CN105056295A - 一种抗炎抗菌可吸收医用缝合线及其制备方法 - Google Patents
一种抗炎抗菌可吸收医用缝合线及其制备方法 Download PDFInfo
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- CN105056295A CN105056295A CN201510496154.9A CN201510496154A CN105056295A CN 105056295 A CN105056295 A CN 105056295A CN 201510496154 A CN201510496154 A CN 201510496154A CN 105056295 A CN105056295 A CN 105056295A
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- coating
- solution
- chitosan
- inflammatory
- water
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 43
- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 41
- 238000000576 coating method Methods 0.000 claims abstract description 100
- 229920001661 Chitosan Polymers 0.000 claims abstract description 96
- 239000011248 coating agent Substances 0.000 claims abstract description 92
- 239000000835 fiber Substances 0.000 claims abstract description 31
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 25
- 102000008186 Collagen Human genes 0.000 claims abstract description 20
- 108010035532 Collagen Proteins 0.000 claims abstract description 20
- 229920001436 collagen Polymers 0.000 claims abstract description 20
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 241000252230 Ctenopharyngodon idella Species 0.000 claims abstract description 19
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims abstract description 19
- 229920002472 Starch Polymers 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 19
- 239000008107 starch Substances 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 42
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 38
- 238000010792 warming Methods 0.000 claims description 38
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims description 36
- 230000004048 modification Effects 0.000 claims description 34
- 238000012986 modification Methods 0.000 claims description 34
- 239000004626 polylactic acid Substances 0.000 claims description 26
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 25
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 21
- 239000001530 fumaric acid Substances 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 19
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 19
- 238000007037 hydroformylation reaction Methods 0.000 claims description 18
- 238000005406 washing Methods 0.000 claims description 18
- 239000004594 Masterbatch (MB) Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 239000003960 organic solvent Substances 0.000 claims description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- 239000001509 sodium citrate Substances 0.000 claims description 14
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 14
- 238000009954 braiding Methods 0.000 claims description 10
- 239000003638 chemical reducing agent Substances 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 9
- 238000001291 vacuum drying Methods 0.000 claims description 9
- 238000002844 melting Methods 0.000 claims description 8
- 230000008018 melting Effects 0.000 claims description 8
- 238000005453 pelletization Methods 0.000 claims description 8
- 230000001954 sterilising effect Effects 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 3
- 239000002253 acid Substances 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000009940 knitting Methods 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 239000002260 anti-inflammatory agent Substances 0.000 description 4
- 230000000845 anti-microbial effect Effects 0.000 description 4
- 230000001741 anti-phlogistic effect Effects 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000007334 copolymerization reaction Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000009958 sewing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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Abstract
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Claims (10)
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CN201510496154.9A CN105056295B (zh) | 2015-08-11 | 2015-08-11 | 一种抗炎抗菌可吸收医用缝合线及其制备方法 |
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CN201510496154.9A CN105056295B (zh) | 2015-08-11 | 2015-08-11 | 一种抗炎抗菌可吸收医用缝合线及其制备方法 |
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CN105056295A true CN105056295A (zh) | 2015-11-18 |
CN105056295B CN105056295B (zh) | 2018-01-05 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105999377A (zh) * | 2016-06-15 | 2016-10-12 | 湖州科达化工燃料有限公司 | 一种具有抗菌功效的医用可吸收缝合线 |
CN106039387A (zh) * | 2016-06-16 | 2016-10-26 | 湖州科达化工燃料有限公司 | 一种医用可吸收缝合线 |
CN112516372A (zh) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | 一种用于可吸收手术缝合线的复合载药纤维 |
CN113274078A (zh) * | 2021-04-07 | 2021-08-20 | 长春圣博玛生物材料有限公司 | 一种医用缝合线及其制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060287676A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use |
CN101406710A (zh) * | 2008-11-25 | 2009-04-15 | 同济大学 | 含生物活性成分的缝合线及其制备方法 |
CN102399305A (zh) * | 2011-12-20 | 2012-04-04 | 江南大学 | 一种壳聚糖富马酰衍生物及其制备方法 |
CN104368039A (zh) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | 一种医用可吸收缝合线及其制备方法 |
CN104774586A (zh) * | 2015-04-14 | 2015-07-15 | 复旦大学 | 新型液晶屏粘合剂及其使用方法 |
-
2015
- 2015-08-11 CN CN201510496154.9A patent/CN105056295B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060287676A1 (en) * | 2005-06-15 | 2006-12-21 | Rita Prajapati | Method of intra-operative coating therapeutic agents onto sutures, composite sutures and methods of use |
CN101406710A (zh) * | 2008-11-25 | 2009-04-15 | 同济大学 | 含生物活性成分的缝合线及其制备方法 |
CN102399305A (zh) * | 2011-12-20 | 2012-04-04 | 江南大学 | 一种壳聚糖富马酰衍生物及其制备方法 |
CN104368039A (zh) * | 2014-11-25 | 2015-02-25 | 苏州市贝克生物科技有限公司 | 一种医用可吸收缝合线及其制备方法 |
CN104774586A (zh) * | 2015-04-14 | 2015-07-15 | 复旦大学 | 新型液晶屏粘合剂及其使用方法 |
Non-Patent Citations (2)
Title |
---|
YONGWEI FENG等: ""Preparation, characterization and antibacterial activity of water-soluble O-fumaryl-chitosan"", 《CARBOHYDRATE POLYMERS》 * |
仲晓萍: ""聚乳酸与壳聚糖及羧甲基壳聚糖的改性研究"", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105999377A (zh) * | 2016-06-15 | 2016-10-12 | 湖州科达化工燃料有限公司 | 一种具有抗菌功效的医用可吸收缝合线 |
CN106039387A (zh) * | 2016-06-16 | 2016-10-26 | 湖州科达化工燃料有限公司 | 一种医用可吸收缝合线 |
CN112516372A (zh) * | 2020-11-12 | 2021-03-19 | 盐城工学院 | 一种用于可吸收手术缝合线的复合载药纤维 |
CN113274078A (zh) * | 2021-04-07 | 2021-08-20 | 长春圣博玛生物材料有限公司 | 一种医用缝合线及其制备方法 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to an anti-inflammatory and antibacterial absorbable medical suture and a preparation method thereof Effective date of registration: 20210112 Granted publication date: 20180105 Pledgee: Tianchang Science and Technology Financing Guarantee Co.,Ltd. Pledgor: ANHUI KANGNING MEDICAL PRODUCTS Co.,Ltd. Registration number: Y2021980000270 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220126 Granted publication date: 20180105 Pledgee: Tianchang Science and Technology Financing Guarantee Co.,Ltd. Pledgor: ANHUI KANGNING MEDICAL PRODUCTS CO.,LTD. Registration number: Y2021980000270 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: An anti-inflammatory, antibacterial, absorbable medical suture and its preparation method Effective date of registration: 20231214 Granted publication date: 20180105 Pledgee: Tianchang Science and Technology Financing Guarantee Co.,Ltd. Pledgor: ANHUI KANGNING MEDICAL PRODUCTS CO.,LTD. Registration number: Y2023980071848 |