 parts; Wherein said beta glucan powder is from the one in highland barley, yeast, oat or barley, and beta glucan mass content >=70% wherein.Described high-quality protein is counted by weight and is made up of the WPC of 10 parts, the skimmed soybean protein of 5 parts and the wheat gluten of 5 parts;

Described medicinal and edible plant extract is counted by weight and is made up of the tomato extract of 2 parts, the kudzu root extract of 5 parts, the yam extract of 5 parts and 5 parts of Bitter Melon P.Es;

Described functional natural ingredients is counted by weight and is made up of the CPP of the antierythrite of 1 part, the xylitol of 1 part, the beta carotene of 5 parts, the inulin of 15 parts, the Tea Polyphenols of 5 parts, the lutein ester of 2 parts, the astaxanthin of 1.5 parts and 5 parts;

Described composite vitamin is counted by weight by the niacinamide of 5 parts, the calcium pantothenate of 5 parts, the dimension A acetate of 3 parts, the thiamine hydrochloride of 0.05 part, the riboflavin of 0.05 part, the VB of 0.1 part ₆, the Vitamin D3 of 0.2 part, the L-AA of 30 parts and 10 parts dimension E acetate composition;

Described composite mineral matter is counted by weight and is made up of the chromium trichloride of the calcium carbonate of 15 parts, the calcium monohydrogen phosphate of 20 parts, the ferrous sulfate of 6 parts, the magnesium sulfate of 10 parts, the zinc lactate of 2.5 parts and 0.2 part.

Present invention also offers a kind of preparation method of the special meals nutrient powder of highland barley compound of auxiliary hyperglycemic, comprise the following steps:

1) select materials and cleaning: selected high-quality plateau highland barley, remove the impurity such as Shi Sha, dust with specific-gravity stoner and vibratory sieve, clean out;

2) pulverize: raw material is pulverized, cross 80 mesh sieves;

3) expanded: to adopt twin-screw extruder puffing highland barley powder;

4) pulverize: the material pulverizer after expanded is pulverized, cross 100 mesh sieves, prepare puffing highland barley powder, for subsequent use;

5) one-level auxiliary material allotment: beta glucan powder, high-quality protein, micro-algae oil-bound distemper, medicinal and edible plant extract and functional natural ingredients are mixed; Prepare mixed accessories;

6) secondary auxiliary material allotment: composite vitamin and composite mineral matter are mixed, prepares secondary mixed accessories;

7) mixing, sterilizing, tinning: above-mentioned puffing highland barley powder, mixed accessories and secondary mixed accessories three-dimensional mixer are mixed, tinning after ultra-violet radiation sterilizing, joint sealing.

Preferably, described step 3) in, the running parameter of twin-screw extruder is screw diameter 65mm, screw speed 0-250r/min, working ability 80-120kg/h, temperature-control range 0-399 DEG C, power of motor 22kW.

Theoretical foundation of the present invention

Highland barley is rich in beta glucan, there is reduction blood sugar, reduce blood fat, reduce cholesterol, improve insulin sensitivity, immunity moderation, the multiple pharmacologically active such as anticancer and anti-infective, therefore highland barley is introduced in the special meals nutrient powder of hypoglycemic by the present invention, and select scientific validation to have medicinal and edible plant extract or the composition of effect of lowering blood sugar, the matching method composition pure natural formula of employing science, increase the active constituent content with effect of lowering blood sugar, and the synergy played between each composition, fundamentally protect the beta Cell of islet of patient, control blood sugar, there is provided full nutrition for patient and improve its quality of the life.This product has no side effect, and can eat for a long time.

Beta glucan selected by the present invention, Puerarin, Charantin, lutein, lycopene, Chinese yam polysaccharide all have function of reducing blood sugar, through the Related Experimental Study of human experiment, animal and rat insulin knurl INS-1 cell (for studying the vehicles cells of β emiocytosis function), find that functional component selected by the present invention has collaborative hypoglycemic effect, hypoglycemic effect than single use beta glucan or beta glucan and Chinese traditional medicine composition obvious.

Highland barley is the 1 year ripe high and cold farming region staple food crop in Qinghai-Tibet Platean, real green non-pollution food, there is the diet structure of " three high two low ", i.e. high protein, high microsteping, homovitamin and low fat, low sugar, be applicable to very much high glucose and high fat crowd and eat.Find according to expert investigation research, the Tibetan area people seldom obtain diabetes, and this is inseparable with long-term edible highland barley.Highland barley has very high nutritive value, except its protein content is more than 11.37% with content of cellulose average out to 1.8%, also higher than beyond other bread crops; Highland barley is also rich in a kind of important physiological activator---and beta glucan, its content is the highest in all wheat crops, and average content is 5.25%.Research finds, beta glucan is a class SNSP, mainly at present to extract from yeast, barley and oat, have reduce blood fat, reduce cholesterol, reduce blood sugar, improve insulin sensitivity, immunity moderation, the multiple pharmacologically active such as anticancer and anti-infective, especially its to fall hypoglycemic activity stronger.The expert group of FDA (Food and Drug Adminstration) (FDA) and EFSA (EFSA) is thought: take in 3g beta glucan every day and effectively can reduce postprandial blood sugar reaction, reduce blood cholesterol levels, improve function of intestinal canal and control satiety.Therefore, for diabetic or the higher crowd of blood glucose value, the edible highland barley flour being rich in beta glucan, is extremely conducive to controlling blood sugar.

The root of kudzu vine is the medicine-food two-purpose food that health ministry is assert, be rich in the materials such as Puerarin, daizeol, daidzin, Puerarin-7-xyloside, arachidic acid, modern medicine study finds, the root of kudzu vine has the improving eyesight that clears away heart-fire, reduces the effects such as blood sugar, blood pressure, blood fat, energy hemangiectasis, increase brain and coronary blood flow, have significant adjuvant treatment effect to the disease such as coronary heart diseases and angina pectoris and hypertension.Research also shows, its composition Puerarin has bidirectional modulation blood sugar, recovers the function that self changes sugar; Impaired β cell can also be repaired fast, make pancreatic cell regeneration, nutrition pancreas, strengthen body immunity.

Balsam pear is a kind of functional food raw material, and containing several physiological active substances, wherein the composition such as Charantin, alkaloid, phytosterol, bitter melon polysaccharide has significant blood sugar reducing function.Bibliographical information, the dosage of balsam pear alkali-extracted polysaccharide 400mg/kg significantly can reduce the blood glucose value of normal mouse and STZ diabetic mice, also can improve the glucose tolerance of diabetic mice and the content of hepatic glycogen.Modern study confirms, balsam pear have antitumor, improve immunologic function, the effect such as hypoglycemic.In addition, clinical research shows, balsam pear can reduce the blood sugar level of diabetes patient effectively, and especially the hypoglycemic activity of its composition Charantin is particularly evident.

Chinese yam contains the nutritional labelings such as aliphatic acid, polysaccharide, protein, amino acid, trace element, and main active component is Chinese yam polysaccharide, has immunoregulation effect, delays senility, protects the liver, antitumor, anti-sudden change, improves the effects such as resist oxygen lack power.Modern pharmacological research confirms, Chinese yam polysaccharide significantly can reduce blood sugar level and the glycosylated hemoglobin rate of diabetes rat, and makes level of insulin secretion have obvious restorative rising, has good to fall hypoglycemic effect.

Lycopene is a kind of redness, fat soluble carotenoids, has the double action of nutrition fortifier and natural colouring matter, is extensively present in various vegetable and fruit.Chinese Soclety of Nutrition recommends adult's lycopene every day intake (SPL) to be 18mg/d.Epidemiological study, tissue cultures and zooperal result all show that it has very strong non-oxidizability, good antioxidant and free radical scavenger, significantly can reduce the pancreaticβ-cell damage that oxidative stress causes, reduce the incidence of disease of the diseases such as cardiovascular, cancer, prevention of osteoporosis disease, hypertensive generation.

Lutein is a Carotenoids, is extensively present in natural plant, and the content particularly in marigold flower is (w/w, dry weight) more than 2%.Marigold Lutein is main mainly with fatty acid diesters compounds, and human body is hydrolyzed to lutein monomer after taking in lutein ester, then digests and assimilates.Chinese Soclety of Nutrition recommends adult's lutein every day intake (SPL) to be 10mg/d.The most important physiological function of lutein is protection retina, can effectively prevent diabetic retina's complication, can also change the release of absorption to cholesterol and bile, increases antioxidant levels, contributes to preventing cardiovascular and cerebrovascular disease.Lutein also has good reduction blood sugar, protects and repairs the impaired of beta Cell of islet, recovering the function of insulin level.

Astaxanthin is a kind of red natural carotenoid, is extensively present in salmon, shrimp, crab, leaves of plants, flower and fruit, marine microalgae, phytoplankton.Natural astaxanthin is as bright protective agent and powerful antioxidant; the various active oxygen that energy cancellation has high light and over oxidation to produce; prevent active oxygen to the injury of cell; its antioxidation activity is 550 times of VE; be described as " supper vitamin E ", be mainly used in strengthening immune system function, anticancer, protection retina from the aspect such as oxidative damage of ultra-violet radiation and photooxidation, anti-inflammatory, preclude blood LDL-cholesterol.Research shows, astaxanthin has good therapeutic action to diabetic mice caused by alloxan especially, has obvious reducing effect to the hyperglycaemia that adrenaline, glucose cause.

Chromium is one of trace element of needed by human, and is uniquely increase and the element of content reduction with the age in human body, has bioactive trivalent chromium and is extensively present in various plant and animal tissue.It is 30 μ g/d that Chinese Soclety of Nutrition recommends adult's chromium every day to be suitable for intake (AI).Trivalent chromium is the one " collaborative hormone " of insulin, and the sensitizer as insulin activates the activity of EGFR-TK on insulin receptor, strengthens the function of insulin.Chromium can reduce diabetes patient blood sugar, improve symptoms of insulin resistance, reduce blood fat, scarce chromium then can cause IGT, β cellular sensitivity reduce, insulin receptor reduce.

Good protein as lactalbumin, WPC, soybean protein isolate etc., have be of high nutritive value, absorption easy to digest, containing features such as various active compositions, be generally acknowledged human body good protein replenishers.Especially lactalbumin is referred to as the king of albumen, its essential amino acid kind and content complete and the protein that human body needs can be provided, and be rich in cysteine and methionine, maintain level and the develop immunitypty of antioxidant in human body, also have other various active compositions, be of value to many health cares of human body.Containing the harmful harmful substance such as excessive saturated fat, cholesterol in food protein, excessive edible body fat and the cholesterol of easily causing raises.Under normal circumstances, need feed 50g protein for each person every day, and diabetic, protein metabolism is disorderly, and show as albumen biosynthesis block, payment imbalance, the negative nitrogen balance that just there will be unable to make ends meet makes resistance against diseases decline, very easily concurrent various infectious diseases.Therefore, improve dietary protein quality, the good protein of some should be ensured in meals.Reasonable supplement good protein, controls blood sugar for diabetic, and prevention diabetic complication tool is of great significance.

The class trace organic substance that vitamin is the normal physiological function of artificial maintenance and must obtains from food, plays an important role in growth in humans, metabolism, growth course.But most of vitamin, body can not synthesize or synthetic quantity deficiency, can not meet the needs of body, constantly by obtaining in food.Meanwhile, although human body is very little to the requirement of vitamin, daily requirement often calculates with milligram or microgram, will cause corresponding vitamin-deficiency, cause damage to health once lack.Diabetic is often with the shortage of multivitamin and mineral matter.Having research report, often there is the shortage such as vitamin A, B1, B2, B6, C, D, E in type 1 diabetes patient, and diabetes B patient is then comparatively common to lack B family vitamin, beta carotene and vitamin C, D, E etc.The effect of " adding fuel to the flames " may be played in the shortage of these vitamins and the unbalance generation in diabetes and development.Vitamin A tool antioxidation, has material impact to lymphocyte activator, propagation, differentiation and apoptosis, and the A that is deficient in vitamin can cause autoimmunity abnormal, may cause type 1 diabetes and Intra-islet Apoptosis.B family vitamin is relevant to coenzyme function.The amide groups of nicotinic acid carries hydrogen coenzyme, as the required composition of two nucleoside of nicotinamide adenine (NAD) and NADP (NADP), vitamin B1 forms the necessary coenzyme of pyruvate oxidation decarboxylation, and vitamin B6 is the main coenzyme in glycolipid metabolism.B family vitamin, as the coenzyme of key enzyme, plays an important role in glycometabolism, can reduce diabetic neuropathy, and reduce homocysteine level, reduces the onset risk of diabetic's cardiovascular complication.Vitamin C has scavenging activated oxygen, the function of protection endothelial cell, reduces the occurrence risk of diabetic's nerve and vascular complication.Vitamin D can suppress the autoimmune response of pancreatic beta cell, and reduce insulin resistance, the D that is deficient in vitamin may cause insulin secretion to reduce.Vitamin E can scavenging free radicals, reduces blood vessel endothelium injury, and plasma vitamin E level reduces can increase the weight of carbohydrate metabolism disturbance, increases the occurrence risk of diabetic vascular complications.Therefore, reasonably combined and replenishing vitamins is conducive to diabetes and must corrects metabolic disorder and prevent and treat complication.

Mineral energy affects the secreting function of human pancreas or tissue insulin sensitivity and glycolipid metabolism, thus lead diabetogenic generation, these mineral matters mainly contain: chromium, zinc, iron, selenium, lithium and manganese etc. and some rare earth element, play an important role in the generation and course of disease evolutionary process of onset diabetes, complication.Medical research shows, diabetic's chromium, zinc, selenium, magnesium, iron level decrease, lower when having a complication, the impaired impairment factor being considered to onset diabetes of chromium and zinc state; Chromium can improve IGT, reduces insulin resistance, reduces antidiabetic drug or insulin requirement amount, can strengthen insulin action in sugar and lipid-metabolism.The minimizing of content of magnesium can cause body insulin sensitivity to decline, and low magnesium diet can cause insulin resistance, and mends magnesium and can improve β cell effect ability.Zinc is the constituent of 160 kinds of enzymes (comprising three large metabolism enzyme and insulin) in body, can affect insulin synthesis, storage, secretion and insulin structure integrality, reduce concurrent retina and peripheral neuropathy.Zn-ef ficiency is mainly present in marine product, pluck.Iron can reduce free radical, reduces diabetes and concurrent vascular lesion.Calcium can strengthen the elasticity of blood vessel, prevents and treats osteoporosis, can reduce cardiovascular complication.Therefore, appropriate reasonable supplement mineral matter, prevents and treats multiple complications to diabetic and has important effect.

The invention has the advantages that:

The present invention uses the scientific research methods of system and experimental verification and screens the medicinal and edible plant composition with function of reducing blood sugar, and carries out compatibility and processing with the method for science, ensures functional components and the content of raw material, improves the utilization rate of bioactivator; Strengthen product prevention blood sugar to raise, reduce hyperglycaemia, prevent and treat the effect that development occurs complication.Being intended to exploitation a is main composition with highland barley Beta-dextran, is particularly conducive to protection and the reparation of islet beta cell function, for preventing, treating the special diet nutrient powder of the medicine-food two-purpose of diabetes and complication thereof.

Simultaneously, the dietary structure that the present invention is directed to current diabetic is unreasonable, the bad present situations such as nutrition is unbalanced, select multiple high-quality protein, medicinal and edible plant extract, functional natural ingredients, composite vitamin, composite mineral matters etc. are made into nutrient powder, not only its blood sugar decreasing effect is better for the nutrient powder of this several functions composition combination, and comprehensive nutritional supplementation can be provided for diabetic, make up the malnutrition that diets of diabetic patients unreasonable structure causes, energy can be provided moderate for diabetic simultaneously, nutritional labeling general equilibrium, mellow in taste, security is high, auxiliary hyperglycemic product easy to use, meet the nutritional need of diabetic population completely.

Accompanying drawing explanation

Fig. 1 is the effect diagram of beta glucan to the INS-1 cell survival rate that AXN damages;

Fig. 2 is the effect diagram of Puerarin to the INS-1 cell survival rate that AXN damages;

Fig. 3 is the effect diagram of Chinese yam to the INS-1 cell survival rate that AXN damages;

Fig. 4 is the effect diagram of Charantin to the INS-1 cell survival rate that AXN damages;

Fig. 5 is the effect diagram of lutein to the INS-1 cell survival rate that AXN damages;

In Fig. 1 ~ 5, #, P<0.05, have significant difference compared with normal group; *, P<0.05, has significant difference compared with model group; *, P<0.01, have pole significant difference compared with model group

Fig. 6 is the effect diagram of different components to INS-1 cell survival rate;

#, P < 0.05 in figure, compared with normal group; *, P < 0.05, compared with model group; &, P < 0.05, compared with beta glucan

Fig. 7 is the effect diagram of different formulations to INS-1 cell survival rate;

#, P < 0.05 in figure, compared with normal group; *, P < 0.05, compared with model group; &, P < 0.05, compared with formula 3

Fig. 8 is the change of each time point mouse fasting blood-glucose and group difference figure;

Fig. 9 is the change of each time point mouse blood sugar TG-AUC and group difference figure;

Figure 10 is the change of each time point Mouse Weight and group difference figure;

In Fig. 8 ~ 10, #, P<0.05, have significant difference compared with normal group; *, P<0.05, has significant difference compared with model group

Figure 11 is gavage the 45th day mice serum insulin level group difference figure;

Figure 12 is that the nutrient powder prepared in embodiment is to the effect diagram of mouse fasting blood-glucose;

Figure 13 is that the nutrient powder prepared in embodiment is to the effect diagram of mice serum insulin level;

Figure 14 is that the nutrient powder prepared in embodiment is to the effect diagram of Mouse Weight;

In Figure 11-14, #, P<0.05, have significant difference compared with melbine group; *, P<0.05, has significant difference compared with model group; *, P<0.01, have pole significant difference compared with model group

Detailed description of the invention

In order to explain the present invention better, illustrate main contents of the present invention further below in conjunction with specific embodiment, but content of the present invention is not only confined to following examples.

The special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic, its raw material according to weight percent frequently meter be made up of the composite mineral matter of the puffing highland barley powder of 30 ~ 45 parts, the beta glucan powder of 1 ~ 5 part, the high-quality protein of 2 ~ 10 parts, the nutrition lipid of 2 ~ 5 parts, the medicinal and edible plant extract of 3 ~ 10 parts, the functional natural ingredients of 10 ~ 20 parts, the composite vitamin of 0.1 ~ 0.5 part and 2 ~ 4.5 parts; Wherein,

Functional natural ingredients is by weight by antierythrite, xylitol 0.1 ~ 2 part, β ~ carrotene 0.1 ~ 5 part, inulin 0.1 ~ 15 part, Tea Polyphenols 0.1 ~ 5 part, lutein ester 0.1 ~ 5 part, astaxanthin 0.1 ~ 5 part, the CPP 0.1 ~ 10 part of 0.1 ~ 2 part.

Medicinal and edible plant extract is counted by ratio of weight and the number of copies and is made up of the Bitter Melon P.E of the tomato extract of 0.1 ~ 3 part, the kudzu root extract of 0.1 ~ 5 part, the yam extract of 0.1 ~ 5 part and 0.1 ~ 10 part;

Composite vitamin is counted by ratio of weight and the number of copies by the niacinamide of 0.1 ~ 15 part, the calcium pantothenate of 0.1 ~ 10 part, the dimension A acetate of 0.01 ~ 10 part, the thiamine hydrochloride of 0.01 ~ 2 part, the riboflavin of 0.01 ~ 2 part, the VB of 0.01 ~ 2 part ₆, Vitamin D3, the L ~ ascorbic acid of 0.1 ~ 40 part and the dimension E acetate of 0.1 ~ 15 part of 0.01 ~ 2 part.

Composite mineral matter counts the chromium trichloride by the calcium carbonate of 0.01 ~ 20 part, the calcium monohydrogen phosphate of 1 ~ 40 part, the ferrous sulfate of 0.01 ~ 10 part, the magnesium sulfate of 0.01 ~ 20 part, the zinc lactate of 0.01 ~ 5 part and 0.01 ~ 5 part by ratio of weight and the number of copies.

High-quality protein is one or more in lactalbumin, WPC, soybean protein isolate, soybean protein, lactoferrin, skimmed soybean protein, wheat gluten and pea protein; Described nutrition lipid is one or more in micro-algae oil-bound distemper, sunflower seeds oil-bound distemper and peanut oil-bound distemper.

Beta glucan content >=20% in beta glucan powder.

In order to show effect of the present invention better; barley nutritional powder has been carried out cell experiment, zoopery and human experiment experiment by respectively; result shows fasting blood-glucose and the sugar tolerance that special dietary powder of the present invention has good reduction diabetic mice; recover diabetic mice insulin level; have good protection and repair to the islet cells of alloxan damage, concrete test is as follows:

1, cell experiment

1.1 use INS-1 islet cells oncocyte alloxan damage model to carry out islet cells experiment

As shown in Fig. 1 ~ 5: experiment finds that beta glucan, Puerarin (kudzu root extract), Chinese yam polysaccharide (yam extract), Charantin (Bitter Melon P.E), lutein (tomato extract) have remarkable protective effect (compared with model group to the INS-1 rat Islet cells oncocyte infringement that alloxan is induced; each concentration (μ g/ml); cell is all significantly bred; P<0.05), this protective effect within the scope of finite concentration comparatively low dosage namely have remarkable result and in dose dependent.

1.2 use INS-1 islet cells oncocyte alloxan damage model to carry out islet cells experiment further

As shown in Figure 6: experiment discovery beta glucan+Charantin+Puerarin is that the protective effect of the INS-1 rat Islet cells oncocyte infringement of composition 1 pair of alloxan induction of 1:1:1 composition is obviously better than single beta glucan (P<0.05) with ratio; beta glucan+Charantin+Puerarin+Chinese yam polysaccharide+lutein+lycopene is that the protective effect of the INS-1 rat Islet cells oncocyte infringement of the composition 2 pairs of alloxans induction of 1:1:1:1:1:1 composition is all obviously better than composition 1 and single beta glucan (P<0.05) with ratio, and namely this protective effect shows as has remarkable result compared with low dosage and in certain dose dependent.Illustrate in the protective effect of the INS-1 rat Islet cells oncocyte infringement that these traditional Chinese medicine ingredients are induced at alloxan that there is cooperative effect.

As shown in Figure 7: the composition 1,2,3 that highland barley flour+beta glucan+Charantin+Puerarin+Chinese yam polysaccharide+lutein+lycopene take ratio as 5:1:0.5:0.5:0.5:0.5,4:1:1:1:0.5:0.5:0.5 and 3:2:0.5:0.5:1:1:1 composition is inquired into, the composition that the protective effect of the INS-1 rat Islet cells oncocyte damage of the composition 2 pairs of alloxans inductions taking ratio as 4:1:1:1:0.5:0.5:0.5 forms due to other ratios is found.Illustrate that the protective effect of different formula rates on the INS-1 rat Islet cells oncocyte damage that alloxan is induced produces different impacts.

2 zooperies

The hyperglycaemia mouse auxiliary hyperglycemic Effect study of 2.1 pairs of alloxan inductions

Select cleaning grade kunming mice, after the modeling of alloxan 160mg/kgBW single intraperitoneal injection, choose the mouse that blood glucose value is stabilized in into mould level (10-25mmol/L) and be divided into model group at random, high, medium and low dosage group, Or Metformin In Treating group, respectively the barley dietary nutrient powder prepared of gavage physiological saline, 888mg/kg, 444mg/kg, 222mg/kgBW the present invention and 100mg/kg melbine.Separately establish normal group and solvent control group, respectively the special meals nutrient powder tested material of gavage 888mg/kgBW highland barley compound and physiological saline, gavage volume is 0.2ml/10gBW.

As shown in Fig. 8 ~ 9: in modeling forward and backward and gavage the 30th and 45 days time, measure body weight, fasting blood glucose level and Area under the curve of blood glucose (reflection Glucose Tolerance).During gavage the 45th day, eye socket gets hematometry serum insulin level.Gavage is after 30 days, compared with model group, high, medium and low dosage group in dose-dependently reducing fasting blood-glucose, improve Glucose Tolerance, (in high dose group, 3 indexs all have significant difference to improve Mouse Weight, P<0.05, and high dose group reduction fasting blood-glucose, raising Glucose Tolerance and body weight effect are suitable with Or Metformin In Treating group);

As shown in Figure 10: gavage is after 45 days, compared with model group, high, in, in dose-dependently reducing fasting blood-glucose, (high dose group has significant difference to low dose group, P<0.05, in, high dose group effect is suitable with Or Metformin In Treating group), raising Glucose Tolerance (in, high dose group has significant difference, P<0.05, effect is suitable with Or Metformin In Treating group), raising Mouse Weight (in, high dose group has significant difference, P<0.05, effect is suitable with Or Metformin In Treating group),

As shown in figure 11: gavage is after 45 days, compared with model group, high, medium and low dosage group in dose-dependently to improve serum insulin level (in, low dose group has significant difference, P<0.05, high dose group has pole significant difference, P<0.01).High dose group serum insulin level is significantly higher than Or Metformin In Treating group, P<0.05.

In sum; the special meals nutrient powder of highland barley compound has the effect of lowering blood sugar significantly reducing fasting blood-glucose, improve sugar tolerance, improve body weight; and can serum insulin level be significantly improved; point out it not only can reduce elevated blood glucose levels; also very likely by protecting and repairing islet beta cell function; thus serum insulin level is improved, play the effect of " treating both principal and secondary aspect of disease ".

The auxiliary hyperglycemic Effect study of the nutrient powder prepared in 2.2 embodiments

Select cleaning grade kunming mice, after the modeling of alloxan 160mg/kgBW single intraperitoneal injection, choose the mouse that blood glucose value is stabilized in into mould level (10-25mmol/L) and be divided into model group at random, the nutrient powder prepared in embodiment 1,2,3 groups, Or Metformin In Treating group, gavage physiological saline respectively, 444mg/kgBW nutrient powder 1,2,3 and 100mg/kgBW melbine.Separately establish normal group and solvent control group, respectively gavage 444mg/kgBW nutrient powder 1 and physiological saline, gavage volume is 0.2ml/10gBW simultaneously.

As shown in Figure 12 ~ 14: forward and backward and gavage is after 30 days in modeling, measure body weight, fasting blood glucose level and serum insulin level.Compared with model group, nutrient powder 1,2,3 all significantly can reduce the fasting blood-glucose of mouse, improves serum insulin level, improves Mouse Weight (P is all less than 0.05), each group reduce fasting blood-glucose and body weight effect suitable with Or Metformin In Treating group.

3 human experiment experiments

The human experiment experiment of the special meals nutrient powder of highland barley compound prepared by the present invention is carried out: with 100 examples over 18 years old in Zhongshan Hospital of Hubei Province, the patient of impaired glucose tolerance is diagnosed as research object through OGTT, according to national health food inspection and assessment technical specification, adopt two kinds of control design between self and group.Be divided into life style to adjust associating test-meal group (test-meal group) and simple life style adjustment group (control group) at random, often organize 50 examples.Two groups of patients to take on basic pharmaceutical (melbine) constant basis row edible special meals nutrient powder 90 days before the meal continuously respectively, 3 times/day, and 20g/ time and column criterion meal test (100g fine powder steamed bun).All patients draw blood respectively during 90d after 60d and test-meal after 30d, test-meal and detect blood sugar (PBG) level of more than 8h (FBG) on an empty stomach and 2h after the meal before test-meal, after test-meal, and glycosylated hemoglobin (HbA1C) level, and assess hepatic and renal function.Result shows, patient eats the special meals nutrient powder of highland barley compound after 90 days continuously before the meal, its FBG, PBG and HbA1C level obviously reduces (the equal <0.05 of P), and FBG declines 38.8% before comparatively testing, and before and after test-meal, hepatic and renal function indices is all normal.

The situation of change (x ± s, n=50) of the two groups of fasting blood glucose levels in front and back tested by table 1

Note: compared with control group, * P < 0.05; * P < 0.01

The situation of change (x ± s, n=50) of the two groups of 2h-plasma glucose levels in front and back tested by table 2

Note: compared with control group, * P < 0.05; * P < 0.01

The situation of change (x ± s, n=50) of the two groups of glycosylated hemoglobins in front and back tested by table 3

Note: compared with control group, * P < 0.05

Prove that from table 1 ~ 3 the present invention has good hypoglycemic effect really, and have no side effect.

Embodiment 1

1) by after highland barley cleaning, removal of impurities, pulverized 80 orders, adopt twin-screw extruder puffing highland barley powder, screw diameter 65mm, screw speed 0-250r/min, working ability 80-120kg/h, temperature-control range 0-399 DEG C, power of motor 22kW, the highland barley flour after expanded pulverized 100 mesh sieves, obtain puffing highland barley powder, for subsequent use;

2) take the lactoferrin of the lactalbumin of 10g, the soybean protein isolate of 15g and 10g, mix, obtain high-quality protein, for subsequent use;

3) take the Charantin of the lutein of 6g, the Puerarin of 10g, the Chinese yam polysaccharide of 10g and 20g, mix, obtain medicinal and edible plant extract, for subsequent use;

4) CPP of the Tea Polyphenols of the inulin of the beta carotene of the xylitol of the antierythrite of 1g, 1g, 4g, 20g, 4g, the lutein ester of 2g, the astaxanthin of 2g and 20g, mixes, obtains functional natural ingredients, for subsequent use;

5) niacinamide of 4g, the calcium pantothenate of 4g, the dimension A acetate of 8g, the thiamine hydrochloride of 0.2g, the riboflavin of 0.2g, the VB of 0.2g is taken ₆, the Vitamin D3 of 0.2g, the L-AA of 20g and 10g dimension E acetate, mix, obtain composite vitamin, for subsequent use;

6) take the chromium trichloride of the calcium carbonate of 10g, the calcium monohydrogen phosphate of 10g, the ferrous sulfate of 10g, the magnesium sulfate of 6g, the zinc lactate of 6g and 0.2g, mix, obtain composite mineral matter, for subsequent use;

7) the composite mineral matter of the puffing highland barley powder of 45g, the beta glucan powder (from highland barley, and beta glucan content >=70%) of 5g, the high-quality protein of 10g, the medicinal and edible plant extract of 10g, the functional natural ingredients of 20g, the composite vitamin of 0.5g and 4.5g is taken.First, beta glucan powder, high-quality protein, medicinal and edible plant extract and functional natural ingredients are mixed, prepares one-level mixed accessories; Then, composite vitamin and composite mineral matter are mixed, prepares secondary mixed accessories; They are put into three-dimensional mixer mix, each material is mixed completely; The material mixed is filling and seal after ultra-violet radiation sterilizing, simultaneously the spray printing date of manufacture, namely obtains the special meals nutrient powder 1 of highland barley compound.

Embodiment 2

1) by after highland barley cleaning, removal of impurities, pulverized 80 orders, adopt twin-screw extruder puffing highland barley powder, screw diameter 65mm, screw speed 0-250r/min, working ability 80-120kg/h, temperature-control range 0-399 DEG C, power of motor 22kW, the highland barley flour after expanded pulverized 100 mesh sieves, obtain puffing highland barley powder, for subsequent use;

2) take the lactoferrin of the lactalbumin of 10g, the soybean protein isolate of 15g and 10g, mix, obtain high-quality protein, for subsequent use;

3) take the Charantin of the lutein of 6g, the Puerarin of 10g, the Chinese yam polysaccharide of 10g and 20g, mix, obtain medicinal and edible plant extract, for subsequent use;

4) CPP of the Tea Polyphenols of the inulin of the beta carotene of the xylitol of the antierythrite of 1g, 1g, 4g, 20g, 4g, the lutein ester of 2g, the astaxanthin of 2g and 20g, mixes, obtains functional natural ingredients, for subsequent use;

5) niacinamide of 4g, the calcium pantothenate of 4g, the dimension A acetate of 8g, the thiamine hydrochloride of 0.2g, the riboflavin of 0.2g, the VB of 0.2g is taken ₆, the Vitamin D3 of 0.2g, the L-AA of 20g and 10g dimension E acetate, mix, obtain composite vitamin, for subsequent use;

6) take the chromium trichloride of the calcium carbonate of 10g, the calcium monohydrogen phosphate of 10g, the ferrous sulfate of 10g, the magnesium sulfate of 6g, the zinc lactate of 6g and 0.2g, mix, obtain composite mineral matter, for subsequent use;

7) the composite mineral matter of the puffing highland barley powder of 38g, the beta glucan powder (from highland barley, and beta glucan content >=70%) of 2.5g, the high-quality protein of 5g, the medicinal and edible plant extract of 5g, the functional natural ingredients of 15g, the composite vitamin of 0.25g and 2.5g is taken.First, beta glucan powder, high-quality protein, medicinal and edible plant extract and functional natural ingredients are mixed, prepares one-level mixed accessories; Then, composite vitamin and composite mineral matter are mixed, prepares secondary mixed accessories; They are put into three-dimensional mixer mix, each material is mixed completely; The material mixed is filling and seal after ultra-violet radiation sterilizing, simultaneously the spray printing date of manufacture, namely obtains the special meals nutrient powder 2 of highland barley compound.

Embodiment 3

1) by after highland barley cleaning, removal of impurities, pulverized 80 orders, adopt twin-screw extruder puffing highland barley powder, screw diameter 65mm, screw speed 0-250r/min, working ability 80-120kg/h, temperature-control range 0-399 DEG C, power of motor 22kW, the highland barley flour after expanded pulverized 100 mesh sieves, obtain puffing highland barley powder, for subsequent use;

2) take the wheat gluten of the WPC of 5g, the skimmed soybean protein of 10g and 5g, mix, obtain high-quality protein, for subsequent use;

3) take the Bitter Melon P.E of the tomato extract of 2g, the kudzu root extract of 5g, the yam extract of 5g and 5g, mix, obtain medicinal and edible plant extract, for subsequent use;

4) CPP of the Tea Polyphenols of the inulin of the beta carotene of the xylitol of the antierythrite of 1g, 1g, 5g, 15g, 5g, the lutein ester of 2g, the astaxanthin of 1.5g and 5g, mixes, obtains functional natural ingredients, for subsequent use;

5) niacinamide of 5g, the calcium pantothenate of 5g, the dimension A acetate of 3g, the thiamine hydrochloride of 0.05g, the riboflavin of 0.05g, the VB of 0.1g is taken ₆, the Vitamin D3 of 0.2g, the L-AA of 30g and 10g dimension E acetate, mix, obtain composite vitamin, for subsequent use;

6) take the chromium trichloride of the calcium carbonate of 15g, the calcium monohydrogen phosphate of 20g, the ferrous sulfate of 6g, the magnesium sulfate of 10g, the zinc lactate of 2.5g and 0.2g, mix, obtain composite mineral matter, for subsequent use;

7) the composite mineral matter of the puffing highland barley powder of 30g, the beta glucan powder (from highland barley, and beta glucan content >=70%) of 2g, the high-quality protein of 3g, the medicinal and edible plant extract of 3g, the functional natural ingredients of 10g, the composite vitamin of 0.1g and 2.5g is taken.First, beta glucan powder, high-quality protein, medicinal and edible plant extract and functional natural ingredients are mixed, prepares one-level mixed accessories; Then, composite vitamin and composite mineral matter are mixed, prepares secondary mixed accessories; They are put into three-dimensional mixer mix, each material is mixed completely; The material mixed is filling and seal after ultra-violet radiation sterilizing, simultaneously the spray printing date of manufacture, namely obtains the special meals nutrient powder 3 of highland barley compound.

Embodiment 4

The present embodiment is substantially identical with the preparation method of embodiment 1, and difference is:

Medicinal and edible plant extract counts the Bitter Melon P.E of tomato extract, the kudzu root extract of 5g, the yam extract of 0.1g and the 10g taking 0.1g by ratio of weight and the number of copies; Mix, for subsequent use

Functional natural ingredients takes the CPP of the antierythrite of 0.1g, the xylitol of 2g, the β ~ carrotene of 0.1g, the inulin of 15g, the Tea Polyphenols of 5g, the lutein ester of 0.1g, the astaxanthin of 5g and 5g by weight, mixes, for subsequent use;

Composite vitamin counts the niacinamide, the calcium pantothenate of 10g, the dimension A acetate of 5g, the thiamine hydrochloride of 0.01g, the riboflavin of 1g, the VB of 2g that take 0.1g by ratio of weight and the number of copies ₆, the Vitamin D3 of 0.01g, the L ~ ascorbic acid of 40g and 15g dimension E acetate, mix, for subsequent use;

Composite mineral matter counts the chromium trichloride of calcium carbonate, the calcium monohydrogen phosphate of 20g, the ferrous sulfate of 5g, the magnesium sulfate of 0.01g, the zinc lactate of 5g and the 0.01g taking 0.01g by ratio of weight and the number of copies, mixes, for subsequent use;

The highland barley compound of auxiliary hyperglycemic special meals nutrient powder raw material takes the composite mineral matter of the puffing highland barley powder of 30g, the beta glucan powder of 1g, the lactalbumin of 10g, the sunflower seeds oil-bound distemper of 5g, the medicinal and edible plant extract of 10g, the functional natural ingredients of 10g, the composite vitamin of 0.1g and 2.9g according to ratio of weight and number meter.

Embodiment 5

The present embodiment is substantially identical with the preparation method of embodiment 1, and difference is:

Medicinal and edible plant extract counts the Bitter Melon P.E of tomato extract, the kudzu root extract of 0.1g, the yam extract of 4g and the 5g taking 3g by ratio of weight and the number of copies, mixes, for subsequent use

Functional natural ingredients takes the CPP of the antierythrite of 1g, the xylitol of 1g, the β ~ carrotene of 3g, the inulin of 10g, the Tea Polyphenols of 3g, the lutein ester of 5g, the astaxanthin of 0.1g and 10g by weight, mixes, for subsequent use;

Composite vitamin counts the niacinamide, the calcium pantothenate of 0.1g, the dimension A acetate of 10g, the thiamine hydrochloride of 2g, the riboflavin of 0.5g, the VB of 0.01g that take 15g by ratio of weight and the number of copies ₆, the Vitamin D3 of 2g, the L ~ ascorbic acid of 20g and 0.1g dimension E acetate, mix, for subsequent use;

Composite mineral matter counts the chromium trichloride of calcium carbonate, the calcium monohydrogen phosphate of 1g, the ferrous sulfate of 10g, the magnesium sulfate of 20g, the zinc lactate of 0.01g and the 5g taking 20g by ratio of weight and the number of copies, mixes, for subsequent use;

High-quality protein takes the lactalbumin of 10g and the WPC of 10g, mixes, for subsequent use;

Nutrition lipid takes micro-algae oil-bound distemper of 5g, the sunflower seeds oil-bound distemper of 10g and the peanut oil-bound distemper of 5g, mixes, for subsequent use;

The highland barley compound of auxiliary hyperglycemic special meals nutrient powder raw material takes the composite mineral matter of the puffing highland barley powder of 40g, the beta glucan powder of 3g, the lactalbumin of 4g, the nutrition lipid of 2g, the medicinal and edible plant extract of 5g, the functional natural ingredients of 15g, the composite vitamin of 0.3g and 2g according to ratio of weight and number meter.

Embodiment 6

The present embodiment is substantially identical with the preparation method of embodiment 1, and difference is:

Medicinal and edible plant extract counts the Bitter Melon P.E composition of tomato extract, the kudzu root extract of 4g, the yam extract of 0.1g and the 8g taking 1g by ratio of weight and the number of copies; For subsequent use

Functional natural ingredients takes the CPP of the antierythrite of 2g, the xylitol of 1.5g, the β ~ carrotene of 0.1g, the inulin of 8g, the Tea Polyphenols of 0.1g, the lutein ester of 2g, the astaxanthin of 1g and 4g by weight, mixes, for subsequent use;

Composite vitamin counts the niacinamide, the calcium pantothenate of 2g, the dimension A acetate of 4g, the thiamine hydrochloride of 1g, the riboflavin of 2g, the VB of 0.5g that take 10g by ratio of weight and the number of copies ₆, the Vitamin D3 of 1g, the L ~ ascorbic acid of 30g and 8g dimension E acetate, mix, for subsequent use;

Composite mineral matter counts the chromium trichloride of calcium carbonate, the calcium monohydrogen phosphate of 30g, the ferrous sulfate of 5g, the magnesium sulfate of 0.01g, the zinc lactate of 1g and the 3g taking 10g by ratio of weight and the number of copies, mixes, for subsequent use;

High-quality protein takes the pea protein of the lactalbumin of 10g, the WPC of 10g, the wheat gluten of 2g and 4g, mixes, for subsequent use;

Nutrition lipid takes the sunflower seeds oil-bound distemper of 5g and the peanut oil-bound distemper of 5g, mixes, for subsequent use;

The highland barley compound of auxiliary hyperglycemic special meals nutrient powder raw material takes the composite mineral matter of the puffing highland barley powder of 42g, the beta glucan powder of 2g, the high-quality protein of 2g, the nutrition lipid of 5g, the medicinal and edible plant extract of 8g, the functional natural ingredients of 12g, the composite vitamin of 0.2g and 3.5g according to ratio of weight and number meter.

Other unspecified part is prior art.Although above-described embodiment is to invention has been detailed description; but it is only the present invention's part embodiment; instead of whole embodiment, people can also obtain other embodiments according to the present embodiment under without creative prerequisite, and these embodiments all belong to scope.

Claims (10)

1. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic, is characterized in that: its raw material forms according to the composite mineral matter of ratio of weight and number meter by the puffing highland barley powder of 30 ~ 45 parts, the beta glucan powder of 1 ~ 5 part, the high-quality protein of 2 ~ 10 parts, the nutrition lipid of 2 ~ 5 parts, the medicinal and edible plant extract of 3 ~ 10 parts, the functional natural ingredients of 10 ~ 20 parts, the composite vitamin of 0.1 ~ 0.5 part and 2 ~ 4.5 parts; Wherein, described medicinal and edible plant extract is counted by ratio of weight and the number of copies and is made up of the Bitter Melon P.E of the tomato extract of 0.1 ~ 3 part, the kudzu root extract of 0.1 ~ 5 part, the yam extract of 0.1 ~ 5 part and 0.1 ~ 10 part.

2. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1, is characterized in that: described functional natural ingredients is made up of the CPP of the antierythrite of 0.1 ~ 2 part, the xylitol of 0.1 ~ 2 part, the β ~ carrotene of 0.1 ~ 5 part, the inulin of 0.1 ~ 15 part, the Tea Polyphenols of 0.1 ~ 5 part, the lutein ester of 0.1 ~ 5 part, the astaxanthin of 0.1 ~ 5 part and 0.1 ~ 10 part by weight.

3. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1 or 2, is characterized in that: described composite vitamin is counted by ratio of weight and the number of copies by the niacinamide of 0.1 ~ 15 part, the calcium pantothenate of 0.1 ~ 10 part, the dimension A acetate of 0.01 ~ 10 part, the thiamine hydrochloride of 0.01 ~ 2 part, the riboflavin of 0.01 ~ 2 part, the VB of 0.01 ~ 2 part ₆, the Vitamin D3 of 0.01 ~ 2 part, the L ~ ascorbic acid of 0.1 ~ 40 part and 0.1 ~ 15 part dimension E acetate composition.

4. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1 or 2, is characterized in that: described composite mineral matter is counted by ratio of weight and the number of copies and is made up of the chromium trichloride of the calcium carbonate of 0.01 ~ 20 part, the calcium monohydrogen phosphate of 1 ~ 40 part, the ferrous sulfate of 0.01 ~ 10 part, the magnesium sulfate of 0.01 ~ 20 part, the zinc lactate of 0.01 ~ 5 part and 0.01 ~ 5 part.

5. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1 or 2, is characterized in that: described high-quality protein is one or more in lactalbumin, WPC, soybean protein isolate, soybean protein, lactoferrin, skimmed soybean protein, wheat gluten and pea protein; Described nutrition lipid is one or more in micro-algae oil-bound distemper, sunflower seeds oil-bound distemper and peanut oil-bound distemper.

6. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1, is characterized in that: beta glucan content >=20% in described beta glucan powder.

7. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1 and 2, is characterized in that: the raw material of the special meals nutrient powder of described highland barley compound forms according to the composite mineral matter of ratio of weight and number meter by the puffing highland barley powder of 45 parts, the beta glucan powder of 5 parts, the high-quality protein of 10 parts, the sunflower seeds oil-bound distemper of 5 parts, the medicinal and edible plant extract of 10 parts, the functional natural ingredients of 20 parts, the composite vitamin of 0.5 part and 4.5 parts; Wherein,

Described high-quality protein is counted by weight and is made up of the lactalbumin of 5 parts, the soybean protein isolate of 10 parts and the lactoferrin of 5 parts;

Described medicinal and edible plant extract is counted by weight and is made up of the tomato extract of 3 parts, the kudzu root extract of 5 parts, the yam extract of 5 parts, the Bitter Melon P.E of 10 parts;

Described functional natural ingredients is counted by weight and is made up of the antierythrite of 0.5 part, the xylitol of 0.5 part, the beta carotene of 2 parts, the inulin of 10 parts, the Tea Polyphenols of 2 parts, the lutein ester of 1 part, 1 part of astaxanthin and 10 parts of CPPs.

Described composite vitamin is counted by weight by the niacinamide of 2 parts, the calcium pantothenate of 2 parts, the dimension A acetate of 4 parts, the thiamine hydrochloride of 0.1 part, the riboflavin of 0.1 part, the VB of 0.1 part ₆, the Vitamin D3 of 0.1 part, the L-AA of 10 parts and 5 parts dimension E acetate composition.

Described composite mineral matter is counted by weight and is made up of the calcium carbonate of 5 parts, the calcium monohydrogen phosphate of 5 parts, the ferrous sulfate of 5 parts, the magnesium sulfate of 3 parts, the zinc lactate of 3 parts, the chromium trichloride of 0.1 part.

8. the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic according to claim 1 and 2, is characterized in that: the raw material of the special meals nutrient powder of described highland barley compound is made up of the puffing highland barley powder of 45 parts, the beta glucan powder of 5 parts, the high-quality protein of 8 parts, micro-algae oil-bound distemper of 3 parts, the medicinal and edible plant extract of 8 parts, the functional natural ingredients of 20 parts, the composite vitamin of 0.5 part, the composite mineral matter of 4.5 parts according to ratio of weight and number meter;

Beta glucan content >=70% in described beta glucan powder;

Described high-quality protein is counted by weight and is made up of the WPC of 10 parts, the skimmed soybean protein of 5 parts and the wheat gluten of 5 parts;

Described medicinal and edible plant extract is counted by weight and is made up of the tomato extract of 2 parts, the kudzu root extract of 5 parts, the yam extract of 5 parts and 5 parts of Bitter Melon P.Es;

Described functional natural ingredients is counted by weight and is made up of the CPP of the antierythrite of 1 part, the xylitol of 1 part, the beta carotene of 5 parts, the inulin of 15 parts, the Tea Polyphenols of 5 parts, the lutein ester of 2 parts, the astaxanthin of 1.5 parts and 5 parts;

Described composite vitamin is counted by weight by the niacinamide of 5 parts, the calcium pantothenate of 5 parts, the dimension A acetate of 3 parts, the thiamine hydrochloride of 0.05 part, the riboflavin of 0.05 part, the VB of 0.1 part ₆, the Vitamin D3 of 0.2 part, the L-AA of 30 parts and 10 parts dimension E acetate composition;

Described composite mineral matter is counted by weight and is made up of the chromium trichloride of the calcium carbonate of 15 parts, the calcium monohydrogen phosphate of 20 parts, the ferrous sulfate of 6 parts, the magnesium sulfate of 10 parts, the zinc lactate of 2.5 parts and 0.2 part.

9. a preparation method for the special meals nutrient powder of the highland barley compound of auxiliary hyperglycemic described in claim 1, is characterized in that: comprise the following steps:

1) select materials and cleaning: selected high-quality plateau highland barley, remove the impurity such as Shi Sha, dust with specific-gravity stoner and vibratory sieve, clean out;

2) pulverize: raw material is pulverized, cross 80 mesh sieves;

3) expanded: to adopt twin-screw extruder puffing highland barley powder;

4) pulverize: the material pulverizer after expanded is pulverized, cross 100 mesh sieves, prepare puffing highland barley powder, for subsequent use;

5) one-level auxiliary material allotment: beta glucan powder, high-quality protein, micro-algae oil-bound distemper, medicinal and edible plant extract and functional natural ingredients are mixed; Prepare mixed accessories;

6) secondary auxiliary material allotment: composite vitamin and composite mineral matter are mixed, prepares secondary mixed accessories;

7) mixing, sterilizing, tinning: above-mentioned puffing highland barley powder, mixed accessories and secondary mixed accessories three-dimensional mixer are mixed, tinning after ultra-violet radiation sterilizing, joint sealing.

10. according to the preparation method of the special meals nutrient powder of the highland barley compound of claim 9 auxiliary hyperglycemic, it is characterized in that: described step 3) in, the running parameter of twin-screw extruder is screw diameter 65mm, screw speed 0-250r/min, working ability 80-120kg/h, temperature-control range 0-399 DEG C, power of motor 22kW.