CN105056119A - Pharmaceutical preparation for treating palpitation - Google Patents
Pharmaceutical preparation for treating palpitation Download PDFInfo
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- CN105056119A CN105056119A CN201510475646.XA CN201510475646A CN105056119A CN 105056119 A CN105056119 A CN 105056119A CN 201510475646 A CN201510475646 A CN 201510475646A CN 105056119 A CN105056119 A CN 105056119A
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Abstract
The invention belongs to the field of traditional Chinese medicine, and particularly provides a pharmaceutical preparation for treating palpitation; the pharmaceutical preparation is prepared from the following raw materials in parts by weight: 20 parts of trigonotis peduncularis, 15 parts of root of cypripedium sp., 10 parts of uncaria rhynchophylla, 10 parts of poria with hostwood, 10 parts of angelica sinensis, 10 parts of fructus schisandrae, 10 parts of radix rehmanniae, 5 parts of radix curcumae, 5 parts of radix asparagi, 5 parts of ophiopogon root, 10 parts of jujube kernel, 5 parts of polygala root, 10 parts of platycladi seed, 10 parts of salvia miltiorrhiza, and 5 parts of platycodon grandiflorum. The pharmaceutical preparation can treat palpitation.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of cardiopalmus and its preparation method and application.
Background technology
Cardiopalmus is become homeless by the heart to support or heresy disturbs the mind, and cause heart beating abnormal, conscious nervous uneasy disease of palpitating from nervousness, is more common in heart neurosis and arrhythmia.Because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of cardiopalmus safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of cardiopalmus disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of cardiopalmus, the active component contained by it is extracted by following weight crude drug and is prepared from: Herba Trigonotidis peduncularis 20 parts, yellow capsule lady's slipper 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Poria cum Radix Pini 10 parts, Radix Angelicae Sinensis 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Rehmanniae 10 parts, Radix Curcumae 5 parts, Radix Asparagi 5 parts, Radix Ophiopogonis 5 parts, Semen Ziziphi Spinosae 10 parts, Radix Polygalae 5 parts, Semen Platycladi 10 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Platycodonis 5 parts.
The described pharmaceutical preparation being used for the treatment of cardiopalmus, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of cardiopalmus, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment cardiopalmus medicine being used for the treatment of cardiopalmus.
Herba Trigonotidis peduncularis, formal name used at school: Trigonotispeduncularis is the plant that Boraginaceae Herba Trigonotidis peduncularis belongs to, and annual herb is high 5 ~ 30 centimetres; Stem is usually from base portion branch, very thin.Cochlear, ellipse or lance-shaped lobule alternate, base portion is narrow, the calm coarse wool of the equal tool in two sides.Spend and be usually born in racemose side, corolla is blue, and inflorescence top is circumvolution shape.4 pieces of tetrahedroid pyrenes.5 ~ June of florescence.Cure mainly phlegm dyspnea, order disease, cataracta etc.The present invention is with all herbal medicine.Yellow capsule lady's slipper is the orchid family Cypripedium plant yellow capsule lady's slipper CypripediumSp., is used as medicine with root.8 ~ JIUYUE is uprooted, and cleans, dries.Heart tonifying diuresis, promoting blood flow to regulate menstruation.For heart failure, menoxenia.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that primary disease is many caused by internal organs negative and positive of qi and blood virtual loss, lack of preservation of spirit, treatment works as benefiting vital QI and blood, regulating YIN and YANG, the product of fit applications tranquilizing by nourishing the heart.Also can to hold concurrently phlegm retention, blood stasis, should note reducing phlegm by drink, blood circulation promoting and blood stasis dispelling, coordinate the product of tranquillization with heavy prescription again, Herba Trigonotidis peduncularis of the present invention, yellow capsule lady's slipper blood circulation promoting and blood stasis dispelling, heart tonifying diuresis are monarch drug, Ramulus Uncariae Cum Uncis, Poria cum Radix Pini, Radix Angelicae Sinensis, Fructus Schisandrae Chinensis, Radix Rehmanniae, Radix Curcumae, Radix Asparagi, Radix Ophiopogonis, Semen Ziziphi Spinosae, Radix Polygalae, Semen Platycladi reduce phlegm by drink, blood circulation promoting and blood stasis dispelling, calm the nerves as ministerial drug, Radix Salviae Miltiorrhizae, Radix Platycodonis are adjuvant, full side's treatment cardiopalmus successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Trigonotidis peduncularis 20g, yellow capsule lady's slipper 15g, Ramulus Uncariae Cum Uncis 10g, Poria cum Radix Pini 10g, Radix Angelicae Sinensis 10g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 10g, Radix Curcumae 5g, Radix Asparagi 5g, Radix Ophiopogonis 5g, Semen Ziziphi Spinosae 10g, Radix Polygalae 5g, Semen Platycladi 10g, Radix Salviae Miltiorrhizae 10g, Radix Platycodonis 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Trigonotidis peduncularis 20g, yellow capsule lady's slipper 15g, Ramulus Uncariae Cum Uncis 10g, Poria cum Radix Pini 10g, Radix Angelicae Sinensis 10g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 10g, Radix Curcumae 5g, Radix Asparagi 5g, Radix Ophiopogonis 5g, Semen Ziziphi Spinosae 10g, Radix Polygalae 5g, Semen Platycladi 10g, Radix Salviae Miltiorrhizae 10g, Radix Platycodonis 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get Herba Trigonotidis peduncularis 20g, yellow capsule lady's slipper 15g, Ramulus Uncariae Cum Uncis 10g, Poria cum Radix Pini 10g, Radix Angelicae Sinensis 10g, Fructus Schisandrae Chinensis 10g, Radix Rehmanniae 10g, Radix Curcumae 5g, Radix Asparagi 5g, Radix Ophiopogonis 5g, Semen Ziziphi Spinosae 10g, Radix Polygalae 5g, Semen Platycladi 10g, Radix Salviae Miltiorrhizae 10g, Radix Platycodonis 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, pharmaceutical preparation treatment cardiopalmus of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation cardiopalmus 80 cases, at 37 ~ 64 years old age, men and women half and half, the shortest person of the course of disease 2 months, and most elder reaches 3 years, average 1.7 years.
4.2 diagnostic criterias:
4.2.1 conscious heartbeat is abnormal, quick or slow, or it is overweight to beat, or suddenly only neglects jumping.In paroxysmal or continue do not understand, nervous, say in mind uneasiness.
4.2.2 with discomfort uncomfortable in chest, vexed difference of sleeping, trembles weak, dizzy grade for disease.Middle-older patient, can with ambition pain, very then dyspnea with rapid and short breath, cold extremities due to sweating, or sees and faint.
4.2.3 number, short, knot, generation, the pulse condition such as slow, slow as seen.
4.2.4 often emotional stimulation is had, in terror, nervous, overstrain, the risk factor such as to drink.
4.2.5 routine blood test, erythrocyte sedimentation rate, anti-" O ", T3, T4 and electrocardiogram, the inspections such as x-ray chest radiography, measuring blood pressure, help and clarify a diagnosis.
4.2.6 syndrome-classification
4.2.6.1 timidness due to deficiency of the heart: cardiopalmus is sent out, uneasiness of palpitating from nervousness, spontaneous perspiration of breathing hard because of terrified, god is tired weak, little sleep disturbed by dreams.Light red tongue, white and thin fur, thready and stringy pulse.
4.2.6.2 deficiency of both the heart and spleen: palpitation and restlessness, insomnia forgetfulness, complexion huang (all of a sudden) is white, and dizzy weak, easy antiperspirant of breathing hard, anorexia is uncomfortable in chest.Light red tongue, white and thin fur, weak pulse.
4.2.6.3 hyperactivity of fire caused by deficiency of YIN: palpitation and uneasiness, ponder over and work with one's mind more so, in the heart dysphoria with smothery sensation, little sleep disturbed by dreams, have a dizzy spell, tinnitus, xerostomia, buccal is warmed.Red tongue, yellow and thin fur, thready pulse stringy and rapid pulse.
4.2.6.4 stagnation of heart-blood: cardiopalmus severe palpitation, pained paroxysm uncomfortable in chest, or face purple lip is dark.The purple gas of body of the tongue or have ecchymosis, thready and hesitant pulse or knot generation.
4.2.6.5 the heart attacked by pathogenic water: endlessly, asthma uncomfortable in chest, coughs and tell a large amount of foam sputum, puffiness of the face and dropsy of the feet, can not put down sleeping severe palpitation, dizzy, oliguria.Tongue is greasy or whiten in vain, stringy and rolling pulse number disease.
4.2.6.6 heart-yang is weak: cardiopalmus is dynamic is then very, sensation of oppression over the chest with shortness of breath, aversion to cold and cold limbs, dizzy, pale complexion.Light red tongue is fat, and tongue is white, and deep-thready pulse is slow or tie generation.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: cure: symptom and arrhythmia disappear, the lab testings such as electrocardiogram recover normal.Take a turn for the better: symptom alleviates or the intermittent time of showing effect extends, and lab testing is improved.Invalid: symptom and arrhythmia unchanged.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Cure | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 40 | 18 | 19 | 3 | 92.5 |
| Blank group | 40 | 2 | 1 | 37 | 7.5 |
Visible the present invention has good therapeutic effect to cardiopalmus, and toxic and side effects does not occur treatments period.
Claims (2)
1. one kind is used for the treatment of the pharmaceutical preparation of cardiopalmus, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Trigonotidis peduncularis 20 parts, yellow capsule lady's slipper 15 parts, Ramulus Uncariae Cum Uncis 10 parts, Poria cum Radix Pini 10 parts, Radix Angelicae Sinensis 10 parts, Fructus Schisandrae Chinensis 10 parts, Radix Rehmanniae 10 parts, Radix Curcumae 5 parts, Radix Asparagi 5 parts, Radix Ophiopogonis 5 parts, Semen Ziziphi Spinosae 10 parts, Radix Polygalae 5 parts, Semen Platycladi 10 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Platycodonis 5 parts.
2. be used for the treatment of the application of pharmaceutical preparation in treatment cardiopalmus medicine of cardiopalmus according to claim 1.
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| CN201510475646.XA CN105056119A (en) | 2015-08-06 | 2015-08-06 | Pharmaceutical preparation for treating palpitation |
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| CN201510475646.XA CN105056119A (en) | 2015-08-06 | 2015-08-06 | Pharmaceutical preparation for treating palpitation |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1718202A (en) * | 2004-07-10 | 2006-01-11 | 肖生红 | Prescription of Chinese herb medicine for nourishing-heart replenishing-qi, and Chinese patent drug or Chinese herb medicine drink therefrom |
| CN1903322A (en) * | 2006-08-15 | 2007-01-31 | 倪文城 | Medicine for treating myocarditis |
| CN102688447A (en) * | 2012-05-08 | 2012-09-26 | 安徽智远生物科技有限公司 | Traditional Chinese medicine for treating palpitation and cardiac pain, and preparation method thereof |
| CN103550532A (en) * | 2013-10-26 | 2014-02-05 | 荣成市科学技术情报研究所 | Traditional Chinese medicine (TCM) composition for treating palpitation |
-
2015
- 2015-08-06 CN CN201510475646.XA patent/CN105056119A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1718202A (en) * | 2004-07-10 | 2006-01-11 | 肖生红 | Prescription of Chinese herb medicine for nourishing-heart replenishing-qi, and Chinese patent drug or Chinese herb medicine drink therefrom |
| CN1903322A (en) * | 2006-08-15 | 2007-01-31 | 倪文城 | Medicine for treating myocarditis |
| CN102688447A (en) * | 2012-05-08 | 2012-09-26 | 安徽智远生物科技有限公司 | Traditional Chinese medicine for treating palpitation and cardiac pain, and preparation method thereof |
| CN103550532A (en) * | 2013-10-26 | 2014-02-05 | 荣成市科学技术情报研究所 | Traditional Chinese medicine (TCM) composition for treating palpitation |
Non-Patent Citations (1)
| Title |
|---|
| 李朝阳: "中药并针刺治愈心悸二例", 《四川中医》 * |
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Application publication date: 20151118 |