CN105031042A - Medicinal composition having weight-loss function and application of medicinal composition - Google Patents
Medicinal composition having weight-loss function and application of medicinal composition Download PDFInfo
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Abstract
The invention discloses a medicinal composition having a weight-loss function and application of the medicinal composition. Active ingredients of the composition are prepared by adopting the following raw materials in part by weight: 110 to 200 parts of calcium pyruvate, 120 to 180 parts of konjac glucomannan, 56 to 187 parts of lotus leaf extract, 18 to 45 parts of tea polyphenol and 3 to 10 parts of chromium-rich yeast. According to a life cultivation and health preservation theory of the traditional Chinese medicine, the composition is processed by adopting a scientific and reasonable production process and is clear in functions, controllable in quality and safe to eat. The composition has a good weight-loss functional effect, takes effects rapidly, has a life cultivation and health preservation function and has no toxicity and side effect.
Description
Technical field
The present invention relates to technical field of medicine, be specifically related to a kind of pharmaceutical composition and the application thereof with weight losing function.
Background technology
The body weight of Healthy People is that height deducts 105, then is multiplied by 2, is standard body weight.The body weight of general obese people all exceeds standard body weight tens kilograms, and somebody also can be more more.Standard body weight is healthy symbol.Society, make rapid progress, traffic is very flourishing, and the time that people walk is fewer and feweri, takes a bus instead of walking, the amount of lacking exercise, and obese people main forces are or else disconnected to be increased, and causes unnecessary potential hazard to the civilization and progress of society.The performance of obese people is except overweight, and maximum problem is that cardiac pressure increases, and stair activity breathe heavily, sits down and enter dream perfume (or spice) soon, neurolysis soon, belong to serious sub-health state.Now, obesity becomes the chronic disease threatening the modern society of human health popular day by day.Overweight and obesity cause the important root of numerous disease, fat except affecting physical and mental health, it can cause or bring out cholelithiasis, diabetes, hyperlipemia, hypertension, cerebrovascular disorders, angina pectoris and myocardial infarction etc., also easily causes suffering from kinds cancer, cholecystitis, respiratory system disease etc. more than 30 and plants complication.Obesity is considered to a kind of chronic disease, is difficult to cure, and also develops just with surprising rapidity at present, has become the public health problem in global range.Therefore obesity is the formidable enemy of human health longevity.Medicine and the health food of exploitation treatment and prevention of obesity have very important significance.
Diet products in the market: 1. teas; 2. chemical industry synthesis; 3. Chinese medicine class.But these products all exist certain defect, mainly in product, absorbable nutrition very little, causes human nutrition seriously bad, just returns bullet after withdrawing, cause health to decline on the contrary after taking, and brings out other diseases and occurs.Compatibility is science not, people to lose weight of can not satisfying the demand.Fat reason takes in overnutrition at ordinary times, do not digest and assimilate and pile up each position of health, in the course of time fat just clearly.
In recent years, some scholars prepare Chinese medicine and carry out Weight-reducing and lipid-lowering, fat-reducing effect significant difference between so different formula, and have in the various products of weight losing function existing, have no the formula of calcium pyruvate, Konjac glucomannan, Folium Nelumbinis extract, tea polyphenols and Rich chromium yeast composition.
Summary of the invention
According to demand and the deficiency in above-mentioned field, the invention provides a kind of pharmaceutical composition with weight losing function, the present composition is theoretical according to Chinese Traditional Medicine health care, scientific and reasonable production technology is adopted to process, definite functions, quality controllable, take safety; Present composition weight losing function is effective, instant effect, health care, without any side effects.
Technical scheme of the present invention is as follows:
A kind of pharmaceutical composition with weight losing function, it is characterized in that, the active component of said composition is made up of the raw material of following weight parts: calcium pyruvate 110-200 part, Konjac glucomannan 120-180 part, Folium Nelumbinis extract 56-187 part, tea polyphenols 18-45 part, Rich chromium yeast 3-10 part.
The raw material of described weight portion refers to: calcium pyruvate 120-180 part, Konjac glucomannan 143-180 part, Folium Nelumbinis extract 56-127 part, tea polyphenols 23-45 part, Rich chromium yeast 3-8 part.
Described active component refers to calcium pyruvate, Konjac glucomannan, Folium Nelumbinis extract, tea polyphenols, Rich chromium yeast, and described compositions also comprises pharmaceutically acceptable adjuvant or complementary composition.
Described Folium Nelumbinis extract is Folium Nelumbinis water extract or Folium Nelumbinis extractive with organic solvent.
Described pharmaceutically acceptable adjuvant or complementary composition are starch, and its proportioning is 63-88 part.
The raw material of described weight portion refers to one of following:
Calcium pyruvate 110 parts, Konjac glucomannan 131 parts, Folium Nelumbinis extract 153 parts, tea polyphenols 18 parts, Rich chromium yeast 8 parts;
Calcium pyruvate 180 parts, Konjac glucomannan 120 parts, Folium Nelumbinis extract 187 parts, tea polyphenols 43 parts, Rich chromium yeast 5 parts;
Calcium pyruvate 160 parts, Konjac glucomannan 180 parts, Folium Nelumbinis extract 83 parts, tea polyphenols 37 parts, Rich chromium yeast 3 parts;
Calcium pyruvate 120 parts, Konjac glucomannan 161 parts, Folium Nelumbinis extract 56 parts, tea polyphenols 45 parts, Rich chromium yeast 7 parts;
Calcium pyruvate 200 parts, Konjac glucomannan 143 parts, Folium Nelumbinis extract 127 parts, tea polyphenols 23 parts, Rich chromium yeast 10 parts.
Comprise the chewable tablet of above-mentioned compositions, buccal tablet, oral liquid, electuary, capsule.
The application of above-mentioned compositions in the medicine of preparation fat-reducing.
A kind of method preparing diet products, it is characterized in that, adopt the raw material of following weight component to prepare the active component of described diet products in process of production: calcium pyruvate 110-200 part, Konjac glucomannan 120-180 part, Folium Nelumbinis extract 56-187 part, tea polyphenols 18-45 part, Rich chromium yeast 3-10 part.
The advantages such as prove through animal experiment, compositions provided by the present invention has good weight losing function, and the compositions having fat-reducing effect provided by the present invention, has production technology simple, easy to use, good effect, instant effect, without any side effects.
The present composition is made up of sky ingredient and foods with high dietary fiber raw material, and by reasonably combined, each component cooperatively interacts, and synergism plays reduction heat absorption, improves metabolism, promotes that fat is discharged thus plays fat-reducing effect.Tea polyphenols is based on catechin, and the hydroxyl phenolic compound be made up of multiple aldehydes matter, has oxidation resistance strong, have no side effect, free from extraneous odour.Folium Nelumbinis clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis, can be used for summer-heat excessive thirst, diarrhea due to summer heat and dampness, heat in blood tell nosebleed, metrorrhagia of having blood in stool.Konjac glucomannan is rich in tens seed amino acids of needed by human body, vitamin, complex polysaccharide and trace element, as functional food, certain curative effect is had to hypertension, obesity, diabetes, constipation, can toxin expelling vivotoxin and rubbish, the cancers such as prevention and dietetic therapy colon cancer, esophageal carcinoma.Rich chromium yeast has the advantages such as biological activity is high, toxicity is little, production cost is low.Add calcium pyruvate to contribute to improving body fat degraded.Hydroxyl phenolic compound, alkaloid, flavone, organic acid, glucomannan trace element etc. are included above in every medicine composition, and in conjunction with calcium pyruvate, complement each other in metabolic cycles in vivo, Synergistic, play effect that is nourshing Yin and drynsessmoistening prescription, lowering blood-fat and reducing weight, the immunity of patient while can not only effectively losing weight, can also be strengthened.Product of the present invention has Mutiple Targets, multipath in a word, omnibearing lowering blood-fat and reducing weight.
Health care screens:
Tea polyphenols has another name called tea tannin, tea polyphenols, is the All Pure Nature antioxidant food extracted from Folium Camelliae sinensis, and based on catechin, the hydroxyl phenolic compound be made up of multiple aldehydes matter, has oxidation resistance strong, have no side effect, the features such as free from extraneous odour.Tea polyphenols antiobesity action is mainly through suppressing body fat deposits and promoting that in body, superabundant fats decomposition realizes.Tea polyphenols can suppress the overexpression of the key enzyme fatty acid synthetase (FAS) synthesizing endogenous triacylglycerol (TG), thus suppress the effect of TG biosynthesis and proliferation function in adipose cell at protein and mRNA level in-site, show effect of weight reducing.Chan etc. find that tea polyphenols can affect the absorption of fat in meals, accelerate fatty acid and discharge in body, and the raw material caused for body synthesis TG reduces, and reduces the level of TG in serum.
Folium Nelumbinis, bitter, flat, return liver, spleen, stomach warp, function clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis, clinically tell nosebleed for summer-heat excessive thirst, diarrhea due to summer heat and dampness, heat in blood, metrorrhagia of having blood in stool, mainly contain the compositions such as alkaloid, flavone, quintessence oil, vitamin C, organic acid.In recent years research shows, Folium Nelumbinis extract has functions of lowering blood-fat and reducing weight.Results of animal shows: Folium Nelumbinis extract has obvious regulating action to high blood lipid model rat, and along with the increase of dosage, the reduction of TG content is remarkable.
Rhizoma amorphophalli (AmorophophallusKonjac) belongs to Araeceae herbaceos perennial, has long plantation history in area, Southwestern China portion and central and west regions.The main component of Rhizoma amorphophalli is glucomannan, the food of a kind of low calorie, low-protein, high dietary-fiber, and be rich in tens seed amino acids of needed by human body, vitamin, complex polysaccharide and trace element, as functional food, certain curative effect is had to hypertension, obesity, diabetes, constipation, can toxin expelling vivotoxin and rubbish, the cancers such as prevention and dietetic therapy colon cancer, esophageal carcinoma.In addition, also there is the multiple physicochemical properties such as water-soluble, thickening, stable, suspension, gel, film forming, bonding, so be a kind of natural health food be again desirable food additive.Konjak glucomannan is commonly called Konjac glucomannan, is " non-Newtonianism " fluid, as natural plant, is widely used in food, medicine, chemical industry and biological field.
Rich chromium yeast: chromium is one of micronutrient element of needed by human is the important composition composition of glucose tolerance factor (glucosetolerancefactor, GTF) in human body.Human body lacks chromium can produce glucose, fat, protein metabolism disturbance, gives rise to diseases, as atherosclerosis, diabetes, coronary heart disease, peripheral neuritis, myopia etc.; Animal lacks chromium and then shows as cholesterol or blood glucose rising, growth retardation, immunity degradation, fertility decline and the lost of life etc., after chromium supplement, and transference cure.Because multi-form chromium combination degree is in the tissue different, cause absorbance different.Inorganic chromium not only toxicity is large, and the level of absorption is extremely low, is about 0.14% ~ 3.0%; Organic chromium absorbs rapidly and safety, and absorbance can reach 10% ~ 25%.In organic chromium preparation, Rich chromium yeast has the advantages such as biological activity is high, toxicity is little, production cost is low, and the important functional component especially as prevention and therapy diabetes medicament causes people to pay attention to greatly.Meanwhile, the biological active matter confrontation organism of yeast itself also has health-care effect, by yeast, inorganic chromium is converted into organic chromium, is referred to as microorganism element carrier yeast.Therefore, the preparation of Rich chromium yeast has important using value.
Calcium pyruvate: mechanism in body: the form storing sugar in body is glycogen, acetone acid in human body is derived by glycogen, because pyruvate molecules is very little, being easy to permeate through cell membranes enters in cell, intracellular energy processing factory is entered again by osmosis---mitochondrion, meanwhile, the fatty acid oxidation burning come will be transported, for organism metabolism provides energy.Human body is when motion, and acetone acid is reduced to lactic acid, and be oxidized again when rest, in this process, acetone acid is partially converted into alanine.Calcium pyruvate is a kind of white crystalline powder, tasteless, is slightly soluble in water.Univ. of Pittsburgh medical center finds through research, and calcium pyruvate contributes to improving body fat degraded, and its fat acid decomposition rate can up to 48%.Add the level that acetone acid can increase ATP in liver, make lipid metabolism keep high level, metabolic rate is higher, consumes fat faster, and the time of acetone acid supply keeps longer, and fat-reducing effect is better.In addition, all right supplementing calcium element of calcium pyruvate, the research of Univ. of Pittsburgh shows that calcium pyruvate can also increase endurance, and does not belong to analeptic.
Combination material of the present invention, its composition proportion is as following table:
| Raw material | Weight portion |
| Calcium pyruvate | X 1＝110－200 |
| Konjac glucomannan | X 2＝120-180 |
| Folium Nelumbinis extract | X 3＝56-187 |
| Tea polyphenols | X 4＝18-45 |
| Rich chromium yeast | X 5＝3-10 |
According to experiment of the present invention, in compositions of the present invention, the content of each component can get the arbitrary numerical value in listed numerical range, specifically, the components by weight percent of calcium pyruvate can be 110, 111, 112, 112, 114, 115, 116, 117, , , , , , 200 parts, the components by weight percent of Konjac glucomannan can be 120, 121, 122, 123, 124, , , , , , 180 parts, the components by weight percent of Folium Nelumbinis extract can be 56, 57, 58, 59, 60, 61, , , , , , 187 parts, the components by weight percent of tea polyphenols can be 18, 19, 20, 21, 22, 23, , , , , , 45 parts, the components by weight percent of Rich chromium yeast can be 3, 4, 5, 6, 7, 8, 9, 10 parts.Select the compositions of these numerical value gained can realize representative formulations as several in specific embodiment part coordination potentiation in the prescription that presents between raw material.
the beneficial effect of the present composition:
There is Mutiple Targets, multipath, comprehensive lowering blood-fat and reducing weight;
Good effect, instant effect, technique is simple, have no side effect.
Detailed description of the invention
Following embodiment is provided to be to understand the present invention further better; be not limited to described preferred forms; content of the present invention and protection domain are not construed as limiting; anyone is under enlightenment of the present invention or any and the present invention the present invention being carried out combining with the feature of other prior aries and draw is identical or akin product, all drops within protection scope of the present invention.
Unreceipted specific experiment step or condition person in embodiment, can carry out according to the operation of the normal experiment step described by the document in this area or condition.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional reagent product of commercial acquisition.
Some compositionss in the present invention in the claimed scope of random choose carry out weight losing function experiment, all demonstrate good fat-reducing effect.
The experiment effect of composition capsule A, B, C, D, E wherein is now presented by following examples; It should be noted that inventor also did the weight losing function zoopery of composition capsule A, B, D, E before the applying date simultaneously, wherein composition capsule A, B, D, E, also can reach the fat-reducing effect similar to composition capsule C.
embodiment 1, for the preparation of protection gastric mucosa compositions
Table 1.5 represents compositions (weight portion) formula:
The preparation method of this example composition is as follows:
1, Folium Nelumbinis extract is prepared:
Get Folium Nelumbinis crude drug, with the water of 35 times of weight, at pH value 2.5 temperature 85 degrees Celsius, extract 2h, by extracting solution concentrate drying, obtain Folium Nelumbinis extract.
2, sieve: get Konjac glucomannan, calcium pyruvate, Folium Nelumbinis extract, tea polyphenols, Rich chromium yeast, starch in proportion, cross 20 mesh sieves respectively by vortex oscillation sieve (model ZS-650), for subsequent use.
3, mix: Konjac glucomannan, calcium pyruvate, Folium Nelumbinis extract, tea polyphenols, Rich chromium yeast, starch are poured into trough type mixing machine (CH-90 type) and mixed, mixes 20 minutes, obtain mixed powder, namely obtain compositions of the present invention.
4, fill: with capsule automatic filling machine filled capsules, specification is 0.45g/ grain, obtains composition capsule of the present invention.Operating condition requires temperature 18 DEG C-26 DEG C, relative humidity 30%-45%.The inspection of content uniformity is carried out during filling.
5, polishing: fill qualified capsule and put in capsule polisher and carry out polishing, remove surperficial medicated powder.
Sieve, mix, fill and the air purity of the production environment such as polishing requires 300,000 grades, meet GB17405-1998 requirement.
The Folium Nelumbinis extract used in the present invention can use said method to prepare, and also can buy from commercial channels and obtain.Konjac glucomannan, calcium pyruvate, tea polyphenols, Rich chromium yeast, starch all can be bought from commercial channels and obtain.
The present invention can make the form of tablet, oral liquid, electuary, capsule, substantially corresponding effect can be reached, but adopt the preparation way of capsule, effectively can prevent dampness, air or light, on the impact of the composition of medicine, keep the drug effect of internal component, are convenient to store the abnormal flavour simultaneously can covering ingredient and are convenient to take, comparatively disintegration of tablet speed is faster, and human body more easily absorbs.
the zoopery of the weight losing function of embodiment 2, product of the present invention
1. materials and methods
1.1 samples: 5 composition capsules prepared by embodiment 1 and calcium pyruvate, Folium Nelumbinis extract, tea polyphenols, Rich chromium yeast single component sample with equivalent specifications in compositions.
The healthy SPF level male SD rat 70 that 1.2 laboratory animals: select Test Animal Centre, Academy of Military Medical Sciences, P.L.A's credit number: SCXK-(army)-2012-0004 breeds.Laboratory animal credit number: SYXK (capital) 2012-003.
1.3 dosage:
Everyone (by 60Kg weighing machine) of compositions C recommended dose 3.6g every day, be equivalent to 0.06g/ day/kgBW.Experimental rat establishes 2.5 times, 5 times, 15 times of human body recommended amounts, and namely every day, 0.15g/kgBW, 0.30g/kgBW, 0.90g/kgBW were low middle high dose group; The using dosage of tea polyphenols single component experimental rat is consistent with the middle dosage group of compositions C, i.e. 5 times of human body recommended amounts (0.30g/kgBW every day); The using dosage of calcium pyruvate experimental rat presses the maximal dose 5 times that human body allows, namely every day 0.08g/kgBW; The using dosage of Folium Nelumbinis extract experimental rat presses the maximal dose 5 times that human body allows, namely every day 0.13g/kgBW; The using dosage of Rich chromium yeast experimental rat presses the maximal dose 5 times that human body allows, namely every day 0.01g/kgBW; Per os gives rat tested material once a day, and continuous gavage observed indices after 6 weeks.Rat oral gavage volume is 0.2mL/10gBW.Establish blank group (0g/kgBW) and model control group (0g/kgBW) simultaneously, replace tested material with sterilized water, every day, gavage volume was identical with each tested material group.
1.4 key instruments: T1000 electronic balance (2012003), MP1100B electronic balance (2013001), solution plane apparatus.
1.5 high heat model feed formulas: normal feedstuff 60%, Adeps Sus domestica 15%, sucrose 15%, casein 8%, calcium hydrogen phosphate 2%.
1.6 experimental procedure
After laundering period terminates, 100 rats are divided into 2 groups at random by body weight, wherein 10 rats give to maintain feedstuff as blank group, and 90 rats give high heat model feedstuff.Feed after 14 days, give the rat body weight weightening finish sequence of high heat model feedstuff, filter out 80 fat Sensitive Rats, be divided into 8 groups at random by body weight, be respectively model control group and seven dosage groups, often organize 10.
Start from experiment, model control group, each dosage group every animal give the high heat model feedstuff (feedstuff administered dose is eaten up as principle with most animals) of equivalent every day, blank group gives to maintain feedstuff in the same manner, feedstuff administered dose is identical with high heat model feedstuff, each dosage group gives the tested material of various dose, and blank group and model control group give same solvent.Experimental session record weekly every animal to appetite, surplus appetite and berley amount, weigh weekly 1 time.Give tested material to weigh after 43 days, get body fat (testis and perinephric fat pad) and weigh, calculate fat/body ratio.
1.7 observation index
Body weight, weight gain, food ration, absorption total amount of heat (food ration per kilogram feedstuff heat), body fat weight (testis and perinephric fat pad) fat/body ratio.
1.8 date processing
Use SPSS statistical software.General employing variance analysis, but need first to carry out homogeneity test of variance by the program of variance analysis, variance is neat, calculate F value, F value <F0.05, conclusion: no significant difference between each group mean: F value F0.05, P0.05, adds up with the comparative approach between two of mean between multiple experimental group and a matched group; Suitable variable transitions is carried out to the data of abnormal or heterogeneity of variance, after meeting normal state or variance and requiring together, adds up by the data after conversion; If do not reach normal state or the neat object of variance after variable transitions yet, use rank test instead and add up.
Before and after obese model is set up, the t inspection that blank group and model control group rat body weight compare employing independent sample is added up.
1.9 results judge
The body weight of dosage group or weight gain are lower than model control group, and body fat weight or fat/body ratio are lower than model control group, and difference has significance, and food ration, not significantly lower than model control group, can judge that this given the test agent animal weight losing function result of the test is positive.
2 results
2.1 tested materials are on the impact of rat body weight
Table 2. tested material is on the impact (X ± SD) of rat body weight
*: compare with model control group that there were significant differences
From table 2, give high heat model feedstuff after 14 days, blank group compares with model control group, and rat body weight significantly increases weight (P ﹤ 0.01), shows that model is successfully established.Give tested material after 43 days, 0.15g/KgBW group compares with model control group, experiment end-body representation work reduces (P ﹤ 0.05), and 0.30g/KgBW group, 0.90g/KgBW group compare with model control group, and experiment end-body representation work reduces (P ﹤ 0.01).Namely this tested material all can reduce obese model rat body weight in 0.15g/KgBW group, 1.00g/KgBW group and 3.00g/KgBW group.
Although single component tea polyphenols and Folium Nelumbinis extract comparatively model control group there were significant differences that (P ﹤ 0.05) has certain weight loss effect, but loss of weight amount and diversity are obviously worse than dosage group in C compositions, other single components and model control group no significant difference illustrate substantially without weight loss effect.
The impact that 2.2 tested materials increase weight on rat body weight
The impact (X ± SD) that table 3. tested material increases weight on rat body weight
*: compare with model control group that there were significant differences
From table 3, give tested material after 43 days, blank group compares with model control group, and rat body weight weightening finish all has significant difference (P ﹤ 0.01).Compare between 0.15g/KgBW group with model control group group, rat body weight weightening finish significantly reduces (P ﹤ 0.05); 0.30g/KgBW group, compare between 0.90g/KgBW group with model control group group, rat body weight weightening finish significantly reduces (P ﹤ 0.01).Namely this tested material all can reduce obese model rat body weight in 0.15g/KgBW, 0.30g/KgBW group and 0.90g/KgBW group and increases weight.
Single component tea polyphenols and compare between Folium Nelumbinis extract with model control group that there were significant differences (P ﹤ 0.05) and possess and necessarily reduce obese model rat body weight gaining effect, but successful is worse than dosage group in compositions C.Other single components and model control group no significant difference illustrate substantially to no effect.
All the other 4 experimental results representing compositions are substantially identical with compositions C, do not enumerate one by one at this.
2.3 tested materials are on the impact of rat body fat weight and fat/body ratio
In table 4., tested material is on the impact (X ± SD) of rat body fat weight and fat/body ratio
*: compare with model control group that there were significant differences
From table 4, give tested material after 43 days, blank is compared with model control group, and rat body fat weight and fat/body ratio have significant difference (P ﹤ 0.01).0.30g/kgBW group compares with model control group, and rat body fat weight significantly reduces (P ﹤ 0.05), and fat/body ratio significantly reduces (P ﹤ 0.05).0.90g/kgBW group compares with model control group, and rat body fat weight significantly reduces (P ﹤ 0.01), and fat/body ratio significantly reduces (P ﹤ 0.01).Namely this tested material can reduce body fat weight and the fat/body ratio of obese model rat in 0.30g/kgBW group and 0.90g/kgBW group.
Compare between single component with model control group except tea polyphenols that there were significant differences with matched group in body fat weight (P ﹤ 0.05) possesses and necessarily fall the effect of body fat, but it falls body fat successful and is worse than dosage group in compositions C, and due to body weight aspect impact no significant difference in fat/body ratio, other single components and model control group no significant difference illustrate substantially to no effect.
All the other 4 experimental results representing compositions are substantially identical with compositions C, do not enumerate one by one at this.
2.4 tested materials are on rat food ration and the impact taking in total amount of heat
In table 5., tested material is on rat food ration and the impact (X ± SD) taking in total amount of heat
*: compare with model control group that there were significant differences
From table 5, give tested material after 43 days, blank group compares with model control group, rat food ration there was no significant difference (P > 0.05), and rat takes in total amount of heat significant difference (P ﹤ 0.01).Each dosage group and single component group compare with model control group, rat food ration there are no significant difference (P > 0.05), and it is more balanced namely to test each group of food ration; Each dosage group compares with model control group, and rat takes in total amount of heat there are no significant difference (P > 0.05), namely obese model rat to take in total amount of heat more balanced.
All the other 4 experimental results representing compositions are substantially identical with compositions C, do not enumerate one by one at this.
3 brief summaries
Through high heat model forage feed after 14 days, before model control group rat gives tested material, comparing body weight with blank group increases, and has significant difference (P ﹤ 0.01).Show that model is successfully established.
Give tested material after 43 days, compare with model control group, tested material can reduce obese model rat body weight (P ﹤ 0.05) and weight gain (P ﹤ 0.01) in 0.15g/kgBW group; Tested material can reduce obese model rat body weight (P ﹤ 0.01) and weight gain (P ﹤ 0.01) in 0.30g/kgBW group, can reduce obese model rat body fat weight (P ﹤ 0.05) and fat/body ratio (P ﹤ 0.05); Tested material can reduce obese model rat body weight (P ﹤ 0.01) and weight gain (P ﹤ 0.01) in 0.90g/kgBW group, can reduce obese model rat body fat weight (P ﹤ 0.01) and fat/body ratio (P ﹤ 0.01); Each dosage group rat food ration, absorption total amount of heat compare with model control group all without significant difference (P > 0.05).
Known to the criterion of weight losing function health food in " the health food inspection and assessment technical specification " of promulgating according to State Food and Drug Administration, tested material weight losing function results of animal is positive, and described compositions has fat-reducing effect.
Can find out according to the comparing result of dosage group in the maximum dose level test group of dosage or permission in the single component comprised in compositions and compositions, in compositions, each composition has and complements each other, the effect of Synergistic thus reach better fat-reducing effect.
More than describe preferably specific embodiment of the present invention in detail.Should be appreciated that those of ordinary skill in the art just design according to the present invention can make many modifications and variations without the need to paying performing creative labour.Therefore, every those skilled in the art, all should within the determined protection domain of claims of the present invention according to design of the present invention available technical scheme of experiment by logical analysis, reasoning or limited number of time on the basis of prior art.
Claims (10)
1. one kind has the pharmaceutical composition of weight losing function, it is characterized in that, the active component of said composition is made up of the raw material of following weight parts: calcium pyruvate 110-200 part, Konjac glucomannan 120-180 part, Folium Nelumbinis extract 56-187 part, tea polyphenols 18-45 part, Rich chromium yeast 3-10 part.
2. compositions according to claim 1, is characterized in that, the raw material of described weight portion refers to: calcium pyruvate 120-180 part, Konjac glucomannan 143-180 part, Folium Nelumbinis extract 56-127 part, tea polyphenols 23-45 part, Rich chromium yeast 3-8 part.
3. compositions according to claim 1 and 2, is characterized in that, described active component refers to calcium pyruvate, Konjac glucomannan, Folium Nelumbinis extract, tea polyphenols, Rich chromium yeast, and described compositions also comprises pharmaceutically acceptable adjuvant or complementary composition.
4. compositions according to claim 3, is characterized in that, described Folium Nelumbinis extract is Folium Nelumbinis water extract or Folium Nelumbinis extractive with organic solvent.
5. compositions according to claim 4, is characterized in that, described pharmaceutically acceptable adjuvant or complementary composition are starch, and its proportioning is 63-88 part.
6. compositions according to claim 1, is characterized in that, the raw material of described weight portion refers to one of following:
Calcium pyruvate 110 parts, Konjac glucomannan 131 parts, Folium Nelumbinis extract 153 parts, tea polyphenols 18 parts, Rich chromium yeast 8 parts;
Calcium pyruvate 180 parts, Konjac glucomannan 120 parts, Folium Nelumbinis extract 187 parts, tea polyphenols 43 parts, Rich chromium yeast 5 parts;
Calcium pyruvate 160 parts, Konjac glucomannan 180 parts, Folium Nelumbinis extract 83 parts, tea polyphenols 37 parts, Rich chromium yeast 3 parts;
Calcium pyruvate 120 parts, Konjac glucomannan 161 parts, Folium Nelumbinis extract 56 parts, tea polyphenols 45 parts, Rich chromium yeast 7 parts;
Calcium pyruvate 200 parts, Konjac glucomannan 143 parts, Folium Nelumbinis extract 127 parts, tea polyphenols 23 parts, Rich chromium yeast 10 parts.
7. comprise chewable tablet, buccal tablet, oral liquid, electuary, the capsule of the arbitrary described compositions of claim 1,2,4,5,6.
8. comprise the chewable tablet of compositions according to claim 3, buccal tablet, oral liquid, electuary, capsule.
9. the application of the arbitrary described compositions of claim 1-6 in the medicine of preparation fat-reducing.
10. prepare the method for diet products for one kind, it is characterized in that, adopt the raw material of following weight component to prepare the active component of described diet products in process of production: calcium pyruvate 110-200 part, Konjac glucomannan 120-180 part, Folium Nelumbinis extract 56-187 part, tea polyphenols 18-45 part, Rich chromium yeast 3-10 part.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510361119.6A CN105031042A (en) | 2015-06-26 | 2015-06-26 | Medicinal composition having weight-loss function and application of medicinal composition |
Applications Claiming Priority (1)
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107080251A (en) * | 2017-04-10 | 2017-08-22 | 新乡医学院 | A kind of green tea polyphenols composition with weight losing function and preparation method thereof |
| CN107981351A (en) * | 2017-12-19 | 2018-05-04 | 张开良 | A kind of meals microcapsule granule for adjusting body fat rate and preparation method thereof |
| CN108478678A (en) * | 2018-05-21 | 2018-09-04 | 路培育 | A kind of pharmaceutical composition of Weight-reducing health |
| CN109275823A (en) * | 2018-10-16 | 2019-01-29 | 山东柳竖脂商贸有限公司 | A kind of weight losing meal-replacing solid beverage and preparation method thereof |
| CN110037310A (en) * | 2019-04-04 | 2019-07-23 | 湖北人缘堂医药生物工程有限公司 | A kind of slimming capsule and preparation method |
| CN110464010A (en) * | 2019-08-14 | 2019-11-19 | 中国农业大学 | A kind of weight-reducing cereal meal replacement powder |
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| CN102205011A (en) * | 2011-05-25 | 2011-10-05 | 遵义陆圣康源科技开发有限责任公司 | Medicinal composition with weight loss function |
| CN103816278A (en) * | 2014-01-20 | 2014-05-28 | 天津铸源健康科技集团有限公司 | Composition for reducing blood sugar and application thereof |
| CN104397697A (en) * | 2014-12-02 | 2015-03-11 | 张满锦 | Weight-losing guarana oral liquid |
| CN104664406A (en) * | 2015-03-03 | 2015-06-03 | 深圳市妍倩科技有限公司 | Safe and healthy food with weight losing function |
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| CN103816278A (en) * | 2014-01-20 | 2014-05-28 | 天津铸源健康科技集团有限公司 | Composition for reducing blood sugar and application thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107080251A (en) * | 2017-04-10 | 2017-08-22 | 新乡医学院 | A kind of green tea polyphenols composition with weight losing function and preparation method thereof |
| CN107981351A (en) * | 2017-12-19 | 2018-05-04 | 张开良 | A kind of meals microcapsule granule for adjusting body fat rate and preparation method thereof |
| CN108478678A (en) * | 2018-05-21 | 2018-09-04 | 路培育 | A kind of pharmaceutical composition of Weight-reducing health |
| CN109275823A (en) * | 2018-10-16 | 2019-01-29 | 山东柳竖脂商贸有限公司 | A kind of weight losing meal-replacing solid beverage and preparation method thereof |
| CN110037310A (en) * | 2019-04-04 | 2019-07-23 | 湖北人缘堂医药生物工程有限公司 | A kind of slimming capsule and preparation method |
| CN110464010A (en) * | 2019-08-14 | 2019-11-19 | 中国农业大学 | A kind of weight-reducing cereal meal replacement powder |
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