CN105031071A - Pharmaceutic preparation for treating asthenopia - Google Patents

Abstract

The invention belongs to the field of Chinese materia medica preparations and particularly provides a pharmaceutic preparation for treating asthenopia. The pharmaceutic preparation is prepared from 25 parts of soroseris erysimoides, 20 parts of dicranostigma leptopodum, 15 parts of maidenhair spleenwort, 18 parts of viola inconspicua, 10 parts of semen cassiae, 15 parts of honeysuckle, 20 parts of chrysanthemums, 25 parts of rehmannia glutinosa, 20 parts of angelica sinensis, 25 parts of codonopsis pilosula, 20 parts of semen cuscutae, 15 parts of fruits of Chinese wolfberries, 15 parts of acanthopanax roots, 15 parts of tuber fleeceflower stems, 25 parts of fruits of Chinese wolfberries, 15 parts of spina date seeds and 5 parts of liquorice. The pharmaceutic preparation is capable of treating asthenopia.

Description

One is used for the treatment of asthenopic pharmaceutical preparation

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of asthenopic pharmaceutical preparation and its preparation method and application.

Background technology

Asthenopia is the common a kind of disease of current ophthalmology, and the symptom of patient is varied, and common are near work can not be lasting, goes out to lose face and pain around eye socket, blurred vision, eyes are dry and astringent, shed tears, severe patient headache, feel sick, dizzy.It is not independently disease, but the one group of fatigue syndrome caused due to a variety of causes.Its occurrence cause is also diversified, common are: the reason of (l) eyes itself, as the ametropia such as myopia, hypermetropia, astigmatism, regulate factors, eye muscle factor, conjunctivitis, keratitis, etc.; (2) systemic factor, as neurasthenia, health overwork, hysteria or involutional women; (3) environmental factors, as illumination is not enough or excessively strong, distribution of light sources is uneven or glimpse, and the target of watching attentively is too small, meticulous or unstable.For this reason, be bursting to develop and manyly treat the needs that asthenopic medicine meets clinical treatment safely and effectively.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of asthenopia disease.In order to reach this object, adopt following technical scheme:

Technical scheme: one is used for the treatment of asthenopic pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Crepidis hookerianae 25 parts, Herba Dicranostigmatis Leptopodi 20 parts, Herba asplenii trichomanis 15 parts, Herba Violae japonicae 18 parts, Semen Cassiae 10 parts, Flos Lonicerae 15 parts, Flos Chrysanthemi 20 parts, Radix Rehmanniae 25 parts, Radix Angelicae Sinensis 20 parts, Radix Codonopsis 25 parts, Semen Cuscutae 20 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Caulis Polygoni Multiflori 15 parts, Fructus Lycii 25 parts, Semen Ziziphi Spinosae 15 parts, 5 parts, Radix Glycyrrhizae.

Describedly be used for the treatment of asthenopic pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.

Describedly be used for the treatment of asthenopic pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

Describedly be used for the treatment of the application of asthenopic pharmaceutical preparation in preparation treatment asthenopia medicine.

Herba Crepidis hookerianae, Classification system is Soroserishookeriana (C.B.Clarke) Stebb.ssp.erysimoides (Hand.-Mazz.) Stebb, Compositae, and Herba Soroseridis erysimoidis belongs to, nourishing the lung to arrest cough, regulating menstruation, hemostasis, antiinflammatory, stimulating milk secretion.For cold cough, bronchitis, agalactia, mastitis, menoxenia, redly collapses, leucorrhea, epistaxis, furuncle carbuncle.The present invention is with all herbal medicine.

Herba Dicranostigmatis Leptopodi is Papaveraceae convex combination algorithm plant Herba Dicranostigmatis Leptopodi Dicranostigmaleptopodum, is generally perennial herb, high 25-80 centimetre, all containing faint yellow juice, by pubescence, rare without hair.Main root is cylindrical.Stem is many, green, tool powder, the most contour branch of top tool.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, parasite killing.For tonsillitis, toothache, tuberculous lymphadenitis; Tinea capitis is controlled in external, tinea corporis.The present invention is with all herbal medicine.

Herba asplenii trichomanis is fern Aspleniaceae spleen wort Asplenium trchomanes L. AspleniumtrichomanesL., with all herbal medicine, and heat-clearing and toxic substances removing, regulating menstruation, hemostasis, convergence leukorrhagia stopping.For infantile hyperpyrexia, leucorrhea, menoxenia; Burn and scald is controlled in external, traumatic hemorrhage, furuncle swelling toxin, venom.

Herba Violae japonicae derives from viola inconspicua Blume V.inconspicuaBlume, with all herbal medicine.Gather herb when Xia Qiu is bloomed, dry.Meridian distribution of property and flavor: bitter, micro-pungent, cold.Heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For acute conjunctivitis, pharyngolaryngitis, acute icterohepatitis, mastitis, carbuncle furuncle and phyma poison, suppurative osteomyelitis, venom.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science is thought, asthenopia mostly is deficiency of liver-blood, the hepatic and renal YIN deficiency is done, Herba Crepidis hookerianae of the present invention, Herba Dicranostigmatis Leptopodi, Herba asplenii trichomanis, Herba Violae japonicae, Semen Cassiae, Flos Lonicerae, Fructus Lycii, Semen Ziziphi Spinosae the liver and the kidney tonifying are monarch drug, Flos Chrysanthemi, Radix Rehmanniae, Radix Angelicae Sinensis, Radix Codonopsis, Semen Cuscutae, Fructus Lycii, Radix Et Caulis Acanthopanacis Senticosi, Caulis Polygoni Multiflori liver heat removing and eyesight improving are ministerial drug, Radix Glycyrrhizae is adjuvant, full side compatibility mutually, treatment asthenopia successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Herba Crepidis hookerianae 25g, Herba Dicranostigmatis Leptopodi 20g, Herba asplenii trichomanis 15g, Herba Violae japonicae 18g, Semen Cassiae 10g, Flos Lonicerae 15g, Flos Chrysanthemi 20g, Radix Rehmanniae 25g, Radix Angelicae Sinensis 20g, Radix Codonopsis 25g, Semen Cuscutae 20g, Fructus Lycii 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Caulis Polygoni Multiflori 15g, Fructus Lycii 25g, Semen Ziziphi Spinosae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Herba Crepidis hookerianae 25g, Herba Dicranostigmatis Leptopodi 20g, Herba asplenii trichomanis 15g, Herba Violae japonicae 18g, Semen Cassiae 10g, Flos Lonicerae 15g, Flos Chrysanthemi 20g, Radix Rehmanniae 25g, Radix Angelicae Sinensis 20g, Radix Codonopsis 25g, Semen Cuscutae 20g, Fructus Lycii 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Caulis Polygoni Multiflori 15g, Fructus Lycii 25g, Semen Ziziphi Spinosae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get Herba Crepidis hookerianae 25g, Herba Dicranostigmatis Leptopodi 20g, Herba asplenii trichomanis 15g, Herba Violae japonicae 18g, Semen Cassiae 10g, Flos Lonicerae 15g, Flos Chrysanthemi 20g, Radix Rehmanniae 25g, Radix Angelicae Sinensis 20g, Radix Codonopsis 25g, Semen Cuscutae 20g, Fructus Lycii 15g, Radix Et Caulis Acanthopanacis Senticosi 15g, Caulis Polygoni Multiflori 15g, Fructus Lycii 25g, Semen Ziziphi Spinosae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment asthenopia of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation asthenopia 80 cases, 15 ~ 48 years old age.The shortest person of the course of disease 3 months, most elder reaches 2 years.

4.2 diagnostic criterias: primary symptom: being unable to see for a long time, dry and astringent scorching hot.Secondary disease: ophthalmic bloated pain, superciliary ridge distending pain, dizzy, headache.Possess primary symptom 2, secondary disease 2 or more is namely diagnosable.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: draft with reference to " clinical disease diagnosis is according to curing improvement standard " and " Chinese medical disease Standardization of diagnosis and curative effect ".Recovery from illness: adhere to that near using eyes time extends more than 1 times or reach more than 45min, eye and General Symptoms, sign obviously improve, n >=70%; Effective: to adhere to that near using eyes time extends more than 1/2 or reach more than 30min, eye and General Symptoms, sign are improved, 30%≤n < 70%; Invalid: indices does not reach effective standard, eye and General Symptoms, sign without improvement, n < 30%.Symptom total mark × 100% before therapeutic index (n)=(before treatment the rear symptom total mark of symptom total mark-treatment)/treatment

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effectively	Invalid	Total effective rate (%)
						Treatment group	40	18	15	7	82.5
Blank group	40	1	2	37	7.5

Visible, the medicine that the present invention obtains can safe and effective treatment asthenopia, and has no side effect.

Claims (4)

1. one kind is used for the treatment of asthenopic pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Crepidis hookerianae 25 parts, Herba Dicranostigmatis Leptopodi 20 parts, Herba asplenii trichomanis 15 parts, Herba Violae japonicae 18 parts, Semen Cassiae 10 parts, Flos Lonicerae 15 parts, Flos Chrysanthemi 20 parts, Radix Rehmanniae 25 parts, Radix Angelicae Sinensis 20 parts, Radix Codonopsis 25 parts, Semen Cuscutae 20 parts, Fructus Lycii 15 parts, Radix Et Caulis Acanthopanacis Senticosi 15 parts, Caulis Polygoni Multiflori 15 parts, Fructus Lycii 25 parts, Semen Ziziphi Spinosae 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of asthenopic pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of asthenopic pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of asthenopic pharmaceutical preparation in treatment asthenopia medicine according to claim 1.