CN105056177A - Traditional Chinese medicinal electuary for treating hebephrenic schizophrenia, and preparation method thereof - Google Patents
Traditional Chinese medicinal electuary for treating hebephrenic schizophrenia, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal electuary for treating hebephrenic schizophrenia, and a preparation method thereof. The electuary comprises, by weight, 6-8 parts of lotus leaf, 5-7 parts of orange peel, 15-30 parts of Chinese Taxillus Twig, 6-10 parts of Rhizoma Alismatis, 9-10 parts of ginger, 6-10 parts of Achyranthes bidentata, 7-9 parts of malva seed, 10-15 parts of coix seed, 4-8 parts of Callicarpa macrophylla, 6-10 parts of Agrimonia eupatoria, 4-9 parts of hawthorn fruit, 10-15 parts of Weeping Forsythia, 15-25 parts of Radix Asparagi, 20-25 parts of Clematis finetiana, 7-12 parts of Fewflower Lysionotus Herb and 10-30 parts of auxiliary materials. The electuary starts with phlegm, emphasizes qi rectifying and phlegm transforming, and greatly improves positive symptoms, negative symptoms and cognition function damage of the hebephrenic schizophrenia; and the electuary selecting the above traditional Chinese medicinal formula has good safety and low price, and also has the characteristics of convenient dissolving and administration, good mouthfeel, and easy carrying.
Description
Technical field
The present invention relates to field of pharmaceutical technology, be specifically related to one and treat schizoid instant particles as Chinese medicine and preparation method thereof.
Background technology
Schizophrenia is the disease be detrimental to health comparatively common clinically, a kind of chronic, seriousness, crippling encephalopathy, the schizoid lifetime prevalence in the whole world is 0.38%-0.84%, although prevalence is not the highest in mental sickness, but the most serious a kind of mental sickness, within 2009, show according to lancet investigation, schizophrenic's number nearly 1,000 ten thousand of China.Treatment of schizophrenia is with high costs, according to statistics, the U.S.'s schizoid treatment totle drilling cost in 2002 reaches 62,700,000,000 dollars, wherein direct cost 22,700,000,000 dollars, the loss etc. caused because looking after patient with family members of early dying young because of suicide is 32,400,000,000 dollars, and schizophrenia has high crippling, most of schizophrenic can remain some symptom all the life, due to schizoid seriousness and chronicity, very large to patient, family and social influence, consume a large amount of public resource, therefore schizophrenia brings serious burden to society and family.
The sickness rate of schizophrenia in male, women is almost identical, but male occurs comparatively early, about 15-25 year onset, women is mainly in 20-35 year onset, patient has the positive symptom such as hallucination, vain hope, autonomic movement increase, there are the negative symptomses such as flattening of affect, speech impairments, Social Withdrawal, there is Cognitive simultaneously, situation is depressed, the symptoms such as social work's functional lesion, therefore effectively the depressed affective symptom that waits for the treatment of is very important for improving, lapsing to, improve the quality of living, reduce homicide rate.
In schizoid treatment, antipsychotic drug is current most widely used therapeutic modality, present mainly western medicine, medicine as the first generation: haloperidol (haloperidol), the medicine clozapine (clozapine) of the second filial generation, risperidone (rispeoidone) etc. can alleviate many symptoms, but cure rate is very low, curative effect is bad, often there is the untoward reaction of extrapyramidal system untoward reaction and autonomic nervous dysfunction, generation body weight increases, hyperglycemia, hyperlipidemia, the sexual function exception that the hyperprolactinemia continued causes and menoxenia, even there is liver function, the side effect such as hemogram abnormity and ECG change, and needs of patients relies on medicine all the life, analyze according to Mate in recent years and show, these medicine offer limited effectiveness, cure the symptoms, not the disease, and be divided into five types due to schizophrenia: (1) intolerance style, (2) hebephrenictype, (3) catatonic type, (4) simple type, (5) undifferentiated type, the pathogenesis of every type is different, therefore research and development are badly in need of a kind of with strong points, good effect, the schizoid Chinese medicine for the treatment of that side effect is little.
Instant particles as Chinese medicine of the present invention effectively can treat hebephrenic schizophrenia, produces comprehensive function to body Mutiple Targets, multiple organ, multisystem, and cheap, with strong points, toxic and side effects is little, and electuary of the present invention has convenience of taking after mixing it with water simultaneously, mouthfeel is good, and the feature such as be easy to carry about with one.
Summary of the invention
The object of this invention is to provide a kind of instant particles as Chinese medicine for the treatment of hebephrenic schizophrenia and preparation method thereof.
The object of the invention is to be achieved through the following technical solutions:
One treats schizoid instant particles as Chinese medicine, comprises the raw material of following weight portion: Folium Nelumbinis 6-8 part, Pericarpium Citri tangerinae 5-7 part, Herba Taxilli 15-30 part, Rhizoma Alismatis 6-10 part, Rhizoma Zingiberis Recens 9-10 part, Radix Achyranthis Bidentatae 6-10 part, Semen Abutili 7-9 part, Semen Coicis 10-15 part, Folium Callicarpae Macrophyllae 4-8 part, Herba Agrimoniae 6-10 part, Fructus Crataegi 4-9 part, Fructus Forsythiae 10-15 part, Radix Asparagi 15-25 part, Caulis Clematidis Finetianae 20-25 part, Herba Lysionoti Pauciflori 7-12 part, adjuvant 10-30 part.
According to described electuary, comprise the raw material of following weight portion: 7 parts, Folium Nelumbinis, Pericarpium Citri tangerinae 6 parts, Herba Taxilli 25 parts, Rhizoma Alismatis 8 parts, 9 parts, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae 8 parts, Semen Abutili 8 parts, Semen Coicis 12 parts, Folium Callicarpae Macrophyllae 6 parts, Herba Agrimoniae 8 parts, Fructus Crataegi 6 parts, Fructus Forsythiae 12 parts, Radix Asparagi 20 parts, Caulis Clematidis Finetianae 22 parts, Herba Lysionoti Pauciflori 10 parts, adjuvant 20 parts.
According to described electuary, it is characterized in that described adjuvant comprises the raw material of following weight portion: sucrose 20-40 part, starch 10-20 part, dextrin 20-70 part.
The method of the electuary described in preparation, comprises the following steps:
1) by Folium Nelumbinis, Pericarpium Citri tangerinae, Herba Taxilli, Rhizoma Alismatis, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae, Semen Abutili, Semen Coicis, Folium Callicarpae Macrophyllae, Herba Agrimoniae, Fructus Crataegi, Fructus Forsythiae, Radix Asparagi, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori, decoct with water twice, first time add water 7 times; Second time adds water 4 times; Time is 2 hours, 1 hour respectively, merges twice decocting liquid, filters, and filtrate reduced in volume is to paste, dry, obtains extract;
2) extract of step 1 is added adjuvant mix homogeneously, sterilizing, make dissolved granule.
The characteristic had for raw material of the present invention and function are:
Folium Nelumbinis: slightly warm in nature is put down, and acrid in the mouth, enters the heart, liver, lung three warp, can rise and send out spleen sun, can treat excessive thirst, have a headache dizzy, edema, lack of appetite abdominal distention.
Pericarpium Citri tangerinae: regulate the flow of vital energy, in tune, dampness, reduces phlegm; Control distension and fullness of the chest and abdomen, anorexia, vomiting hiccup, cough with copious phlegm.
Herba Taxilli: be the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli.Nature and flavor bitter, sweet, flat, return liver, kidney channel, and merit can invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling.
Rhizoma Alismatis: clearing away damp-heat, diuretic just, the function of blood fat reducing.
Rhizoma Zingiberis Recens: Rhizoma Zingiberis Recens is hot in nature, acrid in the mouth.Return spleen, stomach, the heart, lung meridian.Effect: warming middle-JIAO, recuperating depleted YANG, warming the lung to resolve fluid-retention.The dry person of Rhizoma Zingiberis Recens, after dry, dispersing strength weakens, and the common enhancing of warming the interior, therefore partially controls interior cold, and its performance is walked and can be kept, warming lung for dispelling cold and the drink that reduces phlegm
Radix Achyranthis Bidentatae: Radix Achyranthis Bidentatae is longer than liver and kidney tonifying, there is strong waist knee joint and invigorate blood circulation, the effect of conducting blood to flow downwards.
Semen Abutili: the effect with clearing away heat-damp and promoting diuresis, detumescence.
Semen Coicis: integration of edible and medicinal herbs, property slightly sweet flavor is slightly cold, and has the effects such as inducing diuresis to remove edema, invigorating the spleen to clear away damp pathogen, arthralgia relieving by relaxing muscles and tendons, is conventional damp-clearing drug.
Folium Callicarpae Macrophyllae: have antiinflammatory, eliminate the phlegm, anticancer function.
Herba Agrimoniae: anticancer, the cooling blood for hemostasis of relieving internal heat, detumescent of healing the wounds.
Fructus Crataegi: containing multivitamin, citric acid, Crataegolic acid, malic acid etc., also containing mineral such as flavonoid, lactone, protein, calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food, promote gastric secretion and increase the functions such as gastric enzyme element, Fructus Crataegi has promotion uterine myometrium function simultaneously.
Fructus Forsythiae: heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Radix Asparagi: cure mainly fever due to yin deficiency, cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation, dysuria.
Caulis Clematidis Finetianae: Herb heat-clearing and toxic substances removing, pain relieving, invigorate blood circulation, diuresis, cure cold, cystitis, urethritis, traumatic injury impairment caused by overstrain; Flower can treating tonsillitis, pharyngolaryngitis; Again can expelling wind and removing dampness, promoting blood circulation and detoxication, dispelling the wind and dampness pathogens arthralgia, gastroenteritis, malaria, acute mastitis, ulcerative gingivitis, punctate keratitis.
Herba Lysionoti Pauciflori: lung heat clearing expectorant, cooling blood for hemostasis, damp eliminatingization is stagnant, removing obstruction in the collateral to relieve pain.Control cough due to lung-heat, spit blood, metrorrhagia and leukorrhagia, bacillary dysentery, infantile malnutrition, rheumatic arthralgia, traumatic injury.
Traditional Chinese Medicine is thought, schizophrenia is " demented ", and its etiology and pathogenesis is hindered with imbalance of YIN and YANG, seven emotions six, coagulation of QI-blood, phlegm and stagnant QI attacking upwards be for principal element, point out in Jing-Yue Complete Works: " dement, all usually without expectorant, and or with pent-up; or with unsuccessful; or to ponder over, or to feel uncertain, or with in terror; and dull-witted gradually ", the present invention treats demented, starts with, emphasize activating QI to eliminate phlegm from " expectorant ".
The Folium Nelumbinis that the present invention selects, Pericarpium Citri tangerinae, Radix Asparagi drying dampness to eliminate phlegm, regulating the stomach and sending down the abnormal ascending QI; Herba Taxilli, Rhizoma Alismatis make gas fall, and expectorant falls, removing heat-phlegm; Caulis Clematidis Finetianae relieves restlessness and prevents vomiting, and with Radix Achyranthis Bidentatae, Fructus Forsythiae, Semen Abutili phase 5, reducing phlegm and fever is taken into account, and makes the trouble of the clear then unperturbed heart of expectorant heat, helps with Folium Callicarpae Macrophyllae, Herba Agrimoniae activating QI to eliminate phlegm, makes the suitable then expectorant of gas from disappearing; Fructus Crataegi invigorating spleen to remove dampness, makes to wet and goes then expectorant not life, energy mind tranquilizing and the heart calming of holding concurrently, and Rhizoma Zingiberis Recens stomach function regulating reduces phlegm, the poison of all medicines of system of holding concurrently.
The creationary discovery of the present inventor, in the present invention, the conjunctive use of special component can play beyond thought functional effect, specifically:
Folium Nelumbinis it is generally acknowledged to have treatment excessive thirst, has a headache dizzy, edema, lack of appetite abdominal distention effect, and Pericarpium Citri tangerinae is regulated the flow of vital energy, in tune, dampness, the effect of reducing phlegm, but dampness, the effect of reducing phlegm is not obvious, and the present inventor finds by Folium Nelumbinis, Pericarpium Citri tangerinae according to special ratios compatibility, can effective drying dampness to eliminate phlegm, regulating the stomach and sending down the abnormal ascending QI.
Herba Taxilli, was mainly used in the past treat rheumatism, and do not have open source literature to record it before and have removing heat-phlegm effect, but the present inventor was found by zoopery, and Herba Taxilli and Rhizoma Alismatis, can effective removing heat-phlegm according to special ratios compatibility, Be very effective.
Folium Callicarpae Macrophyllae, Herba Agrimoniae in specific proportions compatibility synergism can activating QI to eliminate phlegm, make gas along then expectorant from disappearing.
Radix Asparagi of the present invention, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori three are according to special ratios compatibility, particularly good for hebephrenic schizophrenia patient outcome.
Above drug synergism, the metabolism of human body can be regulated, each organ dysfunction is kept to coordinate, effectively can treat schizophrenia, by carrying out serial experiment research and discussion to schizophrenia mouse Mus, and clinically with Chinese medicine of the present invention, schizophrenic to be treated, obtain satisfactory effect, therefore the present invention has sufficient theoretical foundation and clinical foundation; And Chinese medicine formula chosen by electuary of the present invention, safety is good, and have and take after mixing it with water conveniently, mouthfeel is good, and the feature such as be easy to carry about with one.
Compared with prior art, beneficial effect of the present invention is embodied in:
1) formula selected of the present invention is with strong points: be for schizophrenic feature carry out designing, selection is unique, material combination has good synergism, there is multiple efficacies, it is a kind of compound electuary, electuary of the present invention is applied widely, schizophrenia is according to " Chinese Spirit Obstacles classification and the diagnostic criteria third edition (CCMD-3) ", be divided into five types: (1) intolerance style, (2) hebephrenictype, (3) catatonic type, (4) simple type, (5) undifferentiated type; Electuary of the present invention is all effective to above five types, especially to hebephrenic schizophrenia, and more remarkable effect.
2) electuary of the present invention to the positive symptom and negative symptoms effect improved all remarkable: schizophrenic has the positive symptom, as hallucination vain hope, spontaneous activity increases; Negative symptoms: with apathy, the symptoms such as volitional behavior is shunk back and social behavior shrinks back are main; Cognitive is major obstacle simultaneously.Traditional doctor trained in Western medicine is when treatment, main improvement be the positive symptom, little to the effect report of negative symptoms, the patent of the Chinese medicine aspect announced is ignored especially and is observed the classification of these symptoms, lack effective zoopery evidence, the present invention is by MAM process mouse, manufacture the animal model of hebephrenic schizophrenia, after Drug therapy of the present invention, decreased by the spontaneous activity of spacious field laboratory observation mouse, interact to test by animal society and find that electuary of the present invention adds social behavior in animal, observed by Morris water maze laboratory, it effectively can improve the cognitive function of schizophrenia mouse models, proved by above-mentioned experiment, the schizoid positive symptom, negative symptoms, and cognitive function is obtained for very large improvement.Clinical trial confirms that electuary of the present invention is greatly improved to the Social behaviors of patient, depressive emotion, confirms its improvement to negative symptoms.
3) the invention by Radix Achyranthis Bidentatae, Fructus Forsythiae, Semen Abutili according to 8; The ratio compatibility of 12: 8, plays calmness, anticonvulsant effect; By Folium Nelumbinis, Pericarpium Citri tangerinae, Radix Asparagi according to 7: 6: 7 compatibilities, three medicines are made a concerted effort, can effective drying dampness to eliminate phlegm, regulating the stomach and sending down the abnormal ascending QI; Folium Callicarpae Macrophyllae, Herba Agrimoniae can activating QI to eliminate phlegm by 6: 8 compatibility synergism, make gas along then expectorant from disappearing.
4) Radix Asparagi of the present invention, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori according to 20: 22: 10 ratio compatibility, for the splitting of thought of hebephrenic schizophrenia, the symptoms such as emotion being happy and angry uncertainly, effectively can treat hebephrenic schizophrenia.
5) the present invention has and takes after mixing it with water conveniently, and mouthfeel is good, and the feature such as be easy to carry about with one.
6) the present invention is natural product, also has no side effect to human-body safety, avirulence.
Detailed description of the invention
Embodiment 1
One treats schizoid instant particles as Chinese medicine, comprises the raw material of following weight portion: 6 parts, Folium Nelumbinis, Pericarpium Citri tangerinae 5 parts, Herba Taxilli 15 parts, Rhizoma Alismatis 6 parts, 9 parts, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae 6 parts, Semen Abutili 7 parts, Semen Coicis 10 parts, Folium Callicarpae Macrophyllae 4 parts, Herba Agrimoniae 6 parts, Fructus Crataegi 4 parts, Fructus Forsythiae 10 parts, Radix Asparagi 15 parts, Caulis Clematidis Finetianae 20 parts, Herba Lysionoti Pauciflori 7 parts, adjuvant 10 parts.
Adjuvant of the present invention comprises the raw material of following weight portion: sucrose 20 parts, starch 10 parts, 20 parts, dextrin.
The method of the electuary described in preparation, comprises the following steps:
1) Folium Nelumbinis, Pericarpium Citri tangerinae, Herba Taxilli, Rhizoma Alismatis, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae, Semen Abutili, Semen Coicis, Folium Callicarpae Macrophyllae, Herba Agrimoniae, Fructus Crataegi, Fructus Forsythiae, Radix Asparagi, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori are decocted with water twice, first time adds water 7 times; Second time adds water 4 times; Time is 2 hours, 1 hour respectively, merges twice decocting liquid, filters, and filtrate reduced in volume is to paste, dry, obtains extract;
2) extract of step 1 is added adjuvant mix homogeneously, sterilizing, make dissolved granule.
Embodiment 2
One treats schizoid instant particles as Chinese medicine, comprises the raw material of following weight portion: 7 parts, Folium Nelumbinis, Pericarpium Citri tangerinae 6 parts, Herba Taxilli 25 parts, Rhizoma Alismatis 8 parts, 9 parts, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae 8 parts, Semen Abutili 8 parts, Semen Coicis 12 parts, Folium Callicarpae Macrophyllae 6 parts, Herba Agrimoniae 8 parts, Fructus Crataegi 6 parts, Fructus Forsythiae 12 parts, Radix Asparagi 20 parts, Caulis Clematidis Finetianae 22 parts, Herba Lysionoti Pauciflori 10 parts, adjuvant 20 parts.
Adjuvant of the present invention comprises the raw material of following weight portion: sucrose 30 parts, starch 15 parts, 50 parts, dextrin.
The method of the electuary described in preparation, comprises the following steps:
1) Folium Nelumbinis, Pericarpium Citri tangerinae, Herba Taxilli, Rhizoma Alismatis, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae, Semen Abutili, Semen Coicis, Folium Callicarpae Macrophyllae, Herba Agrimoniae, Fructus Crataegi, Fructus Forsythiae, Radix Asparagi, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori are decocted with water twice, first time adds water 7 times; Second time adds water 4 times; Time is 2 hours, 1 hour respectively, merges twice decocting liquid, filters, and filtrate reduced in volume is to paste, dry, obtains extract;
2) extract of step 1 is added adjuvant mix homogeneously, sterilizing, make dissolved granule.
Embodiment 3
One treats schizoid instant particles as Chinese medicine, comprises the raw material of following weight portion: 8 parts, Folium Nelumbinis, Pericarpium Citri tangerinae 7 parts, Herba Taxilli 30 parts, Rhizoma Alismatis 10 parts, 10 parts, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae 10 parts, Semen Abutili 9 parts, Semen Coicis 15 parts, Folium Callicarpae Macrophyllae 8 parts, Herba Agrimoniae 10 parts, Fructus Crataegi 9 parts, Fructus Forsythiae 15 parts, Radix Asparagi 25 parts, Caulis Clematidis Finetianae 22 parts, Herba Lysionoti Pauciflori 12 parts, adjuvant 30 parts.
Adjuvant of the present invention comprises the raw material of following weight portion: sucrose 40 parts, starch 20 parts, 70 parts, dextrin.
The method of the electuary described in preparation, comprises the following steps:
1) Folium Nelumbinis, Pericarpium Citri tangerinae, Herba Taxilli, Rhizoma Alismatis, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae, Semen Abutili, Semen Coicis, Folium Callicarpae Macrophyllae, Herba Agrimoniae, Fructus Crataegi, Fructus Forsythiae, Radix Asparagi, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori are decocted with water twice, first time adds water 7 times; Second time adds water 4 times; Time is 2 hours, 1 hour respectively, merges twice decocting liquid, filters, and filtrate reduced in volume is to paste, dry, obtains extract;
2) extract of step 1 is added adjuvant mix homogeneously, sterilizing, make dissolved granule.
Implementation result:
The pharmacodynamic experiment result of study of electuary of the present invention is as follows:
One, electuary of the present invention is to the research of mouse
Modeling: choose the female Mus of C57BL/6, SPF level, injection methyl azoxymethanol (MAM) in conceived 17th day of female Mus, 22mg/kg, raise after mice birth and carried out Behaviors survey by about 4 weeks, the experiment of spacious field shows, spontaneous activity in mice increases, before pulse, inhibition test (PPI) confirms that prepulse inhibition is impaired, Morris water maze laboratory finds that latency increases, show cognitive impairment, sucrose experiment simultaneously finds that it has anxiety, proves that hebephrenic schizophrenia model is successfully established.
Carry out drug test
Experimental group: the electuary drinking embodiments of the invention 2 to mice, continuous 14 days.
Matched group: drink the water containing perphenazine to mice, continuous 14 days.
Shown by the experiment of spacious field, experimental mice is compared with control group mice, spontaneous activity reduces, PPI experiment confirms that prepulse inhibition is impaired and improves, Morris water maze laboratory finds that latency declines, show that cognitive impairment is restored, the experiment of sucrose preference finds that anxiety improves, and social interaction experiment finds that its Social behaviors is restored; P < 0.01, has significant difference.
More than test and investigated respectively by the positive symptom to schizophrenia mice, negative symptoms, cognitive function, find that electuary of the present invention effectively can treat schizophrenia in above-mentioned three core symptom.
Clinical data result of the present invention is as follows:
40 routine hebephrenic schizophrenia patients, adopt randomized controlled trial, are divided into two groups, test group 20 example, man 11 example, female 9 example; Age 14-22 year, average 17 years old, matched group 20 example, man 12 example, female 8 example; Age 13-23 year, average 16 years old; In clinical trial, matched group 1 example lost to follow-up, experimental group 1 example lost to follow-up.The data such as two groups of case sexes, age, courses of disease, no significant difference (P > 0.05), has comparability,
Test group patient takes after mixing it with water instant particles as Chinese medicine of the present invention (being prepared from according to the prescription of the embodiment of the present invention 2 and technique), one day 3 times, one time 1 bag, continuous use 6 months.Meanwhile, the oral perphenazine of matched group patient, continuous use 6 months.
Criterion of therapeutical effect is drafted as follows:
Effective: symptom disappears completely or substantially, insight exists;
Effective: symptom disappears substantially, part insight exists;
Invalid: symptom has no to alleviate, and insight does not recover.
Two groups of cases all accept " mental symptom rating scale " (BPRS) scoring before treatment and after treatment; With " Syndrome Scale occurred during treatment) (TESS) carry out curative effect Comprehensive Assessment (with reference to Zhang Mingyuan " psychiatric department rating scale handbook " [M]. Beijing: People's Health Publisher, 2003:81-93,151-152,197-201.) the BPRS total score of two groups of patients and TESS efficacy evaluation compare see table 1, table 2.
A table 1 liang group BPRS total score change is compared
| Group | Case load | Score value when being admitted to hospital | Score value when leaving hospital |
| Matched group | 19 | 35.1 | 18.9 |
| Experimental group | 19 | 35.6 | 16.1 |
A table 2 liang group TESS efficacy evaluation compares [example (%)]
| Effective | Effectively | Invalid | Total effective rate | |
| Experimental group | 3 | 14 | 2 | 89.4％ |
| Matched group | 1 | 12 | 6 | 68.4％ |
Concrete case:
Case 1: river ××, man, 16 years old, occur nearly half a year nervous fidgety, murmur to oneself, behavior is inmature, it is affected to express one's feelings, grimace, auditory hallucination, have the symptoms such as serious vain hope, be diagnosed as hebephrenic schizophrenia by mental hospital, being in hospital, half a year, sb.'s illness took a favorable turn leaves hospital.At home the psychosis medicine such as long-term taking clozapine, bad during fashion, repeatedly falls ill; After take medicine of the present invention, every day 3 times, treat after 3 months, grimace, auditory hallucination, have the symptoms such as serious vain hope to go down, treat after 6 months, social behavior is recovery partly, and prepulse inhibition defect (PPI) improves; After taking medicine 1 year, drug withdrawal is observed, and cognitive competence is restored.
Case 2: appoint ××, female, 15 years old, there is talking nonsense the year before, cry and laugh by turns, without any apparent reason, thinking is odd, beyond one's depth, be on tenterhooks, do not wear the clothes, auditory hallucination, vain hope, gesticulate through conventional various gesture, the head of typewriter, eats the symptoms such as oneself nasal mucus, checks be diagnosed as hebephrenic schizophrenia to mental hospital, be in and take A Li piperazine and frustrate maintenance, but Relapse rate; After take medicine of the present invention, every day 3 times, after taking 6 months, be on tenterhooks, the symptom such as auditory hallucination, confusion of thinking improves, after taking 1 year, social activity ability is recovered, and prepulse inhibition defect (PPI) improves.
Case 3: Zhao ×, female, 17 years old, cans say the ordinary circumstance of oneself during inspection, intelligence checks normal, but it is affected to express one's feelings, think that others is persecuting her, language is absurd, is diagnosed as hebephrenic schizophrenia, take sharp nitrogen and bring treatment under control, limited efficiency, worried, sleep poor; After take medicine of the present invention, every day 3 times, after taking 6 months, the symptom such as vain hope is improved, and after taking 1 year half, social activity ability is recovered substantially.
The above; be only the present invention's preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, is anyly familiar with those skilled in the art in the technical scope that the present invention discloses; the change that can expect easily or replacement, all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (4)
1. treat an instant particles as Chinese medicine for hebephrenic schizophrenia, comprise the raw material of following weight portion: Folium Nelumbinis 6-8 part, Pericarpium Citri tangerinae 5-7 part, Herba Taxilli 15-30 part, Rhizoma Alismatis 6-10 part, Rhizoma Zingiberis Recens 9-10 part, Radix Achyranthis Bidentatae 6-10 part, Semen Abutili 7-9 part, Semen Coicis 10-15 part, Folium Callicarpae Macrophyllae 4-8 part, Herba Agrimoniae 6-10 part, Fructus Crataegi 4-9 part, Fructus Forsythiae 10-15 part, Radix Asparagi 15-25 part, Caulis Clematidis Finetianae 20-25 part, Herba Lysionoti Pauciflori 7-12 part, adjuvant 10-30 part.
2. electuary according to claim 1, comprises the raw material of following weight portion: 7 parts, Folium Nelumbinis, Pericarpium Citri tangerinae 6 parts, Herba Taxilli 25 parts, Rhizoma Alismatis 8 parts, 9 parts, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae 8 parts, Semen Abutili 8 parts, Semen Coicis 12 parts, Folium Callicarpae Macrophyllae 6 parts, Herba Agrimoniae 8 parts, Fructus Crataegi 6 parts, Fructus Forsythiae 12 parts, Radix Asparagi 20 parts, Caulis Clematidis Finetianae 22 parts, Herba Lysionoti Pauciflori 10 parts, adjuvant 20 parts.
3. electuary according to claim 1, is characterized in that described adjuvant comprises the raw material of following weight portion: sucrose 20-40 part, starch 10-20 part, dextrin 20-70 part.
4. prepare a method for the electuary described in claim 1 or 2, comprise the following steps:
1) Folium Nelumbinis, Pericarpium Citri tangerinae, Herba Taxilli, Rhizoma Alismatis, Rhizoma Zingiberis Recens, Radix Achyranthis Bidentatae, Semen Abutili, Semen Coicis, Folium Callicarpae Macrophyllae, Herba Agrimoniae, Fructus Crataegi, Fructus Forsythiae, Radix Asparagi, Caulis Clematidis Finetianae, Herba Lysionoti Pauciflori are decocted with water twice, first time adds water 7 times; Second time adds water 4 times; Time is 2 hours, 1 hour respectively, merges twice decocting liquid, filters, and filtrate reduced in volume is to paste, dry, obtains extract;
2) extract of step 1 is added adjuvant mix homogeneously, sterilizing, make dissolved granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510468950.1A CN105056177A (en) | 2015-07-29 | 2015-07-29 | Traditional Chinese medicinal electuary for treating hebephrenic schizophrenia, and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856482A (en) * | 2010-06-21 | 2010-10-13 | 苗德成 | Pure Chinese medicinal preparation for treating mental illness and preparation method thereof |
| CN102579806A (en) * | 2012-03-23 | 2012-07-18 | 田冬梅 | Drug combination for treating schizophrenia |
| CN102988789A (en) * | 2012-08-12 | 2013-03-27 | 李承平 | Tablets for regulating qi-flowing for eliminating phlegm |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856482A (en) * | 2010-06-21 | 2010-10-13 | 苗德成 | Pure Chinese medicinal preparation for treating mental illness and preparation method thereof |
| CN102579806A (en) * | 2012-03-23 | 2012-07-18 | 田冬梅 | Drug combination for treating schizophrenia |
| CN102988789A (en) * | 2012-08-12 | 2013-03-27 | 李承平 | Tablets for regulating qi-flowing for eliminating phlegm |
Non-Patent Citations (1)
| Title |
|---|
| 杜江: ""温胆汤配合针刺治疗青春型精神分裂症1例"", 《吉林中医药》 * |
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